Method for detecting endothelium-dependent arterial vasodilation due to evaluating alterations in pulse wave distribution rate at the background of reactive hyperemia

FIELD: medicine, cardiology.

SUBSTANCE: one should detect pulse wave distribution rate (PWR) at rest by standard technique, then one should squeeze brachial artery with manometer's gasket to measure arterial pressure (AP) for 3 min. Pressure should be increased by not less than 50 mm mercury column against systolic AP. Immediately on removing the air out of manometer's gasket one should detect PWR after restoration of arterial circulation. Normally one should state upon significant PWR decrease, by 21.2%, on an average. In patients with ICD alterations of PWR are expressed in considerably lower degree and corresponded to 3.9%, in one portion of patients with ICD one may observe increased PWR. The method suggested could be applied as functional probe for evaluating endothelial arterial function being the routine trial in clinical practice.

EFFECT: higher accuracy of detection.

2 ex, 4 tbl

 

The invention relates to medicine, refers to the diagnostic functional test, based on the determination of the propagation velocity of the pulse wave (SST) and SST change that developed after arterial occlusion. The method can be used as a functional test in patients with various cardiovascular pathology for the study of vessel regulation of endothelial function of arteries in the treatment process.

You know the vascular endothelium regulates local hemostasis, proliferation, and migration of blood cells in the vascular wall and affects vascular tone. Endothelial dysfunction implies the presence of an imbalance between factors in these interactions (..Quyyumi. Endothelial function in health and disease: new insights into the genesis of cardiovascular disease // Am. J. Med. - 1998. - V.105. - P. 32S-39S).

It is proved that the rate of changing the speed of blood flow changes the diameter of the large arteries: by increasing blood flow to the arteries expand, but at a lower taper. It is believed that the regulation of the lumen of the arteries is a local reaction (Dashdamirov, Laudanosine, Ojukutu and other Functional state of endothelium in patients with arterial hypertension and ischemic heart disease // Cardiology. - 2000. No. .6. - P.14-17).

The connection of the onset and progression of endothelial dysfunction with age. Increase dilation of the shoulders is howling arteries in response to increased blood flow in normal in persons aged 40 to 55 years remained stable, and in subsequent decreases 0.21% per year. In patients with CHD also revealed a decrease in dilatation of the brachial artery, which is explained by lipid metabolism disorders, heart failure and possible concomitant arterial hypertension. A number of studies have shown that abnormalities of endothelial function in patients with ischemic heart disease occurs in the majority of cases, including, at a young age (under 45 years), and in the early stages of myocardial infarction in patients even more frequent paradoxical vasoconstriction (Vaalputs, Oispecific, Musicnov and other Endothelial dysfunction in patients with debut of coronary heart disease in different age // Cardiology - 2001. No. .5. - P.26-29).

In the studied literature we met data developed tests to assess endothelial function, based on ultrasonic diagnostic methods. Using the ultrasonic device was visualized area of the brachial artery diameter was determined in diastole. Endothelium-dependent dilation of an artery is called reactive hyperemia that occurs in response to cessation of blood flow imposed by the cuff, proximal to the measurement. The diameter and blood flow velocity were measured before and after cross-clamping of the artery. The normal response of the brachial artery on reactive hyperemia is the fast expansion of more than 10%. A smaller degree of vasodilatation or paradoxical vasoconstriction considered pathological response and may indicate the presence of endothelial dysfunction (Dashdamirov, Laudanosine, Ojukutu and other Functional state of endothelium in patients with arterial hypertension and ischemic heart disease // Cardiology. - 2000. No. .6. - P.14-17).

Proposed methods of assessment of endothelial function of arteries have clear advantages, but may not be used for routine applications for a large number of studies, as they require expensive equipment, highly skilled and quite a long time of the procedure itself. Most authors noted that the increase in artery diameter in response to increased blood flow at the expense of reducing the tone of the arterial wall. It can be assumed that when determining the pulse wave velocity (SPV) will also be changes to the test, namely its decline in response to increased blood flow.

The aim of the present invention is to develop a way to assess endothelium-dependent dilatation of the brachial artery by means of registration of change of SST in the background of reactive hyperemia.

