Method of treating bone sarcomas in children and adolescents

FIELD: oncology.

SUBSTANCE: invention is directed, in particular, to treatment of patients with Ewing's sarcoma and osteogenic sarcoma at different stages of malignant process. Method comprises chemotherapy and beam therapy. Samples of venous blood are taken from children in age of 5 to 12 years in amounts not larger than 5% of the total volume of circulating blood per 1 introduced dose of chemical preparation and, from adolescents and young persons, in amount of 200 ml. Then 4 courses of polychemotherapy are fulfilled with autoblood according to standard treatment schemes for given diseases, taking into account stages of disease, in recommended doses. Between 2nd and 3rd chemotherapy courses, radiotherapy is fulfilled on metastatic focuses in lungs. After 4 courses of induction autohemo-chemotherapy, local therapy on the primary focus (radiotherapy and/or surgical treatment) is fulfilled and also radiotherapy on metastatic focuses in other bones, after which follows consolidation involving chemical preparation of the second line.

EFFECT: improved remote results of treatment , suppressed metastatic focuses, reduced tumor dimensions, and weakened toxic manifestations of therapy.

2 ex


The method relates to medicine, namely to Oncology, and can be used in complex treatment of children of primary, secondary and adolescence, and young patients, patients with Ewing sarcoma and osteogenic sarcoma in different stages of the malignant process.

There is a method of treatment of malignant bone tumors in adult patients (see the book "a cancer therapy", reference book, edited by Perevozchikova NI, M, "Medicine", 1993, str-113). The method includes preoperative chemotherapeutic-mechanical treatment, surgery, radiation therapy at different stages depending on the stage of the disease. Introduction chemotherapy is carried out in a continuous 24-hour infusion from the first to the third day. Each schema drug administration is 21 days after the end of the previous course of treatment.

There is a method of treatment of bone sarcomas is intended for the treatment of adults, is particularly inappropriate for the child's body, including the disadvantages that accompany intensive radiation therapy and radiation. Infusion chemotherapy within 24 hours very long, hard tolerated, emergent adverse toxic manifestations of chemotherapeutic agents prolong the course of treatment or make it impossible to continue due to gravity originating the complications.

There is a method of treatment of bone sarcomas in children (see the book "Pediatric Oncology" edited Durnova L.A., Golubenko GV, M "Letter", 1997, str-316), chosen as a prototype. Children and adolescents with osteogenic sarcoma and Ewing sarcoma carry out comprehensive treatment.

Chemotherapeutic treatment of osteogenic sarcoma is conducted according to the scheme of AR, including the introduction of adriamycin (doxorubicin) at a dose of 30 mg/m21, 2, 3 day and the introduction of cisplatin at a dose of 150 mg/m2on the 4th day. After 4 courses of chemotherapy is performed surgical treatment with subsequent courses of adjuvant chemotherapy as described above, or replacing them with second-line drugs (depending on the degree of therapeutic pathomorphosis in the removed tumor).

Ewing sarcoma is a primary vysokokachestvennaya tumor nenastnogo origin, which develops in the bones of the skeleton and adjacent soft tissues. The disease undergoes an intensive integrated treatment: anti-tumor drugs, cyclophosphamide, doxorubicin, vincristine, cisplatin, bleomycin, methotrexate, and others, as well as local effects in the form of radiotherapy or surgical treatment.

Described methods of treatment are effective and can achieve 5-year remission on average 65% of the patients in the early stages of the disease, will not give satisfactory results in the treatment of patients with high-risk groups, and have expressed severe complications and adverse reactions, which affects the duration of treatment and its effectiveness.

The aim of the invention is to improve the immediate and remote results of treatment of osteogenic sarcoma and Ewing sarcoma in children and adolescents, improving the efficiency of anticancer chemotherapy, reduction of side effects and complications from the treatment.

This goal is achieved by the fact that younger children (5 to 12 years) take blood from the cubital vein in an amount of not more than 5% of circulating blood volume at a single injection of chemotherapy drugs in adolescents and young adults with 200 ml; teach 4 courses of chemotherapy for autologous blood by standard treatment for these diseases taking into account the stage in the recommended doses; between 2 and 3 courses of chemotherapy perform radiation therapy for metastatic foci in the lungs in SOD=16-18 Gr, after 4 courses of induction autohemotherapy conduct local therapy to the primary tumor site: radiation and / or surgical treatment and radiation therapy for metastatic lesions in other bones, then spend the consolidation of remission with the use of drugs of the second line.

