Method for predicting labor outcome
SUBSTANCE: method involves carrying out two-dimensional ultrasonic scanning for determining prevailing placenta arrangement side, taking capillary blood sample and counting lymphocyte number. Left-sided placenta arrangement being the case, and lymphocyte content in blood formula being equal to or below 20%, unfavorable labor outcome is predicted.
EFFECT: high accuracy in detecting pregnant women with unfavorable prognosis and placing them among risk group.
The invention relates to medicine, namely to obstetrics, and will be widely used to improve the status of the mother and newborn.
Despite the achievements in addressing reproductive health percentage of obstetric complications remains at a high enough level, fetoplacental insufficiency (NEF) is 22% (Viergangiges, Weltwunder, 1999) and is accompanied by the development of chronic intrauterine hypoxia in 67.5% of cases (Nymphaline et al., 1999), perinatal mortality is according to different authors from 16 to 18‰ (Wasaware, Waspresent, 1999; Gamalia and others, 1999), the threat of miscarriage is registered in 30% (Isidorov, Ioacara 1995-2000; Apirana, 1997).
Generally accepted normative diagnosis and resulting from its results of therapy used to correct the detected violations, often does not lead to a positive effect.
Even widely spread in recent years, sophisticated instrumental methods of control, such as a Doppler ultrasound of the blood vessels of the uterus and the umbilical cord, do not give a full guarantee an objective assessment of the functional state of the system mother-placenta-fetus (FSMP). The outcome of pregnancy and childbirth is determined not so much nosological identity as the degree of severity of drug is deprivation of hemodynamics in FSMP. Our own observations show that the dynamic diplomaticheskii control detects such a significant diurnal and day-to-day variation that the data obtained at a single examination, based on standard rating scales, can be interpreted as indicators of norms, and how serious signs of hemodynamic disturbances. In this regard, do not lose their relevance issues associated with the development of informative prognostic and diagnostic criteria, the search of which is impossible without the study of the phenotypic basics and underlying mechanisms of reactivity and adaptability functional system "mother-placenta-fetus" (Nagarajan, 2003; Chistiakov, 2000).
The prototype of the claimed invention, the selected integrated diplomaticheskaja assessment of blood flow uterine artery and umbilical artery, including Doppler ultrasound of the right uterine artery (MA), measurement of vascular resistance index (ASCS) and systolicdiastolic relations (SRE), while ASCS in the right MA allows the selection of pregnant women at risk of a complicated pregnancy, and improving SRE in more than 2.6 MA to predict adverse pregnancy outcome with a sensitivity of 81% (Doppler uterine-placental - fetal blood flow/http://pregnancy.h1.ru, 20.05.2004).
The objective of the invention RA is to run the algorithm for predicting the nature of pregnancy and birth outcome with regard to adaptive reactions FSMP in its various stereotactically organization.
The problem is solved in that the two-dimensional ultrasonic scanning pregnant determine the direction of the preferential location of the placenta, and then produce a sampling of capillary blood and calculate the percentage of lymphocytes and in the presence of left-sided location of the placenta and content of lymphocytes less than 20% in the formula blood, proving the stress response of the parent body, predict adverse pregnancy outcome.
The most widely known General nonspecific adaptive reactions, first open Gsale in 20-ies of the last century, was supplemented Phharmacy, Abbacies, Tschulena (1988) anti-stress reactions: reaction training and response activation, subdivided into a calm and sensitive (Phharmacy, 1968, 1969). According to the authors, these reactions are formed in the process of evolution as the reaction of anti-stress protection of the body. They develop in response to adequate, relatively weak (reaction training) or medium (reaction activation) acting factors. Changes in each of them different from the stress and from each other and nature is close to various standards (open No. 1958, 1975, Phharmacy, Maunaloa, Ebouaney). Later it was found periodic pattern, objedives what I qualitatively different adaptive response, namely, the periodic repetition of the same name reactions depending on the absolute magnitude (strength, dose) of current stimuli (Phharmacy, Ebouaney, 1975-1997). Because pregnancy causes substantial alterations in the female body and is a serious challenge to its adaptive adaptive system, many authors (I. Arshavsky, 1957; D. Garmashova, NN. Konstantinov, 1978; Savelyeva G.M., 1981) refer to gestational age as stress. Meanwhile, the mechanisms of stress resistance or stress-vulnerability of the pregnant body, are not well understood. Still there are no clear criteria for determining adaptive reactions in pregnant women.
