1-(pyridinyl-2)-2-azolyl-1-(fluorophenyl)ethanols and their using as fungicides

FIELD: organic chemistry, fungicides, agriculture.

SUBSTANCE: invention describes 1-pyridinyl-2-azolyl-1-(4-fluorophenyl)ethanols of the general formula (I)

wherein X means nitrogen atom (N) or -CH, and their using as fungicides. Proposed compounds possess high fungicide activity and can be used as agricultural, industrial, medicinal and veterinary fungicides.

EFFECT: valuable properties of compounds.

3 cl, 1 tbl, 4 ex

 

The invention relates to the chemistry of heterocyclic compounds, namely 1-(pyridinyl-2)-2-azolyl-1-(forfinal)atenoll General formula I

where X denotes a nitrogen atom or CH group, which may find application as an agricultural, industrial, medical or veterinary fungicides.

Known 2-thiazoleethanol General formula II, their salts with acids and complexes with metals, where R1means alkyl, cycloalkyl or phenyl, R2means phenyl or benzyl, which possess fungicidal activity [U.S. Pat. U.S. No. 4623654, class A 01 N 43/653, 1984].

Closest to the claimed structure 1-pyridinyl-2-imidazolidinone General formula III, where R1means a hydrogen atom, alkyl group or halogen atom, R2means substituted or unsubstituted thienyl or substituted or unsubstituted phenyl, R3means a hydrogen atom or methyl group [application Germany No. 3345813 A1, class C 07 D 401/06, 1983], which have antidepressant activity and can be used in medicine:

The technical problem solved by this invention is the extension of the range of fungicides for effective action against harmful fungi.

To solve this problem, synthesize substituted 1-(pyridine is -2)-2-azolyl-1-(forfinal)ataneli General formula I, possessing fungicidal activity.

Substituted 1-(pyridinyl-2)-2-azolyl-1-(forfinal)ataneli can be obtained by the interaction of oxiranes formula IV with imidazole or triazole. Such reactions are well known [European application No. 0015756 A1, class C 07 D 249/08, 1980]:

Example 1. 2-(2-(4-Forfinal)-2-oxiranyl)pyridine. To the mixture to 30.15 g (0.15 mol) of 2-(4-perbenzoic)pyridine, of 14.28 g (0.07 mol) of iodide trimethylsilane and 31.3 ml of DMSO is added dropwise over 30 min a solution of 4,625 g (0,063 mol) of potassium tert-butylate (31.3 ml of DMSO, cooling the reaction mass of ice, the mixture is stirred for 15 min and added dropwise to 150 ml of water. The product is extracted with chloroform, the extract washed with water and the solvent is distilled off. Obtain 14.5 g (45%) of 2-(2-(4-forfinal)-2-oxiranyl)pyridine in the form of oil. NMR1N spectrum (DMSO-d6that δ, ppm): 3,35 (AB-system, 2H, CH2, J=7,3), 7,13, 7,51 (AWH-system, 4H, CH Hairdryer., J1=18,5, J2=8,5), 7,33 (m, 1H, H-4 pyrid.), 7,73 (DD, 1H, H-5 of perid., J1=7,6, J2=2,1), 8,55 (m, 2H, H-2, H-6 pyrid.).

Example 2. 1-(Pyridinyl-2)-2-(imidazolyl-1)-1-(4-forfinal)ethanol (1). To a solution of 1.78 g (8.3 mmol) of 2-(2-(4-forfinal)-2-oxiranyl)pyridine and 0.57 g (8.3 mmol) of imidazole in 5,63 ml of DMF was added 0,033 ml of water, 0.11 g of sodium hydroxide and stirred for 4 h at a temperature of 120°C. the Reaction mass is then cooled, poured into 40 ml of water. Fallen Christ is lly filtered off, washed with water and recrystallized from toluene. Obtain 1.07 g (48%) of 1-(pyridinyl-2)-2-(imidazolyl-1)-1-(4-forfinal)ethanol, TPL 174-176°C. NMR1N spectrum (DMSO-d6that δ, ppm): 4,85, 4,92 (AB-system, 2H, CH2, J=13,7), 6,50 (s, 1 H, HE), 6,63 (s, 1H, CH imide.), is 6.78 (s, 1H, CH imide,), 7,08, 7,53 (AA'BB X-system, 4H, CH Hairdryer, J1=17,0, J2=8,6), 7,38 (m, 2H, CH of perid. SN imide.), of 7.75 (m, 1H, CH of Pirin,), at 8.60 (m, 1H, CH of pyrid.).

