Method for treating uterine subinvolution in cows

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with applying 7%-ichthyol against 0.85% sodium chloride solution and denatured emulsified placenta (DEP), the latter to be introduced subcutaneously at the dosage of 20 ml on the 1st, 5th, and 9th d of therapeutic course. Sterile 7%-ichthyol should be injected thrice subcutaneously being heated up to animal's body temperature on the 1st, 3d and 5th d at the dosages of 25, 30 and 35 ml.

EFFECT: higher efficiency of therapy.

4 ex, 4 tbl

 

The invention relates to the field of veterinary medicine, in particular to methods for treating subinvolution of the uterus in cows.

The subinvolution of the uterus - a disease characterized by a slow process of development of the uterus after delivery to the state inherent in this body of non-pregnant animals. Her special danger to subsequent reproductive function in cows is that its background is very often developed purulent or purulent-catarrhal endometritis and functional disorders of ovaries.

There are three forms of subinvolution of the uterus: sharp develops in the first days after birth and occurs in severe, subacute mild and can be detected, usually in two to three weeks after birth, chronic diagnosed one month or more after birth.

Acute (severe) form of the pathologic process to 6-7 days lochia become brown or dirty-brown color, watery consistency, the admixture of gray-brown flakes kroshkovatyh mass unpleasant putrid smell. The cows are marked attempts, the root of the tail is elevated, the animal takes the position of urination, there are General oppression, loss of appetite and milk yield of cows increased body temperature, become less and weaken the contraction of the scar. By rectal examination Mat is detected and deep within the abdominal cavity, hand is not covered, atonic, fluctuates, the walls of her flabby, without pronounced folding. Clinical features and anatomic condition of the genital organs shows a dramatic impairment of the contractile function and retraction of the muscle fibers of the uterus, the accumulation in the cavity decaying lohii and intoxication of the body of the animal, i.e. a severe form of subinvolution of the uterus often progresses to type postpartum sapremia (the emergence of putrefactive bacteria in the blood).

Subacute (light) flow subinvolution of the uterus is diagnosed with a 15 to 30 day after calving and is characterized by sustained release (up to 25-30 days after birth) red-brown or dark-brown, thick, greasy consistency lohii, usually after a night's rest, or massage the uterus through the rectum. The uterus is usually enlarged, the walls of her flabby, weak tone and response to massage. Restore its size to nonpregnant is delayed up to 35-45 days or more.

Chronic subinvolution of the uterus in cows diagnosed after 30 days or more after calving and is one of the main causes of infertility in cows. It is characterized by increased size of the uterus, thickening of its walls, lowering the tone and weakening the response to massage, lack of allocation lohii. Chronic subinvolution of the uterus in cows manifests as Mogok innymi ineffective by inseminations, and anaphrodisia.

Known analog - treatment subinvolution of the uterus in cows with a 7%solution of Ichthyol in complex with karbaholina as part of the drug "Carbatol" /1/. Drug for the treatment of subinvolution of the uterus containing the karbaholina, Ichthyol medical, glucose and phenol in the following ratio, wt.%:

Karbaholin0,005
The Ichthyol medical7,0
Glucose5,0
Phenol0,1
Distilled waterRest

The disadvantage of this method of treatment is the low efficiency due to the fact that the Ichthyol, which means General-stimulating nonspecific therapy, enters the body of a sick animal in the composition of the drug carbachol limited and does not achieve a high therapeutic effect.

Known analog - treatment subinvolution of cows with the use of biostimulant "Placenta active principle" (PAN) /2/. It is made from the placenta of women without heat treatment using the sterilization effect of cavitation. The disadvantage of this method is that for the treatment of subinvolution of the uterus applies only tool General-stimulating therapy and are not used uterine preparations therefore, therapeutic efficacy of this method is low.

The closest technical solution is a method of treatment of subinvolution of the uterus in cows with the use of General-stimulating nonspecific therapy - 7%Ichthyol 0.85%solution of sodium chloride, uterine myotropic funds - oxytocin and prostaglandin F2α- astutely /3/.

