Device for normalizing rhythms of human brain

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

 

The invention relates to medicine, specifically to experimental and therapeutic physiology, and can be used to control the change in the functional state of the Central nervous system (CNS).

As we all know, the brain of any living individual, including man, generates no signals at certain frequencies, which are called (conditional) δ, θ, α, β rhythms (core rhythms) in relation to the person. It was also observed that in different pathologies changes the ratio of these basic rhythms between themselves and especially in relation to αrhythm, i.e. they determine the state of the Central nervous system.

Naturally, attempts were made on experimental animals, mainly rats, to influence the LF electromagnetic fields (EMFs)on the brain through the inductors with variable induction (117-264 MT), see Pestrjaev VA "Influence of pulse slozhnosochlenennogo electromagnetic fields on the behavior and autonomic reactions of animals". Abstr. scient. proc. The bmrc sgmi, Sverdlovsk, 1989, p.43-44.

It was found that lower frequency EMFs on the order of 0.5-5 Hz efficiently work on braking and higher (closer to 20 Hz) on the excitation, in most cases, effects of pulsed EMFs with the same pulse repetition rate can lead to opposite changes the functional state, how to inhibition and excitation (at the level of the Central nervous system as synchronization and desynchronization of bioelectric activity of the brain). Registration of functional state of the CNS prior to exposure also does not allow prediction of the direction of change is reliable. It is therefore impossible the effective use of this mode of action to control the functional state of the Central nervous system.

The different changes in the functional state of the CNS when exposed to due to the fact that the EMF pulses appearing at regular intervals, not correlated with the bioelectric activity of the brain, wearing aperiodic in nature, and because the action of the field on neurons located in different functional condition varies, then predict with high probability the final result of redistribution of the activity of neurons and orientation changes of the functional state impossible. Under the changes in the functional state here refers to the transition between States of wakefulness, rest, stages of sleep, each of which is characterized as the predominant frequency spectrum, and a certain amplitude range (or certain distributions of instantaneous values) of the electroencephalogram signal.

A device for normalizing rhythms of the brain-the so-called "Bioenergy helmet", senior newspaper "Life", Ekaterinburg, No. 49 (493) of 18 March 2004 On this helmet received the patent of the Russian Federation, and he developed cyto, Moscow Professor Stepanov GA

Helmet is a metal ring which is firmly attached to the patient's head. From the top, around the perimeter, eight riveted plates with slots and sockets. Plates are placed through the same distance to bioenergy evenly distributed over the brain. Action helmet based on the use of bioenergy, which produces the brain of every person. Helmet put on his head and begins to search for pathological lesion in the brain, which is determined by a light tingling it is at this point. After that, the doctor on a particular method sends his own energy in the hearth, and the helmet "zakolerovat the energy that the generator produces the brain. It is a kind of induction coil, in which energy is not only preserved, but enhanced.

According to Stepanov, G. A., "the use of bioenergy resource and patient is the medicine of the future". Helmet was used on many patients, including former President Yeltsin, the results of the most successful.

With all its positive qualities, if any, this method has no scientific about the reasons, most of all, he reminds clean empirico.

A device for "Method of regulation of the functional state of the Central nervous system in a series of "sleep-Wake" by exposure to low-intensity pulsed magnetic field" RF patent No. 2089240, in which pre-recorded the electroencephalogram of the corresponding functional state of the CNS, determine the average and the maximum possible amplitude values and perform synchronization of the electromagnetic field with the electroencephalogram signal from a range of found values - the PROTOTYPE.

The disadvantages of this method are: low physiology and efficiency. This is because the binding of the way only to the phases of the "sleep-Wake" solves a private, albeit an important task, and transition to the effects on various diseases, for example, headaches, high blood pressure, epilepsy, etc. from this method should not be.

An object of the invention is to increase the effectiveness of the stimulation device by obtaining specific directional effects due to General technological transparency signal processing brain and strictly specific exposure conditions of the best stimulation.

