Method for normalizing metabolism in domestic animals
FIELD: veterinary science.
SUBSTANCE: as biologically active substances one should apply succinic acid 4-6 mg%, riboxin 4-6 mg%, vitamin B12 0.8-1.0 mcg%, silver 2 x 10-7 M - 2 x 10-9 M; moreover, the mentioned biologically active substances should be applied in balanced soluble form at applying drinking water purified with a filters system: mechanical, ion-exchange, coal and antibacterial Millipore 0.22 μ that contains no foreign admixtures. The present innovation enables to restore hepatic function, normalize urinary pH, restore renal filtration capacity and this, in its turn, enables to prevent renal lithogenesis, restore intestinal microflora, restore animal hairy integument and prolong their active life period.
EFFECT: higher efficiency of normalization.
1 cl, 3 ex
A metabolic disorder, a fairly common phenomenon, both in people and in animals. The reasons can be different: poor forage conditions, illness, etc.
Currently in the feeding of domestic animals is mainly used dry food. High quality food is very expensive, and cheap food is often unbalanced composition and long-term use can lead to various metabolic disorders; usually affects the liver and kidneys, occurs urolithiasis is the formation of stones in the bladder, the water balance in the body.
The task of the invention is the normalization of metabolic processes in the most gentle way. Usually in such cases, the veterinary doctor prescribes animal diet as an aid in the treatment of urolithiasis order of dissolution of uroliths. Food contains antioxidants and components, stabilizing the pH of the urine, as a rule, these polysaccharides of plant origin (for example, diet diets for cats Walthain feline Diets).
The disadvantage of this method is the need for long-term administration of diets: within 2 months when urine pH over 7.5; preventive courses of four weeks every 3 months; restrictions on use - only for nescetnych cats; the high price of the feed.
However, you can prevent negative consequences of the use of dry feed in the diets of cats and dogs, providing animal access to drinking water containing the necessary regulators of metabolism in the right quantities, in easily digestible form.
We have conducted research on the selection of recipes involving animals of various clubs and nurseries in St. Petersburg, as well as the animals owned by private individuals. During experiments carried out continuous monitoring of biochemical parameters of blood, urine, external examination by a veterinary surgeon.
Was optimal formulation containing as main active substances of Riboxin, vitamin b12, succinic acid, silver ions in a certain ratio; all these components are used in low concentrations, was dissolved in a specially prepared purified water:
- succinic acid 4-6 mg%
- Riboxin 4-6 mg%
- vitamin B120,8-1,0 ug%
- silver 2×10-7M - 2×10-9M
Thus, the received biologically active water - BAS, the solution was used as drinking ("Privaten-AQUA"). The method of purification of drinking water for the preparation of biologically active substances was carried out by applying the 4 - stage cleaning system using filters: mechanical, ion exchange, carbon and antibacterial Millipore 0,22 < .
Studies on animals have not only managed to reduce the pH of the urine, to restore the filtration capacity of the kidneys, but also to restore liver function.
Pharmacological properties of the individual components determine the properties of the whole component of the drug.
Succinic acid is not only highly energetic, stimulant carbohydrate metabolism, this soft feed acidifier; in this case, the organic acid used for the suppression of pathogenic microorganisms in the digestive tract, which violates the condition for feeding. The results of numerous experiments have shown that the use of succinic acid as an additive to feed improves conversion. In addition, it is possible to reduce the pH of the urine and prevent the formation of uroliths.
Vitamin b12is the regulator of hematopoiesis, the factor of absorption of vegetable protein, restores liver function, the regulator of protein synthesis.
Riboxin, the precursor of ATP, hepatoprotector.
Silver in ionic form has a pronounced antimicrobial activity, inhibiting the growth of pathogenic microflora in the digestive tract; in addition, as a trace element is part of a number of important enzymes; has a conservation action.
The dose limits of each component were selected in accordance with its biological effectiveness, co-action with the other component of the mi.
Example 1. Study of the influence of biologically active water (Privaten-Aqua") conducted in German shepherd dogs in the dog kennel Leningrad region.
