Composition for chemical piling

FIELD: medicine, in particular composition for chemical piling.

SUBSTANCE: claimed composition contains component (A) of general formula B-[-(CH2CH2O)m(AO)n-H]a, wherein B is alcohol residue, AO is alkyleneoxy group having from 3 to 18 carbon atoms; a = 1 or more, integer number; m = 4 or more, integer number; n = 0 or 1 or more, integer number; with the proviso that ethylene oxide molar amount (m) is 40 % or more based on total molecular weight of ethylene oxide chain; and phenol compound (B). Composition of present invention has no side effects after treatment such as red spots, pigmentation or cicatrices and is useful in skin regeneration, spot elimination, pimple treatment, fat skin improvement, etc.

EFFECT: composition for chemical piling of improved effect.

3 cl, 5 ex

 

Description

The present invention relates to a composition for chemical peels that can be applied to remove wrinkles, spots (pigmentation, such as senile pigmentation spots and darkened areas of the skin, treatment of acne and to improve oily skin. The term "composition for chemical peels"referred to in this description means a composition for chemical peels, used in medicine and cosmetology.

In the West wrinkle, spots, etc. is considered one of the treatment methods. This method of treatment, mainly used in dermatological, orthopedic hospitals or cosmetic surgeries in Western countries, is applied to the skin of aqueous solutions of various concentrations of the composition for chemical peels, including trichloroacetic acid (TCA), phenol, etc. with the appropriate duration of treatment for the purpose of artificial chemical combustion (corrosion), and then restore the skin cells in a natural way.

However, processing of such a composition for a chemical peel effective only for white people, because Asians after treatment side effects appear: red spots, pigmentation, scars, etc.

Recently discovered that α-hydroxy acid (AHAs) are relatively safe and effective for peeling Asians. At the moment this method of processing is what I most widespread way. Outcomes and side effects when using this method, however, strongly depend on the concentration and pH α-hydroxy acids (AHAs) and suffer due to the complexity of treatment, requiring skill.

Previous treatment with a solution of salicylic acid in alcohol was made in USA and are known to be effective for white people. This treatment, however, has created problems for Asians when using this method because of serious side effects, such as a rush of blood to the face or pain during treatment and pigmentation after treatment.

The result is a comprehensive and long-term studies by the present inventor, it was found that although the composition comprising salicylic acid and polyethylene glycol, can be absorbed through the skin, which may be the reason for the ineffectiveness of its application for the treatment of skin diseases, a mixture of salicylic acid and polyethylene glycol allows salicylic acid to be in the glycol and maintained in the Horny layer of the skin without penetrating into the fatty matter in high concentrations and to remove only the outer layer without any systemic side effects. In addition, it was found that a mixture of a phenolic compound such as phenol or resorcinol, ethylene glycol or equivalent composition can exhibit f is t, similar to the effect of a mixture of salicylic acid and polyethylene glycol.

The present invention is based on this discovery, and its objective is the provision of a composition for a chemical peel that does not cause any side effects such as red spots, pigmentation and scars after the treatment, regenerating the skin (removal of fine wrinkles and giving skin flexibility)that removes stains and darkening of skin color. In addition, the composition for a chemical peel can treat acne and improve oily skin.

Disclosure of inventions

To achieve the above objectives the present invention provides a composition for chemical peels, including the substance (s)having the following General formula:

In-[-(-CH2CH2O)m(AO)n-H]a

(where is the rest of the alcohol;

AO - alkylene group having from 3 to 18 carbon atoms;

and is an integer of 1 or more;

m is an integer of 4 or more;

n is 0 or an integer of 1 or more;

provided that the number of moles m of oxidized ethylene is 40% or more of full molecular weight ethylenoxide chain)and phenolic compound (B)is included in the composition in an amount from 10 wt.% up to 30 wt.%.

Component (A)used in the present invention, can be displayed previously mentioned General formula.

In the previously mentioned General formula alcohol, the which is denoted by In, represents a monovalent alcohol, including, for example, Elgiloy alcohol, such as methanol, ethanol, butanol, lauric (dodecyloxy) alcohol, ministerului alcohol, palmately alcohol, stearyl (octadecanoyl) alcohol, cetyl alcohol, etc., di-valent alcohol such as ethylene glycol and propylene glycol, etc., trivalent alcohol such as glycerin, trimethylolpropane, triethanolamine, etc., tetravalent alcohol, such as pentaerythritol, diglycerin etc. can Also be used other polyvalent alcohols, such as sorbitol, polyglycerol etc.