To study adaptive responses as the most adequate model, we chose the system of blood, the ratio of the formed elements which identified the nature of the adaptive response. The reaction of anxiety, stress observed leukocytosis, reasinable, lymphopenia (number of lymphocytes below 50%), and segmented neutrophils and monocytes in normal or above normal. Unlike stress in stage orientation in rats the number of lymphocytes is within the lower half of the zone standards (51-60%), the number of segmented neutrophils within the upper half of the zone standards, the number of leukocytes, eosinophils, stab neutrophils and monocytes varies. The people who (compared to animals) under reference number of lymphocytes is within the lower half of the zone standards (21-27%), the number of leukocytes, eosinophils, stab neutrophils and monocytes varies. It should be noted that the system of blood during pregnancy is undergoing significant changes: there are variations in the level of red and white blood cells: decreased hemoglobin and hematocrit due to automodelli (MEM, Gambardella, 1997). Along with this gradually increasing leukocytosis, ESR and neutrophiles (Vaalputs, Bavarese, 1979; MTM, Gambardella, 1997). Type of reaction is determined by the percentage of lymphocytes in the leukocyte formula. Other elements of the white blood cells and the total number of leukocytes, being the only additional signs reactions, indicate the extent of usefulness, physiology reaction, the degree of tension and with respect to the standard norm. The effectiveness of the functioning of red and white blood cells largely depends on the level of transplacental exchange, and hence the nature of pregnancy, functional status and development of the intrauterine fetus.
The lateral location of the placenta in humans determines the formation proforientirovanie, levonorgestrelbuy and combined FSMP, with a characteristic for each of them chronometrically functional organization (Nagarajan, Whirlow, TLB tasheva, 1999). The factor of lateralization of the placenta significantly affects the process of lateralization of uterine activity and uteroplacental hemodynamics, modulates the resistance of the female body and largely determines the likelihood of obstetric pathology (Aborescent, 1985; Vierow, 1987; Tolbatova, 1992; Casamassa, 1994; Avernite, 1994; Avilov, 1998). Because of the lateral arrangement and functioning of the placenta causes the formation of gestational dominant in the contralateral (to the placenta) hemisphere of the brain (Aborescent, 1984; Vierow, 1981-2001; Avernite, 1994; Tolbatova, 1999), where it is localized, including the Central link in the regulation of haematopoiesis: according to the literature stimulation paraventrikulyarnoe nuclei of the hypothalamus is accompanied by leukocytosis with neutrophil shift, with a concomitant inhibition of erythropoiesis (MEM, Gambardella, 1997), we should expect certain differences in the dynamics of indicators of red and white blood cells under conditions of atropoisomeric FSMP. Features adaptive responses at different stereotactically organization FSMP in this key has not previously been considered. Is also considerable interest in the study of lateral functional provide basic adaptive responses depending on the nature of the pregnancy.
Our research and discovered for the first time, what adaptive reactions of the parent body modulate the nature of uterine and fetal blood flow: when the stress response is logged increase VS/VD in the uterine and umbilical arteries by 4.2% (p<0,05). When pregnancy is high risk and the probability of adverse birth outcomes is increased in the case of left-sided location of the placenta and the stress response of the parent body (p<0,05). Stereotactically organization FSMP and nature of adaptive responses affect the course of pregnancy, growth and development of the fetus: with left-hand location of the placenta often registered the stress reaction, which is accompanied by the development of gestational complications and adverse birth outcome.
Detailed description of the method
Method two-dimensional ULTRASONIC scanning investigated the scope of preferential localization of the placenta relative to the median line (SONOACE-4800 with the Doppler unit firm "Madison", Korea, registration number №93/68, convex probe 3.5 MHz).