Used in a special way purified drinking water, which has been updated in a balanced soluble form of the following substances: succinic acid at a concentration of 5.5 mg%, Riboxin at a concentration of 4.8 mg%, vitamin b12at a concentration of 0.9 mg%, silver at a concentration of 2×10-9M
Formed 2 groups of dogs: experimental and control.
In the experimental group selected 12 dogs in the control - 9.
All animals were healthy and get the same food.
Control group animals received plain water, experimental group - water content biological additives, taste, appearance and smell different from the purified drinking water, but with a pH of 5.0-5.5. Animals were given daily approximately 1 l of drinking.
The experiment was continued for 2 weeks. The first results were visible within 5-7 days.
Animals of the experimental group were more active, lively, had a better response and very profitable differed from the control dogs quality of the coat is thick, silky, supple wool, elastic clear skin, neat appearance.
Revealed no side effects.
Example 2. Study of the influence of biologically active water (Privet the on-Aqua") was tested on cats.
In a specially purified drinking water was made in a balanced soluble form of the following substances:
succinic acid at a concentration of 4.5 mg%, Riboxin at a concentration of 6 mg%, vitamin B12at a concentration of 0.95 mg%, silver at a concentration of 2-7M
Testing was carried out on 3 animals (breed of cat), owned by different private owners, suffered difficult urination and partial alopecia, taking place every year usually in the spring.
All animals received dry food and normal water. Without changing the diet, the animals were introduced into the diet instead of the usual water biologically active water (BAS). It should be noted that all animals willingly moved to the "experimental" drink, and in case of giving them a choice, chose it, and not just water. urine pH in animals before the experiment was 7,1-7,5. The drinking was given ad libitum. The coat was restored within 7 days. After 14 days was restored urination. urine pH is lowered to 6.0-6.5.
Example 3. Investigated the effects of bioactive water (Privaten-AQUA") on the blood in dogs.
For the experiments used drinking water purified in a special way and containing a balanced soluble form components in the following concentrations: succinic acid 6 mg%, Riboxin 6 mg%, vitamin B121.0 mg%, silver - 2×10-9M.
The experiments were carried out in a dog kennel in the Leningrad region.
Formed 2 groups: 1 - control 2 - experienced by 5 goals breed dog in each group at the age of 12 months. The animals were healthy. Received the same feed. Experimental group received daily biologically active water for 1 month. In the control group dogs were given normal drinking water.
Were studied biochemical indices of the blood, the hemoglobin concentration and the number of erythrocytes.
It is shown that the concentration of hemoglobin in the blood of dogs in the experimental group was 8.0% higher than in dogs in the control group, and the number of erythrocytes was higher by 13%than in the control group after 1 month from the beginning of the experience.
1. The method of normalization of metabolism in domestic animals by soldering them to the solution of biologically active substances, characterized in that the biologically active substances using succinic acid - 4-6 mg%, Riboxin, 4-6 mg%, vitamin B12- 0,8-1,0 µg%, silver - 2×10-7M-2×10-9M
2. The method according to claim 1, characterized in that the said biologically active substance is applied in a balanced soluble form using drinking water purified by the filter system: mechanical, ion exchange, carbon and antibacterial Millipore 0,22 μand does not contain impurities.
FIELD: medicine, stomatology.
SUBSTANCE: it is necessary to perform rinsing with oral remedy named "Corsodil", then comes moisturizing oral mucosa with insulin solution. Additionally, one should apply "Fluorovit" preparation onto mucous membrane of patient's tongue, cheeks and hyoid area by applying spray 30-40 min before meals 3-4 times daily. Moreover, one should apply gel named "Metrogil Denta" onto gingival mucosa once daily. The above-mentioned course consists of 10 seances, this course should be carried out once or twice annually. The innovation enables to decrease clinical signs of xerostomia and the risk for the development of oral mucosal inflammatory diseases in patients suffering diabetes mellitus.
EFFECT: higher efficiency of therapy.
FIELD: organic chemistry, medicine, pharmacology, pharmacy.