The disadvantage of this method are the low efficiency of its use in the treatment of chronic subinvolution of the uterus in cows (1-2 or more after calving), and acute subinvolution of the uterus, and therefore require re-treatment after 12-14 days,

The technical result of the invention is improving the treatment of subinvolution of the uterus in cows, reduced complexity, reduced fertility and the rate of fertilization.

This goal is achieved by the combined application of funds non-specific General-stimulating therapies (Ichthyol and emulsified denatured placenta) for the treatment of subinvolution of the uterus together with symptomatic treatment (oxytocin, sinistral, magistrate).

The inventive method includes the use of General-stimulating actions - emulsified denatured placenta and Ichthyol, symptomatic therapy oxytocin, sines the rol and the drug group prostaglandin F2 α- magistrate.

The Ichthyol (vitaminol, ichthammol, Ichthyol-ammonium, ationality) - ammonium salts of sulfonic acids of shale oil. The Ichthyol - black, in a thin layer of brown, syrupy liquid peculiar pungent smell, soluble in water, glycerine, partially in alcohol and ether. The Ichthyol is a product of the destructive distillation of bitomsky shale containing fossil remains of marine animals and fish. Acts bacteriostatically, antiparasitic, anti-inflammatory, keratoplasticheskie and mestoobitraniya. After intravenous operates on the principle of non-specific therapy - irritant, and therefore develops a number of reflex responses, accompanied by an increase of protective forces of an organism, an increased secretion of adrenaline, serotonin, and vasopressin, constriction of blood vessels and capillaries. When endometritis and subinvolution of the uterus in cows Ichthyol applied intramuscularly or subcutaneously in the form of a 7%aqueous solution of 40%glucose solution or of 0.85%sodium chloride solution /4/.

Placenta centurymany emulsified (PDE) - fabric preparation made from human placenta. The drug is a sterile emulsion of white or white with a yellowish sheen color, peculiar smell, pH of 2.1 and 2.7. PDE contains a complex of biologically active substances (peptides, nucleic KIS is the notes, hexuronic acids, trace elements and so on). The drug has anti-inflammatory effect, has a positive effect on reparative processes, improves metabolism, stimulates sexual function, increases the body's resistance. PDE is used for the treatment and prevention of postpartum diseases in cows and sows. With the preventive purpose of the drug is injected cows twice immediately after birth and after 72 hours subcutaneously at a dose of 20 ml With endometritis or mastitis cows injected PDE subcutaneously at a dose of 20 ml every 48-72 hours 5-7 times. The use of PDE does not exclude the use of other media /5/.

Oxytocin is a solution for injection containing 1 ml 5 IU or 10 IU of synthetic analogue of the polypeptide hormone of the posterior lobe of the pituitary gland. Oxytocin increases energy and enhances contraction of smooth muscles of the uterus. Also causes a reduction myoepithelial cells surrounding the alveoli of the breast, has a slight vasopressin-like, antidiuretic properties. Oxytocin designate agricultural and domestic animals with weak attempts during childbirth, retention of placenta, uterine bleeding, atony, hypotonia and inflammation of the uterus, mastitis, and in reflex agalactia. The drug is injected subcutaneously, intramuscularly, intravenously /6/.

Sinistral (hexestrol) - 4,4-(1,2-diethyl-1,2-ethandiyl bisphenol (in the form of a diacetate or dodecanoate) - transparent oily liquid light yellow color. Sinistral - synthetic estrogen is a derivative of stilbene, estrogenic activity equivalent to estrone. Together with hormone luteum follicular hormone involved in the menstrual cycle. Sinistral increases the sensitivity of the muscles of the uterus to their exciting motility agents. Circulation in the blood of large quantities of estrogen in a short time contributes ovulatory type of the luteinizing hormone. Sinistral used by hypofunction of the ovaries, infertility, vaginitis, weakness of patrimonial activity /7/.

Magestrofan - a synthetic analogue of prostaglandin F2α(cloprostenol). Contains 1 cm3solution of 0.25 mg of active substance - cloprostenol. The product is a colorless transparent solution. The active substance of magestrofana - cloprostenol has specific luteolytic action. Its application in the luteal phase of the estrous cycle causes resorption of the yellow body and, thus, creates the preconditions for the onset of estrus and ovulation. The drug is administered intramuscularly. One of the indications for the use of the drug is the prevention and treatment of subinvolution of the uterus and endometritis. For these purposes, magistrate once imposed cows at a dose of 2 cm3through 6-1 hours after calving. For therapeutic purposes magistrate administered in the same doses in complex with symptomatic treatment /8/.