Example 3. 1-(Pyridinyl-2)-2-(1,2,4-1H-triazolyl-1)-1-(4-forfinal)-ethanol (2). Yield 24%. So pl. 123-125°C. NMR1N spectrum (DMSO-d6that δ, ppm): of 5.05, 5,16 (AB-system. 2H, CH2, J=13.3-inch), 6,55 (s, 1H, HE), 7,08, 7,50 (AA'BB X-system, 4H, CH Hairdryer, J1=16,0, J2=8,4), 7,28 (m, 1H, CH of pyrid.), EUR 7.57 (m, 1H, CH of pyrid.), 7,73 (m, 2H, CH is treas., SN of pyrid.), to 8.20 (s, 1H, CH is triaz.), to 8.57 (m, 1H, CH of pyrid.).

NMR1H spectra were recorded on the instrument Varian XL-400 (400 MHz).

Example 4. Testing the biological activity of the compounds was performed in vitro. In the molten sacharose-potato agar was added to the test substance in the form of a solution in acetone with a concentration of 3 mg/ml 1 ml per 100 ml of agar. To receive agar medium containing 30 mg/l of the test compound. To the medium control was added with pure acetone in the same amount. So prepared medium was poured into Petri dishes, cooled and the surface of the hardened agar were sown pieces of fungal mycelium, after which the Cup is incubated for 3 days at 25± 0,5°C. Inhibition of mycelium growth was calculated in percentage of the untreated control. As a reference used commercial fungicide triadimefon in the same concentration. The test results presented in the table.

Table
The test results of the compounds of formula I in a concentration of 30 mg/l Legend: V.i. - Venturia inaequalis, R.s. - Rhizoctonia solani, F.u. Fusarium oxysporum, F.m. - Fusarium moniliforne, H.s. - Helminthosporium sativum, S.s. - Sclerotinia sclerotiorum.
ConnectionInhibition of radial growth of the mycelium of fungi in % of control
V.i.R.s.F.o.F.m.H.s.S.s.
181-889210050
29949808710092
Standard645673956669

1. 1-(Pyridinyl-2)-2-azolyl-1-(forfinal)ataneli General formula I,

where X denotes a nitrogen atom or CH group.

2. The use of 1-(pyridinyl-2)-2-azolyl-1-(ftorpirimidinov General formula I,

where X represents a nitrogen atom or CH group as fungicides.



 

Same patents:

FIELD: pharmaceutical industry, medicine.

SUBSTANCE: invention relates to 5-membered N-heterocyclic compounds and salts thereof having hypoglycemic and hypolipidemic activity of general formula I , wherein R1 is optionally substituted C1-C8-alkyl, optionally substituted C6-C14-aryl or optionally substituted 5-7-membered heterocyclic group, containing in ring 1-4 heteroatoms selected from oxygen, sulfur and nitrogen; or condensed heterocyclic group obtained by condensation of 5-7-membered monoheterocyclic group with 6-membered ring containing 1-2 nitrogen atoms, benzene ring, or 5-membered ring containing one sulfur atom; { is direct bond or -NR6-, wherein R6 is hydrogen atom or C1-C6-alkyl; m = 0-3, integer; Y is oxygen, -SO-, -SO2- or -NHCO-; A ring is benzene ring, condensed C9-C14-aromatic hydrocarbon ring or 5-6-membered aromatic heterocyclic ring containing 1-3 heteroatoms selected from oxygen and nitrogen, each is optionally substituted with 1-3 substituents selected from C7-C10-aralkyloxy; hydroxyl and C1-C4-alkoxy; n = 1-8, integer; B ring is nitrogen-containing 5-membered heterocycle optionally substituted with C1-C4-alkyl; X1 is bond, oxygen or -O-SO2-; R2 is hydrogen atom, C1-C8-alkyl, C7-C13-aralkyl or C6-C14-aryl or 5-6-membered heterocyclic group containing in ring 1-3 heteroatoms selected from oxygen, sulfur and nitrogen, optionally substituted with 1-3 substituents; W is bond, C1-C20-alkylene or C1-C20-alkenylene; R3 is -OR8 (R8 is hydrogen or C1-C4-alkyl) or -NR9R10 (R9 and R10 are independently hydrogen or C1-C4-alkyl). Compounds of present invention are useful in treatment of diabetes mellitus, hyperlipidemia, reduced glucose tolerance, and controlling of retinoid-associated receptor.