SUBSTANCE: invention relates to derivatives of 1,2-dihydropyridine of the general formula (I)
their salts or hydrates wherein Q means oxygen atom (O); R1, R2, R3, R4 and R5 are similar or different of one another and each radical means hydrogen atom, halogen atom, (C1-C6)-alkyl group or group represented by the formula: -X-A (wherein X means a simple bond, (C1-C6)-alkylene group); A means (C6-C14)-aromatic hydrocarbocyclic group or 5-14-membered aromatic heterocyclic group. Also, invention describes a method for preparing compounds and pharmaceutical composition. Compounds possess the strong inhibitory effect on AMPA receptors and/or kainate receptors.
EFFECT: improved preparing method, valuable properties of compounds and composition.
99 cl, 1 tbl, 414 ex
FIELD: chemico-pharmaceutical industry.
SUBSTANCE: the suggested composition contains prostaglandin-like compound as an active component and it , also, deals with the method to treat disorders of external secretion that includes application of efficient quantity of prostaglandin-like compound for a person who needs such a treatment. The composition is of high efficiency at treating disorders inactivity of lacrimal and sudoriferous glands being of high bioavailability and nontoxic.
EFFECT: higher efficiency of therapy.
33 cl, 5 ex, 7 tbl
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel biologically active compounds. Invention describes compounds or their salts of the general formula (I): A-B-N(O)s (I) wherein s = 2; A means R-T1- wherein R represents radical of a medicinal substance under condition that a medicinal substance by the formula R-T1-Z or R-T1-OZ wherein Z represents hydrogen atom (H) or (C1-C5)-alkyl is taken among paracetamol, salbutamol, ambroxol, alendronic acid,, cetirizine, ampicillin, aciclovir, doxorubicin, simvastatin, diphylline, tacrine, clopidogrel, dimethylomeprazol, diclofenac, ferulic acid, enalapril, propranolol, benfurodil hemisuccinate, tolrestate or sulindac; T1 means (CO), oxygen atom (O) or NH; B means TB-X2-O- wherein TB means bivalent radical R1B-X-R2B wherein R1B and R2B are similar or different and represent linear or branched (C1-C6)-alkylenes and X represents a bond, oxygen (O), sulfur (S) atom or NR1C wherein NR1C represents hydrogen atom (H) or linear or branched (C1-C6)-alkyl; corresponding precursor B is represented by the formula -TB-X2-OH wherein TB means (CO) and free valence in TB represents -OZ wherein Z is determined above, or TB means oxygen atom (O), and free valence in TB represents hydrogen atom (H) under condition that in the formula (I) when X2 in precursor B represents linear or branched (C2-C20)-alkylene then a medicinal substance by the formula R-T1-Z or R-T1-OZ used in the formula (I) doesn't belong to the following substances: enalapril (ACE inhibitors) and diclofenac (NSAID). Also, invention describes pharmaceutical compositions for using in cases of oxidative stress and 4-nitroxybutanoic acid 4'-acetylaminophenyl ester. Invention provides preparing novel compounds possessing useful biological properties.
EFFECT: valuable medicinal properties of medicinal substances and compositions.
7 cl, 8 tbl, 32 ex
FIELD: experimental medicine.
SUBSTANCE: during 5 d one should parenterally introduce erythrocytic autohemolyzate, or intravitreally one should once introduced erythrocytic mass being washed out thrice. Dosage for both ways of introduction corresponds to 0.2 ml/kg animal body weight. The innovation provides blockade of serotonin receptors that leads to the development of serotonin insufficiency.
EFFECT: higher efficiency.
2 cl, 2 ex
FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to novel perfluorinated cycle-containing tertiary amines of the general formula (1): wherein n = 1; m = 2 or 3; X means or and to a mixture of perfluorinated cycle-containing tertiary amines of the general formula (1) wherein n = 1; m = 2 or 3; X means or where at n = 1 Y means CF3 and at n = 2 Y means F as a base for gas-transferring emulsions. Proposed compounds are similar by their physicochemical properties, in particular, by critical temperature dissolving in hexane. Properties of these compounds provide the improved homogeneity of fluorocarbon phase of emulsions and to enhance stability of emulsion particles stabilized with block-copolymer of ethylene oxide and propylene oxide and in the absence of toxicity for small and large animals. Also, invention relates to a method for preparing perfluorinated cycle-containing tertiary amines of the general formula (1) by electrochemical fluorination of p-piperidinoheptafluorotoluene in anhydrous hydrogen fluoride.