The study hemogram red and white blood cells was carried out from 8 to 9 o'clock in the morning, on an empty stomach. Got capillary blood from the Palmar surface of the nail phalanx of the ring finger of the left hand.
Leukocyte formula represents a percentage of the blood of different types of leukocytes, in particular neutrophils, eosinophil is s, basophils, lymphocytes and monocytes. To count leukocyte formula to prepare a blood smear stained by Romanovsky-Giemsa. The smear was fixed within 10 minutes, methyl alcohol, stained with Azur II, methyl alcohol and glycerin, and then was rinsed with water and dried in a vertical position. Stained smear was examined under the microscope with oil immersion system.
The erythrocyte sedimentation rate (ESR) was determined by the method Panchenkov. Mixed with anticoagulant blood was collected in capillary pipette to the mark "0", placed in a vertical position in a rack Panchenkov. After one hour was determined by the value of the ESR, which is measured in millimeters per hour (mm/h).
The efficiency of the method is confirmed by clinical examples.
Pregnant And Jan, 22 years old, pregnancy 32 weeks.
Ultrasound scan detected: biparietal head size 80 mm, which corresponds to 30 weeks and 1 day pregnant, head circumference - 292 mm at 32 weeks and 2 days pregnancy, the length of the thigh - 62 mm at 32 weeks and 1 day, abdominal circumference - 179 mm at 32 weeks of pregnancy. Marked right-sided location of the placenta, the thickness of 32 mm, the amount of amniotic fluid was normal. Diagnosis: Pregnancy 32 weeks.
When diplomaticheskii study found the following indicators of blood flow: ar is a series of umbilical cord - V/S to 2.5; right uterine artery - V/S - 1,73; left uterine - V/S - 1,71. Violations of Feto - maternal-placental hemodynamics is not revealed. In order to predict the nature of pregnancy and birth outcome:
conducted two-dimensional ultrasound examination of the uterine-placental-fetal complex and defined the scope of the preferential location of the placenta is right;
conducted sampling of capillary blood on an empty stomach in the morning to determine the General analysis of blood;
determined the percentage of lymphocytes in the blood content of lymphocytes in the evaluation of complete blood count was 19%.
This pregnant does not belong to the risk group and it is possible to predict a favorable course of pregnancy.
Delivery term. The fruit mass 3 kg 500 g, height 52 cm, with estimation on Apgar scale 9-10 points.
Pregnant N-VA, 24 years, gestational age 30 weeks.
Ultrasound is logged left-hand location of the placenta. When diplomaticheskii study found a violation of fetoplacental hemodynamics. The content of lymphocytes in the evaluation of complete blood count was 19%.
In this case, it is possible to predict adverse pregnancy.
The pregnancy proceeded with symptoms of preeclampsia and placental insufficiency.
Childbirth urgent way the cesarean section in the lower uterine segment. The fruit mass 2 kg 700 g, height 49 cm, with estimation on Apgar scale 6-7 points.
Thus, the pregnant woman's body is in stress response, is a violation of fetoplacental hemodynamics in diplomaticheskii study and signs of placental insufficiency ultrasound.
This pregnant should be considered at risk and to predict adverse pregnancy outcome.
Pregnant With Ko, 22 years, gestational age 32 weeks.
Ultrasound is logged left-hand location of the placenta. When diplomaticheskii the study of disorders of the Feto - maternal-placental hemodynamics is not revealed. The content of lymphocytes in the evaluation of complete blood count was 20%.
In this case, it is possible to predict adverse pregnancy.
The pregnancy proceeded with symptoms of placental insufficiency.
Delivery term. The fruit mass 2 kg 600 g, height 48 cm, with rating on a scale of Apgar scores 7 points.
Thus, the pregnant woman's body is in stress response, is a violation of uteroplacental hemodynamics in diplomaticheskii study and signs of premature sozrevaniya placenta ultrasound. This pregnant should be considered at risk and to predict adverse pregnancy outcome.
the example 4.
Pregnant Peninsula, 22 years, gestational age 29 weeks.
