Method for treating acne at the background of urogenital infection and vaginal dysbiosis

FIELD: medicine, cosmetology.

SUBSTANCE: one should carry out therapy including 3 stages, moreover, at the first 1-2-mo-long stage one should interrupt acute acne process and treatment of urogenital infection due to applying sanitation and antibacterial skin protection, at the second 3-5-mo-long stage it is necessary to conduct hygienic care for patient's skin by applying methods of ultrasound and chemical peeling to remove neoplasms caused by human papilloma virus, remove nevuses in operational area, perform treatment of keloid cicatrices to remove vaginal dysbiosis and urogenital diseases, at the third stage one should fulfill mechanic dermabrasion followed by post-operational 1-2-mo-long care, moreover, as antibacterial preparations during sanitation one should apply butol, after sanitation - butol and baneocin, and after epithelization of acne foci and vaginal epithelium - butol and butolol applied in pre-menstrual period not combining the use of the preparations mentioned with treating surface with alcohol- and metal-containing solutions. The present innovation provides decreased number of relapses due to interrupting inflammatory processes and normalizing diybiosis.

EFFECT: higher efficiency of therapy.

1 ex, 1 tbl


The invention relates to medicine, namely to cosmetology. Acne is a chronic polymorphic multifactorial disease of the hair follicle and sebaceous glands. The disease affects about 80% of persons aged 12 to 25 years and approximately 30-40% of people older than 25 years (Adaskevich. VP of Acne and rosacea. - SPb, 2000). The disease development is clearly contributes to increasing the pH of the skin in an alkaline environment and the reduction of the immunological status, which leads to a decrease in bactericidal properties of sebum and to a sharp increase in growth and reproduction of representatives of saprophytic and pathogenic microorganisms (P.Acnes, Staphylococcus epidermidis, S.aureus, Pityrosporum ovale). In a further development of the disease is accompanied by the annoying property of the modified composition of sebum, therefore, appear inflamed damaged scaly patches and plaques (seborrheic dermatitis), and violated the outflows of fat, forming microcity, when the gap which occurs local immune response.

When mixed bacterial skin lesions, mainly Staphylococcus, there is a pronounced activation of cellular immunity against the background of the failure of humoral. This is reflected in the increasing levels of immunoregulatory index (IRI=2,9 at the rate of 1.8), NK and marker of Mature T-lymphocytes (CD3), the change in the ratio of CD4 to CD8 due to the increase in T-helper cells (marker CD4), the decrease in IgA, IgM and QI is (E.I. Volkov, Butov US Some aspects of the immunopathogenesis of staphylococcal skin lesions // Mat. 1 Ross. Congress of Dermatovenereology, St. Petersburg, 23-26 September 2003, vol. 1 - Dermatology. - P.26-26). Against this background, in patients with different forms of acne is observed immune imbalance in violation of the interaction of T-helpers and T-suppressors with the decline of the immunoregulatory index, indicators of functional activity of neutrophils in HCT-tests and factor activation, with an increase in the percentage of circulating immune complexes and significant increase in back titles to pathogenic microorganisms (Povalyukhina A.S. System actinotherapy in the treatment of various forms of acne // Sat. Dokl. Scientific and practical use. proc. "The beauty Institute 70 years" - M: Cosmetics and medicine, 2002. - S-177). When persistent, severe and recurrent forms of acne are observed associated internal diseases that increase the severity of the disease due to the General decline of the immune status. The frequency of observations of various comorbidities different authors, because not based etiological factors in the research process. The most pronounced factor in the development of acne is the presence of pathology of the genitourinary system or urogenital infections observed in 40-60% of patients (Polonskaya N. Acne: the classification is acacia, pathogenesis, treatment // Cosmetics and medicine, 2000. No. 4. - P.77-83.).

Inflammatory diseases of the genital and urinary organs, etiologic agents which are pathogenic and conditionally pathogenic microorganisms, represent the most frequent cause of the dramatic decline in physiological and/or immune status of the organism. Reducing the level of Contracting STIs and prevention of inflammatory diseases of the pelvic organs with long-term results, including persistent and severe forms of acne, promotes early detection and efficient treatment. Treatment of severe forms of acne attach other infectious agents in the body is one of the most difficult tasks dermatologists.

It is often detected urogenital infections include chlamydia (40-45%), genital herpes (40-43%), mycoplasmosis (30-35%), anaplasmosis (30-33%), cytomegalovirus (28-31%), gardnerelly (25-27%). The most frequent combinations exactly chlamydia with other infections: cytomegalovirus (15%), Mycoplasma (11,2%), Ureaplasma (10%), herpes (8,7%), Candida (7.5 percent). Other combinations are less significant in terms of frequency, for example, Gardnerella - Ureaplasma - 7,5% (Sejdualieva BS, Basin N.E., Shakirov YEAR, urinary tract Infections, detected by the method of gene diagnostics // Mat. scientific and practical use. proc."The technology of gene diagnostics in practical health is wound and international. proc. "Genomics, proteomics and bioinformatics for medicine", M, 20-21 June 2002. - M.: state of NIBH Russian Academy of medical Sciences, 2002. - S.226-228.).