The invention is a Method of treatment of bone sarcomas in children and adolescents" is new, because it is unknown from the level of the medicine I, in particular Oncology in the treatment of Ewing sarcoma and osteogenic sarcoma in children and adolescents.

The novelty of the invention lies in the fact that conduct a comprehensive treatment of children with osteogenic sarcoma and Ewing sarcoma, including mnogochasovuyu anticancer chemotherapy for autologous blood in combination with radiation therapy and surgical treatment.

"A method for the treatment of bone sarcomas in children and adolescents" is industrially applicable, as may be used in health care, in medical institutions, cancer research Institute and cancer hospital, treating children with cancer.

"A method for the treatment of bone sarcomas in children and adolescents" is as follows: after verification of the tumor process for children and adolescents with osteogenic sarcoma and Ewing sarcoma is a complex treatment, one of the leading components which is mnogometrovaya chemotherapy. Introduction chemotherapy is carried out on autologous blood of the patient.

The first step is to draw blood from the cubital vein in a bottle with logician. The volume of the inflowing blood in children under 12 years of age is not more than 5% of circulating blood volume, calculated by age nomogram, in children older than 12 years, the volume of the inflowing blood on one's back is giving an average of 200 ml.

The second stage is in a bottle with blood injected chemotherapy. The dosage of an administered cytostatics meet the application guidelines and are calculated per meter of the patient's body. A bottle of cytostatic diluted autologous blood of the patient, incubated in an incubator for 1 hour at a temperature of 37 degrees. During incubation, the patient infusion therapy glucosinolate solutions to maintain the osmotic pressure.

After incubation, the chemotherapy drug is injected intravenously at the time indicated in the diagram.

Treatment of Ewing sarcoma conduct the following program: 4-e induction course autohemotherapy (AGHT) scheme VACP: vincristine 1.5 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 1200 mg/m2, cisplatin 100 mg/m2. After 2 courses in lung metastases in a total irradiation of light in SOD=16-18 Gr. Radiation therapy of primary tumor applied after the induction of SOD=50-60 Gy in combination with the introduction of vincristine 1.5 mg/m2and cyclophosphamide 600 mg/m 1 time per week. Consolidation of remission is 2 seven-week blocks using vincristine, doxorubicin, cyclophosphamide, bleomycin, methotrexate, dactinomycin.

Treatment of osteogenic sarcoma start with 4 courses of neoadjuvant IGHT using doxorubicin at a dose of 90 mg/m and cisplatin 100 mg/m2if operability is performed radical surgery; consolidation of remission implemented a 12-month treatment using the scheme AR or alternating courses of EP (etoposide 100 mg/m2, cisplatin 100 mg/m2) and the EU (etoposide 100 mg/m2, cyclophosphamide 750 mg/m2), only 6-8 courses.

Examples of specific performance "method of treatment of bone sarcomas in children and adolescent patients.

Example 1.