Ultrasound is logged left-hand location of the placenta. When diplomaticheskii the study of disorders of the Feto - maternal-placental hemodynamics is not revealed. The content of lymphocytes in the evaluation of complete blood count was 25%.
In this case, we can predict a favorable course of pregnancy.
Delivery term. The fruit mass 3 kg 200 g, height 50 cm, with rating on a scale of Apgar 8-9.
For solving the tasks conducted a screening survey of women with physiological and complicated pregnancy and pathology, residing in the city of Rostov-on-don and Rostov region. The total sample consisted of 511 people. The research was carried out in the same period of the day from 8 to 9 hours. The sequence and rate studies every pregnant were identical.
Of these, 106 (20,74%) pregnant first trimester, 191 (37,38%) second trimester and 214 (41,88%) third trimester. The formation of the clinical groups was carried out on the basis of the data of anamnesis, results of ultrasound, cardiotocographic and diplomaticheskogo research.
To accomplish the task all of the studied pregnant women were divided into two clinical groups: group I was 250 be the temporal with no violations on all of the above parameters; pregnant women with placental insufficiency, threat premature birth and chronic intrauterine hypoxia were United in the second clinical group "complicated pregnancy", because each of these pregnancy complications according to the literature (Schechtman M.M., Burduli G.M., 1997; shiffman FD, 2000) is not accompanied by significant changes in the hemogram. In complicated pregnancy (261 female), right-sided location of the placenta was recorded in 76 (29,10%)l - 90 (34,6%), ambilateral - 95 (36,3%).
When examining patients with physiological and complicated pregnancies account of complaints, anamnesis, information about during this pregnancy, the results of laboratory tests.
All pregnant was carried out by ultrasound maternal-fetal-placental complex with ultrasonic Doppler uteroplacental and fetoplacental blood flow, external cardiotocography, General blood analysis, determined the content of sodium, potassium, calcium and iron in the serum.
During the study determined the position and presentation of the fetus, indicators of Geometrie, has been planetography, assessment of fetal status and the amount of amniotic fluid.
In the study of stress reactions in 74 women with left-sided is the eating of the placenta was noted a decrease in the level of lymphocytes in the blood up to 20% or less, all these pregnant women was observed adverse outcome of pregnancy and childbirth.
Thus, the claimed method allows us simply, quickly and with high accuracy (100%) to predict the outcome of pregnancy.
The method can be widely used in obstetric hospitals and antenatal clinics, including monitoring of pregnant women and evaluate the effectiveness of therapy.
A method for predicting pregnancy outcomes, including dopplerometrical study, characterized in that the pre-method two-dimensional ultrasound scanning to determine the direction of the preferential location of the placenta, producing a sampling of capillary blood, calculate the percentage of lymphocytes and in the presence of left-sided location of the placenta and content of lymphocytes in the blood content is 20% or less predict adverse pregnancy outcome.
SUBSTANCE: method involves placing pregnant woman blood drop on microscope slide surface in the amount of 0.02 ml 3-5 days before childbirth and drying at 18-25°C during 18-24 h and studying the produced samples under microscope. Moderate structural composition level and radial-symmetric facies pattern being available, future labor is predicted to be successful. Extremely low structural composition level with no radial-symmetric facies pattern being observed, labor disorders requiring surgical intervention are to be predicted.
EFFECT: enhanced effectiveness in detecting pregnant women oh high labor disorder risk.
SUBSTANCE: method involves incubating case sample of stabilized blood in 0.2% NaCl solution and control sample in 0.65% NaCl solution taken in blood/incubation medium ratio equal to 1:50 during 1 h. Single-layer preparations are formed from each sample in which time sequences of erythrocyte image projection groups each containing erythrocyte images are recorded in two orthogonal planes every 30 s during 10 min and stored. Time sequences of erythrocyte image projection groups each containing erythrocyte images are additionally recorded every 10 min during 1 h and stored. Overall dimensions Am and Bn of all erythrocytes are measured and their volume and thickness are calculated and then, biometric RVK index is determined for every cell belonging to corresponding time group causing the erythrocyte population to be subdivided in every group into recytes and lethaliocytes. Erythropoiesis activity is determined from time the most part of cells transits to lethaliocyte class beginning from incubation start. If tm,n≤30s, erythropoiesis attenuation takes place; 30s< tm,n ≤ 60s erythropoiesis equilibrium is considered to be the case; 60s< tm,n, erythropoiesis activation is stated.