Especially protracted and acute manifestations of pathological processes have the Association of microorganisms, bacterial and/or viral agents (Herpes Simplex, Chlamydia trachomatis, Trichomonas vaginalis, Gardnerella vaginalis, Candida, Candida albicans and others). They create a background in which there is a strong deficit of secondary immunodeficiency, reduce anti-infective resistance, persistent and severe forms of acne. Pathogens of STDs affect people during the period of greatest sexual activity (18-28 years). In the same period, we observed the presence of severe forms of acne. For each pathogen STD characteristic long carriage, the persistent lack of immunity, frequent complications and exacerbations of chronic latent current of diseases of the digestive tract, eyes, joints and other diseases, long-term treatable (N.N. Kuznetsova. The value of genetic diagnostics in the treatment of syndromes of sexually transmitted diseases / Kuznetsov, N.N., Tymoshchuk GI, Tymoshchuk O.A., Khomenko, NP, Lungov V.L., Evgenov O.V. // Mat. scientific and practical use. proc."The technology of gene diagnostics in practical health and mezhdunarodnogo. "Genomics, proteomics and bioinformatics for medicine", M, 20-21 June 2002. - M.: state of NIBH Russian Academy of medical Sciences, 2002. - S-178.). With complex and serious the smaller forms of acne, we see a similar clinical picture.

Bacterial vaginosis (BV) or bacterial vaginosis results from the sudden imbalance of microflora due to excessive growth of anaerobes. BV is characterized by the presence of microorganisms Gardnerella vaginalis, Mobiluncus spp. and insufficient numbers of lactobacilli without evidence of violations of the subepithelial tissue of the vaginal wall (Dmitriev GA Laboratory diagnosis of bacterial infections. - M: Honey. the book, N.Novgorod: C, 2003. - 336 S.). Development BV contributes to the pH of the vaginal flora in alkaline medium (normal pH of 4.1±0,4; BV pH>4,5) with long-term use of contraceptives or drugs. BV is accompanied by severe disturbances in the system of local immunity, which is manifested by a decrease in the concentration of IgA, IgG and increasing concentration of IgM in the content of the vagina with the development background of oppression local antimicrobial protection and dysbiosis with excessively high concentration of obligatory and facultative anaerobic conditionally pathogenic microorganisms with a sharp decline (to lack) of lactic acid bacteria (Kira E.F. Bacterial vaginosis (clinic, diagnostics, treatment) // abstract. Diss. MD - St Petersburg, 1995. - 44 S.; A.S. Ankara Bacterial vaginosis: criteria pathology, diagnosis and treatment // Ross. medj., 1997. No. 4. - P.24-28.).

The reason for the formation of the most severe forms of acne Bo is esni (conglobata and abstemiously, the highest degrees of the scale cook) is the presence of microbial associations (type aerobe + gone anaerobic) with a high degree of contamination of lesions (Springis L.G., Rusak WE, Acteva G.M. Microbial Association is the possible cause of complicated forms of acne // Mat. VIII all-Russian Congress of Dermatovenereology, part 1, Dermatology. - M., 2001. - S.). This situation indicates a clear lack of chemotherapeutic treatment effectiveness and associated with polymicrobial infectious inflammation. The use of traditional antibiotics in this case does not give the same result, because they are focused on selective interaction mainly with only some of the biochemical structures of the germ (Buchin P.I. Current issues in Microbiology anaerobic clostridial infection // proceedings of the scientific session, Kuibyshev, cgmi, 1989. - Ñ.38-40). Therefore, when acne is so important the choice of antimicrobial agent containing several chemically and physically compatible antiseptics that can, in combination enhance the activity and to broaden the spectrum of antimicrobial action.

The current General scheme of treatment that can be adopted for the first prototype has the following stages:

1. Deep cleansing of the skin with a gradual removal of comedones and surface contamination;

2. Antibacte the territorial therapy;

3. Elimination of dysbiosis, deficiency of vitamins and minerals;

4. Suppression of foci of chronic infection and parallel treatment of major chronic diseases relevant experts; and in severe social maladjustment patient treatment by neuropsychiatrist;

5. In severe cases use retinoids.

If necessary, designate re-4-6-month course of treatment.