Patient D., born in 1984, (and a/b No. 4883/R), was admitted to the pediatric Oncology Department of RNII 22.03.2002 with a diagnosis of Ewing sarcoma with lesions of the right iliac bone, the presence of soft-tissue component in the tissues of the gluteal region and the pelvis; metastatic lesions in both lungs, st. IVB, (T2N0M1pulm.); CL gr. 2. Histological analysis No. 133384-95: Ewing sarcoma. The state of admission was regarded as severe: extreme pain, absentation syndrome, periodic hyperthermia to febrile digits, weight loss of 4 kg After the comprehensive examination, 25.03.02 started induction therapy VACP. Just spent 4 courses; total entered on autologous blood vincristine 8 mg, doxorubicin 240 mg of cyclophosphamide 5600 mg, 500 mg cisplatin On one introduction climbed 200 ml of autologous blood. Between 2 and 3 courses completed radiation therapy to the lungs in SOD=16 is R. During the dynamic observation, according to the radiographs of the chest revealed a significant decrease in the size of metastatic foci in the lungs with 5-6 cm to 0.3-0.2 cm after the first year, and after the second course metastases was not determined radiographically. Induction therapy was complicated by radiation 2 degrees after DHT on the light, it was noted the presence of dyspeptic symptoms 1-2 tbsp. after the introduction of cisplatin, which was quickly stopped by the reception of antiemetics. On the control CT image of the pelvis from 12.07.02. - sclerotic changes in the right iliac bone, soft tissue component is not defined. The second stage of treatment was completed local therapy to the primary tumor site in the form of radiation exposure in SOD=60 Gy, the patient underwent treatment satisfactorily. During radiation treatment for autologous blood was injected once a week chemotherapy: vincristine 2 mg, cyclophosphamide 800 mg With 3.09.02 on 30.01.03 conducted two consolidating seven-week course under the scheme Rosen. Doses and these terms was performed according to the program. Treatment of 2-fold was complicated by grade 3 tbsp., was introduced colonystimulating factors; among other side effects, it is necessary to mention briefly mucositis 2 tbsp., which were stopped after symptomatic treatment. After treatment with a comprehensive survey, the result is which revealed a pronounced clinical effect: not detected metastatic foci in the lungs, sclerotic changes in the right iliac bone (according to x-ray computer research), the patient's General condition was satisfactory, no complaints.

Example 2.

Patient P., born in 1993, (and a/b No. 2310/0), was admitted to the pediatric Oncology Department of RNII 11.02.02 diagnosed with osteogenic sarcoma of the right tibia, IIB century, T2N0M0, CL gr. Histological analysis: No. 4501-507: osteogenic sarcoma. 14.02.03 started 1 year induction polychemotherapy according to the scheme of AR with the introduction of products for autologous blood. The volume of the inflowing blood on one introduction was not more than 5% of the BCC, which was calculated on the nomogram (BCC=4,62 l, 5% 230 ml). One introduction took 200 ml of blood. Total for 1st year introduced: cisplatin 100 mg, doxorubicin 90 mg Treatment satisfactorily. As a result of the treatment of pain disappeared, decreased in size of soft-tissue component, improved health. On the second course of chemotherapy, the parents of the girl are not brought, turned to traditional healers. By the beginning of June 2002, the child's condition has deteriorated: there was a very strong pain in the right lower extremity, which almost starred analgesics, soft tissue component of the tumor reached a large size, the skin over them Izyaslavich, of wounds was observed sustained release of exudates in large quantities, the temperature is and kept on subfebrile figures with periodic rises to 38.5-39 degrees, the girl lost 4.5 kg In a serious condition on the 26.06.02 enrolled in the Department of pediatric Oncology, RNII. With 1.07.02 on 4.07.02 held 2nd course OUGHT scheme AR-dose chemotherapy were similar to the first course. Treatment was complicated by radiation 3 tbsp., mucositis 3 tbsp., oral thrush, CSF was administered. After recovery in the General analysis of blood 23.07.02 performed amputation of the right lower extremity at the level of the middle third of the right femur. In the period from 5.08.02 on 21.03.03 held 8 courses of induction IGHT using alternating courses AP schemes, VCP, EC. Total introduced: doxorubicin 370 mg, etoposide 1000 mg of cyclophosphamide 4600 mg vincristine 1,5 mg Treatment endured satisfactorily, it was mentioned only briefly, dyspeptic syndrome, which was quickly stopped by the introduction of antiemetics. After the treatment, a comprehensive examination, which revealed no signs of generalized disease. With pronounced clinical effect, the patient was transferred in 3 clinical group. In October 2003, is in clinical and laboratory remission.

Technical and economic efficiency "method of treatment of bone sarcomas in children and adolescents" is to increase the effectiveness of treatment. Improve the immediate results of treatment docked pain syndrome, decrease toxicus is their manifestations, improves the General condition and quality of life of sick children. Significantly reduced tumor size, decrease and disappear metastatic lesions that affect long-term results of treatment.