EFFECT: high accuracy of diagnosis.
1 dwg, 1 tbl
FIELD: experimental medicine.
SUBSTANCE: on the 3d - 4th d of experimental staphylococcal acute otitis media it is necessary to examine lactoferrin concentration in nasal mucosa and activity of beta-lysines in blood serum in experimental rabbits and at lactoferrin concentration being 119.8 ± 1.6 ng/ml (standard being 86.2 ± 1.4 ng/ml) and activity of beta-lysines being 69.4 ± 0.4% (standard being 54.8 ± 1.7%) it is possible to conclude on acute phase of inflammatory process in patient's middle ear.
EFFECT: higher accuracy of detection.
FIELD: bioassay methods.
SUBSTANCE: invention, in particular, relates to a reagent system for detecting substances. Signal generation system for detecting substances in a sample contains at least one first and second electron transfer agent and redox indicator. Electron transfer agents utilized are those of protein and nonprotein nature, for example phenazine compound and diaphorase. System further contains at least one of following compounds: enzyme cofactor, enzyme manifesting oxidative activity relative to tested substance, e.g. corresponding dehydrogenase. Proposed systems, reagent compositions, test strips, and kits find use in detection of a large number of substances in a sample such as a biological sample, e.g. blood or blood fraction.
EFFECT: increased reaction rate of signal generation system and reduced cost.
8 cl, 1 dwg, 3 tbl
SUBSTANCE: method involves studying properties of deformability DP, erythrocytes aggregation EA, lipids micro-viscosity LMV in their membranes, changes in superficial erythrocyte cytoarchitectonics on diskocytes and degenerative prehemolytic forms number and, additionally, extrahepatic vascular marks. The properties under study are evaluated by means of forecasting coefficients FK, where FK=+5.2, if DP≤0.11 conditional units; FK=-3.5, if DP≥0.12 conditional units; if EA≤1.11 conditional units, FK=+1.0; if EA≥1.12 conditional units, FK=-5.6; if LMV≥4.5 conditional units, FK=+2.3; LMV≤4.4 conditional units, FK=-6.5; the number of diskocytes falling to 70% and lower, FK=+4.1; diskocytes value being ≥71%, FK=-2.6; irreversibly transformed prehemolytic forms number being IRPF≥13%, FK=+2.9; IRPF≤12%, FK=-2.0; increasing reversibly transformed erythrocytes number being RTE≥14%, FK=+2.5; RTE≤13%, FK=-2.3; extrahepatic vascular marks being observed during acute viral hepatitis period, FK=+8.8, no extrahepatic vascular marks being observed, FK=-5.0. The forecasting coefficients are summed up. The sum of FK≥+13, lingering clinical viral hepatitis course is to be predicted.
EFFECT: high accuracy of the method.
FIELD: medicine, laboratory diagnostics.
SUBSTANCE: one should detect the quantity of leukocytes in 10 ml of pre-massage and 10 ml of post-massage portion of patient's morning urine and at increased quantity of leukocytes in post-massage urinary portion by 2000-2500/ml one should diagnose prostatodynia, by 2500-6000/ml - chronic prostatitis, more than by 6000/ml - infectious prostatitis and increased quantity of leukocytes in pre-massage urinary portion demonstrates the presence of urethritis. The present innovation provides the chance for objective topical diagnostics of pathological process in inferior urinary tact.
EFFECT: higher accuracy and efficiency of diagnostics.
3 ex, 1 tbl
FIELD: medicine, diagnostic techniques.
