Antianemic and growth-stimulating preparation for animals

FIELD: agriculture, animal husbandry, fur farming.

SUBSTANCE: invention relates to preparations used in prophylaxis and treatment of domestic and agricultural animals and for maintaining trace elements composition of fodders. The preparation allows balancing the nutrition diet for animals with the optimal ratio of trace elements providing prophylaxis of many diseases. Proposed preparation comprising complex of iron, manganese, copper, cobalt, selenium and zinc with ethylenediamine-N,N1-disuccinic acid disodium or dipotassium salt and water comprises additionally iodine in the following ratio of components: ethylenediamine-N,N1-disuccinic acid disodium or dipotassium salt, 15-25; iron (III), 1.5-5.5; manganese (II), 0.25-3.0; copper (II), 0.12-0.55; cobalt (II), from above 0.05 to 0.3; zinc (II), 0.05-1.5; selenium (IV), from above 0.03 to 0.06; iodine (I), 0.01-0.08; water, the balance.

EFFECT: improved and valuable properties of preparation.

1 cl, 4 tbl

 

The invention relates to animal breeding and fur farming, namely the drugs used for the prevention and treatment of Pets and farm animals, as well as to maintain the microelemental composition of the feed.

The main source of the essential mineral elements for animals are food. However, the mineral composition of the feed is subject to fluctuations. In addition, some feed mineral elements are in trudnousvoyaemoe animal form. Therefore, the problem of mineral nutrition of animals must be dealt with together, as by means of complete feed, and due to the introduction of mineral supplements in the diet. Especially important balance rations for trace elements, as in many regions of the animals suffer from lack of Cu, Co, Se, Zn, Mn, I, Fe.

In practice microelement additives introduced into the premix or feed in the form of mineral salts. It is most expedient to introduce trace elements in the diet is not as feeding on each element separately, but as part of a complex of elements, as is the case in premixes, however, they are experiencing a chemical incompatibility, for example, Cu2+and I-1what can be avoided if to bind Cu2+in the complex compound.

Known Antianemic and growth-stimulating drug for animals "Gambit-M (RU # 2097045, CL And 6 To 33/32, 31/295, 1997), including the complex of iron, copper, cobalt, zinc, manganese disodium or Pikalevo salt Ethylenediamine-N,N1dinternal acid and water.

However, the known drug is not effective enough due to the fact that it contains not a complete composition of microelements, necessary for normal growth and development of animals.

Partly this disadvantage is eliminated in Antianemic and growth-promoting the drug for animals "Gambit" (RU # 2130306, class a 61 K 31/295, 1999), including the complex of iron, manganese, copper, cobalt, zinc, selenium with disodium or Pikalevo salt Ethylenediamine-N,N1dinternal acid and water.

However, and this drug is also not effective because of lack of micronutrients, such as iodine. In places with high water content, with hard calcareous waters, podzolic soils there is a lack of iodine, leading to endemic goiter in calves and lambs. Mass manifestation of endemic goiter contribute to heavy rainfall or drought during the growing season grasses. The content in the diets of a large number of feeds containing thyreostatic medicinal substances, cabbage, canola, beet, turnip, pea, white clover - causes the necessity of increasing the amount of iodine. Iodine deficiency in endemic foci compounded when excess calcium is Oia and iron, because these elements inhibit the absorption of iodine. Iodine deficiency leads to impaired activity of the heart, Central nervous system, liver, as well as lower fertility, birth of weak and non-viable offspring. In addition, the drug Gambit-cannot satisfy the needs of the animals in the separate minerals in the existing drug ratios of trace elements. For example, in some cases, it is necessary in diets to increase the content of certain trace elements such as Mn, Zn, Cu, Se, Co. This may be necessary in some biogeochemical provinces with sandy and peat soils where there is a large deficiency of manganese in the diet of animals. Feeding cattle concentrated rations with the availability of bagasse, the meals, the use of rations siloto-pulp type this deficit increases. When irrational, uncontrolled use of calcium fertilizing the need for manganese increases. Often in these conditions, the animals do not lack in hardware, and its amount can be reduced. However, when the ratio of trace elements present in the drug Gambit, it is impossible to create the necessary content of manganese in the diet. In poultry feed is usually Mn add more than iron, that can be provided by existing Genovate-ratios. When is alsom the calcium content in feed and water there is a negative balance of copper, because calcium reduces the absorption of copper. Hay from alfalfa also reduces the absorption of copper. Use skim milk when the cow-calf leads to copper deficiency in them. In all these cases it is necessary to increase the proportion of copper in the composition of the drug, which is not possible with ratios of trace elements in the drug Gambit-C.

