Method for diagnostics and predicting reserves of eyeball's circulation in case of ischemic opticopathies of optic nerve in patients of gerontological age

FIELD: medicine, ophthalmology.

SUBSTANCE: the present innovation deals with methods for diagnostics of vascular pathology of optic nerve (ischemic opticopathies) and, also, predicting vascular pathology of optic nerve lesion and counterlateral eyeball. One should perform dopplerographic registration of circulatory parameters: peak systolic velocity PSV cm/sec and end diastolic velocity EDV cm/sec on the 2nd, 3d min both before and at the background of functional loading: dealing with lifting legs up to 90° in area of internal carotid artery, central retinal artery and ciliary artery. Moreover, calculation of resistant index RI c. u. should be performed by the following formula (PSV cm/sec - EDV cm/sec)/PSV cm/sec and reactivity index RY c.u. by the following formula PSV cm/sec after loading/PSV cm/sec before loading. At RI value being above 0.7 and RY value being below 1.0 one should detect deterioration of visual functions and the absence of circulatory reserves in tested eye and counterlateral one. At RI value being below 0.7 and RY value being above 1.0 it is possible to detect the maintenance of visual functions and circulatory reserves in tested and counterlateral eyes. The innovation enables to accelerate and simplify the trial and carry out it with available physical loading for a patient without applying any additional appliances and medicinal preparations.

EFFECT: higher efficiency and accuracy of diagnostics and prediction.

6 dwg, 3 ex, 2 tbl

 

The invention relates to medicine, namely to ophthalmology, to methods of diagnosing vascular disease of the optic nerve (Ischemic optimate), and prediction of vascular pathology lesions of the optic nerve of the contralateral eye.

The purpose of the invention offer the methods of diagnosing vascular disease of the optic nerve in geriatric patients with Discirculatory encephalopathy, given the age of the patients (60 years and older), there are many associated diseases, research is desirable to carry out as quickly as possible, it is easier on the available physical burden to the patient, without the use of additional devices and drugs, so as not to cause deterioration of the patient for his research.

The invention consists in the registration of blood flow parameters (peak systolic velocity (PSV cm/s), end diastolic velocity (EDV cm/s), resistant index (RI$), reactivity index (RY$)) when the Doppler on the background of the functional load of the physical nature.

Formula No. 1

RI $ =(PSV cm/s EDV cm/s):PSV cm/s

Formula No. 2

RY $ =PSV cm/s after load/PSV cm/s to load

When conducting research on the affected side have a diagnosis of Ischemic optimate, when performing on the contralateral with the Auron defeat conduct forecasting vascular reserves the eyeball of the contralateral side.

1. There is a method of determining the valuation reserves circulation of the heart and brain in patients with coronary and carotid atherosclerosis using a modified intertonguing samples (ANP) with the location of the lower extremities on the stand at an angle of 60° to the horizontal surface. Check hemodynamic parameters is alone and 5-10 minutes to load. When applying AOP functional response of the circulatory system depends on its reactivity, which determines its functional reserve, the quantification of which is the index of reactivity (IR), as the ratio of the rate of blood flow on the background of functional tests to the original value.

The disadvantage of this method is the volume of the study: the authors observed the changes of reactivity indices cardiac ejection fraction exile; see changes in systolic and diastolic myocardial function, register the volumetric rate of blood flow in stenocereus vessel, determine the total flow in both internal carotid arteries. The authors conduct the prediction of hemodynamic effectiveness of coronary artery bypass surgery by examining the increase in the ejection fraction of the left ventricle in ONP and Doppler sonography of the internal carotid artery (I. N. Vorozhtsov. Reserves krooom the stop of the heart and brain in patients with coronary carotid atherosclerosis: author. Dis...d-pa med. Sciences. - Tomsk, 2000. - 53 S.).

2. Test with hypercapnic hypoxia method of breathing through additional dead space. Changes of blood gas composition was achieved by breathing in for 3 minutes through additional dead space, played horizontally situated elastic tube (diameter 3.0 cm, length 145 cm, with a volume of 1.0 l), equipped with a mouthpiece; in the horizontal position of the patient in the initial state and at the peak of the sample is measured linear velocity of blood flow in the system cerebral arteries using ultrasonic method transcranial Doppler. To exclude nasal breathing on the wings of the nose superimposed clip. To study the dynamics of blood gas composition in the initial state and at the peak of the test in the arterial capillary blood were evaluated by the oxygen content and carbon dioxide using micromethod of Astrup using a BMS-3 of the company "Radiometr" (Denmark). (Astanina I.A. Complex x-ray morphological and functional study of brain blood supply in patients with ischemic heart disease and arterial hypertension asymptomatic atherosclerotic carotid arteries: author. Dis... Kida. the honey. Sciences. - Tomsk, 2001. - 29 S.).