EFFECT: new medicines for treatment of diabetes mellitus, hyperlipidemia, etc.

26 cl, 518 ex, 3 tbl

FIELD: organic chemistry, agriculture, fungicide compositions.

SUBSTANCE: invention relates to compounds of formula I

, wherein R1 and R2 are hydrogen or C1-C4-alkyl; X is C3-C8-cycloalkyl, phenyl or styryl, as well as method for production thereof and fungicide composition containing the same. Compounds of present invention have fungicide activity and are useful in effective controlling of deleterious fungi.

EFFECT: compounds and fungicide composition with improved effectiveness.

3 cl, 2 tbl, 4 ex

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for preparing compound of the formula (I) given in the invention claim wherein substituted are indicated in the description. Method involves interaction of ketone of the formula (II) given in the invention claim with succinic acid anhydride and alkoxide base to yield compound of the formula (III):

. The latter is subjected for interaction with compound of the formula (IV) given in the invention claim to obtain compound of the formula (V):

and interaction of compound of the formula (V) with alcohol to yield the corresponding ester of the formula (VI):

, and interaction of ester with N-methylhydroxylamine. Invention provides enhancing yield, reducing cost as compared to the known methods.

EFFECT: improved preparing method.

9 cl, 6 ex

The invention relates to pharmaceutical compositions for inhibiting integrase, which contains as active substance a compound of the formula (I)

where X denotes a hydroxy-group; Y represents a group-COORAin which RArepresents hydrogen or ester residue, or denotes a group-CONRINRCin which RINand RCeach independently of one another denotes hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl, and1means optionally substituted heteroaryl, with the exception of compounds in which Y and/or AND1denote optionally substituted indol-3-yl, or contains its tautomer, prodrug, pharmaceutically acceptable salt or hydrate, compounds of formulas I, II

where X, Y described above, AND1- optional replaced heteroaryl; Z1and Z2indicate the relationship; Z2means a connection, (ness.)alkylene, -CH(OH)-, -S-, -SO2-, -O - or-CO; Z4means a connection, (ness.)alkylene, (ness.)albaniles or-CO-; R1means neobyzantine substituted heterocycle, R2denotes optionally substituted (ness.)alkyl, optionally substituted (ness.)alkyloxy, optionally substituted (ness.)allyloxycarbonyl, optionally substituted aryl, optionally substituted by alloctype, carboxy or halogen; R=0 or 1, with the exception of compounds in which (1) Y and/or AND1denotes optionally substituted indol-3-yl and (2) X denotes a hydroxy-group, Y represents 2-thienyl, AND1denotes a 1H-1,2,4-triazole-3-yl, Z1and Z3each denotes a bond, Z2denotes-NH-, R1denotes phenyl or para-tolyl and p=0; (3) X denotes a hydroxy-group, Y represents 4-methoxyphenyl, or 4-chlorophenyl, AND1means thiazol-5-yl, Z1, Z2, Z3and Z4each represents a bond, R1denotes phenyl, 4-methoxyphenyl or 4-chlorophenyl, R2denotes methyl and p=1; (4) X denotes hydroxyl, Y represents phenyl, 4-were, 4-bromophenyl or 4-chlorophenyl, AND1signifies imidazol-2-yl, Z1and Z3each denotes a bond, Z2denotes methylene, R1denotes phenyl, Z4denotes a bond, R2denotes 4-dimethylaminophenyl or 4-methoxyphenyl, and p=1; (5) X denotes hydroxyl, Y represents phenyl, 4-were-or 4-met is 1 denotes phenyl and p=0; (6) X denotes hydroxyl, Y represents-COORAwhere RAdenotes hydrogen or ethyl, AND1signifies 3-indolyl, imidazo[1,2-a]pyridine-3-yl or imidazo[2,1-b] thiazole-5-yl, Z1, Z2and Z3each represents a bond, R1denotes optionally substituted phenyl, and tautomer, prodrug, pharmaceutically acceptable salt or hydrate; various farmkompanijam, comprising as active ingredient the compound II, the drug compound having anti-HIV activity; the method of obtaining compounds of formula III

as well as the intermediate products of the formula

where Z2denotes a bond, -CO-, -O-, -CH2- or -(CH2)2and R1denotes phenyl, substituted with fluorine, and

where And denotes C-W, where W denotes hydrogen, (ness.)alkyl, (ness.)haloalkyl or halogen, or N, Q denotes trail and L denotes ethoxypropan