SUBSTANCE: one should study viscous characteristics of clotting blood - period of reaction (r), intensity of spontaneous thrombocytic aggregation (Ar), thrombin constant (k), maximal amplitude (MA), terms for forming fibrin-thrombocytic structure of the clot (T), total value for retraction and spontaneous lysis of the clot (F). At values of r being 3.53±0.48 min, Ar being 8.69±1.37 rel. U, k being 2.60±0.48 min, MA 810.9±54.4 rel. U, T being 37.78±3.25 min, F being 31.14±3.54% one should detect "reaction of tension". At r being 8.76±1.42 min, Ar being 0.44±0.73 rel. U, k being 10.52±1.89 min, MA being 271.2±68.1 rel. U, T being 77.8±10.04 min, F being 32.40±6.91% one should detect hypocoagulation variant of DIC-syndrome. At r being 3.19±0.41 min, Ar being 8.20±1.23 rel. U, k being 2.57±0.41 min, MA 670.4±39.4 rel. U, T being 48.61±7.88 min, F being 18.43±1.63% one should detect hypercoagulation variant of DIC-syndrome. At r being 7.26±0.73 min, Ar being 2.13±1.13 rel. U, k being 6.84±0.60 min, MA 480.3±56.7 rel. U, T being 62.08±2.52 min and F being 24.87±4.41% one should detect combined variant of DIC-syndrome. The method in question enables to quickly diagnose hemostasis system disorders that favors to prescribe adequate curative-prophylactic measures in due time.
EFFECT: higher accuracy of differential diagnostics.
5 dwg, 4 ex
FIELD: medicine, laboratory diagnostics.
SUBSTANCE: the present innovation deals with predicting gestosis development in the 3d trimester of pregnancy. At the terms of 6-13 wk of gestation one should detect the activity of cathepsin D in peripheral venous blood and at its value being either equal or above 0.021 U/h one should predict gestosis development in the 3d trimester. The innovation provides prediction of gestosis development since the early terms of pregnancy.
EFFECT: higher accuracy of prediction.
3 ex, 1 tbl
SUBSTANCE: one should detect the content of ammonia along with organic amines in the air of mouth cavity due to intake of urea of normal isotopic composition of 12C 1H4 14N2 16O and detecting patient's infectiousness degree due to comparing the results of trials, moreover, one should detect the content of ammonia with accompanied organic amines I the air of mouth cavity should be performed after the intake of urea, moreover detection of initial level should be carried out before the onset of urea hydrolysis within 0-1.0 min interval, and detection of ammonia's loading content - during the period of active urea hydrolysis within 1-9 min interval after the intake of urea, moreover, air sampling out of mouth cavity, air supply onto pick up unit for ammonia transformation into a signal, detection of ammonia content with accompanied organic amines in the air and, also, detection of patient's infectiousness should be performed either once or periodically, or continuously. For this purpose one should apply device that contains means for air sampling out of mouth cavity, pick up unit for ammonia transformation into a signal, measuring unit, treatment unit, and indication unit, moreover, measuring unit is designed as a unit for signal measuring with possibility to transform them into digital form, pick up unit for ammonia transformation into a signal is designed as electrochemical sensing device its input being connected with a tube with means for air sampling, this device is additionally supplemented with memory unit and enhancing unit its input being connected with the output of pick up unit for signal measuring, and output of enhancing unit is connected with the input of the unit for signal measuring with possibility to transform them into digital form, its output being connected with the input of memory unit its output being connected with the input of treatment unit, moreover, the output of the latter is connected with the input of indication unit.
EFFECT: higher accuracy of diagnostics.
11 cl, 3 dwg, 5 ex
SUBSTANCE: method involves determining coagulating blood viscosity values like reaction period r, thrombin constant K, maximum amplitude MA, time T for forming fibrin-thrombocytic blood clot, spontaneous blood platelets aggregation intensity Ar, retraction and spontaneous clot lysis total FA. The r being within 5-7 min, Ar from -2 to -6 relative units, K being within 4-6 min, MA within 500-700 relative units, T within 40-60 min and FA equal to 10-20%, low inflammatory process activity is considered to be the case. The r being less than 5 min, Ar equal to -8 to -12 relative units, T less than 40 min and FA less than 10% with no changes in K and MA being observed, inflammatory process activity in chronic glomerulonephritis case is considered to be of high severity degree.