Alkylene group having from 3 to 18 carbon atoms, denoted by AO, can include, for example, oxypropylene, oxybutylene, tetrahydrofuran, α-oxylipin etc Alkylene group having 3 or 4 carbon atoms, such as oxydipropyl and oxygenation and tetrahydrofuran is preferred.

In the previously mentioned General formula, the symbol "a" denotes an integer of 1 or more. When the alcohol used in the present invention, is a monovalent alcohol, a symbol "a" is 1. When the alcohol used in the present invention, is divalentin, the symbol "a" is 2. Similarly, when the alcohol used in the present invention is a trivalent alcohol, the symbol "a" has a value equal the OE 3. Further, when the alcohol used in the present invention is a polyvalent alcohol, a symbol "a" takes an integer value in accordance with the valence of the used alcohol.

In the previously mentioned General formula, the symbol "m" denotes the average number of moles of ethylene oxide added. The number of polymerized chains of ethylene oxide should not be less than 4.

The symbol "n" denotes the average number of moles added of oxidized alkylene. The number of polymerized chain oxidized alkylene can take values of zero or 1 or more values.

Polymerization of ethylene oxide and accelerated can be performed statistical polymerization or block copolymerization.

The number of m moles of ethylene oxide added is set in such a way as to be between 40% and more from total molecular weight chains of ethylene oxide. This requirement is based on the fact that if the number of moles m of ethylene oxide added would be less than the above number of moles, it is unlikely that phenolic compounds, such as salicylic acid, be kept in a derivative of polyethylene glycol.

Component (A) can be synthesized in the usual way, for example, by reaction of ethylene oxide and alkalinized with alkilany alcohol or alkanoyl alcohol in an inert gas, such as nitrogen,in the presence of basic catalysts, such as sodium hydroxide, potassium hydroxide or the like, or acid catalysts, such as chetyrehhloristy boron, tin tetrachloride or the like.

Specific examples of the compounds (A) may include, in particular, poly-ethylene glycol and its derivatives, polyoxyethylene polyoxypropyleneglycol and their derivatives, and long-chain polyoxyethylene alkilany ether and long-chain polyoxyethylene Allenby ether, used as a nonionic surfactant. Among these examples, the polyethylene glycol is shown under the trademark "Macrogol" in the Japanese Pharmacopoeia and the Instructions additives to medicines. Similarly, a block copolymer of ethylene oxide and propylene oxide is listed as their proximity. Phenolic compound added as the main component, can be maintained in these compounds and to remain in the stratum corneum without penetration into the fatty substance in high concentration. Therefore, the use of these components is more preferable, since they only exfoliate the stratum corneum without the risk of any systemic side effect. These components can be used separately or in combination of two or more.

Phenolic compound (C)used in the present invention, can be mentioned the th phenol, resorcinol, salicylic acid, etc.

Among the phenolic compounds (C) salicylic acid is most preferred. Phenolic compounds can be used both separately and in combination of two or more.

The number of added phenolic compounds may be in the range of 10 wt.% up to 30 wt.%. In the case of using a mixture of two or more of phenolic compounds the amount of these compounds should be appropriately selected within this range in order to effectively exfoliate the stratum corneum and not cause side effects.

Composition for chemical peels in accordance with the present invention may preferably include alkylacrylate-methacrylate copolymer in an amount of from 0.1 wt.% up to 5 wt.% as gelling or regulating the viscosity of the agent to prevent softening of the product, especially in the summer.

Composition for chemical peels in accordance with the present invention may include various standard additives for use in ointments or cosmetics that do not impede the effectiveness or not have any impact on the effectiveness of the composition for a chemical peel. Such additives can be, for example, aromatic compounds, surfactants, preservatives, antioxidants, UV is anaudio components, etc., and they should be used in appropriate quantities, which do not reduce the effectiveness of the composition for a chemical peel. It may be additionally added vitamin a-acid. Furthermore, addition of surfactants, etc. can significantly increase the effectiveness of the composition.

