Agent for treatment of articulation diseases

FIELD: medicine, arthrology, pharmacy.

SUBSTANCE: invention relates to agents of topical applying used in treatment of articulation diseases. Proposed agent comprises mixture of chondroitin sulfate and glucosamine salts as a saccharide, the compound taken among the group nonsteroid anti-inflammatory agents, in particular, ibuprofen or nimesulid, or piroxicam, or meloxicam, or diclofenac salt, or indometacin, or ketoprofen, dimethylsulfoxide and an ointment base taken in the definite ratio of components. Invention provides enhancing effectiveness due to the content a mixture of low-molecular and high-molecular saccharides in it that results to increasing diffusion rate of active component to the articulation zone and also the compound taken among the group of nonsteroid anti-inflammatory agents. The combined using these agents provides the curative synergetic effect.

EFFECT: improved and valuable medicinal properties of agent.

2 cl, 14 ex

 

The invention relates to medicine, namely, preparations for external use for the treatment of diseases of the joints.

Disease affects about 70% of the population older than 45 years. They are manifested as pain in the joint, aggravated by motion, sensation of tightness. Inflammatory processes are accompanied by swelling, change in shape of the joints.

In addition, when astrologicheskih diseases of the joints gradually destroys the cartilage covering the articular surfaces, as well as bone tissue and the inner surface of the articular capsule.

Currently widespread in the world of medical practice for the treatment of diseases of the joints (arthritis, arthrosis, osteochondrosis, etc.) received drugs on the basis of saccharides (salts of glucosamine, chondroitin sulfate), mainly in the form of tablets and injections. Treatment with these drugs not only reduce inflammation and pain in the joints, but also produces the restoration of damaged cartilage tissue [Nasonov EL Clinical guidelines and algorithms for medical practitioners. Rheumatology, M., 2004; K.Pavelka, Archives Internal Medicine, №10, 2002, №7, 2003].

Widespread previously found drugs exterior - ointment dosage forms based on a derivative of diclofenac. Recently, however, despite their known therapeutic EF is known, the interest in this group is sharply reduced due to their high gastroepiploic activity and a number of complications. However, it is established that the concomitant use of separate preparations of diclofenac and glucosamine provides an unexpected synergistic therapeutic effect of diclofenac, which allows to decrease the dose (Vguderqa ChondroprotectiveHealth of Ukraine, Kiev, 2004).

Closest to the claimed composition is a preparation containing as active ingredients saccharide - fractions polysulphate, diclofenac sodium and transdermal agent is dimethyl sulfoxide on the known ointment bases [RF patent №2085194, class a 61 K 31/73, a 61 K 9/06, publ. 27.07.1997].

The disadvantages of this tool are that when used as a chondroprotective component of the polysaccharide fractions of polysulfate, which is unstable in the chemical synthesis of semisynthetic connection is not established structure (basis of preparation ARTEPARON, which filmed in the Russian Federation with registration due to the high toxicity) polydisperse and has a high molecular weight (10000-100000 daltons), sharply limited the diffusion of the substance in the joint area, which significantly reduces the pharmacokinetics of the drug, the effect of inhibition of the process of destruction of cartilage and its regeneration.

Ass is cha, solved by the invention is the development of tools for the treatment of diseases of the joints qualification Mikst combining chondroprotective, anti-inflammatory and analgesic effect with high pharmacokinetic parameters of glucosamine and compounds selected from the group of nonsteroidal anti-inflammatory drugs, with prolongation for a long period of assignment due to the high molecular weight polysaccharide is chondroitin sulphate and expanding Arsenal of these funds.

The technical result from the use of the invention is to create a drug with a wide spectrum of action and effectiveness of the drug due to the replacement of volatile toxic polysaccharide fractions of polysulfate a mixture of Monomeric saccharide of low molecular weight salts of glucosamine and stable composition of the polysaccharide is chondroitin sulfate and expansion of the means to treat diseases of the joints due to use as anti-inflammatory compounds one representative of the group of NSAIDs: ibuprofen, nimesulide, piroxicam, meloxicam, diclofenac, indometacin, Ketoprofen, each of which socetanii with saccharide - glucosamine salt exhibits a synergistic effect.