The disadvantages of this method are the need for research on the 2 devices using al the socialist tube, which is the subject of reusable, the necessity of constant sterilization, the absence of nasal breathing, not everyone can breathe easy in a confined space, and the need to specifically make this up.

Given the age of our patients (60 years and older), there are many associated diseases, research is desirable to carry out as quickly as possible, it is easier on the available physical burden to the patient, without the use of additional devices and drugs, so as not to cause deterioration of the patient to his study.

The proposed method is carried out using ultrasound And In-scanner Toschiba-270" convex probe - 4,5 Mhz linear probe of 7.5 Mhz, surface structures, scanning depth up to 6 cm (Petrukhin A.N., Flaps I.A. Study of blood flow velocity in orbital vessels in glaucoma // the Clinical journal of the company Medison on ultrasonography. - 1999. - Vol.5. - P.60-65), (see Figure 1-6)

In the horizontal position of the patient were studied internal carotid artery (ICA), the Central artery of the retina (CAC), posterior ciliary artery (SCA). Was determined by the peak systolic velocity (PSV cm/s), end diastolic velocity (EDV cm/s), resistant index (RI$) or reactivity index (RY$), (see Table no.2).

The measurement was carried out with the patient lying on the back, before the examination not less than 6 hours the patient had received vasoactive drugs and physiotherapy. The sensor is located in the cranial direction at an angle of about 60° to the line of flow in the vessel at a cross-section study of the vessel and in parallel over the vessel 90°, in a longitudinal study of the vessel. (Aghajanova L.P. Ultrasonic diagnosis of diseases of the aortic arch and peripheral vessels: satin. -M.: Vidar, 2000 - 176 C.).

In the study of the carotid arteries chin of the patient slightly elevated and face turned away from the studied artery.

Place the bifurcation of the carotid artery is determined at the intersection of the medial surface of the edge of the sternocleidomastoid muscles and the vocal cords.

The internal carotid artery lazerette under the edge of the lower jaw.

Ophthalmic artery located 15 mm from the posterior pole of the eyeball under the optic nerve, it is easy to visualize when looking the patient in the right side of the left eye and at the sight of the patient in the left side on his right eye. (Harlap SR Anatomic diagnostic Parallels the state of the vessels of the eye and orbital space by the results of color Doppler mapping //News. Oftalmol. - 2000. No. 1. - P.45-48).

The Central artery of the retina, Lozi who was ovalis in the surface of the optic nerve about 5-10 mm from the posterior pole of the eyeball.

The posterior ciliary arteries located at the optic nerve to the medial or lateral side of 5-10 mm from the posterior pole of the eyeball.

Stress test is to lift patients up, bent at the knees of the legs up to 90°and registration hemodynamic parameters is carried out on 2 - 3 minutes.

Studied a group of patients 51 persons (72 eyes) with symptoms of ischemic opticoat. In the first group with symptoms of posterior ischemic opticoat (SIOP) and 39 patients (56 eyes). The average age in this group of 72 years. The second group with symptoms of anterior ischemic opticoat (PIOP) - 12 (16 eyes). The average age in this group of 73 years.

The control group consisted of 25 people (50 eyes). Average age composition of the group of 77 years (smfbl).

Indicators of blood flow before and after AUNP.

The significance of differences of results P<0,05

Table No. 1
The control groupZIPPIOP
PSV cm/sEDF cm/sPSV cm/sEDF cm/sPSV cm/sEDF cm/s
ICA0,29+0,060,11+0,040,2+0,06 0,08+0,020,25+0,060,09+0,02
after0,34+0,070,13+0,040,24+0,060,08+0,020,23+0,070,08+0,02
CAC up0,10+0,020,03+0,0100,8+0,020,03+0,010,06+0,020,02+0,01
after0,12+0,020,03+0,010,09+0,020,03+0,010,05+0,020,02+0,01
SCA to0,14+0,030,04+0,010,11+0,030,03+0,010,08+0,020,03+0,01
after0,15+0,030,05+0,010,11+0,030,03+0,010,08+0,020,03+0,01

Table No. 2
Indicators RY PSV
ICACACCA
The control group1,17+0,061,2+0,021,07+0,03
ZIP1,04+0,061,07+0,020.96+0.03
PIOP0,92+0,070,9+0,021,0+0,02

The significance of differences of results P<0,05

Example 1

lyncheski example from practice:

Getlogin Anatoly Yakovlevich, 75 years. Outpatient map No. 479/95.