To achieve this goal using a standard method of assessing SST, which is simultaneous registration of SF is of hemogram with sleepy, the femoral and radial arteries. Receivers (sensors) of the pulse are: carotid artery at the level of the upper edge of the thyroid cartilage (better to palpate the pulse on the area of the neck where the trachea and the sternocleidomastoid muscle touch), the femoral artery at the point where its exit from under papatowai ligament (preferably slightly below the ligament, for the best reception signal), the radial artery at the point where palpation of the pulse. The accuracy of overlapping sensors pulse produced under visual control of the monitor.

If simultaneous recording of all three pulse curves for technical reasons not possible, the simultaneous write first pulse of the carotid and femoral arteries, and then the carotid and radial arteries. To calculate the velocity of propagation of pulse wave need to know the length of the artery between receivers pulse. Conventionally, in the study of SST, carotid-radial plot corresponds to the muscular type arteries and is measured as follows: the sum of the distances from the place of production of the sensor in the carotid artery to the head of the humerus and humeral head to the place with the best check of the pulse at the radial artery. The length of the elastic type arteries was determined by the sum of the distances from the jugular notch of the sternum to the navel and to the place of registration of the pulse on the a.femoralis.

Manual handling should be noticed is definitely the of another measure - the time lag of the pulse at the distal segment of the artery with respect to the main pulse, which is usually determined by the distance between the beginning of the lifting curves of the Central and peripheral pulse or by the distance between the places of the bend on the ascending part of sphygmogram.

Knowing the length of the portion of the study artery (D) and lag time (t), can be calculated SST for a given vessel (D/t, m/s). In automatic systems, the type of computer consoles Colson (Camplior), the determination of the temporal indicator is relevant program. The measurements are repeated and calculate the average time delay is not less than 10 cardiac cycles. When conducting research with this instrument it is necessary to consider that the results can be considered objective if the coefficient of representativeness of not less 0,890 and the coefficient of repeatability 0,935 respectively (Asmar R, Benetos a, Topouchian j, et al. Assessment of Arterial Distensibility by Automatic Pulse Wave Velocity Measurement Validation and Clinical Application Studies) // Hypertension - 1995 - V.26 - P.485-490).

The test on the background of reactive hyperemia determine SST on carotid-radial plot, namely assess the response of the arteries of the muscular type. We deliberately conducted a study on a large segment of blood vessel, so as atherosclerotic disease may be local, which can affect the final resulttest. Pre-determine SST alone by the standard method. As with the assessment of endothelium-dependent vasodilation under ultrasound control, compress the brachial artery cuff manometer for measuring HELL for 3 minutes, increasing the pressure more than 50 mm Hg from systolic blood pressure, or until the disappearance of complexes of the radial artery (in the case of permanent registration to be noticed on the monitor). Immediately after deflation of the cuff, a pressure gauge, and after 3 minutes determine SST in the studied artery, the difference between figures in percent.

The study included patients (n=16) with coronary heart disease whose diagnosis was confirmed anamnestic data (presence of postinfarction cardiosclerosis) or the results of coronary angiography (identified hemodynamically significant stenosis of the coronary arteries). The control group consisted of healthy volunteers (n=14)who had no indications for the presence of cardiac pathology.

In both groups the definition of SST was performed in the same conditions, all patients were male, the age of the patients was comparable. The work did not include patients with concomitant hypertension, diabetes, obesity or other disorders that can affect the test results. When comparing the obtained results (Table. 1) it turned out that in the group with CHD source of SST for the elastic type arteries (C e) was observed higher than in the comparison group (7.1±0,4%). Differences of the arteries of the muscular type were less pronounced (3,2±0,5%). In fact, all surveyed, and according to SST, par. Only the relationship Withm/Cediffered significantly, normally it was higher by more than 18%, according to Pentagona, 1977, may be one of the confirming signs of atherosclerotic process in the test vessel.

Table 1

The original data rate of spread of the pulse wave
IndicatorsControl (n=14)Patients with CHD (n=16)
Age, years46,7±2,749,8±1,8
Withem/sof 9.21±0,49,95±0,6
Withmm/s9,27±0,39,48±0,5
Withe/Sm1,11±0,040,99±0,04
Notes: Withethe propagation velocity of the pulse wave for the elastic type arteries; Cmthe propagation velocity of the pulse wave of the arteries of the muscular type

The test revealed statistically significant changes reduce sub> min patients with CHD (Table. 2). Normal reduction Withmon average, accounted for 21.2%, at the same time in a group of IBS, this indicator was equal to 3.9 per cent, to 3 minutes after restoration of blood flow in healthy individuals, Withmhe reached the source of the numbers, and the patients had increased even more significantly.