The specified result is a tool for the treatment of diseases of the joints, containing Farid, a compound selected from the group of nonsteroidal anti-inflammatory drugs, dimethylsulfoxide and the ointment base according to the invention, as it contains a saccharide mixture of salts of chondroitin sulfate and glucosamine, as as nonsteroidal anti-inflammatory agents it contains ibuprofen, or nimesulide, or piroxicam or meloxicam or diclofenac salt, or indomethacin or Ketoprofen at the following content, wt. %:

Chondroitin sulphate salt0.5 to 10.0
Glucosamine salt0.5 to 10.0
Ibuprofen0,1-10,0
or Nimesulide0,1-1,0
or Piroxicam0,1-1,0
or Meloxicam0,1-1,0
or Diclofenac salt0,1-5,0
or Indometacin0,1-10,0
or Ketoprofen0,1-5,0
The sulfoxide1,0-20,0
Ointment baseRest

Preferably, as salts of chondroitin sulfate tool has its sodium, potassium or calcium salt, as the salt it contains glucosamine hydrochloride glucosamine, sodium, potassium or calc ewww salt of glucosamine sulfate, and as the salt of diclofenac is its potassium or sodium salt.

These ranges of concentrations of active ingredients are optimally acceptable, pharmacologically meaningful and accepted in medical practice for similar ointment form of this pharmacological group.

As a substance of chondroitin sulfate can be used is registered in the Russian Federation, for example, FS 42-3741-99, or imported, the relevant requirements of United States Pharmacopeia 27 edition, its sodium, potassium or calcium salts.

As salts of glucosamine can be used a known pharmaceutical substance (registered in the Russian Federation, such as the Fund 42-0314-1478-01, or imported, the relevant requirements of United States Pharmacopeia 27 editions): glucosamine hydrochloride, sodium, potassium and calcium salts of glucosamine sulfate. Low molecular weight of these saccharides (573,3 and 215,0 daltons, respectively) and their high pharmacological activity in the treatment of diseases of the joints ensure the creation of effective chondroprotective drugs [Eszteca, Scientific-practical rheumatology, No. 2, 2003].

As salts of diclofenac can it can contain its potassium or sodium salt, for example, ND 42-3714-01.

As an anti-inflammatory component agent contains a compound selected from groups of the NSAIDs: ibuprofen, or nimesulide, or piroxicam or meloxicam or diclofenac salt, or indomethacin or Ketoprofen, advantage each of which is of high anti-inflammatory and analgesic activity.

The use of dimethyl sulfoxide as one of the components of the drug due to the fact that it has anti-inflammatory and analgesic action in diseases of the musculoskeletal system. In addition, the sulfoxide is able to penetrate biological membranes, including skin barriers, thereby increasing the diffusion of drugs through the skin of the patient. Used dimethyl sulfoxide, for example, FS 42-2980-98.

As ointment bases can be used for the basis used to obtain the actual ointments, gels, liniments, creams, pastes.

To neutralize the acidity of the used salts of sulphate glucosamine (pH of 1.5-4.0) to a physiologically acceptable pH values ointments (pH 4.0 to 8.0) composition may further comprise a base such as sodium hydroxide or known pharmaceutical amines such as ethanolamines - diethanolamine (2,2'-iminodiethanol), triethanolamine, trolamine.

The proposed tool refers to the pharmacological group - 8.8, concealer metabolism of bone and cartilage (Register of medicines of the Russian Federation, 2004).

Obtaining before aguinaga funds carried out in a known manner - by mixing the active ingredients with acceptable ointment base with subsequent packaging.

Control the quantitative content of the active ingredients in preparations carried out by known methods adopted for similar legform registered in the Russian Federation and contains chondroitin sulfate, glucosamine or dimethylsulfoxide (spectrophotometric, potentiometric or titration values).

Examples of obtaining the proposed tools

Example 1. 0.8 g of sodium salt of chondroitin sulfate, 16.0 g disodium salt of glucosamine sulfate and 1.6 g of nimesulide dissolve when heated in 34 ml of distilled water. Separately melted at a temperature of 50-70°From 23.2 g of anhydrous lanolin and 70 g of vaseline, filtered and mixed with constant stirring at a temperature not exceeding 65°to obtain a homogeneous mass. Salt solution, a mixture of lanolin and vaseline, 16 g of dimethyl sulfoxide separately bring the pH to 4.0 to 8.0 by adding sodium hydroxide and cooled. The drug is Packed in tubes or cans. 1 g of the end product contains 5.0 mg of sodium salt of chondroitin sulfate (0.5%), 100 mg of disodium salt of glucosamine sulfate (10 wt%), 10 mg of nimesulide (1.0 wt%), 100 mg of dimethyl sulfoxide (10.0 wt%), 145 mg lanolin, 440 mg of vaseline and 200 mg of water.

Example 2. Example 2 carried out as example 1, only the image quality is as compounds from the group of NSAIDs use piroxicam.