This goal is achieved by the fact that a "Device DL is the normalization of the rhythms of the brain", containing the receiving electrodes, block removal electroencephalogram, analog-to-digital Converter and the inductor, characterized in that it introduced a low noise amplifier, a line of software tunable notch filters, sample and hold, random access memory, a microcontroller with a controlled permanent storage device, a liquid crystal display and the external control unit, when receiving electrodes made with the possibility of attaching to the upper part of the patient's head, the output electrode through the block removal electroencephalogram and low noise amplifier associated with a line of software tunable notch filters, the output of which is connected to the input device selection and storage, the output of which is connected to the input analog-to-digital Converter, a data bus which is connected to the memory device and the bus is ready with a microcontroller, which is connected by a bus "write/read" with the control input of the sample and hold, bus "start" input of the start of analog-to-digital Converter, the bus write address input of the memory device, the first control bus - line of software tunable notch filters, the second control bus - LCD indie what ATOR, the output bus with the inductor unit external control of the control bus is connected to the microcontroller, and the output of the memory device data bus connected to the data input of the microcontroller; a persistent storage device of the microcontroller consists of two parts, each of which identifies a corresponding data processing algorithm of the microcontroller; the induction of a magnetic field under the influence of the inductor is within 3-5 MTS, the exposure time is 60±10 sec.

The drawing shows a block diagram of the device showing: 1 - reception electrodes PEL, 2 - block removal electroencephalogram (EEG) or the biopotential amplifier, 3 - low noise amplifier (LNA), 4 - software tunable range of narrowband filters, 5 - liquid crystal display (LCD), 6 - unit sampling and storage (water economy Department), 7 - inducer, 8 - control unit on the microcontroller (MC), 9 - d, 10 - band management MK, 11 - RAM, the first, second and third 4-bit or more bus control unit 8, the first and second data bus RAM 11 (12-bit)bus write/read the water economy Department 6, the bus start ADC bus write and read signals in RAM from MK 8.

The device has the following connections. The receiving electrodes 1 are attached to the upper part of the patient's head (which is conventionally not shown). The output of this power is s 1 through EEG 2 and LNA 3 is connected with a line notch filters 4, the output of which is connected to the input of the water economy Department 6, the yield of the latter is connected to the ADC input 9, which is the 1st data bus connected to the RAM 11; MK 8 is connected by a bus write/read with the control input of the water economy Department 6, the bus start - starting the ADC 9, bus entry with the address input of the RAM 11, the third control bus - line narrowband filter 4, the second control bus from the LCD 5, the output bus with the inductor; an external control 10 (keyboard) the first control bus is connected with MK 8; output RAM 11 12-bit second data bus connected to the data input MK 8.

These blocks can be performed at the following REE and IC: PEL 1 in the form of discs of non-oxidizing material, such as tin, with a diameter of 8-10 mm, thickness 0.5-0.6 mm; EEG 2 - the standard unit is widely used in medical equipment, LNA 3 can be performed on integrated GaAs IC type MGA-866563, see catalogue produced by Hewlett Packard Catalog, 1998", p.6-220; line notch filters 4 on the dielectric resonators in the circuit with distributed parameters, see "Receiving device" edited Tin, M, P and S, 1996, s-202; LCD 5 firms POWERTYPPG-12864A 128×64 dots with backlight, see Aktiv-Matrix-LCD'S LDE052T-12 320×40 5,1 No. 46029, TECHNISCHER KATALOG 96/97,, str; MK 8 is, for example, the microcontroller Jntel 80C188EC-16, see Catalogue "electronic components Sector. Russia-99), DODEKA, 1999, str; ADC 9 IC PA, see Ask the source "of Integrated circuits and their foreign counterparts", M, Radio Software, 2001, Vol.6, str, RAM 11 to the IC 573 RF, see ibid., Vol.6, str; external control 10 is essentially any keyboard that is compatible with the microcontroller.

The device operates as follows.

Reception electrodes PEL 1 perceive the rhythms of the human brain, which are registered by electroencephalography EEG 2 and amplified by a low noise amplifier 3. Simultaneously, the microcontroller 8 signal to an external control 10, for example, the signal "start" begins to rebuild the line notch filters 4, since the lower frequencies, for example, to skip from 2 Hz up to 10 Hz, with increments of 0.1 or 0.2 Hz or 0.5 Hz, BB depending on the external control 10 (typed value readings manually). Selected each frequency in turn is fed to the sampling device and storing the water economy Department of 6, which is stored by the signal "write" at the control input (log.0 or log.1 depending on the specific water economy Department). Then MK 8 outputs the signal "read", which is filled with the value of the selected frequency is supplied to the ADC input 9, which signal "start" with MK 8 (detained at 3-5 μs relative to the signal "read") starts the processing of this frequency in a parallel 12-bit code. After converting this digital code is exposed on the first data bus simultaneously with the signal "ready", which goes to the MK 8. This is the signal MK 8 in turn sends the signal "record" in the RAM 11, on which this code is recorded. Then MK 8 with the selected quantization step skips the next frequency value on the output line notch filters 4 through 6 and water economy Department of the ADC 9 is also written in the form of a 12-bit code at the following address in the RAM 11, etc. After completing and processing all frequencies MK 8 on the signal read from the RAM 11 "pulls" all values and performs the processing of one of the following algorithms.