25.01.01 year when referring to the optometrist registered:

Vis=1,0/1,0 intraocular pressure = 17/17 mm Hg Field of view was determined by the perimeter of the förster, white object 0.5 cm - norm.

Objective: Both eyes (OU) - Anterior segment without features. Biomicroscopic: Both eyes focal opacities in the lens. The fundus of the eye: the Disks of the optic nerve (optic nerve disc) pale pink color, border, clear, arteries are narrowed, twisted. Vienna expanded.

Diagnosis: OU - Primary age-related cataract. Angiosclerosis vessels of the retina.

9.08.01, Complaints sharp decrease of vision in his left eye.

Objective: OU-1,0/ hand movement. Anterior segment without features. Biomicroscopic: Both eyes focal changes in the crystalline lens. The fundus of the eye: Right eye (OD)-the optic nerve disc is a pale pink color, border clear. Left eye (OS)-the optic nerve disc is pale, fuzzy boundaries, swelling of the retina in the posterior pole.

Diagnosis: Ischemic optimate OS.

The patient is examined by a neurologist. Diagnosis: Dyscirculatory atheromatous encefalopatia II - stage, annotationdbi syndrome.

Ultrasonic duplex scanning:
Right sideLeft side
To loadafter loadingto loadafter loading
CAC-0,10-0,030,11-0,040,08-0,020,08-0,02
SCA-0,11-0,030,13-0,050,09-0,03the 0.09-0.03
ICA-0,36-0,100,42-0,120,27-0,060,25-0,05

After the research we calculate the index:
RIRIRIRI
To loadafter loadingup load after load
CAC-0,70,60,80,8
SCA-0,70,60,70,7
ICA0,60,70,80,8

RYRY
PSV cm/sEDV cm/sPSV cm/sEDV cm/s
CAC-1,11,31,01,0
SCA-1,2 1,31,01,0
ICA1,21,20,90,8

15.03.02, Complaints about low vision OS. Held 2-3 times per year rate of vascular, venous therapy.

Objective: Vis - 1,0/0,2 ex. OU-Anterior segment unchanged, turbidity nuclear-cortical lens layers. The fundus of the eye: OD - optic nerve disc is a pale pink color. The paths clear. OS - the optic nerve disc is pale, clear contours. OU - Artery sclerotic (fibrous).

Diagnosis: Ischemic optimate OS.

Ultrasonic duplex scanning:
Right sideLeft side
To loadafter loadingto loadafter loading
CAC - 0,12-0,040,14-0,050,14-0,040,14-0,04
SCA - 0,14-0,040,16-0,050,10-0,030,10-0,03
ICA - 0,42-0,220,48-0,220,23-0,070,23-0,07

After the research we calculate the index:
RIRI
To loadafter loadingup load after load
CAC - 0,60,60,70,7
SCA - 0,70,70,70,7
ICA 0,50,50.70,7

RYRY
PSV cm/sEDV cm/sPSV cm/sEDV cm/s
CAC - 1,21,01,01,0
SCA - 1,11,01,01,0
ICA 1,11,01,01,0

For example, the patient clearly visible good vasodilatation provisions of the ICA, CAC, SCA with the contralateral side RI-0.7 and less RY greater than 1.0; and the lack of response on the load side of lesion of vessels of the eyeball RI-0.7 and more, RY-1.0 and less. This reaction of the vascular bed is observed when handling patient and dynamic monitoring during the year, remains high visual and functional performance of the contralateral eyeball and the lack of recovery of the high functions of the affected eye.

Example 2

The Stashkov Valentin Stepanovich, 79 years. Outpatient map No. 006179.

