Automatic device for recording and analyzing evoked bioelectrical brain activity of testee

FIELD: medical engineering.

SUBSTANCE: device has means for acting upon object under study, means for recording responses having transducers connected to computer via signal input/output unit, photorecorder unit having programmed control mechanism and frame marker unit having in series connected control desk, frame marker, superposed responses photorecorder, programming unit and switchboard connected to control desk, means for acting upon object, means for recording responses and computer. Photorecorder programming unit has cam mechanism, the switchboard has relay circuits, the frame marker unit has means for recording treatment protocol and means for recording current events being tape drive with transparent tape coupled with tape drive with exposed film. The means for recording responses have magnetic tape recorder connected to control desk and transducers via switchboard. Tape recorder signal input is connected to microphone for recording vocal data describing current experiment condition and testee data.

EFFECT: enhanced effectiveness in recording biopotentials and creating feedback links among testees; wide range of functional applications.

2 cl, 6 dwg

 

The invention relates to physiology and experimental medicine.

When developing automated systems for the collection and analysis of physiological data are widely used features powerful personal computers with a large amount of memory and disk space. Known automated collection of physiological data (Piatigorsky et al., 1985; Kalachev, Kaplan 1994; Panteleev et al., 1996 - prototype and others), consisting of interconnected computers, means of influence on the object and means of registration of the responses.

The disadvantages of these systems are:

1. The inability to change the current effects during exposure. This applies particularly to the formation of biofeedback, requiring a combination of high standardization (repeatability) of the test conditions with the necessity to make emergency changes to the terms manually, depending on the current results of experience, state of the test object (the subject, the learner, patient) and the required change of registration options. For example, when working with experimental animals, the researcher is experiencing the greatest difficulties, because in contrast to research on the people he is deprived of the possibility of carrying out verbal installation, ensuring standardization caused potential is Alov and minimizing artifacts with the introduction of bioelectric potentials (EEG, GSR, pupillary reactions, etc. into the computer in the on-line mode. Important in these conditions is the possibility of continuous monitoring by the operator of the information received, it appears, sample analysis, and reliable recording and storing data is not only digital, but also native (analog) form, allowing to estimate and correction results. The solution to this problem using a standard computer systems of collection and analysis of bioelectric potentials is problematic.

2. When using the above computer information systems is an acute lack of means of visual inspection, marking and selective analysis of individual action potentials. With computer-averaged biopotential it is impossible to distinguish the individual EAP superposing answers. Machine averaging forms VP series suppresses the individual characteristics of the EAP in the series, so, according to some researchers, with a large range of forms EAP monitoring impossible. In addition, many EEG phenomena (peak-waves, spikes, paroxysmal discharges, sleepy spindle etc) practically are not amenable to direct computer analysis, making it difficult to machine selection and statistical collection of test potentials, as well as the interpretation of the obtained results.

3. When using a standard computer the situations of data collection systems is also an acute lack of means of visual inspection, marking and selective analysis of bioelectric potentials, as well as the lack of a reliable backup hardware and software, ensuring the preservation of data and the continuation of the planned research when various emergency situations: software errors, failures, disk memory, "freeze" your operating system or hardware problems with your computer and device input/output signals.

4. In neurophysiological experiment is important labeling of recorded action potentials. Known methods of marking can be applied in a digital-only labels that define the sequence number of the recorded potentials and do not provide the necessary information about the conditions of registration of the responses, the functional state of the research object and the current experimental effects.

The closest prototype made device "Automated electrophysiological setup for studying motor function of the gastrointestinal tract in rats" (authors Panteleev S., Chaman V.N., Molodtsov V.O.)described in the Physiological log them. Sechenov, 1996, Vol.2, No. 4, s-140, consisting of means for the effect on the object, means registration of the responses associated with a computer having the above-described disadvantages.

The purpose of the invention - EXT is an extension of field of use of the device and improving the reliability of the obtained results, improving the accuracy of identification, marking and analysis of evoked bioelectric activity, the possibility to change the current impacts and their use in the formation of biofeedback in subjects.