Table 2

Changes the velocity of propagation of pulse wave on the background of reactive hyperemia in normal and concomitant coronary artery disease
IndicatorsControl (n=14)Patients with CHD (n=16)
Sourcemm/s9,27±0,39,48±0,5
Withmafter restoration of blood flow8,18±0,28,92±0,4
% reduction Withmafter sample21,21±0,93,9±0,4
Withmafter 3 min after restoration of blood flow9,16±0,49,9±0,5
Notes: Withmthe propagation velocity of the pulse wave of the arteries of the muscular type.

In addition, we noted that OK none of the patients was not observed paradoxical reaction - increasing SST, in all cases there was a decrease Withmfrom 7% to 41%, and bol is those with coronary artery disease in three changes were observed, and almost a third (5 patients), we observed the increase of SST.

Examples of specific applications.

Example 1. Assessment of endothelium-dependent dilatation of the artery was normal.

As an example, here is the results of observations 2 healthy people. Subjects KN and MS 44 and 56 years, respectively, without evidence of cardiovascular disease. Both estimation of SST alone and background samples with reactive hyperemia. The results are shown in table 3.

Table 3

Indices of pulse wave velocity in patients with normal to and against the background of the test with reactive hyperemia
IndicatorsAge, yearsWithem/sWithmm/sWithmafter restoration of blood flow, m/s% reduction WithmWithmafter 3 min after restoration of blood flow, m/s
KN44a 7.928,657,01207,79
MS5610,810,88,2248,9

As can be seen from the presented data, in response to increased blood flow in the artery is substantially decreased SST (20% and 24%) by reducing SOS the vascular tone, that will indirectly indicate the saved vasodilator capacity of the endothelium of the vessel.

Example 2. Assessment of endothelium-dependent dilatation of arteries in the heart.

Assessed the performance of SST in patients with ischemic heart disease. As an example, here is the results of 2 patients, the appropriate age in the previous observation. Patients CT and RK 47 and 57 years, respectively, both had a confirmed diagnosis of ischemic heart disease (history of the presence of myocardial infarction 4 - and 2-year-old), angina FC II, heart failure II class according to NYHA, with no signs of arterial hypertension. The results of the study are shown in table 4.

Table 4

Indices of pulse wave velocity in patients with coronary artery disease before and background samples with inactive hyperemia
IndicatorsAge, yearsWithe,

m/s
Withm,

m/s
Withmafter restoration of blood flow, m/sThe change in SSTWithmafter 3 min after restoration of blood flow, m/s
CT47of 7.36at 9.538,92The decrease of 6.4%10,81
RK577,538,589,26 9,11

The first patient with ischemic heart disease, we observed a decrease in SST, but to a much lesser degree than normal - only 6.4%, and the second mentioned paradoxical reaction in the form of increased SST, probably associated with a paradoxical vasoconstriction, which would indicate a violation edothelial function of the endothelial lining of the vessel.

Thus we can say that changes the velocity of propagation of pulse wave on the background of reactive hyperemia can reflect the state of endothelial function of arteries. Evaluation of SST quite informative the test on an automatic computer device type Colson. OK, in response to reactive hyperemia, the velocity of propagation of pulse waves in arteries of muscular type will be reduced by at least 20%. In atherosclerotic lesions of the vascular wall changes largely offset and the percentage of reduction will be significantly lower, in addition, the occurrence of paradoxical reactions in the form of increasing SST in patients with ischemic heart disease was observed in a greater degree.

The way to determine endothelium-dependent vasodilation by assessing changes in pulse wave velocity (SPV) on a background of reactive hyperemia, while SST is determined on the part of the carotid artery - radial artery at rest and immediately after the termination of the clamping square the U.S. artery, moreover, in normal celebrate a significant decrease of SST on average 21.2% in patients with ischemic heart disease - SST decrease on average by 3.9%, while some patients saw improvement or no change of SST, clamping of the brachial artery was performed cuff pressure gauge for measuring blood pressure (BP) for 3 min, increasing pressure not less than 50 mm Hg from the systolic blood pressure.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method involves measuring end diastolic size EDS and end systolic size ESS of the left ventricle. Conditionally constant value of these factors are to be determined from formulas: EDS(MEDS)=11.4-lnTV6, where TV6 is the 6 min test value. Difference between real EDS and ESS values and their conditionally constant values M is to be found. The value of M is compared to standard deviations for EDS - 0.52(σR1) and ESS - 0.45(σR2) to establish favorable functional state in EDS M±(σR2), ESS M±(σR1) cases; disharmonic functional state in EDS from M-1σR2 to M-2σR2, ESS M±1σR1 or M+2σR1; unfavorable functional state in EDS from M-2.1σR2 to M-3σR2 and more, ESS M±1σR1 or from M+1σR1 to M+2σR1 and more; unfavorable worsening functional state in EDS from M+1.1σR2 to M+2σR2 and more, ESS M±1σR1 or M±2σR1; extremely unfavorable functional state in EDS from M+2.1σR2 to M+3σR2 and more, ESS M±1σR1 or M±1.1σR1 to M±2σR1 and more.