Example 3. Example 3 carried out as example 1, except that as a compound from the group of NSAIDs use meloxicam.

Example 4. 10 g of the calcium salt of chondroitin sulfate, 0.5 g of glucosamine hydrochloride and 0.1 g of diclofenac sodium was dissolved 15.4 ml of distilled water. Weighed 21 g of polyethylene oxide with a molecular weight of 4000 (PEO-4000) and 42 g of polyethylene oxide with a molecular weight of 600 (PEO-600) and melting the mixture in a water bath at a temperature not exceeding 65°C. To the molten mixture with constant stirring, a solution of glucosamine hydrochloride and salts of diclofenac in water, and then 1.0 g of dimethyl sulfoxide and 10 g of glycerin. The mixture is stirred for 3 h (200 rpm) until completely cooled, adjusted pH to 4.0 to 8.0 by the addition of triethanolamine and Packed in tubes or cans. 1 g of the end product contains 100 mg of the calcium salt of chondroitin sulfate (10 wt%), 5 mg of glucosamine hydrochloride (0.5%), 1.0 mg of diclofenac sodium (0.1 wt.%), 10 mg of dimethyl sulfoxide (1.0 wt%), 100 mg of glycerol, 420 mg PEO-600, 210 mg PEO-4000 and 154 mg of water.

Example 5. Example 5 is carried out as example 4, only as a compound from the group of NSAIDs use ibuprofen.

Example 6. Example 6 is carried out as example 4, only as a compound from the group of NSAIDs use of nimesulide.

Example 7. Example 7 is carried out as example 4, only as compounds of groups the use of NSAIDs piroxicam.

Example 8. Example 8 is carried out as example 4, only as a compound from the group of NSAIDs use meloxicam.

Example 9. Example 9 is carried out as example 4, only as a compound from the group of NSAIDs use indomethacin.

Example 10. Example 10 is carried out as example 4, only as a compound from the group of NSAIDs use Ketoprofen.

Example 11. 10.0 g of the potassium salt of chondroitin sulfate, 0.5 g of Pikalevo salt of glucosamine sulfate, 5.0 g of diclofenac potassium was dissolved in 20 ml of distilled water and poured to the resulting solution of 5.0 g of dimethyl sulfoxide (mixture 1). To 37 g of glycerin was added with stirring 4 g of sodium carboxymethyl cellulose (Na-CMC) and allowed to mix until complete dissolution of Na-CMC (mixture 2). 0.5 g starch is mixed with 10 ml of distilled water and added with stirring a mixture of 1 and 2 (mixture 3). 8 g of emulsifier No. 1 is melted in a water bath at a temperature of 60°and with stirring, add it to the pre-warmed to 60°With mixture 3. Left under stirring for 3 h, adjusted pH to 4.0 to 8.0 by the addition of triethanolamine and Packed in tubes or cans. 1 g of the end product contains 100 mg of potassium salt of chondroitin sulfate (10.0 wt%), 5.0 mg Pikalevo salt of glucosamine sulfate (0.5%), 50.0 mg of diclofenac potassium (5.0 wt.%), 50 mg of dimethyl sulfoxide (5.0 wt.%), 40 mg Na-CMC, 370 mg CH is Carina, 80 mg of the emulsifier No. 1, 5 mg of starch and 300 mg of water.

Example 12. Example 12 is carried out as example 11, only as a compound from the group of NSAIDs use Ketoprofen.

Example 13. 0.5 g of sodium salt of chondroitin sulfate, 5.0 g of the calcium salt of glucosamine sulfate, 10.0 g of ibuprofen, 20 g of dimethyl sulfoxide, 4 g of isopropyl alcohol, 17 g of ethanol, 3 g of carbopol 940 is dissolved at a temperature of 60°With 36 ml of distilled water. The solution is stirred (200 rpm) for 3 h until complete cooling, bring the pH to 4.0 to 8.0 by addition of diethanolamine and Packed in tubes or cans. In the final preparation of 1 g contains 5.0 mg of sodium salt of chondroitin sulfate (0.5%), 50.0 mg of the calcium salt of glucosamine sulfate (5.0 wt.%), 100.0 mg of ibuprofen (10.0 wt%), 200 mg of dimethyl sulfoxide (20.0 wt.%), 40 mg isopropyl alcohol, 165 mg of ethanol, 30 mg of carbopol 940 and 410 mg of water.

Example 14. Example 14 carried out as example 13, only as a compound from the group of NSAIDs use indomethacin.