19.01.00 year when referring to the optometrist registered:

Vis - 0,4-1,0 Diopters (D)=0,5/0,1-20 D=0,5 IOP was 16 mm Hg /27 mm Hg

The field of view of the one norm, OS-top-10 degrees from the nasal side is 10 degrees below - 10 degrees from the temporal side 70 degrees.

Objective: OU-thinning pigmented rims. Biomicroscopic: nuclear-cortical opacities in the lens. The fundus of the eye: OD - optic nerve disc pale pink color, border, clear, artery sclerotic (fibrous), Vienna worthwhile. OS - pale optic nerve disc, monotonous, boundaries clear, artery sclerotic (fibrous), Vienna full.

Diagnosis: OU - Primary age-related cataract, sclerosis of the retinal vessels. OS-Subatrophy the optic nerve disc vascular abnormalities, suspected open-angle glaucoma. The patient is examined by a neurologist. Diagnosis: Dyscirculatory atheromatous encefalopatia stage II-III, microcavia symptoms. Arterial hypertension.

After the research we calculate the index:
RIRI
To loadafter loadingto loadafter loading
CAC - 0,60,6 0,70,7
SCA - 0,70,70,70,6
ICA 0,70,60,50,5

RYRY
PSV cm/sEDV cm/sPSV cm/sEDV cm/s
CAC - 1,01,01,01,0
SCA - 1,01,01,01,0
ICA 1,01,01,01,0

15.01.01, Complaints progressive vision loss during the year on both eyes.

Objective: Vis-0,1 not corrects (n/K)/0,1N/IOP of 18 mm Hg/18 mm Hg

Field of view OD OS-top - 15 degrees, with the bow hand 15 degrees below 15 degrees, from the temporal side is 25 degrees, OS-top - 5 degrees, from the nasal side is 5 degrees below 5 degrees, from the temporal side is 25 degrees. OU - thinning pigmented rims. Biomicroscopic: nuclear-cortical opacities in the lens. The fundus of the eye: OD - optic nerve disc pale pink color, monotonous, boundaries clear, artery sclerotic (fibrous), Vienna worthwhile. OS - pale optic nerve disc, monotonous, boundaries clear, artery sclerotic (fibrous), Vienna full.

Diagnosis: OU - Initial vozrast what I cataract, sclerosis of the retinal vessels. OU - Subatrophy DSN. vascular Genesis. OS - Open-angle glaucoma II phase offset.

Ultrasonic duplex scanning:
Right sideLeft side
To loadafter loadingto loadafter loading
CAC - 0,07-0,020,07-0,020,05-0,020,05-0,02
SCA - 0,09-0,020,09-0,020,07-0,020,07-0,02
ICA - 0,26-0,100,24-0,100,17-0,090,17-0,09

After the research we calculate the index:
RIRI
To loadafter loadingup load after load
CAC - 0,70,70,060,6

SCA - 0,80,80,70,7
ICA 0,60,60,50,9

RYRYPSV cm/sEDV cm/sPSV cm/sEDV cm/sCAC - 1,01,01,01,0SCA - 1,01,01,01,0ICA - 0,91,01,01,0

For example, the patient clearly reveals the lack of vasodilatation provisions of the ICA, CAC, SCA to the load from both sides - RI-0.7 and more, RY-1.0 and less, despite good functional performance of the contralateral right eyeball, turning, and a sharp negative trend of the contralateral eyeball during the year, leading to the phenomena SHOP and, as a consequence, the subatrophy DSN. the left eyeball.

Example 3

Kurochkin Pavel Leonidovich, 75 years. Outpatient map No. 73/85.

18.02.00 year when referring to the optometrist registered:

Vis - 0.5 to+1.0 Diopter (D)=0,7/0,5+1,D=0,7 IOP of 18 mm Hg/18 mm Hg Complaints at the time of inspection does not show.

Field of view OD the top - 50 degrees, from the nasal side is 50 degrees below 55 degrees, with the temporal side 80 degrees.

OS top - 50 degrees, from the nasal side is 50 degrees below 55 degrees, with the temporal side 80 degrees.

Objective: OU - before the Yaya Luggage average depth of dystrophic changes in the iris stroma. Biomicroscopic: nuclear-cortical opacities in the lens. The fundus of the eye: OU - optic nerve disc pale pink color, border, clear, artery sclerotic (fibrous), Vienna full, in the macular area Druze.

Diagnosis: OU - Primary age-related cataract, sclerosis of the retinal vessels. Central involutional retinal degeneration. The patient is examined by a neurologist - Diagnosed with Dyscirculatory atheromatous encefalopatia II-stage.