The invention consists in the fact that automated device for recording and analysis of evoked bioelectric activity of the brain of the subject, containing means to the object of research, tools, registration responses, including sensors, connected through the device I / o signals with a computer equipped with a photographic unit with control software mechanism and the printer frame, made on the series connected control panel, the printer frame, the photographic superposing answers, programming device and the switch associated with the remote control, means of influence on the object, by means of registration of the responses, and computers, and programming device of photoregulatory performed on the Cam mechanism, the switch is made on relay circuits, and the printer frame equipped with means for recording Protocol impacts and means for registering the current information, made in the form of tape transport with transparent tape, paired with the tape cassette is SMOM the exposed film.

2. The invention is also that the registration of the responses provided by the recorder connected through a switch with remote control and sensors, while the signal input of the tape recorder is connected to the microphone for voice recording information about the current conditions of the experiment and registration information from the examinee. The proposed device in the form of a flowchart is depicted in figure 1, where

1 - remote control

2 - printer

3 is a photographic superposing signals

4 - programming mechanism

5 - switch

6 is a block photographic

7 - block interaction with the object of study

8 - computer, for example, computer Pentium IBM PC / AT

9 - device I/o signals

10 - the object of study or of teaching

11 statement

12 - stimulants

13 - sensors

14 - registrars

15 - recorder

16 - amplifiers

Figure 2 shows an example implementation of the device, where

17 - motor

18 - zeitraffer main

19 - position Cam

20 - position Cam

21 - position Cam

22 - position Cam

23 - contact switch

24 - contact switch

25 - contact switch

26 - contact switch

27 - start relay

28 - Executive relay

29 - actuating relay

30 - ispolnitelnitse

31 - button starter

32 - photo magazine (FR)

33 - exposed film

34 - zeitraffer additional

35 - coil reception

36 - coil feed

37 - pulley for winding

38 - supporting panel

39 - flash (photoimpulse lamp)

40 - insulating block electrostimulator

41 is an insulating block of the pacemaker

42 - oscilloscope

43 - frequency modulator

44 - microphone

45 - update device

46 - multivibrator standby

47 - synchrocheck photoemulsions lamp 39

48 - photographic standard FOUR

49 - socket "synchro" photographic 48

50 - in speaker for audio feedback

51 - analog-to-digital Converter

52 - d / a Converter

53 - capacitor for pulse relay

54 - lamp-led-the device is ready to work

55 - infrared pupilometer

56 - the start button fixed mode without magnetic recording

57 - toggle fixing program

58 - tumbler lock magnetic recording

59 - tumbler lock program

60 - toggle multiplying the number of test stimuli

61 - tumbler lock photographic

Figure 3 shows time diagrams of nodes included in the device, where

the X-axis is a plot of the pulse sequence during device operation;

the Y - axis working order the units, included in the device.

Figure 4 shows the block diagram of the device, taken as the closest prototype.

Figure 5 presents the scheme of photoarchive recorded action potentials, where

32 - photo magazine (transparent film with the applied Protocol of experience);

33 - exposed film. Arrows indicate the direction of movement of the film during the registration and marking capabilities.

Figure 6 presents the fragment of the recorded action potentials with a fixed Protocol of experience.

Figure 1 shows the block diagram of the proposed device containing the remote 1 control, which is connected through the printer 2, 3 photographic superposing signals, the programming mechanism 4 and the switch 5, which are part of the block 6 photographic, block 7 of interaction with the research object and the computer 8, which is connected through the device 9 input/output unit 7 interaction with the research object and the research object 10.

Unit 7 interaction with the research object 10 contains as a means of influencing the object, which include stimulants 12, the tape 15 and logging responses, which include a tape recorder that combines the functions of the means and tools registration response, the sensors 13, the registers 14.

The unit provides the opportunity ISM is in current impacts as operator, and the object of study (the study), and their interaction during impact.

