Composition for seed pickling and method for controlling of plant diseases

FIELD: agriculture.

SUBSTANCE: invention relates to composition for seed pickling in form of water suspension concentrate containing thebuconazole and thiabendazole in ratio from 20:1 to 1:20 as active ingredients, nonionic and anionic surfactants, thickener, antifreeze, antifoaming agent, conserving agent, pigment, mineral or vegetable oil, lubricating agent, and water. Preparation of present invention has long shelf-life, freeze resistance, heat aging stability, beneficial effect on plant germination and harvest, and high biological activity. Method for controlling of plant diseases also is disclosed.

EFFECT: seed pickling composition of improved quality.

6 cl, 6 tbl, 5 ex

 

The present invention relates to a new composition for seed treatment, containing as active substances tebuconazole and thiabendazol, more specifically to a new preparative form of water suspension concentrate, comprising, in addition to the active ingredients necessary to obtain this formulation components.

The tebuconazole - common name of the active substance systemic broad-spectrum fungicide (formula I)-(RS)-1-(4-chlorophenyl)-3-(1,2,4-triazole-1-yl-methyl)-4,4-dimethyl-pentane-3-ol. Crickets seeds on the basis of tebuconazole known under the trademark Raxil® (trademark of Bayer.) (see EP 0040345, US Pat. No. 4723934, DE OS3333411, Pflanzenschutz Nachr Bayer, 40.2.81-129).

Thiabendazol - common name of active ingredient of fungicide contact action (formula II) - 2-(4'-thiazolyl)benzimidazole, first obtained from Merck & Co (United Kingdom Patents No. 1071421, France No. 2014326, USA No. 3017415 from 16.01.1962 year).

It is known that as tebuconazole and thiabendazol widely used in combination with other fungicides or substances with a different activity, including for presowing treatment of seeds. This allows to expand the range of drugs, and also to some extent to counteract the already acquired resistance against an individual acting the substances (See, for example, EP 0275013, EP 0316970, EP 0393746, EP 0423566, EP 0487451, EP 0897665, EP 0271579, US Pat. No. 4906648).

As for known mixtures of tebuconazole and thiabendazole, microbicide combination of tebuconazole and thiabendazole, which is added to the original components in the polymerization process to protect receiving technical materials described in EP 0522393. In EP 0539332 mentioned about the possibility of using a mixture of thiabendazole and tebuconazole to protect Luke from the disease caused by the pathogen Sclerotium cepivorum. Any information about formulation and the effectiveness of their action against plant pathogens in these sources are not available.

The closest the present invention to the technical essence is the composition for seed treatment in the form of a water-suspension concentrate containing as active substances (E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazole-1-yl)1-penten-3-ol (diniconazole) and 2-(4 thiazolyl)benzimidazole (thiabendazole) in the ratio of 1-2:2-1 in combination with other components that provide the necessary consumer properties of the drug as a fungicide seed. This composition (prototype), described in the patent of the Russian Federation No. 2206204, is a highly effective drug that protects crops against a wide spectrum of diseases, however, has certain disadvantages.

The PE is o, the presence in the commercial diniconazole about 20% (+)-optical isomer with herbicide and retardante properties, has a definite negative effect on crop quality, growth and development of plants, especially in the early stages. In addition, the necessity of use of the composition required for their additional technological operations optically active (-)enantiomer leads to higher prices for the drug.

Secondly, the drug was not sufficiently stable under conditions of prolonged storage at low and high temperatures.

Finally, indicators of uderzhivaemoi drug on seeds during storage was not high enough.

These disadvantages lacks new and improved composition for seed treatment in the form of a water-suspension concentrate, which is an object of the present invention.

In the composition for seed treatment according to the present invention as active ingredients used tebuconazole and thiabendazol in a ratio of 20:1-1:20 with the content of active substances from 2.0 to 40.0 wt.%.

Unlike the prototype instead of diniconazole in the form of the (-)enantiomer composition contains its close structural analogue - tebuconazole. Unlike diniconazole the tebuconazole recommended for use in the form of a rat is standard mixture (50:50) (-)-S and (+)-R optical isomers. As shown by the experiments, crop quality processed new fungicide seed has improved. It was possible to expand the range of ratios of active substances and their contents in the preparative form.

Stability of the drug in conditions of prolonged storage at high and low temperatures were achieved by the partial or complete replacement of propylene glycol in glycerin, which is injected in an amount of from 0.5 to 20.0 wt.%. In addition to lowering the freezing temperature of the glycerol in the new song plays the role of "gravity" component, which provides the alignment of the densities of all the contained components. In addition, glycerol is a homogenizing agent to enter into the composition of mineral or vegetable oil.

Add in the formulation of disinfectants mineral or vegetable oil in an amount up to 15 wt.% provides education on the treated seeds of a homogeneous film, which leads to uniform distribution of fungicides on the entire surface of the caryopsis.

It also turned out that along with the addition of the oil introduction in receipt of a small amount dibutil or dioctylphthalate (up to 5 wt.%), the so-called "samalia-EES", increases the fixation of fungicide on the seed surface and increases stability treated with the s seeds to mechanical abrasion. Often after repeated pouring or simply during storage of treated seeds with them showered dye and fungicide, which further reduces the resistance of crops to various diseases. Field tests have shown that after the introduction into the composition of the above components are formed is capable of withstanding prolonged mechanical abrasion without changing fungicidal activity.

As wetting, dispersing agents, thickeners and antispyware patentable composition, in addition to the components specified in the prototype, can also contain their counterparts on the chemical structure and nature of the actions that are interchangeable when used for its intended purpose.

As wetting, in addition to Rodosha 860/R was other suitable nonionic surfactants from the group polyethoxysiloxane and politprosveshenya fatty alcohols and alkyl phenols, such as Vitanol NP (trademark of AKZO-Nobel) (Akzo Nobel Surface Chemistry LLC Witconol NP-80/ Ethoxyleted Nonyl Phenol), Igepal VS (trade mark of the company Rhodia) (Surfactants and Specialites for Plant Protection, Rhodia) and well-known domestic emulsifiers OP-7 and OP-10 and Neonol (Surfactants. Handbook edited Art and Gamgebeli. Leningrad, "Chemistry", 1979; Surface-active substances and compositions. Handbook Ed. by M. letnev, Moscow, OOO firm Clavel, 2002).