The method of treatment of bone sarcomas in children and adolescents, including chemotherapy and radiation therapy, characterized in that the younger children from 5 to 12 years take blood from the cubital vein in an amount of not more than 5% of circulating blood volume at a single injection of chemotherapy drugs in adolescents and young adults with 200 ml; teach 4 courses of chemotherapy for autologous blood by standard treatment for these diseases taking into account the stage in the recommended doses software; between 2 and 3 courses of chemotherapy perform radiation therapy for metastatic foci in the lungs in SOD=16-18 G, after 4 courses of induction autohemotherapy conduct local therapy to the primary tumor site: radiotherapy and/or surgical treatment and radiation therapy for metastatic lesions in other bones, then consolidate with the use of chemotherapy 2nd line.


Same patents:

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to new substituted derivatives of pyrrole of the formula (I): wherein R1 and R1' mean independently hydrogen atom (H) or (lower)-alkyl, unsubstituted or substituted (lower)-alkoxy-group; R2 means hydrogen atom (H), nitro-group (-NO2), cyano-group (-CN), halogen atom, unsubstituted (lower)-alkyl or substituted with halogen atom or (lower)-alkoxy-group; R2' means thiazolyl, thiophenyl, isothiazolyl, furanyl and pyrazolyl that is unsubstituted or substituted with (lower)-alkyl, pyrimidinyl, unsubstituted morpholinyl, unsubstituted pyrrolidinyl and imidazolyl that is unsubstituted or substituted with (lower)-alkyl, unsubstituted piperidinyl or piperazinyl that is unsubstituted or substituted with (lower)-alkyl, or ethoxy-group substituted with imidazolyl, or its pharmaceutically acceptable salt. Compounds of the formula (I) inhibit cell proliferation in G2/M phase of mitosis that allows their using in the pharmaceutical composition.

EFFECT: valuable biological properties of compounds.

36 cl, 4 sch, 1 tbl, 21 ex

FIELD: medicine.

SUBSTANCE: invention proposes applying bis-phosphonic acids (bis-phosphonates) for the embolic treatment of angiogenesis and corresponding methods for prophylaxis or treatment of angiogenesis by embolization. Invention provides suppression of growth, invasion or metastasis of tumors, treatment of angiogenesis in myocardium ischemia, rheumatic arthritis, osteoarthritis by embolization of newly formed vessels in intra-arterial route of administration of bis-phosphonate (for example, pamidronic acid or zoledronate).

EFFECT: valuable medicinal properties of medicine agents.

10 cl, 3 dwg, 7 ex

FIELD: medicine, oncology.

SUBSTANCE: invention relates to a method for treatment of patients with disseminated forms of prostate cancer. Method involves administration of navelbine in the dose 30 mg/m2 on the background of anti-androgenic therapy. The course time in navelbine administration is 4 weeks and from 7-th day after the last injection of navelbine method involves administration of strontium-89 chloride in the dose 4 mKi (150 MBk), once time per 3 months, two injections. For patients with the amount of osseous metastases above 6 the dose of strontium-89 chloride is 8 mKi per one administration (300 MBk). In further courses of systemic therapy are repeated in 3 months, not early. Method shows the optimal regimen set in administration of preparations and provides the maximal effect of navelbine on osseous metastases followed by damaging effect of strontium-89 chloride on blood vessels of tumor and its cells and the absence of the potentiation toxicity on the hemopoiesis system.

EFFECT: improved and enhanced effectiveness of treatment.

3 dwg, 2 ex

FIELD: medical engineering.

SUBSTANCE: method involves exposing an intraocular neoplasm after vitrectomy and retinotomy, smoothening retina with perfluororganic compound later substituted with silicon oil. After having removed the neoplasm, intravenous 10% Perfluorane emulsion transfusion is carried out at a rate of 60 drops per 1 min in the amount of 80-100 ml. Next to it, photosensitizer is intravenously drop-by-drop introduced into cubital vein of the same arm. Laser irradiation of blood is carried out with power of 20-50 mW through laser light guide set in advance into cubital vein of the other arm in 5-15 min after starting introducing Perfluorane. When applying 0.1-1% water solution of Khlorine as photosensitizer at a dose of 0.2-0.5 mg/kg, irradiation is carried out at wavelength of 630-633 nm during 10-45 min. The treatment is administered twice with 5 days long pause.