The disadvantage of this prototype is that the treatment using these modern methods is long and consists of several courses (one course of treatment for at least 6 months), and without the treatment of painful lesions persist for decades (Glubokov IS the Status of the traditional way of acne treatment // J. struct. Dokl. 3 National Congress of aesthetic medicine, M., 5-7 September 2003. Journal of Aesthetic Medicine, 2003. No. 3, Volume 2. - S-209.).

The following prototype is accepted by the patent RF №2221570 from 07.05.2002, (Glubokov IB Way to treat acne). The positive qualities of the prototype is that while treatment of these diseases on the 1st stage is marked efficacy of therapy, especially when taking into account etiopathogenetic factors. The disadvantage of this prototype is concluded that despite the inclusion of traditional methods of suppressing or treating the main chronic the ski diseases relevant experts, these 4 Palma scheme acne treatment, in the presence of urogenital infections or BV imply prolonged use of antibiotics, which suppresses the immune system and develops a dysbacteriosis, therefore, is a factor in maintaining chronic acne (Glubokov IN Pathogenesis and treatment of acne: an analytical review // Issues of cosmetology, - 2003. No. 1. - 42 S.). Thus, preventive procedures within 1-2 months may be insufficient for the normalization of immune status in the presence of urogenital infections (Dmitriev GA Laboratory diagnosis of bacterial infections. - M: Honey. the book, N.Novgorod: C, 2003. - 336 S.). Additionally, there is no complexity techniques on the 2nd and especially the 3rd stages of treatment, when the operation is the short-term (within 1-3 weeks of the postoperative period) reduction of secondary immunodeficiency (Orlov E.V., Glubokov IB Methods of dermabrasion and peels: textbook. - Samara: Samara state medical University, 2003. - 24 C.), which may lead to the outbreak of the nidus of chronic urogenital infections, and as a consequence - to the recurrence of acne.

The third prototype adopted one of the most effective ways to prevent infectious complications after surgery, dermabrasion - (RF patent No. 2210369 from 28.05.2001, Glubokov IB, Thick is AV, Fayzullin NI Method of prevention of infectious complications in the operation of mechanical dermabrasion using antiseptic; Glubokov IN Prevention and treatment of local infectious complications after mechanical dermabrasion // abstract. Diss. CMN): clique, 2002. - 16 C.) and the treatment of sexually transmitted diseases in women, in particular urogenital polimorfnih infections (Tolstov V., Osipova, L.V., L.A. Borisov results of the application of Butola in the complex treatment of women suffering from sexually transmitted diseases // abstracts of the reports. 2 scientific-practical use. proc. "Modern technologies of diagnostics and treatment of the wounded and sick in the clinic and hospital), May 20, 1999): MVD MBO of the Russian Federation, 1999. - P.76-77.). United they are in the 3-m prototype that use the same antibacterial agent BOTOL (product received Tolstov AV Combo chemotherapeutic agent BUTAL for local treatment of wound infections and inflammatory diseases" - patent of RF №2115418 from 23.01.1998 year). The authors emphasized the effectiveness of the drug in the initial stages of treatment. The disadvantage of the prototype is that after epithelization (1 phase of healing) components Butola already not able to overcome the skin barrier, so can't provide an antimicrobial effect in the dermis. This disadvantage is significant in the presence of the vaginal infecti is, which may be located between layers of the epithelium (Dmitriev GA Laboratory diagnosis of bacterial infections. - M: Honey. the book, N.Novgorod: C, 2003. - 336 S.). In accordance with the physiological cycle of cell renewal underlying layers are moved outwards, which leads to increasing contamination of the mucous membrane. It is therefore prolonged courses of antibacterial protection, developing BV, but without them there are relapses and attach a secondary infection that significantly complicates further treatment.

Given the large values of the performance indicators previously stated method (2nd prototype), it is advisable to include it in a new way, and to overcome the above disadvantages of the use of new antibacterial agents BUTANOL used in the form of ointment (Tolstov AV Combo chemotherapeutic agent for the treatment of septic wounds, local wound infection and inflammatory diseases" - patent # 2197968 from 5.11.2001 year). However, previously, this tool was not used in the treatment of acne, the more complex forms. Taking into account the fact that the disease of urogenital infection occurs in women in 2 times more often than men, applicable description of the proposed method for the treatment of acne complex shapes in women. For men this with the persons includes similar methods of application of the antibacterial agents, as well as traditional methods of treating urogenital infections.