Composition for chemical peels in accordance with the present invention can be obtained in the usual way, for example, by mixing the component (A) in the molten state with the component (C) At ambient temperatures or at elevated temperatures or under pressure and with addition of various additives, if necessary.

Composition for chemical peels in accordance with the present invention can be used, for example, by applying the composition for a chemical peel the skin and remove it from the skin after a space of a predetermined period of time. This composition can be used to remove the epidermis (mainly cuticle) of the skin and affect the cells of the spinous layer of the epidermis and basal layer of the epidermis, thus causing the reproduction of fibroblasts of the dermis. The old part of the dermis may be substituted reproduced by fibroblast to call revitalize skin actions. This composition can remove wrinkles on the skin and restore skin elasticity. At the same time, cuticula of the hair follicle also exfoliates, and accumulated the cuticle can be removed, thereby treating acne. Disinfecting action of the major components of the composition for a chemical peel can be synergistic against acne and improve oily skin.

As the composition for chemical peels in accordance with the present invention can restructure the dermis of the skin by exfoliation of the stratum corneum and recovery of the fibroblast in the dermis, melanin, starasia the skin, can be removed from the place of treatment over time. In addition, fibrous tissue reproduces in the upper melanocyte of neoblast so that bluish-brownish color in the shade can also be disguised when you look at the appearance. Therefore, chromatosis caused by these reasons can be cured so that the spots and black or dark areas of the skin may disappear.

The duration of application of the composition for a chemical peel may be preferably from 3 to 20 minutes, although it is not limited to a specific period of time. This period may be selected in accordance with the processing time so as not to cause side effects and effective exfoliating action.

It should be noted that if phenolic compounds, such as salicylic acid, is used in low end is Tracii, a composition for a chemical peel, it is preferable to apply to the skin after removal of the cuticle, whereby the cuticle remaining in the hair follicle or skin, can be effectively removed without any side effects.

The best ways of carrying out the invention

The present invention will be described in more detail using examples. In the following description describes an example in which the glycol is used as component (A). It should also be noted, however, that the use of other components (A) can also give the effect is basically identical or similar to the example in which the glycol is used as component (A). Further, it should also be noted that although in each example uses a polyethylene glycol having a molecular weight of 1500, can also be used a polyethylene glycol having a molecular weight of from 1500 to 20000, preferably from the point of view of the penetration of the main component in skin tissue and the disparity of occurrence of side effects or other factors. In addition, these glycols may be used singly or in combination of two or more components when adjusting the viscosity, penetrating power, and other properties.

Example 1

Composition for chemical peeling was obtained by mixing polyethylene glycol with a molecular is Arnau weight 1500 in amount of 90 wt.% and salicylic acid in an amount of 10 wt.%.

The face of each of the 20 women aged over 60 years had a lot of composition for peeling, and this composition was removed after 20 minutes. The anointing was performed once a month for three months. It should also be noted that used salicylic acid is one of the agents that are usually used as a softening agent for the stratum corneum of the skin or for disinfection.

The monitoring was carried out through a digital camera. Observation showed a slight disappearance of fine lines and slight increase in hue and brightness for all the tested people. A study using scanning electron microscope imprint cheeks showed a slight disappearance of wrinkles on the skin.

In addition, none of subjected to testing people no side effect, such as red spots, pigmentation, scars, etc. was not detected.

It was also discovered that a composition comprising salicylic acid at a concentration of 10 wt.% or less, can effectively remove the Horny layer remaining in the hair follicle and the skin, without any side effects in the case when the skin was treated with the composition after removal of the stratum corneum.

Example 2

Composition for chemical peels was prepared by mixing politi-langille with a molecular mass of 1500 in the amount of 80 wt.% and Sali the sludge acid in the amount of 20 wt.%.

The face of each of the 50 women aged over 60 years had a lot of composition for chemical peels, and this composition was removed after 10 minutes. The anointing was performed once a month for three months.

The monitoring was carried out through a digital camera and showed the disappearance of fine lines and increase shade and brightness for all the tested people. A study using scanning electron microscope imprint cheeks showed the apparent disappearance of wrinkles on the skin. Comparison before and after treatment composition for chemical peels showed an increase in water content in the stratum corneum, increasing the number of evaporated moisture through the skin and improve the skin (when observed through cuticular).