The algorithm first. All measured values of the amplitudes of frequencies calculate the RMS value by the known formula:

where: U1...Un- the measured value of the maximum amplitudes of each rhythm brain;

n - number of measured rhythms.

Then compare this quadratic value with the maximum amplitude of each rhythm and in the case of obtaining the difference more valid (determined empirically) in relation to any rhythm, MK 8 selects the frequency of this rhythm and through the inductor 7 is the effect of electromagnetic field on the upper hemisphere of the brain with the induction of the order of 3-5 MTS within 1.0 minute ± 10 seconds depending on the age of the patient.

The second algorithm.

For all measured frequencies MK 8 determines the maximum energy of the signal, which is determined by the area of the removed amplitude-frequency performance is key, then is determined by its "centre of gravity", i.e. the geometric center, the amplitude of the frequency at which it is located, and is required. Then again compares the maximum amplitude of each rhythm with the found search etc.

The difference between the algorithms is the following. By standard algorithm have high performance, maximum energy - high efficiency or reliability, increased immunity, but lower performance.

Here is the example used to normalize blood pressure in 12 patients, see table.

110/65
Table
No.Before exposureAfter exposure
SD/DD mm HgThe average pressure DD+0,42(SD-DD)SD/DD mm HgThe average pressure
1119/8096.4110/7584,7
2160/110131148/110126
3100 / 80g88,490/7078,4
4140/100116,8130/95109,7
5130/70for 95.283,9
6125/80the 98.9115/7591,8
7145/105the level of 121.8135/95111,8
8105/7084,795/6074,7
9150/100121145/100118.9
10150/100121140/95113,9
11145/100119135/98113,5
12160/105128145/95116

Thus, the table shows significant decrease: systolic - P<0,01 (12 out of 12), diastolic - P<0,05 (10 of 12) and medium - P<0,01 (12 out of 12) blood pressure.

In control: the 17 experiments with mismatched or on-time effects or time delay. In 9 cases there is no pressure change in 5 cases a slight increase and only in 3 cases a slight decrease in pressure.

It should be noted that the device may be equipped with the liquid crystal display 5 to display the current information, also MK8 has bus serial interface RS-232C, which can be used for communication with the cents the actual post and additional service for example, an alarm sound or light alarm (in the drawing conventionally not shown).

1. Device for normalizing rhythms of the brain containing the receiving electrodes, block removal electroencephalogram, analog-to-digital Converter and the inductor, characterized in that it introduced a low noise amplifier, a line of software tunable notch filters, sample and hold, random access memory, a microcontroller with a controlled permanent storage device, a liquid crystal display and the external control unit, when receiving electrodes made with the possibility of attaching to the upper part of the patient's head, the output electrode through the block removal electroencephalogram and low noise amplifier associated with a line of software tunable notch filters, the output of which is connected to the input device selection and storage, the output of which is connected to the input of analog-to-digital Converter, a data bus which is connected to the memory device and the bus is ready with a microcontroller, which is connected by a bus "write/read" with the control input of the sample and hold, bus "start" input of the start of analog-to-digital Converter, the bus write address input of the memory device is a, the first control bus - line of software tunable notch filters, the second control bus - with LCD indicator, the output bus with the inductor unit external control of the control bus is connected to the microcontroller, and the output of the memory device data bus connected to the data input of the microcontroller.

2. Device for normalization of brain waves according to claim 1, characterized in that the permanent memory of the microcontroller consists of two parts, each of which identifies a corresponding data processing algorithm of the microcontroller.

3. Device for normalization of brain waves according to claim 1, characterized in that the magnetic field under the influence of the inductor is within 3-5 Ts, the exposure time is 60±10 C.



 

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11 cl, 6 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychiatry.

SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.

EFFECT: higher efficiency of diagnostics.

1 ex, 1 tbl

FIELD: medicine, neurophysiology.

SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.

EFFECT: higher efficiency of evaluation.

1 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.

EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.

9 cl, 3 dwg

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.

EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl

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