Syringe-container

FIELD: medical equipment, in particular, devices for injections, formed as syringes containing medicinal substances.

SUBSTANCE: apparatus is formed as syringe with hermetically sealed reservoirs containing different substances, piston mechanism including piston chamber, piston and piston stem. Chamber clearance with continuous internal surface is formed as successively arranged reservoirs or sectors with different diameters or sections, with one of reservoirs being formed as piston cylinder. Piston chambers are hermetically separated within piston chamber clearance further than line of transition of smaller diameter or other section by movable device.

EFFECT: simplified construction.

2 cl, 5 dwg

 

The invention relates to medical equipment, namely, devices for injection in a syringe with the drug substance.

A device in the form of a multi-chamber syringe comprising two movable relative to each other reservoirs with substances and the mechanism to move the liquid in the form of a perforating device (1). The disadvantage of this syringe is the design complexity using mobile tanks and special devices for perforating a sealed compartment between the tanks.

Object of the invention is the creation of a more simple design of the syringe sequential sealed tanks or compartments in one chamber, and a simple mechanism or device for moving fluid between the pressurized compartments without destroying the elements of the syringe.

This task is solved in that the device is a syringe with sealed tanks with different substances and piston mechanism comprising a piston cylinder, piston and piston rod has a piston chamber with a continuous inner surface and a lumen, which is made as consistently located the tanks or compartments having different diameters or cross-section, the inner surface of which are located in different planes and where one of the compartments presents piston cylinder,and through which the tank is hermetically divided distal to the line of transition into the lumen of the smaller diameter mobile device with the ability reciprocating motion, which hermetically closes the inlet distal reservoir, in the embodiment, when the distal compartment or reservoir of smaller diameter sealed at the entrance of the actual piston and includes a solvent, and the piston rod forms a movable sealed connection with the hole in the bracket at the entrance to the proximal compartment with a dry substance, and also in a variant, when the tanks or compartments in the piston chamber separated by a movable separating device located at the entrance to the distal compartment of smaller diameter and provided on the outer surface oriented along an axis of motion of the device running grooves with an exit at the end, which turned into the lumen distal of the tank or compartment.

Figure 1 presents one of the variants of the syringe with dual substance in the section, side view. Figure 2 presents the second variant of the syringe with dual substance in the section, side view. In figure 3,and 4.5 shows the principle of operation of the syringe with dual substance in the section, side view.

The device 1 consists of a piston rod 2 with the piston 3 and the piston chamber 4, a pressurized container is a tank with two successive compartments 5 and 6 with a single continuous inner surface and a lumen in the form of one of the hollow device, but different diameters or cross-sections throughout and cu is topognosis transition between the compartments, divided distal to the transition or the actual piston 3 or a separate mobile device in the form of a movable separating piston 7 with special grooves 8 on the outer surface. The output piston chamber is equipped with an adapter 9 or needle for injection, which is hermetically closed by a stopper or other device, such as a rubber cap 10. The piston rod 2 with the piston 3 are standard elements of the piston mechanism designed to move fluid in the piston cylinder in a reciprocating motion. Actually the piston 3 may be made in the form of tightly adjacent the perimeter to the inner wall of the cylindrical channel rigid, elastic or rubber piston fixed on the piston rod 2 as the supporting device of a different material or the piston 3 and the piston rod 2 are made of the same material, for example of plastic material in the form of a single elastic or rigid devices with their own specific functional characteristics. In the first embodiment (Fig 1) device 1, the piston 3 divides the openings of the tanks 5 and 6 with different substances distal to the line of transition from one compartment to another and represents a movable element dividing device for moving fluid or the partition wall, the second variant (figure 2), the piston 3 at the same time hermetically closes the input piston in the cylinder 4 or the proximal reservoir 6. Hermetically separated inside the lumen of the piston chamber sealed compartments 5 and 6 are tanks with different substances, one is the solvent 11 and the other dry substance of the medicinal product 12. Consistently located in the piston chamber 4 compartments 5 and 6 are of different diameter or cross-section of the inner lumen, and an output or distal vessel 5 is made with a smaller diameter, and the input or proximally tank 6 has a larger diameter or may have a different cross-section at the transition 13 one tank to another. One tank or both tanks in the piston chamber 4 is performed as piston cylinders, one of which has a corresponding diameter and the cross section for the formation of mobile hermetic reciprocating connection with the piston 3, and the output compartment 5 in the second case (figure 2) has a diameter and cross-section, forming an airtight mobile or piston connection with separating piston 7. Thus, the piston chamber 4, providing a single, hollow device, may be partially designed as a piston cylinder, and is divided into sealed tanks piston chamber 4 provides not only long kept separate substances, but also the work piston mechanism, performing the function of the piston of the cylinder moves where or with whom bstone the piston 3 or separating piston 7. Consistently located the tanks 5 and 6 in case of differences in diameter have in place a transition on the perimeter bent at an angle or curve of the transition line 13 and the inner surface of the tank to another tank. Thus, the continuous inner surface of the sealed tanks or compartments passes or in parallel or angled planes with curved transition on the perimeter.