As a dispersant, in addition to Saprovore fluorescence, can be used other anion active surfactants from the group of amine salts of di - or christiantamilringtonesj esters of phosphoric or sulfuric acids, such as Suprior 3D/33, Suprior 4D/ 384 and Suprior BCA/7, which are interchangeable for this formulation (Surfactants and Specialites for Plant Protection, Rhodia).

As thickeners, except Rhodopol 23, can be applied to other polysaccharides, including cellulose thickeners, such as Bermocoll® (trademark of Akzo-Nobel) of Akzo-Nobel (ethoxylated cellulose ethers) (Brief technical description Bermocoll®. Cellulosic thickeners. Akzo Nobel) and domestic carboxymethyl - or karboksimetilcelljulozy (Surfactants. Handbook edited Art and Gamgebeli. Leningrad, "Chemistry", 1979).

As a non besides Rodoreda was possible with the same result, to use domestic polydimethylsiloxane antifoam Penta 469.

It also turned out that the composition of a new composition allows to use not only water-soluble dyes such as Cationic red 2C, but water-insoluble, the so-called lucky, including Lacquer ruby SC and Varnish Rubin SC, representing the calcium salt of 2-hydroxy-4-[(4-methyl-2-Sul is o(phenyl)]-azo-2-naphthaleneboronic acid (GOST 7436-74).

When added to the composition of varnishes it remains homogeneous, and when applied fungicide on grain achieves a uniform dispersion staining protravlivanija material.

As a preservative in a new composition used in the same Kobata With® (trade mark of the company Rhodia) or its full equivalent of Globull (trade mark firm Rhome and Haas).

Thus, an object of the present invention is a new composition for seed treatment in the form of a water-suspension concentrate containing as active ingredients a mixture of tebuconazole (I) and thiabendazole (II) in an amount of 2.0 to 40.0 wt.%, with a ratio of I:II is from 1.0: of 20.0 to 20.0: 1.0 in.

As the wetting composition contains at least one nonionic surfactant selected from the group polyoxyethylene or politprosveshenya alcohols or polyoxyethylenated ALKYLPHENOLS, including Nadasurf 860/R, Vitanol NP 80, Igepal SU 10 and OP-7 or OP-10 or Neonol, in the amount of from 0.1 to 5.0 wt.%.

As the dispersant composition contains at least one anion surface-active substance selected from the group of ammonium salts of di - or christiantamilringtonesj esters of phosphoric or sulfuric acids, including Suprior FL, Suprior 3D/33, Suprior 4D/384, Suprior BCA/7 in the amount of from 1.0 to 15.0 wt.%

As thickeners composition may contain anion is the first heteropolysaccharide Rhodopol 23, or nonionic derivative of cellulose Bermocoll in the amount of from 0.1 to 10.0 wt.% or carboxymethyl - or carboximetilzellulozu (in terms of a 2% solution of thickening agent).

As a preservative in the composition used hexahydro-1,3,5-Tris(2-hydroxyethyl)Symm.-the triazine in number to 0.045 wt.% (Kobata With or Glocker).

As the non use polydimethylsiloxane (Rodosil 426 or Penta 469).

To obtain the signal of color in the composition of the injected dye or water-soluble (cationic red 2C), or water-insoluble (Lac Rubin SC or SC) in an amount of not more than 25 wt.%.

Unlike the prototype of a new composition as antifreeze and co-solvent comprises glycerin in an amount of from 0.5 to 20.0 wt.% or its mixture with propylene glycol, and the content of the latter does not exceed 10 wt.%, and the ratio of glycerol and propylene glycol is from 1:0.1 to 0.1:1.

Unlike the prototype of the new composition also contains mineral (transformer, vaseline, industrial) or vegetable oil (soybean, vegetable) in an amount of from 0.5 to 15.0 wt.%, and the so-called sizing, at least one of the esters of phthalic acid (dibutil, dipropyl or dioctylphthalate) in an amount of 0.01-5.0 wt.%.

The introduction of glycerin and oils in the composition, as shown by the experiments, increases its agregation the Yu stability and increases frost resistance. New drugs unlike the prototype can be stored without changing the properties at temperatures from minus 10°C to + 35°and exhibit high resistance to heat aging.

Add oil and oil ensures uniformity of staining and a high degree of uderzhivaemoi drugs on the seed surface, which leads ultimately to increase the effectiveness of their action against pathogens that cause plant diseases.

A mixture of tebuconazole and thiabendazole in different ratios, as shown by the experiments, but is not inferior to the prototype of both the level and spectrum of biological activity, although unlike the prototype of a mixture of active substances not find such a significant and explicit synergies in relation to the causative agents of plant diseases.

The field of biological testing patentable composition showed high biological efficacy against root rot of spring wheat and barley, and efficiency of patentable composition against rot Helminthosporium was much higher than the efficiency of the drug on the tebuconazole (drug Raxil) due to the presence of the second fungicide - thiabendazole. The drug also showed high efficacy against the most dangerous diseases of cereal crops is dusty and hard.

In General, we can say that the proposed composition of the drug on the basis of tebuconazole and thiabendazole showed high efficacy against pathogens placevine fungi (Rhizopus spp., Penicillium spp., Trichothecium spp.), fusariose-snow mold (Fusarium culmorum, F.oxysporum, F.graminearum, F.avenacium), fusariose-Helminthosporium rot, bacterial diseases (Pseudomonas spp., Xhanthomonas spp., Corynebacterium spp.), protection from diseases (Ustilago nuda, Ustilago laevis, Tilletia tritici, Sphacelotheca panici on miliaceae, Ustilago zeae, Sorosporium reilianum) cereal, maize and millet.