In addition, none of subjected to testing people no side effect, such as red spots, pigmentation, scars, etc. was not detected.

Example 3

Composition for chemical peels was prepared by mixing politi-langille with a molecular mass of 1500 in amount of 70 wt.% and salicylic acid in the amount of 30 wt.%.

The face of every 10 women aged over 60 years had a lot of composition for chemical peels, and this composition was removed after 5 minutes. The anointing was performed once a month for three months.

The monitoring was conducted by qi the world of the camera and showed the disappearance of fine lines and increase shade and brightness for all the tested people. Observation using a scanning electron microscope imprint cheeks showed the apparent disappearance of wrinkles on the skin. Comparison before and after treatment composition for chemical peels showed a slight increase in water content in the stratum corneum, a small increase in the number of evaporated moisture through the skin and improve the skin (when observed through cuticular).

In addition, none of subjected to testing people no side effect, such as red spots, pigmentation, scars, etc. was not detected.

Example 4

Composition for chemical peels was prepared by mixing politi-langille with a molecular mass of 1500 in the amount of 90 wt.% and phenol in an amount of 10 wt.%.

The face of every 10 women aged over 60 years had a lot of composition for chemical peels, and this composition was removed after 3 minutes. The anointing was performed once a month for three months.

The monitoring was carried out through a digital camera and showed the disappearance of fine lines and increase shade and brightness for all the tested people. Observation using a scanning electron microscope imprint cheeks showed the apparent disappearance of wrinkles on the skin. Comparison before and after treatment composition for chemical peels showed a slight increase in water content in the region of govem layer, a small increase in the number of evaporated moisture through the skin and improve the skin (when observed through cuticular).

None of subjected to testing people no side effect, such as red spots, pigmentation, scars, etc. was not detected.

It was also discovered that a composition comprising a phenol at a concentration of 5% by weight or less, can effectively remove the stratum corneum, the remaining hair in the bag and on the skin without side effects in the case when the skin was coated composition after removal of the stratum corneum.

Example 5

Composition for chemical peels was prepared by mixing polyethylene glycol with a molecular weight of 1500 in the amount of 90 wt.% and resorcinol in an amount of 10 wt.%.

The face of every 10 women aged over 60 years had a lot of composition for chemical peels, and this composition was removed after 10 minutes. The anointing was performed once a month for three months.

The monitoring was carried out through a digital camera and showed the disappearance of fine lines and increase shade and brightness for all the tested people. Observation using a scanning electron microscope imprint cheeks showed the apparent disappearance of wrinkles on the skin.

Comparison before and after treatment composition for chemical peels showed a slight increase in the receiving water in the stratum corneum, a small increase in the number of evaporated moisture through the skin and improve the development of the skin (when examined through cuticular).

In addition, none of subjected to testing people no side effect, such as red spots, pigmentation, scars, etc. was not detected.

It was also discovered that a composition comprising resorcinol at a concentration of less than 10 wt.%, can effectively remove the Horny layer remaining in the hair follicle and the skin, without any side effects in the case when the skin was smeared component after removal of the stratum corneum.

Industrial applicability

Composition for chemical peels in accordance with the present invention may contain phenolic compound in the component (A) and hold this phenolic compound in the stratum corneum without penetration into the fatty substance in high concentration, thus flaking off only the stratum corneum layer without the risk of any systemic side effects. Consequently, the composition for chemical peels in accordance with the present invention can effectively remove wrinkles, spots (pigmentation, such as senile pigmente spots and darkened areas of the skin. This composition can also be used to treat acne and to improve oily skin.

In the present invention, the polyethylene is likely is used as the substrate, which serves to provide adhesion of the composition to the skin during application on the skin of the composition without any irritation. In addition, the composition can be easily soluble in water so that he could easily washed off with water. Consequently, the composition for chemical peels in accordance with the present invention can be effectively and safely used without special experience.

1. Composition for chemical peels containing polyethylene glycol and salicylic acid.

2. Composition for chemical peels according to claim 1, containing from 90 to 70 wt.% of polyethylene glycol and 10 to 30 wt.% salicylic acid.

3. Composition for chemical peels according to claim 1, wherein said polyethylene glycol is a polyethylene glycol 1500.

Priority items:

06.09.1999 according to claims 1,3;

25.05.2000 according to claim 2.



 

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