The novelty of the claimed method consists in the combined use of two drugs General-stimulating actions - 7%Ichthyol, emulsified denatured placenta (PDE). These drugs are used as follows. The EAP is administered subcutaneously at a dose of 20 ml in the first, fifth and ninth days of therapeutic course; sterile 7%Ichthyol, prepared by 0.85%solution of sodium chloride, is injected three times subcutaneously in warmed up to body temperature of the animal, on the first, third and fifth day in doses of 25, 30 and 35 ml. At the same time animals use tools symptomatically therapy oxytocin, sinistral, magistrate.

PDE is injected subcutaneously at a dose of 20 ml in the first, fifth and ninth days of therapeutic course. Sterile 7%Ichthyol, prepared by 0.85%solution of sodium chloride, is injected three times subcutaneously in warmed up to body temperature of the animal, on the first, third and fifth day in doses of 25, 30 and 35 ml. of Oxytocin administered subcutaneously at a dose of 8-10 UNITS/100 kg of body weight four times, starting from the second day of treatment with 24-hour interval in the treatment of acute and subacute subinvolution of the uterus and at a dose of 6-8 UNITS/100 kg of animal body weight, three times at 24-hour intervals from the second day therapeutic Kursaal (2%oil solution) is injected intramuscularly twice with a 24-hour interval in a dose of 2 ml from the first day therapeutic course in the treatment of acute and one - in the treatment of subacute subinvolution of the uterus. If the treatment of subacute subinvolution begins with 20-22 days after calving, instead of sinistral intramuscularly once on the first day of treatment the drug is administered group of prostaglandin f-2α - magistrate at a dose of 2 ml Magestrofan is administered intramuscularly in a dose of 2 ml on the first day of treatment in chronic subinvolution of the uterus.

To test the effectiveness of the treatment method was carried out on cows LLC Warniproduct" novousmansky, SHA "Levashova" Anninsky areas of the Voronezh region.

The essence of the method is illustrated by examples.

Example 1

The rationale for the combined use of Ichthyol and placenta denatured emulsified

Cows with subinvolution of the uterus was introduced 7%sterile Ichthyol, prepared by 0.85%solution of sodium chloride subcutaneously in warmed up to body temperature in doses of 25, 30 and 35 ml in the first, third and fifth days of treatment, PDE were injected with subcutaneously at a dose of 20 ml in the first, fifth and ninth days of therapeutic course. Before treatment and on day 9 from the beginning took the blood for holding immunobiological studies. The results of the experiment are presented in table 1.

Table 1
The rationale for the combined use of Ichthyol and plantaginaceae emulsified (PDE).
№№ p/pIndicatorsBefore treatmentAt the end of the treatment
1.Bactericidal activity, %83,993,5
2.The authors estimated the effect activity, ug/ml0,63±0,080,86±0,08*
3.Complementary activity, %3,123,02
4.Phagocytic activity of leukocytes, %56,687,5
5.Phagocytic number11,5±0,8623,7±1,12***
6.Phagocytic index6,48±0,5020,7±0,94***
* - P<0,05

*** -P<0,001

From table 1 it is evident that the use of iterature in complex with tissue drug - emulsified denatured placenta leads to increased overall nonspecific resistance of the organism. The use of these drugs contributes to the enhancement of bactericidal activity of blood serum 9.6%, lysozyme activity - 36.5% (P<0.05), and phagocytic activity of leukocytes - 30.9%.

Compatible with the uniform application of Ichthyol and placenta denatured emulsified improves indices of cellular and humoral protection.

Example 2

The experiment was carried out on cows red-and-white breed 3-6 years of age weighing between 450 and 550 kg Diagnosed with acute subinvolution of the uterus was set on the basis of anamnestic data and obstetric-gynaecological examination 6-7 day after calving.