Separating the openings of the tanks 5 and 6 of the mobile device in the form of the actual piston 3 or the separating piston 7 is located distal (closer to the exit of the syringe) line transition from one tank to another, or at the input to the output tank 5 with a smaller diameter, which provides the mechanism for moving fluid with the movement of the piston 3 or 7 in the lumen or in the direction of the lumen of the proximal reservoir 6 having a larger diameter or other cross-section of the inner lumen at the transition than the diameter or cross-section of the separating tanks of the piston element 3 or 7. Piston cylinder, performed as consistently spaced compartments 5 and 6, is a standard element of the syringe and piston mechanism in the form of a housing with a cylindrical channel within which moves a piston 3, and the second variant, the distal piston cylinder moves the separating illuminate the s compartments piston 7, which is hermetically attached to the inside of the walls of the respective cylindrical channel of the corresponding reservoir to provide a piston effect. Piston chamber 4 may be integral with the pipe circumferential or angular transition from one compartment to another layer, where the inner wall is made of glass and outer plastic, which makes the storage of the substance in a glass tank more stable. When the compound piston chamber 4 both sections 5 and 6 can be connected via a rubber sleeve, thus forming a single lumen with different diameter and angle or pipe passing through the perimeter in place of transition from one tank to another, which provides the mechanism for movement of the fluid between the pressurized tank and does not prevent the piston mechanism. In all cases, the inner surface of the divided tanks are in different planes, which can be parallel or arranged at an obtuse angle to each other, thus providing a continuous inner surface.

The device 1 with two substances 11 and 12 in the first embodiment (Fig 1,3) represents the piston chamber 4, having an inlet proximal the tank or compartment 6 has a larger diameter than the distal reservoir 5 or compartment at the outlet. The latter is designed as a piston is iLink, which forms the piston 3 piston connection. Located in the initial state when the input piston in the cylinder 5, the distal line 13 transition from one compartment to another, the piston 3 at the same time hermetically separates the two openings of the tanks 5 and 6, which allows you to place in a single device two different substances. The proximal compartment 6 from the entrance tightly closed, fixed on the housing of the piston chamber 4, with the special cap 16 with an opening 17 for the passage of the piston rod 2, which has the ability to move freely in the hole 17, preserving the integrity of the connection and therefore the tightness formed proximal of the tank 6. In another embodiment, the piston rod 2 can have two spaced apart and simultaneously moving the piston, respectively, for each compartment, designed as a piston-cylinders. In this case, the long distal and proximal piston cylinders should be relatively the same, which is not very convenient, as in the device 1 the loss of volume due to lower long proximal reservoir 6 is compensated by a larger diameter. Placing substances in a particular tank is not important for the operation of the mechanism for moving the fluid and the device in General.

The device 1 in the first embodiment (Fig 1) is completed as follows : the m In a closed outlet cap 10 and piston chamber 4, in its distal compartment 5, which is designed as a piston cylinder, the injected solvent 11 (water) or dry substance 12 of the medicinal product. The distal compartment 5 is sealed itself piston 3 with the piston rod and the designated stub 16, the piston 3 is positioned in the initial part of the distal piston cylinder 5, hermetically closing the container with a substance, for example with a solvent 11. In the remaining volume of the piston chamber 4 is introduced, another substance and the compartment 6 is sealed by a plug 16, which is tightly fixed on the housing of the piston chamber 4 at the entrance or additional piston on the piston rod 2. In this form, the syringe 1 is a container for long term storage and device for obtaining a solution of the drug directly into the lumen of the syringe prior to use.

The device with the two substances in the second case (figure 2,4,5,includes the constituent elements of the first variant and is characterized by the fact that both reservoirs 5 and 6 can be designed as a piston-cylinders of different diameters and separated independently movable within the lumen of the reservoir 5 a separating device in the form of a movable stopper or piston 7 that is installed at the entrance of the distal reservoir 5 and forming with the wall of the tank 5 mobile is sealed or piston connection. Separating tanks with different substances, the device 7 in the second embodiment is in the form of independently movable piston works as a standard element piston mechanism from changes in pressure in one of the tanks, as well as mobile tube, which is set by movement of the piston rod 2 with the piston 3. Unlike piston 3, the separating piston 7 on the outer or piston surfaces adjacent to the wall of the cylindrical channel is oriented along the axis of movement of the piston running open grooves 8, which are connected only at one end of the device 7, oriented in the lumen distal of the tank 5. The other end of the flow-through groove 8 does not reach the opposite end of the piston and the remaining portion 18 of the piston 7 forms a hermetic mobile or piston connection with the distal wall of the piston cylinder 5. Thus, the movable separating piston 7 includes a flow part with the slots 8 and the proximal portion 18, is made for sealing a movable connection with the piston cylinder, which hermetically closes the distal vessel 5 with the substance. In these embodiments, separating the reservoirs of the device is made with the possibility of reciprocating motion. This separation of the piston 7 in the device for moving fluid based the on the movement of the separation device 7 in the proximal side of the tank 6 and the output flow of the slots 8 in the lumen of the proximal tank 6 when the pressure in this reservoir. In this scenario, you receive the message flowing through the grooves 8 between the two separated compartments 6 and 5. The operation of the device 7 in the form of a tube at this stage does not differ from the operation of the device in the form of a piston.