Experiments have also shown a beneficial effect of a new drug on the quantity and quality of wheat and barley.

Another object of the invention is a method of combating plant diseases by pre-sowing seed treatment an effective amount of the above composition.

This is followed by examples illustrating, but not limiting the invention.

Example 1. A composition for seed treatment.

The reactor is heated predetermined amount of propylene glycol, glycerol, wetting agent, dispersant and non and mix thoroughly. To the resulting mixture add tebuconazole, thiabendazole, oil, lubricant and water and mix thoroughly. The resulting mixture is ground in a bead mill, dyno-mill until the particle size of m is 5 μm. Milled suspension is served in the capacity to which is added the estimated amount of the previously prepared 2% solution of thickener containing the required amount of preservative and the estimated amount of dye. After adding all components, the mixture is again thoroughly mixed.

In table 1 presents some of the formulas derived drugs.

andNadasurf 860/P

bSuprior 4D/ 384

inRhodopol 23

gKobata

dCationic red 2C

eVaseline oil

WThe dioctylphthalate

CRodosil 426

andIgepal sun/10

toSuprior FL

lOil transformer

mSuprior 3D/33

nLacquer ruby SC

aboutIndustry oil

pBermocoll

RDibutyl

withPenta 469

tVitanol NP 80

ySuprior BCA/7

fGlocker

xLacquer ruby SC

CDIPROPYLENE

hOP-7

WCarboxymethylcellulose

shchKarboksimetilcelljuloza

üSoybean oil

As examples of the obtained formulas can cause the following structures:

Composition 1.

The tebuconazole- 100 g/l
Thiabendazol- 100 g/l
Propylene glycol- 30 g/l
Glycerin- 60 g/l
Suprior 4D/384- 40 g/l
Nadasurf 860/P- 20 g/l
Vaseline oil- 40 g/l
The non Rodosil 426- 20 g/l
Rhodopol 23 (2% solution)- 1.0 g/l

Table 1

The compositions of the obtained formulations
Content, g/lSample numberYou provide. in wt.%
Name. components12345678910
The tebuconazole10030506080150102001702001-20,0
Thiabendazol1008050803020200101502001-20,0
Propylene glycol30-- 100-10010020100300-10,0
Glycerin601001005015010150200505,0of 0.5 to 20.0
The wetting20and10and10and20and40and50t10t1and5t3t0,1-5,0
Disperser40m80b80to80b120m60y150m150b10y150b1,0-15,0
Thickener 2% solution1,0in10in40in30in0,6p2p100W50shch80in100in0,1-10,0
Preservative0,45g0,042g0,42g0,3sup> g0,00,20f0,1f0,15g0,030,04g0,0-0,045
Dye100d100d200d100n250n80x250x50,0d-50n0-25,0
Oil40e100e150l50l80about30e35ü10l5l100eof 0.5 to 15.0
Sizing0,1W1W1W1W30R5C45C50R30R50Cof 0.01 to 5.0
The non20C40C30C4C0,4with1C20with30with35with40C0,05-4,0
Water To 1 lTo 1 lTo 1 lTo 1 lTo 1 lTo 1 lTo 1 lTo 1 l1 lTo 1 lTo 1 l

The dioctylphthalate0.1 g/l
Cationic red SK100 g/l
Preservative0.45 g/l
Waterto 1 liter

Physico-chemical characteristics of the drug:

Viscosity1100 MPa*s
Density1096 kg/m3
pH8,3
Dispersion88% of particles less than 4 microns
The stability of the 5% suspension95%

Part 2.

The tebuconazole30 g/l
Thiabendazol80 g/l
Glycerin100 g/l
Suprior 4D/38480 g/l
Nadasurf 860/P10 g/l
Vaseline oil100 g/l
The non Rodosil 42640 g/l
Rhodopol 23 (2% solution)10 g/l
The dioctylphthalate1 g/l
Cationic red SK100 g/l
Preservative0,042 g/l
Waterto 1 liter

Physico-chemical characteristics of the drug:

Viscosity940 MPa*s
Density1076 kg/m3
pH8,2
Dispersion92% of the particles less than 4 microns.
The stability of the 5% suspension97%

Part 3.

The tebuconazole50 g/l
Thiabendazol50 g/l
Glycerin100 g/l
Suprior FL80 g/l
Igepal sun/1010 g/l
Oil transformer150 g/l
The non Rodosil 42630 g/l
Rhodopol 23 (2% solution)40 g/l
The dioctylphthalate10 g/l
Preservative0,42 g/l
Cationic red SK200 g/l
Waterto 1 liter

Physico-chemical characteristics of pre is Arata:

Viscosity890 MPa*s
Density1078 kg/m3
pH8,3
Dispersion91% of particles less than 4 microns
The stability of the 5% suspension91%

Part 4.

The tebuconazole60 g/l
Thiabendazol80 g/l
Propylene glycol100 g/l
Glycerin50 g/l
Suprior 4D/38480 g/l
Nadasurf 860/P20 g/l
Oil transformer50 g/l
The non Rodosil 4264 g/l
Rhodopol 23 (2% solution)30 g/l
The dioctylphthalate1 g/l
Lacquer ruby SK100 g/l
Preservative0.3 g/l
Waterto 1 liter

Physico-chemical characteristics of the drug:

Viscosity1090 MPa*s
Density1075 kg/m3
pH7,7
Var is rnost 89% of particles less than 4 microns
The stability of the 5% suspension98,5%

Part 5.