EFFECT: high accuracy of diagnosis; enhanced effectiveness of treatment method selection.
SUBSTANCE: method involves carrying out location measurements using transducer of 7.5 L in B mode, color dopplerometry mapping mode and in D mode. When obtaining an image characterized by anechogenic elongated formation having echogenic banding in B mode, high speed flow image with blood circulation directed towards the arteriovenous malformation in color dopplerometry mapping mode and bypass pattern image with high systolic and diastolic blood circulation speed and low pulsation index and resistance index values in D mode, adductor blood vessel in cerebral arteriovenous malformation is verified when having all the images located at the same place.
EFFECT: high reliability and accuracy of diagnosis.
FIELD: medicine, functional diagnostics, cardiology.
SUBSTANCE: on isolating the trunk of pulmonary artery one should measure circulation in its wall with the help of a laser-doppler flowmeter to detect average value of microcirculation, root-mean-square and interval of deviation against average value. Then one should detect average value of microcirculation and the value for circulation decrease after replacing the trunk of pulmonary artery into aortic position. If average value of microcirculation in the wall of pulmonary artery in position of aortic valve has been decreased by the value either equal or below 1.282xσ, one should predict favorable result of operation, if the decrease occurred by more than 1.282xσ, one should predict unfavorable result of operation. The method broadens the number of diagnostic means applied in the field of cardiosurgery.
EFFECT: higher efficiency and accuracy of prediction.
SUBSTANCE: method involves determining hemodynamic characteristics of blood circulation in vascular anastomosis area in standard zones distal and proximal with respect to the vascular anastomosis by means of ultrasonic dopplerography during the first 6 months, after vascular plastic operation being applied. Dynamic changes in the characteristics are interpreted in terms of full-valued vascular anastomosis condition.
EFFECT: high accuracy of diagnosis; high accuracy of ultrasonic blood circulation condition criteria.
11 dwg, 2 tbl
SUBSTANCE: method involves carrying out cardiotocographic examination taking into account day rhythmostasis and following data analysis. Diagnostically significant cardiotocographic characteristics like basal rhythm, accelerations, acceleration durations, motor fetus activity and integral fetus state characteristic are determined. Non-conjugated estriol/progesterone coefficient is calculated with day rhythmostasis taken into account. Maternal and fetal blood circulation hemodynamic values synchronization coefficient is determined. Diagnostically significant characteristics values typical for fetus hypoxia are determined. When carrying out cardiotocographic examination, basal rhythm (strokes/min) is equal to 156±2.9 at 12 o'clock and 159±3.7 at 20 o'clock; accelerations (strokes/min) 3.0±0.2 at 12 o'clock and 2.2±0.3 at 20 o'clock; acceleration durations (s) 14.2±0.7 at 12 o'clock and 13.6±1.2 at 20 o'clock; motor fetus activity (during 10 min) 2.0±0.4 at 12 o'clock and 1.7±0.3 at 20 o'clock; integral fetus state characteristic 1.25±0.15 at 12 o'clock and 1.37±0.22 at 20 o'clock. When determining noncojugated estriol/progesterone coefficient: 0.57±0.05 at 8 o'clock and 0.67±0.06 at 20 o'clock. When determining maternal and fetal blood circulation hemodynamic values synchronization coefficient: 2.35±0.19 before 37 pregnancy weeks date and 2.78±0.18 after 37 pregnancy weeks date. The values corresponding to the above referenced ones, functional fetus state change and chronic fetal hypoxia are to be diagnosed.
EFFECT: high accuracy of diagnosis.
FIELD: medicine, oncology.
SUBSTANCE: before the onset and 10-14 d after the end of chemotherapy course it is necessary to carry out chromatic Doppler mapping to evaluate maximal tumor rate of circulation, and at its decreased value being 25% lower against initial data one should establish process stabilization, and at its increase being 25% higher against the initial data - process progressing should be stated upon. The innovation enables to objectively evaluate efficiency of chemotherapy at applying safe, simple ultrasound trial for the purpose to specify subsequent therapeutic tactics.