In areas with sandy, sandy loam, sod-podzolic soil, peat-boggy soils in parallel with the copper deficiency manganese animals lack cobalt. Deficiency of cobalt increases with the same type siloto-pulp or siloto-concentrated rations. All this raises the need to increase the proportion of cobalt in the composition of the drug.

In areas with acidic soils, the location of pastures and hayfields on low flood plain frequently flooded areas animals experience a deficiency of selenium. The incidence of white-muscle disease pronounced in the winter-spring period and increases after the rainy or dry season. Side effects cause the need for increased doses of selenium in the product.

In addition, the ratio of the elements in the composition known drug can get it only in the form of paste, which narrows the possibilities of its application.

The objective of the invention is to develop a new drug, providing one is temporary presence of Cu 2+and I-1that allows you to balance the diet of animals with an optimal ratio of trace elements, ensuring the prevention of many diseases and to expand opportunities of the drug not only in the form of paste, but in the form of a solution.

This object is achieved in that in Antianemic and growth-promoting the drug for animals, comprising a complex of iron, manganese, copper, cobalt, selenium and zinc disodium or Pikalevo salt Ethylenediamine-N,N1-dinternal acid and water, according to the invention, it is additionally contains iodine in the following ratio, wt.%:

disodium or dikalova salt

the Ethylenediamine-N,N1-dinternal acid15-25
iron (III)1.5 to 5.5
manganese (II)0,25-3,0
copper(II)0,12-0,55
cobalt (II)0,05-0,3
zinc (II)0,05-1,5
selenium (IV)0,03-0,06
iodine (I)0,01-0,08
waterrest

As a source of iodine (I) the product contains potassium iodide and/or sodium iodide as the most available and cheap connection.

If stated in the report of the preparation of iodine (I) is less than about 0.001 wt.%, it will not be effective, and if iodine is more than 0.08 wt.%, it is not absorbed by the body and can be toxic.

Antianemic and growth-promoting drug was prepared as follows.

In enameled reactor or in the reactor of stainless steel was dissolved 71,6 kg (1,7898 KMOL) of NaOH in 136 liters of softened water. At a temperature of 50°in the alkali solution portions were loaded 87,7 kg (0,8949 KMOL) of maleic anhydride. After each batch is on the rise the temperature to 75-80°C. Subsequent portion of maleic anhydride were loaded after the temperature in the reactor will be reduced to 60-65°C. In the boot process of maleic anhydride, the temperature in the reactor should not exceed 80°C.

In this way the resulting disodium salt of maleic acid for 0.5 hour add 26,85 kg (0,44745 KMOL) Ethylenediamine. After downloading Ethylenediamine temperature in the reactor was raised to 105-108°and maintain the reaction mass with stirring for 8 hours. At the end of a specified period of time to define the content of Terentieva salt Ethylenediamine-N,N1-dinternal acid (ligand) in the reaction mass.

Antianemic and growth of the drug is produced in the same reactor by reacting TETRANITRATE salt Ethylenediamine - N, N1-dinternal acid solution and iron (III)salts, copper (II), manganese (II), cobalt (II), zinc (II). The salt solution was prepared as follows. In 42 liters of softened water was dissolved 43,75 kg (0,26940 KMOL) FeCl3, 21.5 kg (0,12722 KMOL) MnSO4* N2Oh, 2.8 kg (0,02053 KMOL) ZnCl2at 5.1 kg (0,02040 KMOL) CuSO4* 5 H2O, 1.0 kg (0,00420 KMOL) CoCl2* 6 H2Oh, the resulting solution of salts of trace elements transferred to the reactor containing the ligand and at a temperature of 70-80°With was stirred for 1 hour. A solution of compounds of iodine and selenium, obtained separately by dissolving 0.24 kg (0,00139 KMOL) NaSeO3and 0.15 kg (0,0090 KMOL) of KI in 1 l of water, was added 1 hour after the connection of the other trace elements, cooled the reaction mass to 70°C and stirred 5 minutes.

As salts of trace elements used them chlorides or sulfates. Acceptable use both crystalline and anhydrous salts.

As a source of selenium (IV) used selenological sodium, as a source of iodine (I) used potassium iodide or sodium iodide.

Upon receipt of a complex of microelements and Ethylenediamine-N,N1-dinternal acid, changing the number of individual trace elements, it is possible to obtain a product containing specified for a particular case, the ratio of trace elements. Upon receipt of the drug amount (KMOL) Ethylenediamine-N,N1-dinternal keys which the notes must be greater than the total amount (KMOL) of all micronutrients 0.5 to 1.5%.

The resulting product is a dark brown liquid (pH 6-8, the mass fraction of iron 3,4%). The drug is infinitely soluble in water and insoluble in organic solvents. The solution should be stored in glass or plastic containers. Store in containers made of ferrous metals or aluminum is unacceptable due to the corrosive activity of the drug.