The tebuconazole80 g/l
Thiabendazol30 g/l
Glycerin150 g/l
Suprior 3D/33120 g/l
Nadasurf 860/P40 g/l
Oil industrial80 g/l
The non-Penta 4694 g/l
Bermocoll0.6 g/l
Dibutyl30 g/l
Lacquer ruby SK250 g/l
Waterto 1 liter

Physico-chemical characteristics of the drug:

Viscosity1320 MPa*s
Density108 8 kg/m3
pH8,9
Dispersion94% of particles less than 4 microns
The stability of the 5% suspension89%

Composition 5*

The tebuconazole80 g/l
Thiabendazol30 g/l
Glycerin150 g/l
oprator 3D/33 120 g/l
Neonol40 g/l
Oil industrial80 g/l
The non-Penta 4694 g/l
Bermocoll0.6 g/l
Dibutyl30 g/l
Lacquer ruby SK250 g/l
Waterto 1 liter

Physico-chemical characteristics of the drug:

Viscosity1410 MPa*s
Density1092 kg/m3
pH8,6
Dispersion93% of particles less than 4 microns
The stability of the 5% suspension87%

Part 6.

td align="right"> 5 g/l
The tebuconazole150 g/l
Thiabendazol20 g/l
Propylene glycol100 g/l
Glycerin10 g/l
Suprior BCA/750 g/l
Vitanol NP 8050 g/l
Vaseline oil30 g/l
The non - Rodosil 4261 g/l
Bermocoll2 g/l
DIPROPYLENE
Lacquer ruby SK80 g/l
Preservative0.2 g/l
Waterto 1 liter

Physico-chemical characteristics of the drug:

Viscosity1280 MPa*s
Density1093 kg/m3
PH9,4
Dispersion86% of particles less than 4 microns
The stability of the 5% suspension90%

Example 2. Evaluation of the stability of drugs during storage.

To assess the possibility of storing drugs for 2 years at a temperature of from minus 10 to plus 35°conducted the following tests:

1. Test accelerated storage: drugs kept in a thermostat at plus 54°C for 2 weeks (method CIPAC MT 46);

2. Test for frost resistance: the drugs were kept in a thermostat at a temperature of minus 15°C for 10 days (GOST 9.707-81 and Surfactants and Specialties for Plant Protection, Rhodia);

3. Test heat ageing: the drugs were kept in a thermostat at a temperature of 45°60 days (GOST 9.707-81 and Surfactants and Specialites for Plant Protection, Rhodia);

The repetition of the tests is 3-fold.

The viscosity of drugs both before and after storage was determined on a Brookfield viscometer, stability was determined by the GOST 16484-79 and Method CIPAC MT161, the dispersion was determined by a laser particle analyzer Fritsch-Analysette 22. The results are presented in table 2.

As can be seen from table 2, the new composition is superior to the composition of the prototype in terms of frost resistance and resistance to thermal aging.

Table 2

Evaluation of the STABILITY of DRUGS DURING STORAGE
No.MedicationType of testPhysico-chemical indicators
Viscosity, MPa*s 293 KDensity kg/m3, 293 KpHDispersion, %The stability of the 5% suspension %The crystallization temperature, °
1Sample No. 1To storage111010968,3<4 μm - 88%95Minus 22
After storage at +54°C for 14 days118010928,3<4 μm - 85%95,8
After storage at -15°With 10 days116010928,2<4 μm - 85%96,0
After storage at +45°With 60 days113 10938,3<4 μm - 84%for 95.3
2Sample # 2To storage94010768,2<4 μm - 92%97Minus 25
After storage at +54°C for 14 days94510788,2<4 μm - 87%96
After storage at -15°With 10 days95010778,3<4 μm - 85%97
After storage at +45°With 60 days94510778,3<4 μm - 88%92
3Sample # 3To storage89010788,3<4 μm-91%91Minus 12
After storage at +54°C for 14 days88010788,4<4 μm - 94%90
After storage at +45°With 60 days88010718,0 <4 μm - 86%91
4Sample # 4To storage109010757,7<4 μm - 89%98,5Minus 22
After storage at +54°C for 14 days109610757,8<4 μm - 90%98
After storage at -15°With 10 days109610767,7<4 μm - 89%of 98.2
After storage at +45°With 60 days109710767,7<4 μm - 90%99,0
5Sample prototypeTo storage109010527,6<4 μm - 85%for 95.3Minus 19
After storage at +54°C for 14 days108010407,45<4 μm - 74%90,0
After storage at -15°With 10 days102010227,3<4 μm -60% 83,2
After storage at +45°With 60 days100010206,4<4 μm - 36%60,3
The drug was stratified by 20%

Example 3. Study of biological activity in in vitro experiments (pure cultures)

The experiments were carried out in respect of such pathogens of cereal crops as Fusarium frost, Botritis cinerea and Pseudomonas atrofociens.

In a Petri dish filled with planted them in colonies of fungi were placed etched preparations of the seeds were kept in the incubator for 3-5 days. After curing was measured zone decontamination of colonies of fungi, comparing the growth of colonies in control and on the environment entered into them protravlennye seeds before and after mechanical abrasion.

For the mechanical abrasion of the treated seeds used mechanical vibrator, which established the sieve containing the seeds treated, and carried out the course vibrating processing for 15 minutes at a frequency of 35-50 vibrations per second.

As can be seen from table 3, patent-pending blend in the form of the drug in the form of a water-suspension concetrate had a higher fungicidal activity than the reference drug on the basis of one of tebuconazole (raxil, VSC). Analysis of resistance to shattering of seeds after mechanical in the action, certainly shows the improvement of these characteristics in patentable compositions compared with standard - Maxilom and drug prototype based on a mixture of diniconazole and thiabendazole.

Table 3

FIXATION of DISINFECTANTS in the FORM of a WATER-SUSPENSION CONCENTRATES ON BARLEY SEEDS AFTER MECHANICAL ABRASION
MEDICATIONNORM,

l/tonne seed
The area around the seed disinfection, cm
Pseudomonas atrofociensFusarium frostBotritis cinerea
To the tavern. abrasionAfter the tavern. abrasionTo mechanical abrasionAfter the tavern. abrasionTo mechanical abrasionAfter mechanical abrasion
Drug-prototype0,4the 3.82,04,02,74,53,5
Composition 10,45,95,85,55,56,06,0
Part 20,4a 4.9the 4.74,64,55,2 5,2
Part 30,45,25,2a 4.9a 4.95,15,0
Part 40,46,16,1the 5.7the 5.75,35,2
Part 70,4the 5.75,65,25,25,65,5
RAXIL0,400000
Control without treatment000000

Example 4. The effect of disinfectants on crop quality, growth and development of barley.