EFFECT: higher efficiency and accuracy of detection.
8 dwg, 3 ex
SUBSTANCE: one performs ultrasonic echo-dopplerometric investigation of regional blood flow in prostate before and after treatment to determine quantitative parameters. When pulsation index is reduced from 1.39±0.12 before treatment to 1.10±0.09 after treatment and venous blood flow velocity increases, respectively, from 3,91±0.36 to 5,22±0.47, treatment is regarded effective and completed.
EFFECT: increased accuracy of estimation.
SUBSTANCE: method involves determining microcirculation indices in rest state by applying Doppler laser flowmetry method and capillary blood circulation reserve indices in occlusion sample under cuff pressure being 30 mm of mercury column as high as the systolic patient blood pressure during 3 min. Cardiorespiratory disorders development is predicted in postoperative period, The microcirculation indices being greater than 6.0 perfusion units in combination with capillary blood circulation reserve indices being greater than 300% or microcirculation indices being below than 4.5 perfusion units in combination with capillary blood circulation reserve indices being greater than 200%.
EFFECT: high accuracy of prognosis.
SUBSTANCE: method involves carrying out visual and rectal examination. Peripheral blood circulation speed is measured in rectovaginal partition blood vessels. Rectovaginal partition folds are detected and increase in its thickness. Levators separation exceeding 20 mm is determined. Fibrous degeneration of rectovaginal partition is detected. Reduced blood circulation speed in levators is detected. Anterior rectocele is diagnosed. Values are measured by introducing ultrasonic transducer into the rectum. One of versions assumes introduction of hygienic intravaginal tampon into the vagina.
EFFECT: high reliability of diagnosis.
2 cl, 8 dwg
SUBSTANCE: method involves examining retina light sensitivity degree using computer-aided perimetry approach within 60° bandwidth from fixation point. Direct orbital muscle thickness and retrobulbar space volume is additionally determined by applying ultrasonic b-scanning method. Linear blood circulation speed and resistance index are also determined in the central retinal artery and posterior short ciliary arteries. Macular or general light sensitivity reduction 25% and more relative to age-specific norm being observed together with 50% growth and more in direct orbital muscle thickness, retrobulbar space volume growth by more than 35% in combination with linear blood circulation speed reduction in the central retinal artery and posterior short ciliary arteries by 40% and more and increasing resistance index by 20% and more relative to physiologic norm, optic nerve abnormality is diagnosed at early disease stages.
EFFECT: high reliability of diagnosis.
SUBSTANCE: method involves diagnosing gestosis severity degree with clinical signs and blood circulation being studied. Ultrasonic examination with Doppler color mapping is carried out in female patients manifesting fuzzy clinical symptoms. Intrarenal artery resistance index is determined. The value being within 0.62-0.65%, mild gestosis is to be diagnosed. The value being within 0.66-0.69%, moderate severity degree gestosis is to be diagnosed. The intrarenal artery resistance index being equal to or greater than 0.7%, severe gestosis cases are to be diagnosed.
EFFECT: high accuracy of diagnosis; noninvasive diagnosis method.
SUBSTANCE: method involves carrying out ultrasonic scanning examination of subclavian artery over its whole extent in physiological arm position with arterial blood pressure being measured in the middle one third of the arm. Next, when applying compression tests, blood circulation parameters variations are recorded in distal segment of the subclavian artery with arterial blood pressure being concurrently measured. Three degrees of superior thorax aperture syndrome severity are diagnosed depending on reduction of linear blood circulation velocity and arterial blood pressure compared to their initial values. Mild one takes place when linear blood circulation velocity reduction reaches 40% and arterial blood pressure 20% of initial level, moderate one when linear blood circulation velocity reduction reaches 70% and arterial blood pressure 50% and heavy one when linear blood circulation velocity reduction is greater than 70% of initial level and arterial blood pressure is greater than 50% to the extent of no blood circulation manifestation being observed in the subclavian artery.
EFFECT: high accuracy of diagnosis.