Figure 2 depicts the implementation of the proposed device, where the photographic unit 6 consists of photographic superposing answer 3, a motor 17, which via a gearbox associated with carratera 18 tape mechanism and Cam programming mechanism 4, consisting of a position of Cams 19, 20, 21, 22, tappets which abuts the spring loaded them contact switches 23, 24, 25, 26; start relay 27; Executive relays 28, 29, 30; engine start button 31, the coding device comprising a transparent photo printed marking the entry - photo magazine 32, which is perpendicular to the exposed film 33 in contact with the photosensitive layer of the latter, and passes through the additional film channel and the tape drive mechanism of the photo. The latter contains zeitraffer 34 additional mounted on the distributor shaft gear, receiving 35 and the feeding coil 36 and a pulley for winding 37 and the support panel 38 for emergency application of the information in the provided footage tape photo journal. The flash unit 39 is fixed in the window of the tube body of photographic and intended for exhibition marking the record. Block interaction with subjectam study consists of a 2-channel electrical stimulator 12; insulating blocks 40 and 41 in the output circuits of the pacemaker; oscilloscope 42; biopotential amplifier 16; a frequency modulator 43; microphone 44; update device 45; multivibrator 46; photographic superposing answer 3; photoflash 39 in the form of standard photoemulsions lamp; singleconnect 47 photoemulsions lamp 39; photographic FAURE production of the Institute of physiology. Bohomolets, Kyiv 48; nests "Synchro" 49 photographic 48 (terminals normally open contact pair of relay triggered synchronously with the shutter photographic); tape 15; a speaker for audio feedback 50; device input/output signals 9, includes an analog-to-digital Converter 51; d / a Converter 52; computer 8 (IBM PC AT computer); infrared pupilometer 55 for registration pupillary reactions, the capacitor 53 for pulsed operation of the relay. The composition of the control unit 1 includes: button 31 engine start; button 56 start fixed mode without magnetic recording; switch 57 fixation of the program; the toggle switch 58 lock magnetic recording; switch 59 lock program; the toggle switch 60 multiplying the number of test stimuli; switch 61 lock photographic; the led indicator light 54 unit ready to work.

The operation of the device shown in figs 2, 3, 5, 6. Device is on mode pairwise testing which is typically used for electrophysiological studies related to the study of the effect of the stimulation of various brain structures, the formation of behavioral responses when combined with the irritation of various analyzers, as well as provide feedback by sensory stimulation test. Work programming mechanism based on automatic construction of replacement control circuits by successive education temporary logical relationships, their preparatory and Executive elements. When this control circuit is interrupted by means of feedback or operate in pulsed mode. Education preparatory items chain by a group of positional Cams 19-22 contact switches 23-26, and tumblers 57-61 control and actuating elements - group relay 27-30. Registration consists of the following acts: control, test control, and labeling. Each of them is started manually using the button 31 or automatically by the pulse generated from the output of the digital to analog Converter 52 computer. If automatic start on the marking phase can be integrated testing, to give instructions to estimate and correction of functional state of the subject, change the pair is EAN lead and conditions of registration.

Figure 2 shows the position of the Cams 21, 22 pre-mode "test-control". Normalized unit operates, when the switches 57-59 included, and 60, 61 at the initial position (see figure 3. a graphic illustration of automatic operation).

Clicking on the launch button 31 is triggered, the relay 27, samplonius contact P1/1. In the process of holding the button using the contact P1/2 closes the circuit of the motor 17, which, rotating the Cam 19, using his contacts limit switch 23 becomes "self-locking" on nutrition. Group P1/3 starts the tape drive mechanism of the tape recorder, and P1/4 connects the signal input to the output of the frequency modulator 43; group P1/5 prepares a chain running photographic FAURE 48. During the rotation of the engine 17 is a drawing of the exposed photographic film superposing answers 3 and the marking film photo journal 32; a power circuit through the contacts 23 charging the capacitor 53; contact switch 26 under the influence of the Cam 22 moves into a new state 2, disabling the trigger circuit of the relay 27 and preparing the output circuit of the first channel of the pacemaker 12 to the object of research. Staffing ends in the actuation of the Cam 19 on the power supply to the motor circuit contact of the switch 23. Thus vos is adjusted chain through the other contact of the contact switch 23 pulse discharges the capacitor 53 to the relay coil 28, the resulting pulse is triggered group P2/1 and together with the "holding" circuit group P1/5 and the contact switch 26 includes a shutter, and with it the tape drive mechanism of the photographic 48. P2/2 and P2/3 trigger idle. At the end of the shutter closes private synchrocheck photographic 48, forming the power supply circuit of relay 29, after tripping the shutter is self-locking with contacts P3/1; connects the output of the first channel of the pacemaker 12 groups P3/3, limit switch 26 and contacts P3/2 to the object of research, which results in the sending of the test stimuli in the "test-control" and simultaneous registration photocapacitance packs evoked bioelectric responses (IN) on the photographic superposing answers 3 and a single IN the photographic 48 and the tape 15 in the appropriate manner, as well as digitizing of biopotentials and their input into the computer 8 through the analog-to-digital Converter 51. Potentiate IN is on the screen oscilloscopes 42 and the computer display. After passing a series of pulses from the output of the second channel of the pacemaker 12 (the number of pulses that are multiples of 10, set by turning on the toggle switch 59) triggers the relay 30, interrupting the supply circuit of the relay 29 and 27, the result of which involved the s elements of the Executive group of the relay switch are transferred to the initial state, interrupting the process of stimulation and registration.