The experiments were carried out in laboratory conditions in accordance with the guidance for conducting greenhouse and field trials, seed disinfectants, fungicides and bactericides", Cherkassy, 1996 Etched in the specified rate of the seeds was tested on laboratory germination by seed in the coils by controlling the number of germinated seeds and counting the germination percentage. Then for seedlings after 14 days of growth was determined by the lengths of the stem and root systems is, then dried plant weight and were determined by dry weight of stems and seedlings compared with the control. Seeds were protravlivanie using dry etching with the flow : solution - 10-11 l/tonne of seed.

In table 4 shows the results of the experiments, according to which the patented structure increases the germination of seeds as compared with the prototype and comparison with the standard (the drug on the basis of tebuconazole Raxil, SK). At the same time patentable composition has a growth-stimulating effect in comparison with the prototype - drug based diniconazole and thiabendazole.

Table 4

The EFFECT of DISINFECTANTS ON CROP QUALITY, GROWTH AND DEVELOPMENT of BARLEY PLANTS
MEDICATIONRate, l/t seedLaboratory germination, %
Control, without processing-984/1006/100
The preparation of the prototype0,475the 3.5/855,5/90
Composition 10,4905,5/1358,0/118
Part 20,494 5,9/1488,5/128
Part 30,4925,3/1307,3/115
Part 40,4965,6/1367,6/116
Part 50,4884,9/1267,0/112
Part 60,4905,2/1338,0/117
Part 70,4926,3/1398,2/120
Part 80,4855,3/1357,4/114
Raxil0,4855,5/1208,0/110

Example 5. Evaluation of biological activity against root rot and protection from diseases in field trials.

The experiments conducted on spring wheat (Sanita) and spring barley (variety Zasursky) in the Moscow region and the southern Piedmont area of Krasnodar Territory.

Bookmark and conduct experiments were conducted according to the "guidance on the state tests of fungicides, antibiotics and disinfectants seeds of agricultural crops", M, 1985, Seeds of wheat and barley were protravlivanie in : machine PS-10 with a consumption rate of solution : - 10 litres/ tonne of seed. Seeds were planted in the segment is Ah 10 m 2. Control the degree of infestation of Fusarium and Helminthosporium the rot at different phases of development was carried out by digging 10% of the plants and to assess the degree of infestation of crops. After ripening was performed continuous manual cleaning of each plot and assessed the total yield of crops.

The results are presented in table 5 and 6.

It is established that the patented drug on the basis of tebuconazole and thiabendazole has a high degree of oppression, Helminthosporium and Fusarium rot on spring wheat and barley, and the introduction of thiabendazole in the drug significantly reduces the spread of rot Helminthosporium than one drug on the basis of tebuconazole - Raxil, Fri.

The effectiveness of dust suppression and particulate smut on wheat is 100%, the suppression of Fusarium root rot is 95-97%.

0,4
Table 5

BIOLOGICAL EFFICACY of the COMPOSITION FOR SEED TREATMENT AGAINST ROOT ROT of SPRING WHEAT varieties ANITA and SPRING BARLEY varieties ZASURSKY 85 (tested 2003)
MedicationConsumption rate, l/tSpring wheat, grade AnitaSpring barley variety Zasursky is 85
Natural infection backgroundNatural infection background
The overall prevalence %The incidence of Fusarium root-rot, %The incidence of Helminthosporium the rot, %.The overall prevalence, %The incidence of Fusarium root-rot, %The incidence of Helminthosporium the rot, %
The control Phase is the second half of tillering24,713,311,421,04,216,8
Composition 10,4the 4.71,13,63,60,43,2
Part 20,47,91,76,26,61,15,5
Part 30,45,81,44,4a 4.90,94,0
Part 40,44,31,42,93,70,42,9
Part 70,48,62,16,56,31,35,0
Part 87,51,46,15,31,24,3
Drug-prototype0,47,62,55,16,81,9a 4.9
RAXIL0,413,31,411,97,81,46,4
Control Phase-lactic ripeness37,523,813,7and 88.87,781,1
Composition 10,413,7a 4.98,839,50,339,2
Part 20,418,09,48,667,30,866,5
Part 30,416,36,89,548,40,551,2
Part 40,412,34,08,330,60,530,1
Part 70,419,69,9the 9.745,30,844,5
Part 80,419,5 9,69,969,30,668,7
The product prototype0,420,49,910,570,32,467,9
RAXIL0,420,611,29,275,00,974,1

Table 6

The effectiveness of the composition for seed treatment against diseases of wheat (Variety Anita, testing 2004)
CULTUREMEDICATIONConsumption rate, l/tonne seedHarmful objectBiological efficiency, %Yield, kg/ha
The wheatComposition 10.4Helminthosporium root rot56
Part 20,447
Part 30.451
Part 40,466
Part 70,457
Part 80,449
Drug-prototype0,448
RAXIL0,413
Composition 10,4Fusarium root rot99
Part 20,495
Part 30,497
Part 40,499
Part 70,496
Part 80,495
Drug-prototype0,492
RAXIL0.497
Composition 10,4Fusariose-rot Helminthosporium7267
Part 20,46561
Part 30,46765
Part 40.47768
Part 70,46660
Part 8 0,46260
Drug-prototype0,46361
RAXIL0,45053
Composition 10,4Dusty and bunt10045,6
Part 20,410041,7
Part 30,410043
Part 40,410043,8
Part 70,410042,1
Part 80,410041,9
Drug-prototype0,410043,8
RAXIL0,410040,2