The invention relates to amide derivative of the General formula I, the symbols in the formula have the following meanings: D is pyrazolidine group which may have 1-3 halogenated derivatives or unsubstituted lower alkyl group as the Deputy(I)her is fenelonov or topendialog group, X represents a group of formula-NH-CO - or-CO-NH -, and a represents a phenyl group which may be substituted by one or more halogen atoms, or a five - or six-membered monocyclic heteroaryl group which may be substituted by one or more of lower alkyl groups

The invention relates to a method of deriving 3-halogenated-1H-pyrazole of the formula II, where R is selected from the group comprising trifluoromethyl, deformity, pentafluoroethyl and getopterror, R3represents phenyl, optionally substituted at substitutable position by one or more substituents selected from fluorine, chlorine, bromine, methyl, ethyl, methoxy, ethoxy methylthio and

The invention relates to compounds of dehalogenation, insecticide/acaricidal agents containing these compounds as active ingredients and intermediates for their production

FIELD: organic chemistry, agriculture, fungicide compositions.

SUBSTANCE: invention relates to compounds of formula I

, wherein R1 and R2 are hydrogen or C1-C4-alkyl; X is C3-C8-cycloalkyl, phenyl or styryl, as well as method for production thereof and fungicide composition containing the same. Compounds of present invention have fungicide activity and are useful in effective controlling of deleterious fungi.

EFFECT: compounds and fungicide composition with improved effectiveness.

3 cl, 2 tbl, 4 ex

FIELD: organic chemistry, chemical technology, fungicides.

SUBSTANCE: invention describes substituted 1-(pyridinyl-3)-2-phenoxyethanols-1 of the general formula (I):

wherein R1 means alkyl, cycloalkyl, substituted or unsubstituted phenyl; R2 and R3 mean hydrogen or halogen atom, These compounds are prepared by interaction of oxiranes of the formula (II) with phenols of the formula (III) in the presence of a base at 100-150oC. Also, invention describes a fungicide composition based on compounds said. Invention provides preparing compounds that are effective against harmful fungi.

EFFECT: improved preparing method, valuable properties of compounds.

4 cl, 1 tbl, 7 ex

The invention relates to the chemistry of heterocyclic compounds, namely to substituted 1-(pyridinyl-3)-2-azolylmethyl General formula I

where R means a hydrogen atom, an unbranched or branched alkyl with a number of carbon atoms of from one to eight, cycloalkyl with the number of carbon atoms from three to eight, cycloalkenyl with the total number of atoms from four to ten, alkylsilanes with the total number of atoms from four to ten, X denotes a nitrogen atom or CH group, which possess fungicidal activity and can be used as agricultural, industrial, medical or veterinary fungicides

FIELD: organic chemistry, chemical technology, herbicides, agriculture.

SUBSTANCE: invention relates to new sulfonamides of the formula (I):

and their salt wherein A represents substituted or unsubstituted benzene ring or 5-membered, or 6-membered substituted or unsubstituted heteroaromatic ring taken among the group comprising thienyl, pyrazolyl, imidazolyl, pyridyl wherein optional substitutes are taken among the group consisting of halogen atom, substituted or unsubstituted (C1-C4)-alkyl, unsubstituted or substituted (C1-C4)-alkoxy-group, nitro-group, phenyl, phenoxy-group, benzoyl and (C1-C4)-alkylcarboxylate when any alkyl fragment in the latter indicated substituted is substituted with one or some halogen atoms, (C1-C4)-alkoxy-groups, cyano-group and phenyl; Q represents -O-, -S- or group of the formula: -CXX' wherein X and X' can be similar or different and each represents hydrogen atom, halogen atom, cyano-group, alkyl comprising 1-8 carbon atoms, or the group -ORa, -SRa; or one of X and X' represents hydroxy-group and another has values determine above; Ra means (C1-C8)-alkyl, phenyl; Rb means (C1-C8)-alkyl, phenyl; Y means nitrogen atom or the group CR9; R1 means unsubstituted (C1-C8)-alkyl or that substituted with halogen atom, cyano-group, phenyl or (C1-C4)-alkoxycarbonylamino-group, or it represents phenyl; R2 means hydrogen atom (H), (C1-C4)-alkyl; R3 and R4 can be similar or different and each represents (C1-C4)-alkyl, (C1-C4)-alkoxy-group, halogen atom; R9 means hydrogen atom (H) under condition that when Q represents oxygen atom (O) or -S- then ring A represents 5-membered substituted or unsubstituted heteroaromatic ring and determined above. Compounds of the formula (I) possess the herbicide activity that allows their using for eradication of weeds. Also, invention describes a method for preparing compounds of the formula (I).