Then we act program, which implements the marking information (figure 2, 3, 5, 6).

For his initiation in position "II" Cams 20-22 click the launch button 31. Through appropriate contacts button to start the tape drive mechanism of the tape 15. When this signal input through the initial position of the groups P1/4, connected to the microphone 44. Holding the button undertaken by the voice recording information about the current conditions of experience or text mark photo journal 32 and rooms next entry handicap, which fits into the marking frame photo journal 32 when planned (Protocol) of the experiment. Simultaneously, through the appropriate contacts of the contact switch 23 and the button 31 charging the capacitor 53. After recording release button 31, the result of which stops the feed of the magnetic film, and the capacitor 53 pulsed discharges on the relay coil 28, which pulse is triggered. The circuit through the contact group P1/2, the contact switch 24 and the contacts P2/3 start the engine 31 photographic superposing answer 3, blockerase power groups of the contact switch 23, and by the formation of the next frame of the exposed film 33 photographic 3, and combining with it the brand photo journal 32 (5, 6). the place with the Cams 20-22 lead their contact switches in new condition, in the result due to the switching contact of the switch 24 is cut off preparatory communication power of the engine of the chain run, by changing the position of the contact switch 25 is prepared the trigger circuit photoemulsions lamp 39, and in connection with the switching contact of the switch 26 is formed preparatory communication start relay 27. After actuation of the contact switch 23, as a result of transition of the Cam 19 in the symmetric condition of the engine 17 is stopped, and the relay 28, discharging the capacitor 53 on its winding, a pulse is triggered. With the help of the group P2/2 is triggered photoimpulse lamp 39, exposing the photo frame on the photographic film superposing answers 3.

Next, the 3rd act program provides for the registration in the "control". Figure 2 shows the corresponding working position Cam software 20-22, in which they move from the position II. The transition in this position can also be initiated by pressing the button 31, and the subsequent work of the Executive elements is similar to the process mode "test-control" (discussed above) with the difference that the preparatory connection of the output of the first channel of the pacemaker 12 through a contact group switch 26 is not formed, and therefore the expected R the realizations of "control".

The inclusion of the preferred modes of registration (photographic FAURE 48, tape recorder, computer), and repeated exposure information or idling Registrar is carried out by the manipulation of switches 57-61 and buttons 31, 56 remote control. Further control is performed automatically or in cycles with successive clicks on the trigger button 31. The program of the experiment can be easily modified and/or supplemented by changing the position of software Cams on the shaft of the engine, and connecting the backup Cam 20 with the contact switch 24, which can be used to automatically turn on in accordance with the requirements of the experiment, additional devices (photo-, Phono-, Mechanochemistry, drive microinjector etc). It should be noted that full electrophysiological experiment can be achieved when working in the installation of one photographic superposing answers with a software mechanism and a coding device (computer, tape recorder and the photographic 48 is turned off). This mode of operation is most useful when an organization search (pilot) experiments on laboratory animals related to the necessity of using a large number of samples, multiple changes during experience localization of the electrodes and p the parameters of stimulation, as well as a strengthening of monitoring the functional status of the object of study, accompanied by a view of long sequences allocated evoked potentials. Engine photographic superposing answer 3 engaged in scrubbing the exposed tape and photo, if necessary, can be disabled, run the test stimulus in this case is also carried out using the trigger button 31.

Thus, the introduction of semi-automatic operation mode electrophysiological setup involving the transfer of part of the functions associated with the programming of the experiment, control testing, conversion and recording equipment, computer specialist electro-mechanical device - a switch is made to relay circuits and controlled by the operator, optimally organizes human-machine interface in the system managed electrophysiological experiment using personal VMS computer.