The evaporation of the solution at a temperature of 110-115°you can obtain the product in paste form. For example, upriv of the obtained solution and 120 l of water, get a pasty substance from dark brown to black color, a pH of 10%solution 6-8, mass fraction of iron of 4.75%. Upon receipt of the preparation in paste form solutions of iodine compounds (I) and selenium (IV) is added to the reaction mass after the distillation of a given quantity of water, cooled the reaction mass to 70°C. the Pasty preparation should be stored in an airtight container, because it is hygroscopic.

Studies to determine the acute and sub-chronic toxicity of the preparation was carried out according to the "guidance on determining the toxic properties of drugs used in veterinary medicine and animal husbandry (extract from the normative documents approved by the USSR Ministry of health, agricultural Sciences, BS Gosagroprom USSR), Handbook of Veterinary drugs", 1988

In the operation of the test material were used batch cooked poultry, fur animals, cats, dogs, calves, piglets and sows, as brand a and brand B (with filler).

The study of acute and sub-chronic toxicity of the drug was carried out on two species of laboratory animals: 100 white mice with a live weight of 16-20 g and 20 white rats live weight at the beginning of the experience 80-100 g, and 30 heads of chickens masaichi breed chickens at two months of age. The drug quality indicators and chemical composition corresponded to the requirements of products of industrial manufacturing. Acute experiments on mice allowed us to determine that it belongs to the 4th class of hazard (slightly hazardous), the calculated ratio of cumulation was 2,47, indicating the absence of the cumulative properties of the drug.

The efficacy of the drug can be illustrated by the following examples.

Example 1. Tests were conducted on livestock pastelowych mink second year of use in the pre-rut, rut, pregnancy, menenia and lactation females on the background of General diet, corresponding to modern standards of feeding. An experienced group of drug gambit - plus in addition to the ration received: Fe 3 mg, Mn 1.5 mg, Zn 0.3 mg, Cu 0.3 mg, 0.06 mg, Se 0.03 mg, I 0,035 mg per head daily. In the control group Minks in the composition p is eparate gambit was a lack of iodine. The results of the tests are presented in table. 1. The results of breeding females pastelovej painting, the duration of the experiment 159 days. On January 3, 2002 June 10, 2002

Table 1
IndicatorsGroup of animals(mink)
The product (experience)Control
Only females heads211210
Abortion, dysfunctional was danilos, goals614
%2,86,7
Safely danilos, goals205196
%to 97.193,3
Born puppies
total goals13741269
living goals13571203
%98,894,8
dead heads1766
%1,25,2
The fecundity of females, goals6,76,5
Palo puppies prior to registration, heads,1654
%1,24,5
Registered puppies, goals13411149
The output of the youngsters on the main female
head to the control6,355,47
%116,1

As follows from the data table. 1, in the experimental group successfully selivshihsya females was higher by 3.8%, the number of stillborn pups was lower by 4.0%, pre-departure pups was lower by 3.2%, and the output of puppies on the main female was higher by 16.1%. Among stillborn and died before the registration of the puppies obtained from females of the experimental group, there was hairless and with rare hair puppies, which is usually explained by a lack of iodine in the diet of females.

Example 2. Studies were continued on the downhole youngsters from jigging to slaughter. We selected 250 heads puppies males obtained from each group of females and divided into two groups of 125 goals. Experimental group received gambit - plus based: Fe 2 mg, Manganese 1 mg, Zn 0.2 mg, Cu 0.2 mg, 0.05 mg, Se 0.04 mg, I 0.025 mg per head per day. In the control group in the drug iodine was absent. The conditions the animals were identical.

The results of the use of drugs to face the young are presented in table. 2.

table 2
IndicatorsExperience medicationControl Gambit-
The average size of the skins cm21170,7±13,41065,2±10,6
Offset skins quality, %116,4102,4

The results of the experiments we can conclude that the introduction of the drug, which contains iodine, which stimulates the reproductive capacity of females, increases quality fur products.

Example 3. Drug use in dry cows of black-motley breed.

In the North-Western region of the cows often suffer from a lack of Fe, Mn, Zn, Cu, Co, Se, I. When the shortage of water and feed iodine in animals is a metabolic disorder that leads to reduced productivity and disturbance of reproductive function complications at calving, retention of placenta, in connection with what the veterinary experts have to have animals help with the hotel, to treat animals with postpartum complications. In cows increases the service period, you need multiple insemination after calving.

The drug was given to the dry cow, having experience of 30 days before calving, at the rate of 200 mg Fe, 120 mg, Zn, 100 mg, Mn, 20 mg, Cu, 5.0 mg, 3.5 mg Se, 3,3 mg per 1 head per day.