1. The composition for seed treatment in the form of a water-suspension concentrate containing as active substances the triazole fungicide range and 2-(4'-thiazolyl)benzimidazole (thiabendazole) (II), nonionic and anion active surfactants as wetting agent and dispersant, respectively, non, thickener, anti-freeze and dye, preservative, and water, characterized in that the triazole fungicide series composition contains (RS)-1-(4-chlorophenyl)-3-(1,2,4-triazole-1-yl-methyl)-4,4-dimethyl-pentane-3-ol (tebuconazole) (I), moreover, the ratio of the active substances I:II can vary from 20:1 to 1:20, as antifreeze - glycerine, or mixtures thereof with propylene glycol in a ratio of from 1:0.1 to 0.1:1, and further comprises a mineral or vegetable oil and the oil, which is used esters of phthalic acid, when the next General ratio of components, wt.%:

The tebuconazole1-20
Thiabendazol1-20
The wetting0,1-5,0
Disperser1,0-15
Thickener, 2%solution0,1-10,0
Glycerinof 0.5 to 20.0
Propylene glycol0-10,0
Mineral or
vegetable oilof 0.5 to 15.0
Sizingof 0.01 to 5.0
The non0,05-4,0
Dye0-25,0
PreservativeNo more than 0,045
Water100

2. The composition for seed treatment according to claim 1, characterized in that the wetting agent contains at least one nonionic surfactant selected from the group of polyoxide the new and politprosveshenya fatty alcohols or alkyl phenols, including Nadasurf 860/R, Vitanol NP, Igepal SU 10 and OP-7 or OP-10, Neonol, and as a dispersant is at least one anion surface-active substance selected from the group of ammonium salts of di - or christiantamilringtonesj esters of phosphoric or sulfuric acids, including Suprior FL, Suprior 3D/33, Suprior 4D/384, Suprior BCA/7.

3. The composition for seed treatment according to claim 1, characterized in that as a thickener it contains a polysaccharide selected from the group Rhodopol 23, Bermocoll, carboxymethyl - or karboksimetilcelljuloza, and as a preservative of hexahydro-1,3,5-Tris(2-hydroxyethyl)symmetrizing.

4. The composition for seed treatment according to claim 1, characterized in that as lubricant it contains one of the esters of phthalic acid, such as DIPROPYLENE, dibutyl phthalate or dioctylphthalate, as a non - polydimethyl siloxane selected from Rodosil 426 and Penta 469, and as a dye, a cationic red 2C, or Varnish Rubin SC, or Lacquer ruby SC.

5. The composition for seed treatment according to claim 1, characterized in that the number of active of active ingredient in it is from 2 to 40 wt.%.

6. A method of combating plant diseases by pre-treatment of seed, wherein the seed is treated with an effective amount of a composition according to claims 1-5.



 

Same patents:

FIELD: organic chemistry, pesticides, agriculture.

SUBSTANCE: invention relates to compounds that elicit high pesticide activity and can be used in control of pests of domestic and agricultural animals. Indicated compounds show the formula (I):

wherein R1 means halogen atom, (C1-C6)-halogenalkyl; R2 means hydrogen atom (H), (C1-C6)-alkyl, (C1-C6)-alkylene-phenyl; X1 means nitrogen atom (N); X2 means group C(CN); X3 means oxygen atom (O); Q means CH; R3 and R4 mean independently of one another hydrogen atom (H) or in common with carbon atom with which they are bound form (C3-C7)-cycloalkyl ring; R5 means a substitute taken among group including (C1-C6)-halogenalkyl, halogen atom being if m above 1 then substitutes R5 can be similar or different; m = 1, 2 or 3; n = 0 or 1. Also, invention describes a method for their preparing and method for control of pests.

EFFECT: valuable pesticide properties of compounds.

7 cl, 3 tbl, 14 ex

The invention relates to new compounds of the formula (I) or their salts, where X, Y independently is hydrogen, halogen; Z is oxygen; Q is chosen among the Q1-Q9described in the claims and containing heterocycles with nitrogen, and sulfur; Ar is pyridyl, pyrimidyl, pyridazinyl, triazolyl, thiazolyl, isothiazole or phenyl, or pyridyl, pyrimidyl, pyridazinyl, triazolyl, thiazolyl, isothiazole or phenyl substituted with up to five substituents, when Q - Q3or Q6substituted phenyl is excluded

The invention relates to benzylchloride formula I or its salts, where R1- (C1-C6)alkyl, (C1-C4)cianelli, (C1-C4)hydroxyalkyl, (C3-C6)cycloalkyl, (C1-C6)halogenated, benzyl which may be substituted with halogen, thiazolyl; R2and R3independently - H, (C1-C4)alkyl, or R1and R2together with the sulfur atom and the carbon form a 3-8-membered ring; R4- H, halogen; And - hydrazinoacetate or hydrosonography group of formula A1 or A2; R9- H, halogen, NO2, CN, (C1-C4)alkyl, (C1-C4)halogenated, (C1-C4)alkoxy, (C1-C4)halogenoalkane, (C1-C4)alkylthio, (C1-C4)allogenicity, (C2-C4)alkylsulfonyl, (C1-C4)halogenated.sulphonated, phenyl which may be substituted with halogen, phenoxy, which may be substituted with halogen; R10- H; R11, R12, R13independently - H, (C1-C6)alkyl, (C1-C4)halogenated, (C2-C10)alkoxyalkyl, (C3-C8)alkoxyalkyl, (C2-C6)alkylthiol, (C1-C4)cianelli, benzyl which may be substituted with halogen, (C1-C4)halogenation, (C1-C4)alkyl, -COR14, -COOR15THAT IS SOP(R16R17, -SO2R20-C(R21)= HR22; or R12and R13together can form a group of the formula = CR23R24; R14- (C1-C20)alkyl, (C1-C8)halogenated, (C2-C12)alkoxyalkyl,oxyalkyl, phenyl; R16- H, (C1-C4)alkyl; R17- H, (C1-C6)alkyl, phenyl which may be substituted; R20- (C1-C4)halogenated, (C2-C4)dialkylamino; R21- (C1-C6)alkyl; R22- acyl, (C2-C6)alkoxycarbonyl; R23, R24independently - H, halogen, (C1-C6)alkyl, -NR25R26; R25and R26independently - H, (C1-C4)alkoxy, (C2-C12)alkoxyalkyl; Q1and Q2is nitrogen or CR9m = 1 to 3, n = 0, 1, 2