Use in installation designed by us with photographic control software mechanism and a special coding device allows to simplify (optimize) the work of a researcher at almost all stages of the electrophysiological experiment: 1) in the preparation and planning of the former is eriment to write a photo/photo-report of the planned experience, installing a Cam mechanism to programmatically connect the necessary instruments and devices); 2) when doing research (monitoring of single and superpositioning EAP selection for biopotential their photo, magnetic and mechanical registration); 3) when editing and analysis of recorded data (based on the complete database of the experiment synchronously recorded on a standard photographic 48, photographic superposing answer 3, the tape recorder and the computer's hard disk).

It should also be noted that the use of the installation sessions with formation feedback allows subjects to produce self-starting process sensory stimulation and registration of the test electrophotographic parameters (EEG, EP, GSR, pupillary reactions) using the remote press the trigger button 31. This makes it possible to free the subjects from having contact with the screen, keyboard and additional instructions of the experimenter during the training session, allowing you to create the subject of a favorable treatment conditions (off extraneous sensory stimuli, to lie down on the couch, close his eyes, and so on)necessary for control and correction of the subjects of their functional status. This also ensures the best possible conditions DL is muscle relaxation, required for bitartarate lead test electrophotographic reactions. In experimental animals, the conditions for bitartarate discharge of action potentials is provided by the use of elaborated atraumatic growdelegates [Albertin 1989], which allows electrophysiological studies with rigid fixation of the head of the animal without the use of drugs and muscle relaxants.

The ADVANTAGES of the DEVICE

1. The device allows you to create optimal conditions for recording biopotentials, to minimize the influence of artifacts when data is entered into the computer and their subsequent machine processing by introducing a new node - photographic managing a software mechanism and a printer connected with the computer by remote control, means of influence on the object and means of registration of the responses.

2. Automated device for recording and analysis of evoked bioelectric activity of the brain of the test provides the ability to modify the current impacts upon registration potentials, their labeling and provide feedback in the subjects. This advantage is achieved by introducing a new node - photographic managing a software mechanism and a printer associated with the computer means of influence on bject and by means of registration of the responses.

3. The device provides reliable recording and storing potentials (EEG, EP, GSR) is not only digital, but also native (analog) form, allowing to estimate and correction of the experimental results. The device also ensures that data is stored and the continuation of the planned experiment when various emergency situations: software errors, failures, disk memory, "freeze" your operating system or hardware problems with your computer and device input/output signals. This advantage is achieved through the use of the photographic unit with a software mechanism and a printer.

4, the Device allows you to automate the process of labeling with the possibility of emergency introduced in marking the frame, and also frees the researcher from the need of logging in the process of experience. This advantage is due to the fact that the marking is in the form of concise writing specific values, fiksirovannykh on a separate tape - photo magazine (photo-report)entered into the plane of the aperture of the photographic, as well as a substantial increase in the marking field in comparison with frame of standard photoregistration.

5. The device allows you to automate the management of photographic, otrabatyvat flow test stimuli and to connect external devices, and also to automate the electrophysiological setup by switching its electrical circuits. This advantage is achieved due to automatic construction removable control circuits by successive education temporary logical relationships, their preparation and actuators, while the control circuit is interrupted by means of feedback or operate in pulsed mode, the preparatory education of the circuit elements by a group of positional Cam mechanisms of the photographic unit, and actuating elements - relay group.

6. The device allows you to apply a simple (cheap) schematic ADC/DAC controller for digitizing and inputting registered biopotential connected to a serial or parallel ports of the computer to control external feedback signal, and to simplify the writing of control programs and data. This advantage is achieved by the introduction of semi-automatic operation mode electrophysiological setup, providing for the transfer of functions related to programming, research, management, testing, conversion and recording equipment, computer specialist Electromechanical device is the switch, performed at the relay circuits and controlled by the operator.

7. The device allows you to release subjects from having contact with the screen, keyboard and additional instructions of the experimenter during the training session, and thus to create the subject in the session with the formation of feedback favourable treatment conditions (off extraneous sensory stimuli, to lie down on the couch, close his eyes, and so on)necessary for control and correction of the subjects of their functional status. This advantage is achieved by allowing the subject to produce self-starting process sensory stimulation and registration of the test electrophotographic parameters (EEG, EP, GSR, pupillary reactions) using the remote pressing the start button after the evaluation test their functional status.