EFFECT: improved preparing method and valuable properties of compounds.
4 cl, w dwg, 3 tbl, 4 ex
SUBSTANCE: complex therapeutic mixture consisting of 32 un lidase, 4 mg dexametasone, 40 mg lidocain diluted with 6 ml of 40% glucose solution is introduced into bulk of interspinous ligament at levels C7-Th1 and Th8-Th9. Procedure is repeated 5 times with 48 h intervals.
EFFECT: achieved rapid stopping of esophagitis manifestations owing to improved lymphovenous interactions in posterior mediastinum region.
FIELD: medicine, gynecology.
SUBSTANCE: intravaginally one should introduce proteolytically immobilized enzyme - imosimase at the dosage of 5 ml (300PU) and basic combined antimycotic preparation on the 1st, 5th and 10th d of therapy. The present innovation enables to decrease the number of complications during pregnancy, in the course of delivery, during puerperal and early neonatal periods due to valuable vaginal sanitation.
EFFECT: higher efficiency of therapy.
FIELD: medicine, surgery.
SUBSTANCE: one should sanitize a fistulous canal with antiseptic solution by introducing a medicinal substance of the following composition: homogenized placental tissue 30-35 ml; 5% ε-aminocaproic acid 6-10 ml; kanamycin sulfate 1.0-2.0 g; collagen 400-600 mg; omnipak-350 10-35 ml; patient's native plasma - up to 100 ml. The innovation suggested provides rapid healing in case of fistulas due to developing reticular structure along the whole fistulous route that contains components complexly affecting the process for fistula's healing.
EFFECT: higher efficiency of obturation.
3 dwg, 5 ex, 3 tbl
SUBSTANCE: method involves applying physiologic saline with ozone concentration of 5-10 mcg/l that is introduced in rectal way in the amount of 40 ml at a rate of 30 drops/min with pause 1-2 times per week within 2 months on the background of antibacterial treatment.
EFFECT: enhanced effectiveness in closing disintegration cavities and stopping bacterioexcretion.
FIELD: medicine, stomatology.
SUBSTANCE: for treating one should apply successively 3%-hydrogen peroxide solution followed by 1%-silver nitrate solution. This provides high antiseptic effect in combination with minimal dental dyeing with solver nitrate solution.
EFFECT: higher efficiency.
6 ex, 1 tbl
FIELD: pharmaceutics, in particular, curative agent and device for its preparation.
SUBSTANCE: the invention is in the fact that the curative agent on the basis of a sodium chloride solution includes ions of copper within 6.0 to 24.0 mg/l; citric acid - 100 mg/l; and ions of silver, the amount of silver makes up at least 1/1,000 part of the amount of copper. The ionator for preparation of a curative agent of antimicrobic effect has two short-circuited of antimicrobic effect has two short-circuited electrodes, one electrode is made of copper, and the second electrode - of silver. The area of the surface of the copper electrode relative to the area of the surface of the silver electrode makes up within 1:0.8 to 1:1.
EFFECT: enhanced antimicrobic effect, improved regenerative processes and accelerated recovery.
5 cl, 1 tbl, 1 dwg
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a medicinal preparation comprising propolis, dimethylsulfoxide and accessory substances as active substance and it comprises novocaine, anaesthesin as additional active components, and glycerol and 70% ethyl alcohol as accessory substances. The preparation can comprise 1% aqueous solution of ionized silver. The proposed treatment method is realized by applying the indicated preparation, once per 24 h, for 30 min, treatment course involves 7-10 procedures. Invention provides reducing treatment period of patients with diseases of locomotor system, peripheral nervous system and skin integuments and enhancing effectiveness of the preparation also.
EFFECT: improved treatment method, enhanced and valuable properties of preparation.
5 cl, 7 ex
FIELD: applied immunology.