EFFECT: improved preparing method, valuable properties of compounds.

9 cl, 5 tbl, 18 ex

Herbicidal agent // 2266648

FIELD: organic chemistry, agriculture.

SUBSTANCE: invention relates to herbicidal agent containing effective amount of active compound mixture including a) 2-(2-methoxycarbonylsulfonyl aminocarbonyl)-4-methyl-5-propoxy-2,4-dihydro-3H-1,2,4-triazole-3-one of general formula I 1 or sodium salt thereof; and b) one compound improving resistance of agriculture plants, namely diethyl-1-(2,4-dichlorophenyl)-4,5-dihydro-5-methyl-1H-pyrazole-3,5-licarboxylate in ratio a/b of 1:0.025-25 pts.

EFFECT: herbicidal agent reducing damage of agriculture plants, in particular cereals.

1 cl, 24 tbl, 2 ex

FIELD: organic chemistry, agriculture, insecticides.

SUBSTANCE: invention relates to a substituted anilide derivative of the formula (I): wherein R1 represents hydrogen atom, (C1-C6)-alkyl group; R2 represents hydrogen atom, halogen atom or halogen-(C1-C6)-alkyl group; R3 represents hydrogen atom, halogen atom, (C1-C6)-alkyl group, hydroxyl group or (C1-C6)-alkoxy-group; t = 1; m = 0; each among X that can be similar or different represents (C2-C8)-alkyl group, hydroxy-(C1-C6)-alkyl group or (C3-C6)-cycloalkyl-(C1-C6)-alkyl group; n = 1 or 2; Z represents oxygen atom; Q means a substitute represented by any of the following formulae: Q1-Q3, Q6, Q8-Q12, Q14-Q19, Q21 and Q23 (wherein each among Y1 that can be similar or different represents halogen atom, (C1-C6)-alkyl group, and so on); Y2 represents (C1-C6)-alkyl group or halogen-(C1-C6)-alkyl group; Y3 represents (C1-C6)-alkyl group, halogen-(C1-C6)-alkyl group or substituted phenyl group; p represents a whole number from 1 to 2; q represents a whole number from 0 or 2; r represents a whole number from 0 to 2. Also, invention proposes a chemical for control of pests of agricultural and fruit crops. The chemical comprises substituted anilide derivative of the formula (I) as an active component and represents insecticide, fungicide or acaricide. Also, invention proposes a method for addition of the chemical for control of pests of agricultural and fruits crops. Also, invention proposes aniline derivative represented by the general formula (II): wherein R1 represents hydrogen atom, (C1-C6)-alkyl group; R2 represents hydrogen atom, halogen atom or halogen-(C1-C6)-alkyl group; R3 represents hydrogen atom, halogen atom, (C1-C6)-alkyl group, hydroxyl group or (C1-C6)-alkoxy-group; t = 1; m = 0; each among X that can be similar or different represents (C2-C8)-alkyl group, hydroxy-(C1-C6)-alkyl group or (C3-C6)-cycloalkyl-(C1-C6)-alkyl group; n = 1 or 2. Invention provides the development of anilide derivative as insecticide, fungicide and acaricide against pests of agricultural and fruit crops.

EFFECT: valuable properties of compound.

5 cl, 6 tbl, 27 ex

FIELD: organic chemistry, insecticides.

SUBSTANCE: invention describes derivative of 1-aryl-3-cyano-5-pyridylalkylaminopyrazole represented by the following formula (1): wherein X represents C-halogen; R1 represents halogenalkyl group comprising from 1 to 4 carbon atoms with exception of perhalogenalkyl group; R2 represents hydrogen atom; R3 represents hydrogen atom; R4 represents hydrogen atom. Also, invention describes an agent used for control of insects comprising this derivative as an active component. Invention describes two methods for preparing compound of the formula 91). Compounds of the formula (1) are useful for control of insects in agriculture and for domestic animals.

EFFECT: improved preparing methods, valuable properties of compound and agent.

7 cl, 7 tbl, 7 ex

FIELD: organic chemistry, herbicides, agriculture.