Cows with acute subinvolution of the uterus was injected intramuscularly 2%oil solution of sinistral at a dose of 2 ml twice with the first day of treatment with 24-hour interval. In the first, fifth and ninth days) was subcutaneously injected PDE in a dose of 20 ml of the Ichthyol was introduced in the form of a 7%aqueous solution prepared by 0.85%sodium chloride, warmed to body temperature of the animal, with 48-hour intervals at doses of 25, 30 and 35 ml. Oxytocin dose of 8-10 UNITS/100 kg of animal body weight were injected with subcutaneously four times at 24-hour intervals, starting from the second day of treatment.

Animals of the control group was treated using the prototype. They have introduced a 7%Ichthyol, prepared by 0.85%sodium chloride solution, warmed to body temperature of the animal with a 48 hour interval from the first day of treatment in polysoude-lowering doses: 20, 25, 30, 35, 30 and 25 ml. of animals was injected intramuscularly 2%oil solution of sinistral twice with a 24-hour interval with the first day of treatment at a dose of 2 ml per second, third, fourth and fifth days) was subcutaneously injected oxytocin dose of 8-ED/100 kg m the ssy body.

For animals was performed daily clinical examination, taking into account the time of the disappearance of clinical signs of disease, the number of recovered and fertilized animals, the rate of fertilization, the duration of the period from calving to insemination.

Table 2
Therapeutic efficacy declared and known methods of treatment of acute subinvolution of the uterus in cows.
IndicatorsUsing prototypeUsing the inventive method
The number of animals, goal2325
Recovery time, days13,9±0,4110,8±0,28
Recovered, goal2024
Therapeutic effectiveness, %86,996,0
The period from calving to insemination, days62,1±1,1943,6±0,87
Were fertilized at the first insemination: goal1620
%69,580,0
The rate of fertilization1,61±0,051,41±0,05
Toxic the effect goal00

From table 2 it follows that the best therapeutic effect in the treatment of acute subinvolution of the uterus achieved by combined use of Ichthyol, placenta denatured emulsified and oxytocin on the background of sinistral.

Example 3

The experiment was carried out on cows red-and-white breed 3-6 years of age weighing between 450 and 550 kg Diagnosed with subacute subinvolution of the uterus was set on the basis of anamnestic data and obstetric-gynaecological examination 15-17 and 20-22 days after calving.

On the first day of treatment cows with subacute subinvolution of the uterus (15-17 days after calving) was injected intramuscularly 2%oil solution of sinistral at a dose of 2 ml If treatment begins with 20-22 days after calving, instead of sinistral intramuscularly once on the first day of treatment the drug is administered group of prostaglandin f-2α - magistrate at a dose of 2 ml In the first, fifth and ninth days) was subcutaneously injected PDE in a dose of 20 ml of the Ichthyol was introduced in the form of a 7%aqueous solution prepared by 0.85%sodium chloride, heated to a temperature of the animal's body, on the first, third and fifth day in doses of 25, 30 and 35 ml. Oxytocin dose of 8-10 UNITS/100 kg of animal body weight were injected with subcutaneously four times at 24-hour intervals, starting from the second day of treatment

Animals of the control group were treated with used the eat prototype. They have introduced a 7%Ichthyol, prepared by 0.85%sodium chloride solution, warmed to body temperature of the animal, with 48-hour intervals from the first day of treatment in polysoude-lowering doses: 20, 25, 30, 35, 30 and 25 ml. of animals was injected intramuscularly 2%oil solution of sinistral on the first day of treatment at a dose of 2 ml per second, third, fourth and fifth days) was subcutaneously injected oxytocin dose of 8-ED/100 kg body weight.

Table 3
Therapeutic efficacy declared and known methods of treating subacute subinvolution of the uterus in cows.
IndicatorsUsing prototypeUsing the inventive method
The number of sick animals1115
Clinical recovery, %81,893,3
Were fertilized goal712
%63,680,0
The period from calving to insemination, days70,7±4,3956,7±2,96
The rate of fertilization1,45±0,281,33±0,07

The animals were daily the second clinical examination, given the time of the disappearance of clinical signs of disease, the number of recovered and fertilized animals, the rate of fertilization, the duration of the period from calving to insemination.