The essence of the proposed method lies in the fact that the treatment of complicated forms of acne with attached background urogenital infections has 3 stages. The assessment of acne treatment is conducted at each stage (monthly) on a scale of cook and system SCORAD (Glubokov IS Dominant aspects curing defined by the SCORAD index // Review of applied and industrial mathematics, 2002. - Vol.10, issue 2. - S-632), and the treatment of urogenital infections on diagnostic methods in accordance with the recommendations of the health Ministry. It does not combine with Butola, Baneuoqin and Bucolome treatment skin alcohol - and metal-containing solutions.

stage 1 continuation of 1-2 months is used to relieve acute process of acne and treatment of urogenital infections and includes deep derma-cosmetic rehabilitation of acne lesions on the face and body, elimination of intestinal dysbiosis and deficiencies of vitamins A, B1B6B12C, zinc concurrent diagnostics, prevention and term therapies for chronic diseases, as well as the methods previously stated method for the treatment of acne (RF patent No. 2221570 from 07.05.2002,) and method of treatment of urogenital diseases antibacterial agent BUTAL, but characterized in that after healing (epit the implementation) acne lesions and epithelial vaginal use ointment BUTANOL.

stage 2 continuation of 3-5 months serves to maintain a low level of current acne and correction of the immune status of the patient preparation for 3 phase and includes traditional beauty treatments and skin care; including removal of skin growths caused by the human papilloma virus, removal of nevi in the operating area, the treatment of keloid scars, eliminate vaginal dysbiosis and prevention someoneorother validation provocations, characterized in that in the prevention of acne, urogenital infections and vaginal dysbiosis in premenstruation period of use ointment BUTANOL.

stage 3 is used to correct skin defects and radical changes in the architectonics of skin capillaries and includes mechanical dermabrasion with postoperative care within 1-2 months earlier reported methods (patent RF №2210369 from 28.05.2001, the application for the invention, the priority memo No. 2002114876/14(015600) from 05.06.2002 g), characterized in that prevention, as infectious complications of acne after the end of the postoperative period, and urogenital infections and vaginal dysbiosis, especially in premenstruation period, carried out with the use of ointments BUTANOL.

The method is as follows.

At stage 1 a continuation of 1-2 months spend opertion is kind of dermatology and cosmetology sanitation lesions of acne - it is a complex medical procedure with the use of invasive methods derma-cosmetic cleansing of the sebaceous duct with the opening, mechanical extraction, exfoliative, expression and electrocoagulation purulent acne items, infiltrates, open, closed comedones, atheroma, Miliukov, cysts, empiem, granulomas, which combined with peels, methods, hardware and manual therapy of mandatory compliance with the principles of surgical sanitation and antibiotic protection skin Butola and Baneuoqin. When complicated forms of acne sanitation is carried out only by doctors dermatology (dermatologist specializing in cosmetology)with work experience not less than 5 years of age and eligibility category is not less than 1 (in this specialty). The elimination of intestinal dysbiosis and deficiencies of vitamins A, B1B6B12C, zinc with parallel treatment of major chronic diseases in patients spend on the recommendations of experts for suppressing chronic infection. As antiseptic use combined drug BUTAL for skin treatment before the rehabilitation procedures, the skin in the form of applications of gauze swabs soaked in 10-15 ml of solution Butola, during the rehabilitation procedures in the form of wetting of the treated surface, PEFC is the completion of rehabilitation of the skin in the form of applications of gauze napkins, impregnated 10-15 ml solution Butola, and then 2-3 times a day the patient makes the applications themselves within 15-25 days. In complicated form of acne or secondary infection alternate application of Butola with Baneuoqin. This BANEUOQIN used in the form of powders on the surface of the skin peeled from papulo-pustular elements and inflammatory infiltrates. After the procedure, and after each further application of Butola or Baneuoqin, increase their infra-red radiation within 5-7 minutes. After applying antiseptic drug use ultrasonography and IPV. After healing acne lesions apply ointment BUTANOL. In women, the treatment begins 5-7 days after the end of the menstrual cycle. In patients with known urogenital infection in parallel for suppressing chronic infection treatment in accordance with the recommendations of the Russian Ministry of health according to the following scheme: in the first 5-7 days every day twice a day patient self sprintout vagina by Butola and plugging, leaving the vagina soaked Butola tampon 12 hours; and then over the next days until the onset of the menstrual cycle every day, 2 times a day impose ointment BUTANOL. At the time of the menstrual cycle treatment is interrupted. Diagnosis and evaluation izlesene the tee is conducted according to the methodical recommendations of the Ministry of health of Russia.