The invention relates to a means to control weeds, in particular to the herbicide agent containing as an active ingredient (A) nitrile 1-(3-chloro-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyridine-2-yl)-5-(methylpropylamine)-4-pyrazolecarboxylate acid, and optionally, as an active ingredient (B) a substance selected from the group comprising bentazon, molinet, Diuron, thiobencarb, butachlor, pretilachlor, timepart, fenoxaprop-ethyl, clomipram, cinmetacin, bromobutyl, chinkara, mefenacet, pyrazosulfuron-ethyl, asbroker, chinaculture, tanishlar, cumyluron, MK 243, nitroanilide, anilofos, belforest, bifenox, SN-900, MSRA, nitrofen, oxadiazon, pendimethalin, simetryn, sulcotrione (SA), trifluralin, piperophos, perimutter, ethoxysulfuron, benzylbromide, pyrazolate, paradoxien, benzefoam, cycloaliphatic, cyhalofop, NBA-061 and azimsulfuron

The invention relates to new chemical substances, which can be a fungicidal active substance means, in particular to Amida alkoxybenzenes acid, fungicidal tool and method of controlling fungal diseases of plants

The invention relates to ether compounds and their use

The invention relates to a new above-mentioned compounds, method of their production and the means of containing this compound, useful for combating fungi and insect pests

FIELD: agriculture, fungicides.

SUBSTANCE: invention describes a fungicide composition comprising the following components, wt.-%: tebuconazole or epoxyconazole, or flutriafol, 10-30; emistim, 0.5-2.5; potassium lignohumate in mixture with salts, 20-60; water, the balance. Invention provides enhancing immuno- and growth-stimulating activity of biologically active substances in the initial stage of growth of plants to be protected.

EFFECT: enhanced effectiveness of composition.

2 cl, 5 tbl, 2 ex

FIELD: organic chemistry, agriculture.

SUBSTANCE: invention relates to herbicidal composition containing synergetically effective amounts of (A) and (B) components, wherein (A) has formula II (R1 is C1-C6-alkyl, substituted with halogen; R2, R3 and R4 are hydrogen; R5 is rest of formula -B1-Y1, wherein B1 is direct bond and Y1 is acyclic C1-C6-hydrocarbon or cyclic C3-C6-hydrocarbon; F is -CH2-CH2-, -CH2-CH2-CH2- and CH2-O-; X are independently halogen or C1-C4-alkoxy; n = 0-2; and (B) represents one or more herbicides, selected from group containing isoprothuron, flufenacet, anylophos, ethoxysulphuron, mecoprop-(P), ioxinyl, florazulam, pendimethalin, MV 100, etc. Also disclosed is method for weed controlling using abovementioned composition.

EFFECT: composition with improved herbicidal action.

12 cl, 23 ex, 23 tbl

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention describes the improved method for preparing 1-(4-chlorophenyl)-3-(1,2,4-triazol-1-yl-methyl)-4,4-dimethylpentane-3-ol. Method involves interaction of 1,2,4-triazole with 2-(4-chlorophenylethyl)-2-tert.-butyloxirane in the presence of potassium hydroxide in n-butanol medium. Process is carried out in reaction mixture directly containing 2-(4-chlorophenylethyl)-2-tert.-butyloxirane prepared by interaction of 4,4-dimethyl-1-(4-chlorophenyl)-pentane-3-one with trimethylsulfonium methylsulfate in n-butanol medium at 50-55°C without preliminary isolation of oxirane and its purification. Method provides reducing number of operations, time for carrying out the process and to retain high yield of product.

EFFECT: improved method for preparing.

4 cl, 3 ex

FIELD: agrochemistry.

SUBSTANCE: invention provides a stable aqueous formulation of hydrophobic pesticide by emulsifying aqueous phase and a water-immiscible phase, the former containing poly(alkylene glycol) ether and the latter hydrophobic pesticide and one or several emulsifiers selected from group including carboxylate, sulfate, sulfonate, alcohol solutions of ethoxylated and alkylphenolethoxylate, fatty acid ethyl ester, sorbitol ester, ethoxylated fat or oil, aminoethoxylate, ethylene oxide/propylene oxide copolymer, fluorocarbon, and siliceous polymer.

EFFECT: increased stability of formulations.

38 cl, 1 tbl, 12 ex

FIELD: organic chemistry, agriculture.

SUBSTANCE: invention relates to new substituted thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)ons of general formula I

(wherein Q represents oxygen or sulfur; R1 represents unsubstituted alkyl; R2 represents hydrogen, halogen, unsubstituted alkyl; R3 represents hydrogen, halogen, alkyl optionally substituted with alkoxy, alkoxy or arylthio, optionally substituted with alkoxy or halogen, unsubstituted cycloalkyl or cycloalkyloxy, or unsubstituted arylalkoxy or aryloxy; R4 represents unsubstituted alkyl, alkoxy, dialkylamino, cycloalkyl) and their salts. Compounds of present invention are useful as herbicide agents. Also disclosed is herbicide composition and new synthetic intermediates for compounds of formula I.

EFFECT: new compounds and intermediates thereof with herbicide activity.

16 cl, 13 tbl, 67 ex

FIELD: organic chemistry, agriculture, herbicide composition.