EFFECT: enhanced effectiveness of treatment; reduced risk of tumor cells dissemination and metastases formation.

3 cl

FIELD: medicine.

SUBSTANCE: after keeping during pharmaceutically acceptable period oxaliplatinum is placed in transparent, colorless and residue-free solution at concentration of, at least, 7 mg/ml, and a solvent contains sufficient quantity of, at least, one hydroxylated derivative chosen among of 1.2-propandiol, glycerol, maltite, saccharose and inositol. The innovation describes the way to obtain such a preparation. The preparation is stable during pharmaceutically acceptable period of time, that is it remains transparent, colorless and free of any residue within the range of 2-30 C that could be available during its transportation, storage and/or any handling.

EFFECT: higher efficiency of application.

14 cl, 6 ex, 4 tbl

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to new compounds of the formula (I):

eliciting inhibitory activity with respect to metalloproteinases and wherein R1 means phenoxy-group wherein phenyl residue can be substituted with one or some halogen atoms, hydroxy-, (C1-C6)-alkoxy-group, (C1-C6)-alkyl, cyano- or nitro-group; R2 means pyrimidine, pyrazine or its N-oxide or phenyl substituted with -SO2NR3R4 wherein R3 and R4 can be similar or different and mean hydrogen atom, direct-chain or branch-chain (C1-C6)-alkyl that can be substituted once or some times with the group OH, N(CH3)2, or it can be broken by oxygen atom, or it represents COR5 wherein R5 means (C1-C)-alkyl group that can be substituted with NH2. Also, invention relates to a pharmaceutical composition comprising above said compounds.

EFFECT: valuable biochemical properties of compounds and composition.

5 cl, 1 sch, 1 tbl, 10 ex

FIELD: medicine.

SUBSTANCE: method involves applying surgical intervention and antitumor therapy. After having removed a part or the whole lung, mediastinum is opened by cutting out horseshoe-shaped or rectangular flap of mediastinal pleura and carrying out lymphodissection. Then, hemostatic sponge is placed in mediastinum. The sponge is impregnated with antitumor chemotherapeutical preparations in intraoperative mode. Pleura is sutured above the sponge. Another hemostatic sponge impregnated with cytostatic preparations in intraoperative mode is attached to visceral pleura of interlobular sulcus.

EFFECT: prolonged chemotherapeutical preparations delivery to malignant neoplasm foci or subclinical metastases.

The invention relates to medicine, namely to chemoradiation treatment of bone metastases

The invention relates to chemical-pharmacological industry and relates to an inhibitor of the expression of integrin, comprising as active ingredient a compound sulfonamida formula IaIbthat means, containing an inhibitor of the expression of integrin formula IaIbfor the treatment of arteriosclerosis, psoriasis, osteoporosis, angiogenesis, retinal angiogenesis, diabetic retinopathy, inflammatory diseases, and how to prevent, treat or alleviate disease associated with increased expression of integrin

The invention relates to medicine, in particular to chemotherapy of metastatic brain lesions

FIELD: medicine.

SUBSTANCE: the present innovation deals with measuring radioactivity in alive organisms and could be applied for detecting really absorbed dosage under conditions of intra-operational impact. The method suggested includes detecting clinical volume for the target of radiation impact including the volume of healthy tissues to be subjected for radiation impact, developing the plan of radiation impact based upon data obtained with the help of tissue-equivalent phantoms, location in interest sites of clinical volume of sterilized separate fragments of dosimetric device being the matrix of functional units and designed as thermoluminescent detectors being hermetically isolated at the distance of 10 mm between their edges and fixed between the layers of flexible biocompatible material, registering the location of detectors, performing the séance for intra-operational radiation therapy followed by removing the fragments of dosimetric device out of target's volume. Information should be read from thermoluminescent detectors.

EFFECT: higher accuracy of measuring.

1 cl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with treating malignant tumors of central bronchi and trachea due to argonoplasmatic recanalization of tracheal lumen and/or bronchi, at power being 60-90 W followed by brachitherapy at source's trajectory length being 5-20 cm, pace of 5 mm and the depth of reference isodose being 10 mm against the source. Moreover, one should move applicator above and below the tumor ranged 1-3 cm to apply the dose ranged 14-28 Gy once weekly per 7 Gy. Additionally, one should carry out distance radiation therapy 5 times weekly per 1-2 Gy up to total focal dose of 30-40 Gy. The present innovation enables to highly increase the passability of respiratory tract in case of malignant stenosis and prevent the development of their relapse.