The device 1 in the second embodiment is completed as follows. After sealing adapter 9 or needle cap 10 in the distal compartment 5 is introduced dry substance 12 of the medicinal product. The tank 5 at the entrance tightly closed separating piston 7, which is introduced before the formation of the tight connection of the proximal portion 18 of the piston 7 with the distal wall of the compartment 5. In this part of the piston 7 with the slots 8 are oriented in the lumen of the compartment 5. The proximal compartment 6 of the piston chamber 4 is filled with a dry substance 12 of the medicinal product and on the output side sealed the actual piston 3 with the piston rod 2. Similar used, and the device 7 in the form of a mobile tube.

The device in the first embodiment, with a dry substance in the proximal reservoir 6 and the solution in the distal vessel 5, is as follows. The piston rod 2 with the piston 3 is allocated back either by the existing of air in the distal compartment, either due to the depressurization of the adapter or needle at the output. In this case, the piston 3 is displayed in the proximal compartment 6 or tank with a large the m in diameter, than the actual diameter of the piston, which violates the integrity between the sections 5 and 6 and the liquid 11 moves freely between the compartments, dissolving the dry substance 12 of the medicinal product. After dissolution of the drug and the vertical position of the syringe drug solution 19 is translated in the distal compartment 5, and the piston rod 2 with a piston 3 is moved back and the piston 3 again closes the distal piston cylinder 5 on the input side. The syringe is ready to use.

The syringe in the second variant (4, 5) is as follows. When moving the piston rod 2 with the piston 3 back reduced pressure or vacuum is created in the proximal vessel 6 due to air in the compartments or admission of air at the open needle. When lowering the pressure in the compartment 6 of the separating piston 7 or mobile tube begin to move in the lumen of the distal piston cylinder 5 toward the proximal reservoir 6 with a larger diameter. When moving area of the piston 7 with running grooves 8 in the lumen of larger diameter (proximal compartment) leaking of the connection of the piston 7 with the wall of the piston cylinder 4 and stops the movement of the piston 7. When this flow grooves 8 are left open towards the distal 5 and 6 proximal tanks that allows the liquid 11 is freely displaced Atsa between compartments via a flow message 20. Unlike options for performing a separating device 7 in the form of a tube, the device is in the form of a piston 7 with running grooves 8 remains fixed at the entrance into the distal vessel 5 and is available to effect reverse movement, while the tube moves freely in the lumen of the proximal vessel. After dissolving the dry substance of the medicinal product 12 air from the syringe is removed by raising the output end with the needle upwards and the pressure on the piston rod. However, the two compartments remain filled with a medical solution 19. The syringe is ready for use. When the pressure on the piston rod 2 the actual piston 3 displaces ready solution 19 of the piston chamber 4 through the needle 23 to the moment when the piston 3 will move the separating piston 7 back and closed grooves 8, and therefore, will not close the message 20 between the compartments. In the distal compartment 5 remains part of the finished solution 19 corresponding to its free volume. If this volume cannot be neglected, then contact the end faces of both pistons are counting its incomplete contact. for example, using cookology the end face 21 on the separating piston. In the final phase of movement of the slots 8 in the lumen of the distal compartment and the disappearance of flow messages 20 further on the pressure on the separating piston 7 is slight residual volume of solution 22, which remains in the proximal compartment 6 due to the difference of the diameters of the displaced piston 7 and the diameter of the proximal compartment 6 and which can be neglected. This cookery end 21 of one of the pistons and incomplete contact leaves a part of the area of the end face on the separating piston 7 to fluid pressure. Using extended separating piston 7, corresponding to the length of the distal compartment 5, it is possible to exclude completely a significant residual amount of the medicinal solution corresponding to the original volume of the distal compartment. The device may have at the outlet of the syringe is sealed at the outlet 4 of the needle 23, which is sealed with a removable cap.

This device can be widely used in industrial pharmacology for the production of finished dosage forms of certain drugs, in particular syringes with two medicinal substances.

Sources of information

1. U.S. patent No. 5785682, publ. G.

1. The device is a syringe with sealed tanks with different substances and piston mechanism including a piston chamber, a piston and piston rod, wherein the lumen of the camera with a continuous inner surface is performed as consistently located the tanks or compartments with different diameters or cross-sections, one of which presents porshneva the cylinder, hermetically separated inside the lumen of the piston chamber distal to the line of transition into the lumen of smaller diameter or other cross-section mobile device.

2. The device according to claim 1, wherein the piston chamber is partially designed as a piston cylinder with a solution, and mobile device in the form of a piston with the possibility of reciprocating motion has on the outer surface centered on the axis of movement of the piston flow grooves with an exit at the end, which turned into the lumen distal of the tank, and the other part is obliquely beveled edge.



 

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