SUBSTANCE: composition contains, wt parts: borax decahydrate1-25, sodium thiosulfate pentahydrate 10-5-10-4, potassium carbonate 30-150, refined sugar 30-200, and water 100-200 per 100 wt parts of sodium metasilicate pentahydrate. In addition to its capability of improving resistance to diseases, body weight increase, productivity of agricultural plants, quality of crop, and ripening term (harvest time), composition according to invention possesses nonspecific immunostimulating activity, including production of antibodies and enhancement of immunity through activation of immunocytes thereby maximally strengthening vaccination effect regarding diseases caused by malignant neoplasm viruses.
EFFECT: increased assortment of immunostimulating agents.
10 cl, 11 dwg, 12 ex
FIELD: medicine, ophthalmology, pharmacology, pharmacy.
SUBSTANCE: invention proposes a new agent for applying in therapy of inflammatory diseases of eye anterior site, namely, the silver-containing preparation "Argogel" "Argogel" represents argovite dispersion in polyethylene oxide gel. The preparation shows an antibacterial and virucidal effect and gel base shows additional keratoplastic effect. Invention can be used in therapy of conjunctivitis and retina suppurative ulcers.
EFFECT: valuable medicinal properties of agent.
FIELD: medicine, in particular disinfectant for domestic and industrial compartments, surfaces, tools, transport.
SUBSTANCE: claimed composition contains mixture of tetramethylenediethylene tetramine with silver ninrate, stabilizer and silica gel. Tetramethylenediethylene tetramine is obtained by reaction of at 50-70°C for 60-80 min in absence of alkali, then formed solution is cooled to 18-20°C for 12-18 h.
EFFECT: disinfectant with improved quality, higher bactericide and virulicide action; method with increased yield.
2 cl, 4 tbl, 6 ex
SUBSTANCE: method involves introducing cauterizing necrotizing composition like paste containing silver nitrate and dextrane into uterine cavity. Paste contact to target tissue is supported during time enough for reaching chemical necrosis. Then cauterizing composition is brought in contact with deactivating agent like aqueous solution of sodium chloride and removed from the uterine cavity later on. It is proposed to protect non-target tissue by supplying protection agent to it and carrying out previously described steps.
EFFECT: enhanced effectiveness of cauterization controlled in time and action intensity degree; avoided other tissue injuries.
30 cl, 8 dwg
FIELD: medicine, pharmacology, pharmacy.
SUBSTANCE: invention proposes an agent for treatment of infected wounds that comprises zeolite of Kcholinskiy deposit that represents zeolite powder modified with silver with particles size 17-20 . The proposed form provides enhancing the curative effect of agent due to elevating porosity of zeolite and increasing area in interaction of precipitated silver with wound surface. Invention can be used in surgery for healing wounds, among them chronic sluggish wound and trophic ulcers showing refractory properties to treatment with conventional agents.
EFFECT: improved and valuable properties of agent.
1 tbl, 7 ex
SUBSTANCE: method involves preparation dental surface, covering it with 30% aqueous solution of silver nitrate and recovery agent for precipitating insoluble silver salts. Silver salts precipitation is carried out by exposing silver nitrate covering tooth surface with halogen radiation of the kind produced by halogen lamp of 12 W or 75 W having spectral bandwidth of 400…500 nm provided with light guide for concentrating luminous flux for 60 s.
EFFECT: enhanced effectiveness of treatment; localized treatment; reduced risk of complications and stress action upon child.
FIELD: veterinary medicine.
SUBSTANCE: preparation has riboxin, glycolysis activator, vitamin B12, ascorbic acid, citric acid and glucose. The preparation calcium glycerophosphate as the glycolysis activator and additionally has succinic and folic acid and fructose taken in the following ingredient proportions in % by mass: riboxin -10,0-40, calcium glycerophosphate - 30,0-40,0, vitamin B12 - 0.02-0.04, ascorbic acid - 2-4, citric acid - 2-4, succinic acid - 2-4, folic acid - 1-2, fructose 5-10, glucose to 100.
EFFECT: increased laying ability of hens; reduced fodder consumption.