EFFECT: higher efficiency of therapy.

3 ex

FIELD: medicine, neurooncology.

SUBSTANCE: one should carry out chemotherapy and irradiation till radical dosage. Moreover, 2-3 d before the onset of radiation therapy and during the whole course of irradiation one should indicate the intake of indometacin at daily dosage being 300 mg, and 8-14 d before the end of therapy course or the stage of radiation therapy it is necessary to conduct chemotherapeutic cycle with vincristine at total dosage being 4 mG and lomustine at total dosage 160-240 mg. At performing a split course of irradiation the intake of indometacin should be indicated between the stages. The innovation enables to increase radio sensitivity of malignant tumor, suppress angiogenesis, proliferative activity and increased cytotoxic activity of chemopreparations.

EFFECT: higher efficiency of therapy.

1 cl, 3 ex

FIELD: medicine, oncology, gynecology.

SUBSTANCE: method involves external irradiation and using chemopreparations combined with autoplasma. External irradiation in the dose 2 Gr is carried out from 1 to 4 day of treatment followed by intravenous administration of cisplatin on 5 day in the dose 10 mg with 250 ml of physiological solution. On the following day 10 ml of autoplasma incubated with 10 mg of cisplatin is administrated by paratumoral route by right and left of tumor into paravaginal cellular tissue and by intratumoral route into projection of cervical channel. Blood cellular elements are incubated with 600 mg of cyclophosphane and reinfused by intravenous drop route. Effects are repeated in indicated sequence once per a week, 4 times per treatment course. Method provides increasing percent of tumor regression due to the complex effect on tumor, enhancing the topical concentration of cytostatic drug and prolongation of its contact in malignant growth zone, and providing radiosensibilizing effect in diminishing the general toxic effect of therapy. Invention can be used in treatment of patients with topically disseminated forms of uterus cervix cancer at the stage T3NxM0.

EFFECT: improved and enhanced treatment method.

1 ex

FIELD: medicine, oncourology.

SUBSTANCE: the present innovation deals with conservative treatment of patients with malignant prostatic tumor at different stages. The method includes testicular enucleation, introduction of anti-tumor chemopreparations and radiation therapy. Moreover, in the onset of radiation therapy one should introduce 25 mg Cisplatin incubated with 10 ml patient's plasma into both prostatic lobes and paraprostatic fiber from the right and from the left. At achieving a focal dosage of 20 Gy one should repeat introduction of chemopreparation in similar dosage, and radiation therapy should be continued up to total focal dosage of 40 Gy. The innovation enables to decrease tumor sizes, side manifestations of radiation therapy at decreasing radiation loading and improve patient's life quality due to mitigating the urination.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine, oncology.

SUBSTANCE: before irradiation it is necessary to cool the tumor to achieve the temperature of freezing at clinically detectable border between the tumor and healthy tissue to perform irradiation directly after natural tissue defrosting with a single focal dosage (SFD) being 2-2.5 Gy daily for 5 d a week at 2-d-long interval to achieve total focal dosage (TFD) of 60-65 Gy. Moreover, the area of healthy tissue should be protected with a shielding applicator - a lead plate - during irradiation. The present innovation enables to maximally keep anatomical relief and function of local tissues.

EFFECT: higher efficiency of therapy.

1 cl, 4 ex

FIELD: medicine, oncology.