EFFECT: high accuracy and reliability of diagnosis.

3 tbl

FIELD: medicine, cardiology.

SUBSTANCE: a patient should undergo clinico-instrumental survey: it is necessary to measure systemic vascular resistance (SVR), cardiac index (CI), stroke work index (SWI), left-ventricular myocardial weight (LVMW), end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF). One should conclude upon the variants of arterial hypertension flow according to particular values of measured parameters. The innovation enables to improve differential diagnostics according to predominant lesion of target-organs.

EFFECT: higher accuracy of differential diagnostics.

6 ex

FIELD: medicine, resuscitation.

SUBSTANCE: one should detect cerebral perfusion pressure (CPP), intracranial pressure (ICP), values for blood saturation with oxygen in radial artery and jugular vein bulb (SaO2, SjO2), additionally one should study lactate level in jugular vein bulb and radial artery, calculate venous-arterial difference according to lactate (▵lactate), cardiac ejection (CE) due to thermodilution and hemoglobin level. Values for cerebral oxygen transport function should be calculated by the following formulas: mĎO2 = 0.15 x CE x CaO2 x 10; mVO2 = 015 x CE x (CaO2 - CjO2) x 10; CaO2 = 1.3 x Hb x SaO2; CjO2 = 1.3 x Hb x SjO2. In case of noninvasive detection - due to pulsoxymetry one should measure peripheral saturation (SpO2), due to parainfrared spectroscopy - cerebral oxygenation (rSO2) and cardiac ejection due to tetrapolar rheovasography (CEr), detect and calculate the values of cerebral oxygen transport system according to the following formulas: mĎO2 = 0.15 x CEr x CaO2 x 10; mVO2 = 0.15 x CEr x (CaO2 - CjO2) x 10; CaO2 = 1.3 x Hb x SpO2; CjO2 = 1.3 x Hb x rSO2. At the value of mĎO2 86-186 ml/min and more, MVO2 33 - 73 ml/min, ▵lactate below 0.4 mM/l one should evaluate cerebral oxygen transport system to be normal and the absence of cerebral metabolic disorders. At mĎO2 values below 86 ml/min, mVO2 being 33-73 ml/minO2, ▵lactate below 0.4 mM/l one should state upon compensated cerebral oxygen transport system and the absence of metabolic disorders. At mĎO2 being below 86 ml/min, mVO2 below 33 mM/l, ▵lactate below 0.4 mM/l one should conclude upon cerebral oxygen transport system to be subcompensated at decreased metabolism. At the values of mĎO2 being 86-186 ml/min and more, MVO2 below 33 ml/min, ▵lactate below 0.4 mM/l one should establish subcompensated cerebral oxygen transport system at decreased metabolism. At values of lactate being above 0.4 mM/l and any values of mĎO2 and mVO2 one should point out the state of decompensation in cerebral oxygen transport system and its metabolism. The innovation enables to diagnose disorders and decrease the risk for the development of secondary complications.

EFFECT: higher efficiency and accuracy of evaluation.

1 cl, 3 ex, 1 tbl

FIELD: medicine, resuscitation.