Ultrasonic duplex scanning:
To loadafter loadingto loadafter loading
CAC - 0,13-0,040,14-0,040,12-0,030,13-0,04
SCA - 0,15-0,07of 0.16 and 0.080,14-0,040,15-0,05
ICA 0,34-0,180,42-0,190,26-0,120,32-0,14

After the research we calculate the index:
RIRI
To loadafter loadingto loadafter loading
CAC - 0,50,7 0.70,7
SCA - 0,60,50,60,6
ICA 0,60,50,50,5

RYRY
PSV cm/sEDV cm/sPSV cm/sEDV cm/s

CAC - 1,21,01,21,3
SCA - 1,11,11,01,3
ICA 1,11,11,11,2

19.06.01 year when referring to the optometrist registered:

Vis - 0.4 to+1.0 Diopter (D)=0,7/0,7+1,D=0,9 IOP - 19 mm Hg/19 mm Hg

Complaints at the time of inspection does not show.

Field of view OD the top - 50 degrees, from the nasal side is 50 degrees below 55 degrees, with the temporal side 70 degrees.

OS top - 50 degrees, from the nasal side is 50 degrees below 55 degrees, with the temporal side 70 degrees.

Objective: OU - front camera average depth of dystrophic changes in the iris stroma. Biomicroscopic: nuclear-cortical opacities in the lens. The fundus of the eye: OU - optic nerve disc pale pink color, border, clear, artery sclerotic (fibrous), Vienna full, the macular area Druze.

Diagnosis: OU - Primary age-related cataract, sclerosis of the retinal vessels. Central involutional dystrophy of the retina.

Ultrasonic duplex scanning:
Right sideLeft side
To loadafter loadingto loadafter loading
CAC - 0,08 0,030,09-0,040,09-0,030,10-0,04
SCA - 0,10-0,030,11-0,040,11-0,030,12-0,04
ICA - 0,22-0,080,30-0,100,22-0,080,34-0,10

After the research we calculate the index:
RIRI
To loadafter loadingto loadafter loading
CAC - 0,60,60,60,6
SCA - 0,60,60,60,7
ICA 0,70,70,70,7

RYRY
PSV cm/sEDV cm/sPSV cm/sEDV cm/s
CAC - 1,11,31,11,3
SCA - 1,11,31,11,3
ICA - 1,41,31,51,3

In the patient reported good reserves circulation of the eyeball from both sides, as evidenced by RY than 1.0 at all points of measurement, RI 0.7 and below to load and after samples; good functional characteristics are stored for the entire period of observation.

The proposed method of diagnostics and forecasting reserves circulation of the eyeball in ischemic optimate optic nerve in persons gerontological age is faster, easier, with available physical burden to the patient, without the use of additional devices and drugs, so as not to cause deterioration of the patient for his research.

The correlation between RY, RI and reserves circulation: with increasing RI more than 0.7 and the reduced RY less than 1.0, a marked deterioration of visual functions studied and the contralateral eye, with decreasing RI is less than 0.7 and increasing RY greater than 1.0 are retained good zritel the major tasks and reserves circulation on the researched and the contralateral eye.

The method of determining reserves circulation and visual functions of the eyeball in ischemic optimate optic nerve in persons geriatric age, including Doppler check blood flow parameters: peak systolic velocity PSV cm/s and end-diastolic velocity EDV cm/s on 2-nd, 3-th minute before and on the background of functional load, which consists in lifting the legs up to 90 degrees in the field of the internal carotid artery, the Central artery of the retina and ciliary artery, the calculation of resistance index RI $ by the formula (PSV cm/s EDV cm/s)/ PSV cm/s and reactivity index RY $ by the formula PSV cm/s after load/ PSV cm/s to load and when the value of RI is more than 0.7 and RY less than 1.0 are determined deterioration of visual functions and the lack of reserves circulation of the studied and the contralateral eye, and a value of RI is less than 0.7 and RY greater than 1.0 determine the preservation of visual function and reserves the circulation of the studied and the contralateral eye.