SUBSTANCE: the method deals with applying chemopreparations incubated with autolymph and radiation therapy. Lymph taken out of patient's thoracic duct should be centrifuged for 30 min at 2200 rot./min, lymphatic plasma should be taken and frozen at -40 C, lymphatic formic elements should be incubated in a thermostat at 37 C for 1 h together with chemopreparations by a certain scheme to be reinfused for a patient intravenously by drops according to the given scheme. Then, 2 wk later, one should perform therapy with a split course of distance gammatherapy at single focal dosage (SFD) of 4 Gy. At the first stage one should apply per 2 Gy twice daily at 4-5-h-long interval 5 times weekly, at achieving focal dosage of 28 Gy it is necessary to have a week-long interval. Then radiation therapy should be continued but SFD of 4 Gy should be applied at once. One should fulfill 3 fractions of irradiation per a week, there are 6 fractions during the second stage, totally. Total focal dosage (TFD) per the whole course of irradiation corresponds to 52 Gy. About 4 wk after radiation therapy one should defrost lymphatic plasma to incubate it with the same chemopreparations in a thermostat at 37 C for 1 h to be then reinfused for a patient intravenously by drops. The method enables to decrease tumor volume and tumor process metastasing without any operative interference.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: experimental medicine, oncology, biology.

SUBSTANCE: invention relates to a method for inhibition of tumor growth using radiation therapy as ionizing radiation with additional administration of mixture of octa-4,5-carboxyphthalocyanine sodium cobalt salt or oxocobalamine with sodium ascorbate in the ratio = (1:10)-(1:30). Method of combined using irradiation and indicated mixture of substances provides enhancing the effectiveness of anti-tumor treatment resulting to 70-100% recovery of experimental animals and reducing radiation loading and toxicity.

EFFECT: improved method for inhibition.

2 tbl, 3 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: the method deals with 2 courses of polychemotherapy at the first stage due to regional intra-arterial introduction of cisplatin at the dosage of 100 mg/m2 during the first day of every course and 6-h-long intra-arterial infusion of 5-fluorouracil at total dose of 750 mg/m2 in the morning since the 2nd to the 6th d of every course. Chemotherapy should be performed at the background of total magnetotherapy at frequency of magnetic field being 98-112 Hz, intensity of 25-30 oersted, duration of every seance being 30 min, the number of seances corresponds to the duration of chemotherapeutic courses. At the second stage in 2-3 wk after finishing chemotherapy it is necessary to conduct the course of distance radiation therapy (DRT) at multifractioning the dosage by SFD being 1.2 Gy twice daily 5 times weekly up to TFD being equivalent to TDF (time-dosage-fraction) of 62-70 Gy onto primary focus and 40-46 Gy onto areas of regional lymph outflow. As modifiers one should apply cisplatin during the first 2 wk of radiation therapy, hyperbaric oxygenation during the first 10 d of radiation therapy and total magnetotherapy since the 11th d of DRT course till its ending. At the third stage in case of residual metastases in lymph nodes of patient's neck in 2-3 wk after the end of radiation therapy one should conduct operative interference in lymph outflow pathways. The method enables to decrease toxicity of chemo-and radiation therapy due to decreased radiation reactions, stimulation of immune system and improved microcirculation.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medical engineering.

SUBSTANCE: device has active zone of water-to-water nuclear reactor, biological reactor protection concrete mass, slow neutron collimator, which internal surface is coated with material like polyethylene having large scattering cross-section and conically shaped, filter for cleaning slow neutron radiation beam from gamma-quanta and aperture for regulating slow neutron radiation beam diameter. Retarder manufactured from beryllium or graphite or heavy water is available in the space between whole-metal water pool tank casing and adjacent active zone surface. Retarder height and width is not less than corresponding dimensions of the adjacent active zone surface. A hole is available in the bulk of biological reactor protection concrete mass for discharging slow neutrons. The collimator is arranged in the hole so that spatial angle cut out with it contains the whole active zone surface. Its outlet opening is manufactured flush with the external wall of the bulk of biological reactor protection concrete mass and conjugated with the aperture.

EFFECT: high density of slow neutron flux; reduced share of fast neutrons.

3 cl, 3 dwg

FIELD: medicine, infectology.

SUBSTANCE: in acute period of bacterial dysentery one should perorally introduce azitromycin once daily at the dosage of 5 mg/kg for 5 d at simultaneous introduction of 1.5%-rheamberin solution by drops at its daily dosage being 10 ml/kg, course of 1.5-2 d. The present innovation enables to overcome antibioticoresistance of dysenteric microbes at the background of keeping and restoring intestinal microflora.

EFFECT: higher efficiency of therapy.

2 ex, 2 tbl