SUBSTANCE: one should detect cerebral perfusion pressure (CPP), intracranial pressure (ICP), values for blood saturation with oxygen in radial artery and jugular vein bulb (SaO2, SjO2), additionally one should study lactate level in jugular vein bulb and radial artery, calculate venous-arterial difference according to lactate (▵lactate), cardiac ejection (CE) due to thermodilution and hemoglobin level. Values for cerebral oxygen transport function should be calculated by the following formulas: mĎO2 = 0.15 x CE x CaO2 x 10; mVO2 = 015 x CE x (CaO2 - CjO2) x 10; CaO2 = 1.3 x Hb x SaO2; CjO2 = 1.3 x Hb x SjO2. In case of noninvasive detection - due to pulsoxymetry one should measure peripheral saturation (SpO2), due to parainfrared spectroscopy - cerebral oxygenation (rSO2) and cardiac ejection due to tetrapolar rheovasography (CEr), detect and calculate the values of cerebral oxygen transport system according to the following formulas: mĎO2 = 0.15 x CEr x CaO2 x 10; mVO2 = 0.15 x CEr x (CaO2 - CjO2) x 10; CaO2 = 1.3 x Hb x SpO2; CjO2 = 1.3 x Hb x rSO2. At the value of mĎO2 86-186 ml/min and more, MVO2 33 - 73 ml/min, ▵lactate below 0.4 mM/l one should evaluate cerebral oxygen transport system to be normal and the absence of cerebral metabolic disorders. At mĎO2 values below 86 ml/min, mVO2 being 33-73 ml/minO2, ▵lactate below 0.4 mM/l one should state upon compensated cerebral oxygen transport system and the absence of metabolic disorders. At mĎO2 being below 86 ml/min, mVO2 below 33 mM/l, ▵lactate below 0.4 mM/l one should conclude upon cerebral oxygen transport system to be subcompensated at decreased metabolism. At the values of mĎO2 being 86-186 ml/min and more, MVO2 below 33 ml/min, ▵lactate below 0.4 mM/l one should establish subcompensated cerebral oxygen transport system at decreased metabolism. At values of lactate being above 0.4 mM/l and any values of mĎO2 and mVO2 one should point out the state of decompensation in cerebral oxygen transport system and its metabolism. The innovation enables to diagnose disorders and decrease the risk for the development of secondary complications.

EFFECT: higher efficiency and accuracy of evaluation.

1 cl, 3 ex, 1 tbl

FIELD: medicine, reflexodiagnostics.

SUBSTANCE: anamnesis of patient's internal organs state should be introduced into computer according to Tibetan medicine standards by the state of three origins interpreted as "wind", "bile" and "mucus". One should select the highest point in the course of treatment to be coded by a 3-point system, study patient's pulse in six points of radial artery: left-hand "tson", "kan", "chag" and right-hand "tson", "kan", "chag", calculate the value of pulse signal coefficient in conventional units to compare the obtained anamnesis data against three origins mentioned above and conclude upon patient's body state.

EFFECT: higher accuracy of computer diagnostics.

1 cl, 1 dwg, 5 ex, 5 tbl

FIELD: medicine, neurology.

SUBSTANCE: a patient should be in initial position when his/her sight is directed towards the ceiling and in 3-5 min it is necessary to register a background rheoencephalogram, then a patient should fix the sight at a pointer's tip being at the distance of about 30 cm against the bridge of nose along the middle line, then the sight should be directed into marginal position due to shifting pointer to the left. Then the sight should be returned into initial position and 3 min later it is necessary to register rheoencephalogram of vertebro-basilar circulation, calculate rheographic index (RI), coefficient for RI ratio on returning the sight from left-hand marginal position into initial one (k2) and at k2>1.098 from the left and (or) k2>1.085 from the right one should detect alteration in vertebro-basilar circulation by reflector mechanism. The method excludes biomechanical impact in stimulating proprioceptive receptors of muscular-ligamentous system under stretching.

EFFECT: higher accuracy and reliability of detection.

2 ex, 2 tbl

FIELD: medicine, surgery, proctology.

SUBSTANCE: into inter-gluteal space at patient's side position one should apply a reduced latex gas cylinder connected to Riva-Rochi apparatus to force the air till separation of inter-gluteal folds for 1 cm and 3 cm, measure the pressure at rest and at squeezing gluteal muscles at the distance of 1 cm and 3 cm, and at the values of pressure in inter-gluteal space being: 1 cm-2 mm mercury column at rest and 10-15 mm mercury column at squeezing gluteal muscles , and at the distance of 3 cm-30-40 mm mercury column and 60-70 mm mercury column, correspondingly one should diagnose normal inter-gluteal pressure; at the decrease of these values: by 1 cm at rest up to 1 mm mercury column and at squeezing gluteal muscles up to 5-8 mm mercury column, and 3 cm at rest - 20-25 mm mercury column and at squeezing 30-50 mm mercury column, correspondingly, one should diagnose the affected work of rectal obturation apparatus. The present innovation enables to carry out necessary prophylactic means to prevent the disease progression.