SUBSTANCE: invention relates to herbicide composition, containing conventional inert additives and mixture of a) herbicidically effective amount of substance satisfying the formula I [in formula R1 and R3 are the same or different C1-C4-alkyl; R4 and R5 together form groups of formulae: -C-R6(R7)-O-C-R8(R9)-C-R10(R11)-C-R12(R13)-(Z1), -C-R14(R15)-C-R16(R17)-O-C-R18(R19)-C-R20(R21)-(Z2), or -C-R22(R23)-C-R24(R25)-C-R26(R27)-O-C-R28(R29)-(Z3), wherein each R6-R29 is hydrogen; G is hydrogen or -C(X2)-X3-R31; X2 and X3 independently are oxygen; R31 is C1-C10-alkyl]; b) herbicidic synergic amount of at least one herbicide selected from group containing sulfonylureas, phenoxyacetic acids, as well as florsulam, tralcoxidim, klodinafol-propargil, phenoxaprop-P-ethyl, trifluramine, pendimethaline, picolinafen, etc. Composition also may contain safety effective amount of protective agent, such as chloquintocet-mexyl and additive (e.g., mineral oil or C8-C22-fat acid alkyl esters) in amount of 0-2 mass %. Also disclosed is method for selective controlling of weeds and grassy plants in cultural plants by treatment of cultural plants, seeds or seedlings thereof, or vegetation area thereof with claimed composition.

EFFECT: effective composition and method for weed controlling.

5 cl, 11 tbl, 7 ex

FIELD: organic chemistry, agriculture.

SUBSTANCE: claimed mixture from herbicides and antidotes contains (A) herbicidically active substance based on phenylsulfonylureas of formula I and salts thereof (in formula R1 is hydrogen or C1-C6-alkyl; R2 is C1-C3-alkyl; R3 is C1-C3-alkoxy; R4 is hydrogen or C1-C4-alkyl; Hal is fluorine, chlorine, bromine, or iodine); and (B) antidote of formulae II or III , wherein X is hydrogen, halogen, C1-C4-alkyl; C1-C4-alkoxy, nitro or C1-C4-haloalkyl; Z is hydroxyl, C1-C8-alkoxy, C3-C6-cycloalkoxy, C2-C8-alkenyloxy, C2-C8-alkynyloxy; R5 is C1-C2-alkandiyl chain optionally substituted with one or two C1-C4 alkyl residues or (C1-C3-alcoxy)carbonyl; W is bivalent heterocyclic residue; n = 1-5; in weight ratio herbicide/antidote of 100:1-1:100. Also disclosed is method for protection of cultural plants against phytotoxic side effect of herbicidically active substance of formula I. Claimed method includes antidote application of formulae II or III on plant, plant parts, plant seeds or seeding areas before or together with herbicidically active substance in amount of 0.005-0.5 kg/hectare in weight ratio of 100:1-1:100.

EFFECT: mixture for effective selective weed controlling in cultural plant, particularly in maize and grain cultures.

8 cl, 2 ex, 7 tbl

FIELD: organic chemistry, herbicides, agriculture.

SUBSTANCE: invention describes substituted benzoylcyclohexanediones of the general formula (I):

wherein m = 0 or 1; n = 0 or 1; A means a single bond or alkanediyl (alkylene) with 1-4 carbon atoms; R1 means hydrogen atom or unsubstituted alkyl with from 1 to 6 carbon atoms; R2 means methyl; R3 means hydrogen atom, nitro-, cyano-group, halogen atom, alkyl with from 1 to 4 carbon atoms substituted with halogen atom, alkoxy-group with from 1 to 4 carbon atoms or alkyl sulfonyl with from 1 to 4 carbon atoms; R4 means nitro-group, halogen atom, unsubstituted alkyl with from 1 to 4 carbon atoms of that substituted with halogen atom; Z means heterocycle, and herbicide agent based on thereof. Also, invention describes substituted derivatives of benzoic acid of the general formula (III):

wherein values n, A, R3, R4 and Z are given above. These compounds represent the parent substances used for preparing compound of the formula (I). Compounds of the formula (I) elicit high and selective herbicide activity.

EFFECT: valuable properties of compounds.

7 cl, 8 tbl, 7 ex

FIELD: organic synthesis.

SUBSTANCE: invention provides substituted 1-pyridyl-2-azolyl-1-(2-phenylethenyl)ethan-1-ols having general formula I:

where Py denotes 2-, 3-, or 4-pyridyl, Z nitrogen atom or CH group, and R1 and R2, independently from each other, are hydrogen or halogen atom, or trifluoromethyl group. Claimed compounds are applied as agricultural, industrial, medical, or veterinarian fungicides for controlling harmful fungi.

EFFECT: enhanced fungi control efficiency.

2 cl, 3 tbl

FIELD: organic chemistry, herbicides, agriculture.

SUBSTANCE: invention relates to new substituted benzoylketones of the general formula (I): , all possible tautomeric forms and possible salts that can represent active substance as a component of herbicide agent. In the formula (I) A means (C1-C4)-alkyl; R1 means cyclo-(C3-C6)-alkyl; R2 means hydrogen atom (H), cyano-group (CN); R3 means hydrogen atom (H), halogen atom, CF3, (C1-C4)-alkylsulfonyl; R4 means halogen atom; X means groups: or wherein R5 means (C1-C4)-alkyl, (C1-C4)-alkoxy-group, (C1-C4)-alkylthio-group, di-(C1-C6-alkyl)-amino-group; R6 means (C1-C4)-alkyl, (C1-C4)-alkoxy-group, cyclo-(C3-C6)-alkyl; n = 0 or 1 including all possible tautomeric forms and possible salts. Compounds of the formula (I) elicit herbicide activity and can be used in herbicide composition.

EFFECT: valuable properties of compounds.

3 cl, 1 sch, 3 tbl, 13 ex

FIELD: herbicides, agriculture.

SUBSTANCE: invention describes a herbicide composition comprising components in the following their contents, g/l: phenmedifam, 30-160; desmedifam, 30-160; mixture of non-ionogenic and anion-active surface-active substance, 150-350; liquid carboxylic acid amide, 20-200; co-solvent, 30-300; citric acid, 2-6; 1-phenyl-(1,2,4-triazole-4-yl)urea, 2-20; solvent, the balance, up to 1 l. The composition can comprise additionally ethofumezat in the amount 30 g/l. Invention provides the development of herbicide composition based on phenmedifam and desmedifam possessing the enhanced herbicide activity that allows reducing doses of preparations in their consumptions.

EFFECT: improved herbicide activity of composition.

2 cl, 2 tbl, 1 ex

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