In phase 2 continuation 3-5 months performing the traditional treatments for skin of the patient. Using methods of ultrasonic peeling, monotherapie, cryotherapy, ultrasonography, IPV (short-term low-level radiation). For the preventive treatment of acne conducted the autopsy granulomas and cysts with rehabilitation centers. Use the antiseptic BUTAL and BANEUOQIN, and after epithelization foci - ointment BUTANOL. Check for outbreaks of acne. To do this, use different methods of provocation. Upon detection acne spend additional treatment similar to stage 1. Regardless of the presence of acne outbreaks preventive treatment of acne with the use of ointments BUTANOL menstrual syndrome, severe stress. After elimination of the inflammatory process, defined on the smooth skin color, not different from normal, remove benign skin growths caused by the human papilloma virus. Nevi located in the operating area, remove doctors dermatologists specializing in Oncology or surgeons oncologists with the obligatory subsequent histological examination. If you suspect melanomamelanoma nevus resection performed only by a surgeon oncologist. Parallel to the doctors dermatologists treat keloid scars profilaktika someoneorother validation provocations, and also recommend eliminating vaginal vaginal dysbiosis dysbiosis in premenstruation period ointment BUTANOL. At the final stage of this phase, conduct psychological preparation of the patient for surgery. But if there is a high risk melanomamelanoma nevus and contraindications to mechanical dermabrasion stage 3 do not hold.

At stage 3 carry out mechanical dermabrasion with postoperative care within 1-2 months earlier reported methods (Glubokov IB, Tolstov AV, Faizullin NI RF patent №2210369 from 28.05.2001, and Glubokov IB Claim to the invention of the Russian Federation. Priority reference No. 2002114876/14(015600) from 05.06.2002 year). After the end of the postoperative period (spontaneous removal of the peel - healing of the epidermis) continue the prevention of acne and vaginal dysbiosis using ointments BUTANOL (for women before the onset of the menstrual cycle, men - for 10-15 days).

This assessment acne treatment at all stages of the treatment under generally accepted in the world practice the SCORAD system (Glubokov IS Dominant aspects curing defined by the SCORAD index // Review of applied and industrial mathematics, 2002. - Vol.10, issue 2. - S-632) and the scale cook, determining the severity of acne on 8-point scale. Procedures performed by the doctors dermatologists with qualificat the Onna category not lower than 1 in outpatient specialized cosmetic surgeries and on the recommendations and prescriptions of the doctor patient performs some procedures in the home. It does not combine with Butola, Baneuoqin and Butollo treatment skin alcohol - and metal-containing solutions.

Effective acne treatment is shown in the following example. Patient A., Jr, 35 years. 3.03.2002, he complained of pain, redness and swelling of acne-like rashes, and severe psychological discomfort from the disease. When viewed objectively: on both cheeks, chin, perioral, nasal and frontal areas multiple infected and single conglobata and cystic purulent elements, blackheads, newly formed and well-formed normotrophic scars from acne, increased the intensity of the erythema of the entire skin of the face, body temperature 36,6°, papillomatosis multiple lesions at the base of the neck, 2 nevus on the cheeks is not affected by inflammatory acne items. Because of the swelling of the skin granulomas are not diagnosed. When revision inflamed elements found scant detachable gel-like character. On a scale cook the severity of acne, the patient is equal to 7 (very much). According to PCR and ELISA defined diagnosis: vaginal chlamydia.