 

Same patents:

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SUBSTANCE: one should perform ultrasound scanning of the 1st volar metacarpal artery both before and at the background of radial artery compression, moreover, at decreased peak systolic rate of circulation in the 1st volar metacarpal artery at the background of compression by 40% or less against peak systolic rate of circulation before compression one should diagnose ulnar type of wrist's circulation and at decreased peak systolic rate of circulation at the background of compression by more than 40% against peak systolic rate of circulation before compression or at appearance of retrograde circulation one should diagnose radial type of wrist's circulation.

EFFECT: higher efficiency and accuracy of diagnostics.

6 dwg, 2 ex

FIELD: medicine, otorhinolaryngology.

SUBSTANCE: one should detect amplitude-frequency circulatory characteristics in mucosal microcirculation system of inferior concha at the side of lesion due to laser Doppler flowmetry: AmaxCF/σ - circulatory fluctuations synchronized with cardiorhythm; IFM - index of flux motions, the ratio between active and passive mechanisms of circulatory regulation in microcirculation system. In 3-4 d all measurements should be repeated. If AmaxCF/σ value is increased at simultaneous decrease of IFM value one should consider the treatment to be efficient. The present innovation enables to obtain objective parameters of maxillary sinus state.

EFFECT: higher accuracy of detection.

3 ex

FIELD: medicine, cardiology.

SUBSTANCE: one should perform colored duplex sonography by measuring the resistance index in tibial arteries to evaluate the degree of functional insufficiency in lower limbs, that is at R1 being above 1.0 - the first stage, at R1 being 1.0-0.4 - the second stage, at R1 being below 0.4 and up to 0.2 - the third stage and at R1 being below 0.2 - the fourth stage should be detected. The method enables to objectively and quantitatively evaluate ischemic stages in case of occluding arterial diseases of lower limbs.

EFFECT: higher efficiency of evaluation.

12 dwg, 2 ex, 1 tbl

FIELD: medicine, juvenile neurology.

SUBSTANCE: one should measure the values of cerebral hemodynamics, calculate the index of resistance (IR) in fetal internal carotid artery in pregnant woman at 38-41-wk-long gestation due to ultrasound dopplerography. At IR values ranged 0.8 and higher one should predict the development of perinatal cerebral lesion of light and average severity degree, and at 0.6 and lower - severe degree. The method applies more adequate value of circulation.

EFFECT: higher accuracy of prediction.

3 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: method involves making clinical investigation of digestive apparatus. Doppler flowmetric examination of main visceral arteries and biochemical blood test are carried out. Blood circulation speed drop in abdominal aorta being found to be equal to or greater than 9%, in celiac trunk 33.6% and more, in superior mesenteric artery 25% and more, and cholesterol concentration growth being greater than 38% and triglyceride 23% and more, chronic digestive apparatus ischemia is to be diagnosed.

EFFECT: high diagnosis accuracy.

FIELD: medicine.

SUBSTANCE: method involves examining eyeball and retrobulbary styate and retrobulbary space by means of multi-functional ultrasonic scanner device. Ultrasonic gray-scale orbit scanning in real-time mode is carried out. Kinematic test is performed for estimating extraocular muscle function condition. When recording full eye movement amplitude within 15° to 40° without extraocular direct muscles thickness change being found, normal muscle function condition is diagnosed. When recording incomplete movement amplitude within to 15° with extraocular direct muscles thickness change being found, disturbed muscle function is recorded and pathological state is diagnosed.

EFFECT: high objectivity of obtained information; detected morbid muscle changes not detectable in clinical examination; high accuracy of diagnosis.

1 tbl

FIELD: medicine, juvenile surgery, urology.

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1 dwg, 1 ex, 1 tbl

FIELD: medicine.

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EFFECT: high reliability of diagnosis.

2 tbl

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EFFECT: higher efficiency.

3 ex, 6 tbl

FIELD: medicine.

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EFFECT: more reliable and objective information.

1 ex, 1 tbl

FIELD: medicine; medical engineering.

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EFFECT: high accuracy of measurements; wide range of functional applications.

2 cl, 2 dwg

FIELD: medicine.

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EFFECT: enhanced effectiveness of prediction.

FIELD: medicine.

SUBSTANCE: method involves measuring forced exhalation volume per 1 s (FEV1) in l, full right ventricle evacuation time (RVE) in ms and angiotensin II value (AII) in ng/l. Discriminant relationship is built as D=0.504·RVE+3.038·FEV1 - 2.0·AII. D being less than 83.88, pulmonary hypertension occurrence is predicted within 1 year. D being equal to or greater than 83.88, no pulmonary hypertension is predicted to occur.