EFFECT: higher accuracy of diagnostics.

2 ex

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording patient electrocardiogram in maximum comfort state in one lead and photopletysmogram. Vascular tone index (VTI) is measured as time interval from next in turn R-tooth peak to the next following pulse oscillation. Set of values is built and statistically processed. Mode value MoVTIR is calculated as patient rest state characteristic to estimate current functional state of patient regulation and control systems. Electrocardiogram in maximum comfort state is recorded in one lead and photopletysmogram at the same time. A set of RR-intervals and time intervals from next in turn R-tooth peak to the next following pulse oscillation is built and statistically processed. Amo, Mo and MoVTI values are calculated to estimate current functional state of patient. Neighboring cardio-interval values are additionally measured and mean square deviation MSDP is calculated and then variational pulse ametria SAT index is calculated from formula SAT=0.1 x Mo/MSDP and integral regulation and control system stress index of patient (IRCSS)is calculated from formula IRCSS=(SAT) x [1+(Movtir-MoVTI)MoVTI. Patient organism regulation and control system state is estimated as one corresponding to normative neuropsychic stress characteristic for rest state or when working without significant psychic tension with IRCSS value being within interval from 40 to 300, working neuropsychic stress characteristic for significant tension belonging interval from 300 to 900. Neuropsychic overstress showing necessity of rest belongs to an interval from 900 to 3000. Neuropsychic overstress threatening health belongs to an interval from 3000 to 10000. Attrition showing emergency of escaping from the current state with obligatory cardiologist advice takes place when the value is greater than 10000. The device has unit for recording electrocardiogram, data processing unit and calculation unit connected to estimation unit with its output and unit for recording pulse oscillations, analog-to-digital converter unit having inputs connected to electrocardiogram-recording unit and pulse oscillations-recording unit outputs and its output are connected to calculating unit inputs via the data processing unit, and display unit for showing patient regulation and control systems state. Units for processing and calculating are manufactured on microprocessor base. Signals are form on exit from the microprocessor, their values being corresponding to integral regulation and control system stress index value of a patient(IRCSS). The unit for recording pulse oscillations is designed as electronic transducer set on patient finger. The unit for recording electrocardiogram, records cardiac pulses in single lead.

EFFECT: high accuracy in estimating functional state of human organism regulation and control system.

3 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: method involves compressing artery in extremity through bulk of soft tissues with variable compensating pressure and fixing pressure in soft tissues, determining time intervals in which derivative of the pressure in soft tissues is equal to zero. The compensating pressure is changed discretely in time with delay after determining each time interval beginning and at time moment coinciding with each interval end. Arterial blood pressure value is determined as a set of discrete values of pressure in soft tissues fixed on determined time interval boundaries. Initial value of the compensating pressure is selected to be less than arterial blood pressure and time discretization step is not to be less than half of cardiac cycle duration.

EFFECT: applicability for creating digital tonometers measuring arterial blood pressure within shorter time period and under more comfortable conditions for a patient.

12 dwg

FIELD: medicine.

SUBSTANCE: method involves measuring arterial blood pressure and pulse in arterial hypertension patient. Systolic pressure value, diastolic arterial blood pressure value and heart beat rate in rest state is measured. The like measurement are taken under loading on bicycle ergometer and after its being over. Double product is calculated at each stage. After the treatment being over, area under systolic pressure plot, diastolic arterial blood pressure plot and heart beat rate plot is also calculated during loading test and in rest period. The obtained data are compared to reference values. The values are used for determining treatment effectiveness.

EFFECT: high accuracy of estimates.

6 dwg, 5 tbl

FIELD: medicine.

SUBSTANCE: method involves recording heart beat rate and systolic arterial blood pressure before and after two-stage exercise stress. The first stage is of 50 W within 3 min and the second one is of 75 W during 2 min. Patient rest pause is available between loading stages to recover initial heart beat rate. Prognostic estimation of cardiopulmonary complications is carried out with mathematical formula applied.

EFFECT: reduced risk of complications in performing tests.

FIELD: medicine.

SUBSTANCE: method involves measuring cardio- and hemodynamic values, calculating estimates of the values and displaying the estimates on monitor. Measuring and calculating each cardio- and hemodynamic value is carried out during basic periods of their oscillations corresponding to heart contraction cycle and respiratory cycle related to absolute time.

EFFECT: high accuracy of estimation.