From table 3 it follows that the best therapeutic effect in the treatment of subacute subinvolution of the uterus achieved by combined use of Ichthyol, placenta denatured emulsified and oxytocin on the background of sinistral or magestrofana.

Example 4

The experiment was carried out on cows red-and-white breed 3-6 years of age with a body weight between 450 and 550 kg were Diagnosed on the basis of anamnestic data and obstetric-gynecological examination on 30-60 day after calving.

On the first day therapeutic course cows intramuscularly injected magistrate at a dose of 2 ml In the first, fifth and ninth days) was subcutaneously injected PDE in a dose of 20 ml of the Ichthyol was introduced in the form of a 7%aqueous solution prepared by 0.85%sodium chloride, warmed to body temperature of the animal, on the first, third and fifth day in doses of 25, 30 and 35 ml. per second, third and fourth days of treatment) was subcutaneously injected oxytocin dose of 6-8 UNITS/100 kg of body weight of the animal.

Animals of the control group was treated using the prototype. They have introduced a 7%Ichthyol, prepared by 0.85%sodium chloride solution, warmed to body temperature animal is go with a 48-hour interval from the first day of treatment in polysoude-lowering doses: 20, 25, 30, 35, 30 and 25 ml. of animals was injected intramuscularly magestrofan on the first day of treatment at a dose of 2 ml per second, third and fourth days) was subcutaneously injected oxytocin dose of 6-8 UNITS/100 kg of body weight.

The animals were housed under supervision, take into account the number of recovered and fertilized animals, the duration of the period from the start of treatment before fertilization.

Table 4
Therapeutic efficacy declared and known methods of treating chronic subinvolution of the uterus in cows.
IndicatorsUsing prototypeWith the use of the claimed method
The number of sick animals4845
Clinical recovery, % (30 days)of 87.3for 95.3
Were fertilized (for 3 months): goal4042
%83,393,3
The period from the start of treatment before fertilization days32,7±2,2427,1±1,94
Remained barren: goal83
%16,36,6

From table 4 it follows that the better therapeutic effect achieved by the combined use of Ichthyol, placenta denatured emulsified, oxytocin and magestrofana.

Sources of information

1. Serebryakov, Y.M. Comprehensive system of measures to combat retention of placenta and acute postpartum endometritis (Recommendations). - Novosibirsk, 1991, - 19 C.

2. Lobodin K.A. Clinical-morphological changes in the genitals and hormonestazorac ovarian function in dairy cows during the postpartum period/ abstract. dis.... Kida. wet. Sciences. - Voronezh, 2003,to 23 C.

3. Cheremisinov GA, Azizyan R.N. Diagnosis and treatment of chronic subinvolution of the uterus in cows // veterinary medicine. - 1989. No. 10. - P.40-43.

4. Worms D.K. and other Drugs in veterinary medicine. - M.: Kolos, 1977. - S-389.

5. Guidance on the application of the placenta denatured emulsified (PDE) in the treatment and prevention of postpartum diseases in cows and sows, the Ministry of agriculture of the Russian Federation, 13.05.1996,

6. Guidance on the application of a solution of oxytocin in veterinary medicine. The Ministry of agriculture and food, 23.10.1995,

7. Instructions for use of the drug sinistral, Department of state control of quality, effectiveness, safety of medicines and medical technology, 2000. Registration certificate 000310/01 - 2001.

8. Guidance on the application of magestrofana, the Ministry of agriculture and food, 22.03.2000,

A method for the treatment of subinvolution of the uterus in cows, kiuchumi use of funds symptomatic therapy and means General-stimulating nonspecific therapy - 7%Ichthyol 0.85%sodium chloride solution, characterized in that additionally use another means of General-stimulating nonspecific therapy - denatured emulsified placenta (PDE), and the introduction of funds General-stimulating nonspecific therapy carried out according to the following scheme: PDE injected subcutaneously at a dose of 20 ml in the first, fifth and ninth days of therapeutic course; sterile 7%Ichthyol, prepared by 0.85%solution of sodium chloride, is injected three times subcutaneously in warmed up to body temperature of the animal on the first, third and fifth day in doses of 25, 30, and 35 ml.



 

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