EFFECT: enhanced accuracy of prediction.

FIELD: medicine, nephrology.

SUBSTANCE: one should detect circulation rate characteristics and vessel's diameter due to dopplerography, moreover, on should measure vessel's diameter directly in area of anastomosis, as for circulation rate characteristics they should be determined in constant-wave Doppler mode in area of circulation's maximal rate. Moreover, one should measure anastomosis' cross-sectional area and heart rate, moreover, one should calculate circulatory volume through anastomosis by the following formula: V(ml/min) = A VTI HR, where A - anastomosis' cross-sectional area (sq. cm), VTI - integral of circulatory linear rate through anastomosis (cm), HR - heart rate.

EFFECT: higher accuracy of detection.

4 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: method involves determining linear blood circulation speed above and below diaphragm using dopplerography approach. State severity class is determined as healthy, recovering and heavy from measured linear velocities ratio. Applied therapy effectiveness is determined on the measured linear velocities ratio exiting beyond the scope of severity class range, when analyzing patient state dynamics.

EFFECT: high accuracy in estimating patient health state.

4 tbl

FIELD: medicine, hepatology.

SUBSTANCE: one should detect splenic length in mm (X1) and circulation in portal vein, moreover, additionally, on should detect volumetric circulation in splenic vein in cu. cm/min. (X2), the index for the ratio of volumetric circulation in splenic vein to the area of longitudinal splenic section (X3), circulatory direction in left-hand gastric vein (X4) by establishing its direction towards the liver to be 1, from the liver to be 2, diameter of splenic artery in cm (X5) and transhepatic portal volumetric circulation in cu. cm/min. (X6), then one should calculate discriminant function Z = 15.9850 - 0.0187X1 + 0.2006X3 - 1.9025X4 - 19.0493X5 - 0.0025X6, where Z - the criterion for predicting "healthy-sick" state; then it is necessary to detect the group with hepatic diseases by the value of Z ≤ 1.621 to calculate for them discriminant function Y = 9.7396 - 0.0279X1 - 0.0018X2 + 0.1873X3 - 4.9174X4, where Y - the criterion to predict "patients with chronic hepatitis - patients with cirrhosis" state and at Y > 1.239 one should diagnose chronic hepatitis, at Y ≤ 1.239 - cirrhosis.

EFFECT: higher efficiency of diagnostics.

3 ex

FIELD: medicine, cardiology, endocrinology, gynecology.

SUBSTANCE: one should detect informational-valuable signs of patient's state, such as either the presence or absence of hypertonic disease and uterine extirpation together with adnexa, the value of body weight index, predominance of disorders according to modified menopausal index (MMI)such as autonomic, metabolic-endocrine or psycho-emotional ones, the type of metabolic structures of blood serum, moreover, it is necessary to echocardiographically detect stroke volume, cardiac index and systemic vascular resistance (SVR), at ultrasound testing one should detect maximal linear rate of circulation (LRC max) by medial cerebral artery and thyroid alterations, rheovasographically one should detect specific circulation (SC) of shins, at testing laser doppler flowmetry one should detect microcirculation index, biochemically it is necessary to detect the value of beta-adrenoreactivity, cholesterol level and that of B-lipoproteides, crystallographically - the presence of serotonin and dopamine crystals, due to immunoenzymatic assay on should detect the values by Table 1 and then after obtaining the values of diagnostic coefficients of every parameter it is necessary to summarize them and obtain diagnostic index (DI), at its value being below 10 one should state no alteration, at its value 10-10 - undetermined state, at its value being 21-30 - the 2nd severity degree of disorders, and at DI value being above 31 one should state the 3d severity degree of disorders available.

EFFECT: higher accuracy of evaluation.

5 ex, 2 tbl

FIELD: medicine, obstetrics, gynecology.

SUBSTANCE: one should study circulation in one of fetal renal arteries during the second half of third trimester of pregnancy. At increased resistance index from 0.81 and higher and, correspondingly, systolodiastolic ratio - from 5.1 and higher - one should fix the presence of fetal hypoxia and the necessity for urgent correction of this state. The suggested method increases the number diagnostic preparations and enables to increase the significance of predicting the state of neonatals.

EFFECT: higher accuracy of evaluation and prediction.

5 dwg, 5 ex, 1 tbl

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