4 dwg, 1 tbl

FIELD: animal science.

SUBSTANCE: the present innovation deals with dynamic loading onto cardio-vascular system in animals. Selection should be carried out by the following parameters: , ΔT3 and Δn, where ΔT1 - the time for pulse increase at running, ΔT2 - the time for pulse stabilization after running, ΔT3 - the time for pulse increase after running, Δn - the increase of pulse frequency after running. One should select animals into milking herd at the following values; ΔT3 ≤ 10 sec, Δn ≤ 10 beats/min. The method enables to present perspective evaluation of lactation capacity in animals.

EFFECT: higher efficiency of selection.

1 dwg, 1 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: method involves recording rheogram from feet and legs lifted and fixed at an angle of 45є. Then, rheogram is recorded on inhaling from legs directed vertically downward. Functional blood circulation reserve index is calculated as product of results of dividing and subtracting rheographic indices recorded under conditions of lifted and lowered extremities that means under conditions of functional venous system relief and venous hypertension, respectively.

EFFECT: enhanced effectiveness in recognizing patient group suffering from severe lower extremities ischemia.

6 dwg

FIELD: medicine.

SUBSTANCE: method involves recording rheogram from feet and legs lifted and fixed at an angle of 45є. Then, rheogram is recorded on inhaling from legs directed vertically downward. Functional blood circulation reserve index is calculated as product of results of dividing and subtracting rheographic indices recorded under conditions of lifted and lowered extremities that means under conditions of functional venous system relief and venous hypertension, respectively.

EFFECT: enhanced effectiveness in recognizing patient group suffering from severe lower extremities ischemia.

6 dwg

FIELD: medicine.

SUBSTANCE: method involves applying a set of reference values like body mass, arterial blood pressure, pulse rate in rest state and general physical condition values. Exercise stress is sequentially applied for evaluating vertebral column flexibility, response quickness, dynamic leg force, speed-and-force tolerance. Each value is compared to a reference value, the differences of each item between reference and actual values are summed and the total value is interpreted in terms of complex human physical condition.

EFFECT: high reliability of the method; simplified testing process requiring no complex and expensive equipment and high skill personnel.

6 cl

FIELD: medicine.

SUBSTANCE: method involves applying a set of reference values like body mass, arterial blood pressure, pulse rate in rest state and general physical condition values. Exercise stress is sequentially applied for evaluating vertebral column flexibility, response quickness, dynamic leg force, speed-and-force tolerance. Each value is compared to a reference value, the differences of each item between reference and actual values are summed and the total value is interpreted in terms of complex human physical condition.

EFFECT: high reliability of the method; simplified testing process requiring no complex and expensive equipment and high skill personnel.

6 cl

FIELD: medicine, juvenile clinical nephrology.

SUBSTANCE: disease duration in case of obstructive pyelonephritis should be detected by two ways: either by detecting the value of NADPH-diaphorase activity, as the marker of nitroxide synthase activity in different renal department and comparing it to established norm, or by detecting clinico-laboratory values, such as: hemoglobin, leukocytes, eosinophils, urea, beta-lipoproteides, lymphocytes, neutrophils, the level of glomerular filtration, that of canalicular reabsorption, urinary specific weight, daily excretion of oxalates, arterial pressure, and estimating their deviation against average statistical values by taking into account a child's age.

EFFECT: higher efficiency of detection.

7 dwg, 1 ex, 6 tbl

FIELD: medicine, neurosurgery.

SUBSTANCE: one should measure blood pressure in afferent vessel of cerebral arteriovenous malformation (AVM). If measured pressure is above that of functionally insignificant vessel being 25% against systemic arterial pressure for AVM at blood flow of 1000 ml/min and 50% for AVM at blood flow of 500 ml/min one should conclude the vessel to be functionally valuable. The method enables to decrease complications due to increased reliability in detecting functional value of ABM-supplying vessels.

EFFECT: higher efficiency of detection.

1 ex

FIELD: medicine, cardiology.

SUBSTANCE: in male patients of elderly and senile age one should register electrocardiogram and its first derivative in 12 leads to evaluate the rate of ventricular activation. In case of this rate being below 34.9 one should evaluate high degree of lethality risk. The method enables to detect the risk for availability of complex cardiac rhythmic disorders more rapidly and non invasively in case of exacerbation of bronchoobstructive diseases.

EFFECT: higher efficiency of diagnostics.

4 ex, 1 tbl

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