Internal organs without pathologies, all the indicators are normal. Appointed: a parallel treatment of acne and chlamydia on the proposed method. Produced 5 complex procedures (1 time) - Rev.), includes: deep dermatology and cosmetology sanitation lesions of acne with the use of invasive methods derma-cosmetic cleansing of the sebaceous duct with the opening, mechanical extraction, exfoliative, expression and electrocoagulation purulent acne items, infiltrates, open, closed comedones, cysts, empiem with antimicrobial product protection skin Butola and Baneuoqin. After healing acne lesions applied the ointment BUTANOL. Treatment of vaginal chlamydia started on the 7th day after the end of the menstrual cycle (which coincided with the 3rd complex procedure) and was performed as previously described until the onset of the menstrual cycle. On the 2nd month of treatment produced a diagnostic PCR tests (chlamydia is not detected) and evaluation of the treatment of acne by the SCORAD index and scale cook (severity = 3 - low), which identified the positive dynamics of the disease. Examination: the single-comedogenic and purulent acne elements, the intensity of moderate erythema, oedema of the skin is preserved in the deep places of the skin lesions. Assigned to the following treatment according to the above scheme 5 complex procedures. In the premenstrual period, there was prevention of chlamydia. On the 3rd month of treatment during the inspection: the intensity of erythema and weak swelling was observed only in the deep skin lesions in which palpation detected granuloma, the severity of the disease on a scale cook is 2 - low; PCR tests chlamydia is not detected, vaginal dysbiosis diagnosis is not confirmed, i.e. all 3 symptoms was not found. Assigned courses of treatment phase 2: electrocoagulation papillomatosis elements, removal of nevi, opening granulomas with readjustment foci of inflammation, weekly during premenstrual periods procedures to prevent acne (chemical and ultrasonic peeling, applications with Butola and ointment BUTANOL) and chlamydia (plugging ointment BUTANOL). On the 5th month of treatment during the inspection: color of skin is normal microtemp no; severity of illness cook on a scale of 0 (absent); found spots of hyperpigmentation in areas of former deep skin lesions; lesions former granulomas artificial encapsulation when sanitizing, including and after electrocoagulation nevi and papillomas did not lead to the appearance of keloid and normoandrogenic scars - skin has a smooth surface. Histological analysis: nutritionally nevus. In place of nevi depigmentation. Contraindications of mechanical dermabrasion no. Appointed: psychological preparation of the patient for surgery and the course of preparation of the skin to mechanical dermabrasion. At 6 months of treatment (beginning of the 3rd stage) on the 7th day after menstruation held circular dermabrasion unit is normoandrogenic scars and layered dermabrasion rest of the face on the previously stated methods. Postoperative period was without infectious complications, the temperature within the low-grade, swelling of no more than 1.6 points (on 5-point scale), and painless. Prevention of acne and vaginal chlamydia in further postoperative period was carried out using the ointment BUTANOL. One month after surgery rashes acne and chlamydia is not detected, the color of the skin smooth pink, epithelialization is complete, minus the fabric normoandrogenic scars barely visible (filling tissue after surgery, 87%), edema no, hyperpigmented spots, no, the demarcation line is missing. Recommended: use within 3 months ointment solcoseryl night and sunscreen with an SPF of>30 done once before going out on the street. Six months after surgery (a year after the start of treatment) skin condition is satisfactory, with no signs of post-acne (except for a barely noticeable indentations normoandrogenic scars - filling tissue after surgery, 75%), psychological status in normal, symptoms of chlamydia and vaginal dysbiosis no, no complaints. Further correction of defects of post-acne patient temporarily refused, shifting the time of surgery 2006 - after feeding the infant (planned pregnancy, which is a contraindication for surgery), In the following year (2003-2004) manifestations of acne, x is amitiza and vaginal dysbiosis not found.

The above example allows you to clearly see the approver fact: the advantage of the application of the method is obvious. The claimed method treated 17 patients (2002-2004). In the comparison (control group) were 57 patients (1998-2002), the treatment was carried out traditional ways of preventing acne. The results of the effectiveness of treatment of complicated forms of acne proposed method is shown in the table.

Indicators of treatment of complicated forms of acneWhen the method of treatment in groups
The number of patients in groups1757
Including attached infection:
Mixed urogenital infections519
The deadline acute inflammation
(day from the moment of the first
is anali - holistic treatments)31±763±7
Duration of erythema, the day85±16150±35
The duration of treatment, months7±1,512±3
The presence of recurrence after 1 year of treatment5(29%)20(35%)
The presence of recurrence after complete treatment0,0%4(7%)

In any case, a severe form of acne, to suppress which was used this way, there was no evidence of recurrence of acne in the acute form. The presence of recurrence after 1 year of treatment in a small number of patients due to insufficient time for recovery of the immune status of the organism. The application of the method allows to stop infectious infiltrates no later than the 4th day (after an average of 3.73±0.32 days). For comparison, the traditional treatment of this term is equal to 11±1,2 days, i.e. clearly more almost 3 times. It does not require additional use of chemotherapeutic drugs and pre-decrypt any microbiological method etiological patterns of microbial contamination of the skin and infectious inflammation of acne items. This circumstance is especially valuable when a small cosmetologicas the x salons and offices, where there is no possibility of using research in the Microbiology laboratory. However, the parallel treatment of urogenital infections provides modern diagnostics, which is possible only in clinics and skin and venereal dispensaries. The presence of specialized cosmetic centres and offices in the ARCS and in the clinics, staffed by highly qualified specialists, allows to apply the method, i.e. provides the industrial applicability of the method.

Thus, the clinical observations confirm the high efficiency of the method for the prevention and treatment of acne. Developed by the authors of the method, as claimed in the invention may be recommended for implementation in modern cosmetology.

A method for the treatment of complicated forms of acne in patients with urogenital infection and vaginal dysbiosis, including 3 stages of treatment, at the first stage, a continuation of 1-2 months, spend the relief of acute process of acne and treatment of urogenital infections with the use of rehabilitation and antibacterial protection of the skin, in the second stage, the continuation of 3-5 months, are hygienic care of the skin of the patient using ultrasonic methods and chemical peel, remove growths caused by the human papilloma virus, remove nevus is in the operating area, treatment of keloid scars, eliminate vaginal dysbiosis and urogenital diseases, the third phase will cover the mechanical dermabrasion with postoperative care within 1-2 months, at the same time as antibacterial agents used in the rehabilitation of drug butal, after renovation - drugs butal and baneuoqin, and after epithelization acne lesions and epithelium of the vagina - drugs butal and butanol, which are used in the premenstrual period, not combining the use of these drugs with surface treatment of alcohol - and metal-containing solutions.