SOURCES of INFORMATION

1. Albertin SV Device for immobilization of the head of the animal. Auth. mon. SU 1528473 A1, bull. Fig., 1989, No. 46.

2. Kalachev A.P., Kaplan AJ, System computer analysis of bioelectric signals. PC world, 1994, No 8, p.95.

3. Panteleev S., Chaman VI, Molodtsov V.O. Automated electrophysiological setup for studying motor function of the gastrointestinal tract in rats. Fiziol. W is pH, them. Sechenov. 1996, CH, No. 4, s-140 (prototype).

4. Pyatigorsk BJ, Zitman GA, Cherkasy, VA, plane trees, VA Automated electrophysiological experiment. Kiev, "Naukova Dumka", 1985, s.

5. Khilko I.S. (ed) the Photographic waveform biological for-2. Description and passport FOR-PS, Kiev, 1986.

1. Automated device for recording and analysis of evoked bioelectric activity of the brain of the subject, containing means to the object of research, tools, registration responses, including sensors, connected through the device I / o signals with a computer, characterized in that it is provided with a photographic unit with control software mechanism and the printer frame, made on the series connected control panel, the printer frame, the photographic superposing answers, programming device and the switch associated with the remote control, means of influence on the object, by means of registration of the responses, and computers, and programming device photographic performed on the Cam mechanism, the switch is made on relay circuits, and the printer frame equipped with means for recording Protocol impacts and means for registering the current information, made in the form of the tape mechanism is transparent tape paired with the tape drive mechanism of the exposed film.

2. Automated device according to claim 1, characterized in that the means registration response equipped with a tape recorder connected through a switch with remote control and sensors, while the signal input of the tape recorder is connected to the microphone for voice recording information about the current conditions of the experiment and registration information from the test.



 

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4 cl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to obstetrics. Cardiointervalography (CIG) is performed. Analysis of heart rate variability (HRV) is carried out. Value of the following indices is estimated: standard deviation, pRR50,coefficient of variation, total power of HRV (TP), power of slow LF-waves, mode amplitude, index of adequacy of regulation processes (IARP), voltage index (VI), value of maximal R-R interval, mean-square difference between duration of neighbouring cardiointervals (RMSSD), normalised power of slow LF-waves, normalised power of fast HF-waves, vegetative index of rhythm (VIR). On the basis of obtained data each of the above mentioned indices is given points from 0 to 2. Also evaluated is value of systolic and diastolic arterial pressure with assigning points. Degree of cervix "maturity" is determined by Bishop scale with giving points. Obtained points are summed up. If sum of points equals 7 or more woman is related to group of risk in of uterine inertia development.

EFFECT: method makes it possible to carry out prediction of uterine inertia before beginning of urgent delivery, which gives possibility to take measures for prevention of initial uterine inertia, in addition, method is non-invasive and safe for parturient woman and newborn baby.

4 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: patient is trained by challenging to imagine a paretic limb movement and controlling the imagined movement. An electroencephalography is recorded; the recorded data are transferred to a computer for synchronous processing, and arousal reaction signals of a sensorimotor rate responsible for the imagined movement are isolated by means of an EEG pattern classifier according to the Bayes method. Identification results of the mental challenge are presented to the patient by a visual feedback in the form of a mark on a monitor. The mark re-position testifies to accuracy of the challenge. The imagined movement challenge is presented for 10 seconds. The training course makes 6-12 days, one training a day, of the length of 20-30 minutes every 1 to 4 days.

EFFECT: method provides more effective rehabilitation that is ensured by the feedback training in the conditions enabling the patient controlling the imagined paretic limb movement visually.

3 dwg, 4 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: pulse electric activity of sensorimotor central neurons is recorded in experimental animals adapted to hypoxia. The recorded activity frequency is modulated by a multivibrator and an electroacoustic transducer; the signals are copied and transferred onto a carrier. The patient is exposed to distant acoustic signals with the use of the laser generator. The exposure is sequential and starts with sessions at frequency 5-8 Hz for 5-7 minutes and follows with sessions at frequency 10-15 Hz for 5-8 minutes. The sessions are daily, one session a day; the therapeutic course is 10-14 sessions.

EFFECT: method enables using the drug-free modalities and normalise the blood pressure that is ensured by providing the mode and sequence of acoustic signal flow.

2 tbl, 3 ex

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