SUBSTANCE: invention elates to novel derivatives of uracil of the formula [I] possessing herbicide activity, a herbicide composition based on thereof and to a method for control of weeds. In derivatives of uracil of the formula [I] the group Q-R3 represents a substituted group taken among:

wherein a heterocyclic ring can be substituted with at least a substitute of a single species taken among the group involving halogen atom, (C1-C6)-alkyl-(C1-C6)-alkoxy; Y represents oxygen, sulfur atom, imino-group or (C1-C3)-alkylimino-group; R1 represents (C1-C3)-halogenalkyl; R2 represents (C1-C3)-alkyl; R3 represents OR7, SR8 or N(R9)R10; X1 represents halogen atom, cyano-group, thiocarbamoyl or nitro-group; X2 represents hydrogen or halogen atom wherein each among R7, R8 and R10 represents independently carboxy-(C1-C6)-alkyl and other substitutes given in the invention claim; R9 represents hydrogen atom or (C1-C6)-alkyl. Also, invention relates to intermediate compounds used in preparing uracil derivatives.

EFFECT: improved preparing method, valuable properties of compounds.

40 cl, 16 sch, 12 tbl, 65 ex

FIELD: organic chemistry, insecticides.

SUBSTANCE: invention describes insecticide composition comprising the active amount of one pyridine compound of the formula (I)

or its salt wherein Y represents halogenalkyl group comprising from 1 to 2 carbon atoms and halogen atoms from 1 to 5; m = 0; Q represents compound of the formula:

wherein X represents oxygen atom; R1 and R2 represent independently hydrogen atom, alkyl group comprising from 1 to 6 carbon atoms and substituted with cyan-group, and one insecticide taken among carbofuran, carbosulfan, cipermethrin, bifentrin, acetamiprid, chlorfauazuron, fluphenoxuron, piriproxiphen, spinosad, emamectine benzoate, avermectin, buprophezin and fipronil taken in the weight ratio of compound of the formula (I) and other insecticide = from 1:2 to 100:1. The composition provides stable and strong effect and eradicates insects.

EFFECT: strong insecticide effect of composition.

4 cl, 11 tbl, 5 ex

FIELD: agriculture, in particular method for controlling of specific insect pests.

SUBSTANCE: invention relates to method for controlling of lepidopterous, homopterous, hemipterans, coleopterous, and physopods by contacting of said pests or environment thereof with effective amount of compound of formula I SSS1, N-oxide or agriculturally acceptable salt thereof being effective against abovementioned insects, wherein A and B are independently O or S; R1, R2 represent H, C1-C6-alkyl; R3 represents H, optionally substituted C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, or C3-C6-cycloalkyl; R4 represents H, C1-C6-alkyl, C2-C6-alkinyl, C1-C6-haloalkyl, CN, halogen, C1-C4-alkoxy, C1-C4-haloalkoxy, NO2;. R5 represents H, C1-C6-alkyl, C1-C6-haloalkyl, C1-C4-hydroxyalkyl, CO2R11R12, halogen or C1-C4-alkoxy; R6 represents H, C1-C6-alkyl, C1-C6-haloalkyl; R7 represents H, C1-C6-alkyl, C2-C6-alkenyl, C1-C6-haloalkyl, phenyl ring, benzyl ring, or 5-6-membered heteroaromatic rind, naphthyl ring system, or 8-10-membered condensed heterodicyclic system. Also claimed are compound of formula I and benzoxazine derivative of formula 10 .

EFFECT: compounds effective against agriculture spineless depredators.

22 cl, 13 tbl, 1 dwg, 24 ex

FIELD: organic chemistry, fungicides, agriculture.

SUBSTANCE: invention describes pyrazolcarboxamide of the formula (I) wherein if X means oxygen atom (O) then R1 represents (C1-C3)-alkoxy-(C1-C3)-alkyl; R2 means (C1-C3)-halogenalkyl; R3 means fluorine (F), chlorine (Cl) or bromine atom (Br), and if X means sulfur atom (S) then R1 means (C1-C3)-alkyl; R2 means (C1-C3)-halogenalkyl; R3 means halogen atom. Also, invention describes a method for preparing compounds of the formula (I), a composition for control of microorganisms and prevention for their attack and damage of plants, and a method for control of phytopathogen organisms, and compound of the formula (V) wherein X means sulfur atom (S); R1 means (C1-C3)-alkyl; R2 means (C1-C3)-halogenalkyl; R3 means chlorine, bromide or iodine atom. Invention provides control and prevention in infection of plants with phytopathogenic microorganisms - fungi in agriculture and horticulture.

EFFECT: valuable agricultural properties of compounds.

9 cl, 4 tbl, 12 ex

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