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1 ex

FIELD: organic chemistry, medicine, dermatology.

SUBSTANCE: invention relates to zinc and aliphatic halogen-carboxylic acid salts that can be used in treatment of benign neoplasms of skin and visible mucosa tissues. Invention proposes the following formula of zinc and aliphatic halogen-carboxylic acid salts: (1): wherein R means -CHal3, -CHHal2, -CH2Hal and (2): wherein R' means Alk, hydrogen atom (H); R'' means Hal; R' means Alk; R'' means H, Alk wherein in these formulae halogen atom can be represented by fluorine atom (F), chlorine atom (Cl), bromine atom (Br) or iodine atom (J). Invention provides the development of original preparation used in treatment of benign neoplasms of skin and visible mucosa tissues with low toxicity, rapid effect, expressed therapeutic effect and eliciting good tolerance, absence of complications in treatment, healing without formation of scar tissue. The development of the preparation provides expanding assortment of agents used in treatment of such diseases.

EFFECT: enhanced and valuable properties of agents.

13 ex

FIELD: medicine, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to a method for preparing an anti-inflammatory, wound-healing, capillary-strengthening, immunomodulating agent. Method for preparing an anti-inflammatory, wound-healing, capillary-strengthening, immunomodulating agent is carried out for four stages. At the first stage violet tricolor and/or field milled herb is extracted with fluidized carbon dioxide under the definite condition followed by separation of grist from lipophilic fraction of extract; at the second stage defatted grist is subjected for three-fold extraction by remaceration method under the definite condition followed by treatment and purification of combined extract, treatment, condensation and preparing liquid alcoholic extract; at the third stage liquid alcoholic extract is used for preparing polysaccharide and flavonoid complexes by precipitation of polysaccharide with three-fold volume of 96% ethyl alcohol and the following drying at the definite temperature; at the forth stage grist after isolation of polysaccharide and flavonoid complexes is used for preparing pectins by treatment with three-fold volume of ammonium oxalate solution at the definite temperature, evaporation and drying. Liquid alcoholic is evaporated to 1/5 of the parent volume, dried by spraying drying or lyophilic drying at definite temperatures. Each end product prepared at each stage can be used as both independent medicinal formulation and can be used for preparing other medicinal formulations (tablets, capsules, suppositories, films). Also, invention relates to a method for preparing an anti-inflammatory, wound-healing, capillary-strengthening, immunomodulating agent that involves extraction of violet tricolor and/or field milled herb with 70% ethyl alcohol by infusion for a definite time followed by purification of the end product, settling at the definite temperature and filtration. Method provides preparing agent with broad pharmacological pattern of action and provides the maximal using the medicinal vegetable raw.

EFFECT: improved preparing method, valuable medicinal properties of agent.

5 cl, 5 tbl, 17 ex

FIELD: medicine, cosmetology.

SUBSTANCE: the suggested wound-healing remedy includes a gel-forming agent, an active substance and distilled (deionized) water. As the active substance it contains Mexidol (2-ethyl 6-methyl 3-oxypyrridine succinate) at the following ratio of components, weight%: gel-forming agent 0.5-5.0, stabilizing agent 0.01-0.8, conservant 0.01-1.0, Mexidol 0.01-10.0, distilled (deionized) water - the rest. The suggested remedy is highly efficient. It is of pronounced wound-healing action in 1, 2 and 3 phases of wound process. It quickly liquidates inflammatory processes, decreases painfulness, edema, considerably improves the state of affected tissues, accelerates reparative-degenerative processes and terms of epithelization. It possesses the wide spectrum of action, manifests pronounced action at treating different skin and mucosal lesions - wounds, fissures, bedsores, trophic ulcers of different genesis, surface burns of 1-3 degree, radiation lesions, it, also, removes skin microlesions that possess the nature of cosmetic defects, moreover, it improves skin structure.

EFFECT: higher efficiency of application.

2 ex

FIELD: medicine, therapeutic stomatology, dermatology.

SUBSTANCE: the present innovation deals with introducing desensitizing remedies, local application of hormonal preparation onto oral mucosa and, also, a keratoplastic preparation as 4%-chitosan water-insoluble colloid solution at deacetylation degree of 0.95, molecular weight of 100-120 kD. This preparation should be applied with a thin layer onto affected parts of oral mucosa for 30 d which should be pre-treated with 1%-hydrogen peroxide solution and dried. Then therapy should be continued with the above-mentioned chitosan solution once daily after meals and once nocturnally, for 30 d, as well. The innovation provides quick interruption of inflammation, complete epithelization due to high adhesion of preparation at oral mucosa.