The control group received in addition to the diet of all trace elements in the same doses, the including iodine. The results of the experiment are presented in table. 3.

Table 3
№p/pIndicatorsExperience, n=50Control n=50
1The number of attendants, goal114
2The time separation of placenta, h4,614,1
3Ill clinical endometritis, a goal.623
4The service period, days31,265,4
5The insemination index1,52,6
6Dyspepsia newborn calves goal.628
7Cases of stillborn animals13
8The live weight of calves at birth, kg29,027,0
9Born calves with thinned hair, have hairless areas on the skin, a goal.-6

As can be seen from the results table. 3, in cows of the experimental group reduced the number of assisted births, the incidence of endometritis, reduced service period and quantities shall spermatos for successful insemination. Among those born from an experienced group of calves was absent in animals with clinical signs of endemic goiter. Calves obtained from cows of the experimental group had a well-developed physique, raised on legs, sucking reflex they appeared through 45-70 minutes after birth. 49 calves, obtained from cows of the experimental group, dyspepsia mild chickenpox 6. For 3-4 days they celebrated diarrhea, General condition was satisfactory, the food excitability saved, intestinal peristalsis is slightly strengthened. 28 calves, obtained from cows of the control group, diarrhea was noted for 2-3 days. When this overall condition was oppressed, food anxiety is reduced. For 4-5 hours in 9 of them were observed progressive depression, General weakness, lack of appetite, frequent bowel movements, weak response to external stimuli. As a result of dehydration in animals decreased body weight. The mucous membranes of the oral and nasal cavity were pale with a bluish tinge. Hair disheveled, tugor skin is reduced. With the development of dehydration showed signs of cardiovascular insufficiency. 7-8 day 6 calves fell.

Example 4. Study of the effectiveness of the drug on the calves black-motley breed was carried out on a group of 60 calves at the age of 5-7 days, divided into experienced and entry checkpoints for important locations is th groups of 30 animals each. The number of steers and heifers, feeding and housing conditions of both groups were similar. Calves from the experimental group received medication in addition to diet at the rate of 100 mg Fe, 60 mg Zn, 50 mg, Mn, 10 mg Cu, 5.2 mg, 3.5 mg Se, 1.6 mg I per head daily. The control group received in addition to the diet of all trace elements in the same doses, excluding iodine. The results of the experiment are given in table. 4.

Table 4
IndicatorsExperience (n=30)Control (n=30)
Live weight when putting on experience, kg31,532
The live weight of 30 days, kg53,248,4
% of control109,9-
Average daily gain, kg0,7230,547
Hemoglobin, g/l102,097,4
The number of red blood cells10,8×10129,7×1012
Total protein, g/l60,157,4

Calves from the experimental group had a better appearance, were more active. Had a smooth, shiny coat, was actively eating food. In the experimental group had two calves were observed diarrhea in mild form, DV is x calves celebrated bronchopneumonia.

In the control group, diarrhea was observed in 11 calves, 9 calves marked bronchopneumonia, 5 calves to 11-14 day life marked depression, long a lie, decreased muscle tone, loss of appetite, tachycardia. Despite intensive therapy, 3 calf fell. At autopsy discovered damage to the heart muscles, degenerative changes in skeletal muscle.

The drug had a positive effect on the increase in live weight of calves in the next 30 days after the experience. The average increase during this time was in the experimental group 0,723 kg, and in control - 0,547 kg. While watching the calves up to the age of 7 months from 8 animals from the control group found clinical signs of iodine deficiency: pronounced growth of hair on the head and neck. Hair, grown in the frontal and occipital regions, form the hair on the neck formed mane and expressed as folds. The coat is uneven, some areas of alopecia, skin fold. These animals are markedly stunted.

In the experimental group of animals such phenomena are not detected.

Trials of the drug showed good results. Currently, the company LLC "Gambit prepares its serial production.

1. Antianemic and growth-stimulating drug for animals, comprising a complex of iron, manganese, copper, cobalt, selenium and the Inka with disodium or Pikalevo salt Ethylenediamine-N,N'-dinternal acid and water, characterized in that it additionally contains iodine in the following ratio, wt.%:

Disodium or dikalova salt Ethylenediamine-N,N'-dinternal
acid15-25
Iron (III)1.5 to 5.5
Manganese (II)0,25-3,0
Copper (II)0,12-0,55
Cobalt (II)From more than 0.05 to 0.3
Zinc (II)0,05-1,5
Selenium (IV)From 0.03 to 0.06
Iodine (I)0,01-0,08
WaterRest

2. The preparation according to claim 1, characterized in that as a source of iodine (I) it contains potassium iodide and/or sodium iodide.



 

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