EFFECT: higher efficiency of therapy.

4 dwg, 2 ex, 2 tbl

FIELD: medicine, ophthalmology.

SUBSTANCE: one should perform laser coagulation for all retinal departments except papillomacular bundle at radiation power being 400-500 mW, diameter of light bundle being 100 mcm, exposure time of 0.4 sec, total quantity of applications corresponds to 500-600, distance between applications is 1000 mcm. Moreover, one should apply coagulates at the distance of not less than 1500 mcm against macula. Before laser retinal coagulation one should introduce "Polyosm" preparation intravenously by drop-to-drop technique at the dosage of 1.0 g/kg body weight once daily in morning hours daily for 3 d.

EFFECT: higher efficiency of therapy.

1 ex, 1 tbl

FIELD: organic chemistry, polymers, immunochemistry of high-molecular compounds.

SUBSTANCE: invention describes a synthetic hapten based on copolymers of N-vinylpyrrolidone, crotonic acid and p-crotonoyl aminophenol comprising covalently joined 2-naphthyl amine as a hapten of the following general formula:

wherein m = 88.5 mole%; n = 6.8-10.3 mole%, and l = 1.2-4.7 mole%. Invention provides specificity of antibodies raised against 2-naphthylamin as a hapten and possibility for preparing highly specific antibodies raised against carcinogen 2-naphthylamine as a hapten by immunization of rabbits with synthetic antigen comprising a copolymer of N-vinylpyrrolidone, crotonic acid and p-crotonoyl aminophenol as a macromolecular carrier. Also, invention provides possibility for practice using these antibodies for immunological recording 2-naphthylamine as a hapten in blood of industrial workers subjected for exposition with 2-naphthylamine. The proposed compound elicits antigenic features and can be used for detection of oncological risk among workers subjecting with contact with 2-naphthylamine.

EFFECT: valuable properties of antigen.

1 tbl, 1 dwg, 6 ex

FIELD: medicine.

SUBSTANCE: at performing curative endoscopy one should apply pneumoapplication of granulated sorbent - diovine at the quantity of 0.2 g, the pressure being 15 atm. at the distance of 1.5 cm against the defect onto the surface of bleeding rupture of gastric mucosa. Diovine's coarse-grained structure enables to keep the integrity of mucous-bicarbonate barrier due to providing normal vapor exchange and moisture medium in the defect. Moreover, diovine's antimicrobial action helps to suppress gram-positive and gram-negative microflora that enables to shorten terms for defects healing and decrease the frequency of repeated hemorrhages.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine, hepatology.

SUBSTANCE: the suggested preparation is being polyprenols obtained out of woody greens of coniferous trees, of general formula

known earlier as a hepatoprotector. The innovation keeps organ stromas without any considerable proliferation of connective tissue, activates metabolic processes at no activation of spontaneous pathology (that is affected synthesis of ribosomal RNA and hepatocytic mitosis being not typical for hepatic tissue).

EFFECT: higher efficiency of stimulation.

5 tbl

FIELD: medicine, hematology.

SUBSTANCE: polyfunctional blood substitute for treatment of blood loss and shock comprises polyethylene glycol with molecular mass 20 000 ± 3 000 Da. As saline base electrolytes the blood substitute comprises sodium chloride, potassium iodide and iodine additionally in the following ratio of components, g/l: polyethylene glycol, 13.5-16.5; sodium chloride, 8.6-9.6; potassium iodide, 0.45-0.55; iodine, 0.05; water for injection, up to 1 l. Invention provides hemodynamic effect and simple medicinal formulation providing good injection usefulness.

EFFECT: valuable medicinal properties of blood substitute.

1 tbl, 3 ex

The invention relates to medicine, more specifically to the treatment of wounds

The invention relates to medicine, namely to ophthalmology, and for the treatment of edematous maculopathy
The invention relates to medicine, specifically to means for treating purulent wounds, local wound infection and inflammatory diseases

The invention relates to medicine and can be used to treat allergic reactions

The invention relates to the specific polymer matrix is poly(ethylene carbonate resulting)am, the way they are received, the pharmaceutical compositions based on them, intended for the treatment of diseases, such as chronic inflammatory condition

FIELD: veterinary science.

SUBSTANCE: invention proposes preparation used in treatment and prophylaxis of bacterial-fungal infections in animals. The preparation comprises neomycin, furazolidone and dimethylolurea taken in the following ratio of components, wt.-%: neomycin, 1.2-1.5; furazolidone, 1.2-1.5, and dimethylolurea, the balance. Invention provides expanding spectrum of the preparation effect and enhanced effectiveness of its effect.

EFFECT: improved and valuable properties of preparation.

3 tbl, 5 ex