The effectiveness of the tools studied in models of post-traumatic osteoarthritis, the collapse of the ears of rabbits and aseptic inflammation of the limbs of rats.

When the subchondral defects of the femoral head in rats caused by surgical injury of the articular cartilage, the proposed tool significantly reduces the size of the defect compared to troinymi animals.

When intravenous papain in rabbits there is a collapse of the ears - sagging their peripheral end. The use of the proposed tool allows you to restore turgor ears, which indicates the inhibition of the destruction of the cartilage of the ears.

Aseptic inflammation caused by injection of dextran under the aponeurosis of the hind paws of rats. Anti-inflammatory effect of the proposed tools is manifested in the inhibition of the development of aseptic swelling of the limbs of rats.

The harmlessness of the proposed tool was evaluated by its impact on the conjunctiva of the eyes and skin of rabbits. Studies have shown no irritant effect means on the conjunctiva of the eye and intact skin.

The toxicity of the tools investigated in the chronic experience (2 months) in 12 pigs by cutaneous applications. It is established that it is not toxic and does not cause violations of the histology of the epidermis, dermis and subcutaneous tissue.

The proposed tool has been tested in a clinical setting in 11 patients with osteoarthritis and knee. As the test tools used the ointment of the following composition (wt.%): the calcium salt of chondroitin sulfate - 10,0, hydrochloride glucosamine - 0,5, diclofenac sodium 0.1, DMSO - 1,0, ointment base - the rest (example 4 description of the of the application). The ointment was applied on the affected joint daily 3-4 times a day and creeping until completely absorbed within 3 weeks. Efficiency study was conducted double-blind method, where as the comparison drug used drug Ointment handaxe (5% chondroitin sulfate and 10% dimethyl sulfoxide in the ointment base).

The intensity of the pain syndrome according to the visual analogue scale YOUR alone decreased from 3.8 to 2.4 points when moving from 6.9 to 3.0 points, when walking on the stairs from 6.8 to 5.0 in the control group, respectively with 3.75 to 2.8; from 6.9 to 4.1 and from 7.0 to 5.6 points). A functional index Lekena decreased from 12.7 to 7.2 points (control from 12.3 to 8.9 points).

The tests have shown the effectiveness of the test drug almost 79% of patients versus 65% for ointment handaxe, and the positive effect was reduced on average by 40% due to high pharmacokinetics Monomeric saccharide.

1. For the treatment of diseases of the joints, containing a saccharide, a compound selected from the group of nonsteroidal anti-inflammatory drugs, dimethylsulfoxide and ointment base, characterized in that as the sugar it contains a mixture of salts of chondroitin sulfate and glucosamine, as well as non-steroidal anti-inflammatory agents it contains ibuprofen, or nimesulide, or piroxicam, or is meloxicam, or diclofenac salt, or indomethacin or Ketoprofen at the following content, wt.%:

Chondroitin sulphate salt0.5 to 10.0
Glucosamine salt0.5 to 10.0
Ibuprofen0,1-10,0
or Nimesulide0,1-1,0
or Piroxicam0,1 -1,0
or Meloxicam0,1-1,0
or Diclofenac salt0,1-5,0
or Indometacin0,1-10,0
or Ketoprofen0,1-5,0
The sulfoxide1,0-20,0
Ointment baseRest

2. The tool according to claim 1, characterized in that as the salt of chondroitin sulfate use its sodium, potassium or calcium salt, glucosamine salt use glucosamine hydrochloride, sodium, potassium or calcium salt of glucosamine sulfate, as well as salts of diclofenac its potassium or sodium salt.



 

Same patents:

FIELD: medicine, arthrology, pharmacy.

SUBSTANCE: agent comprises glucosamine salt as saccharide, dimethylsulfoxide, ointment base and ibuprofen or nimesulide, or piroxicam, or meloxicam, or diclofenac salt, or indometacin, or ketoprofen as a nonsteroid anti-inflammatory agent. Glucosamine hydrochloride, glucosamine sulfate sodium, potassium or calcium salt is used as glucosamine, and diclofenac potassium or sodium salt is used as diclofenac salt. New ointment shows high perfusion rate of active substances to the articulation zone and enhanced effectiveness. Invention expands assortment of agents used in treatment of articulations.

EFFECT: improved, enhanced and valuable medicinal properties of agent.

2 cl, 14 ex

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EFFECT: valuable medicinal properties of derivatives.

4 cl, 1 tbl, 4 ex

Substituted indoles // 2255087

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention relates to new substituted indoles of the formula (I): and/or stereoisometic form of compound of the formula (I) and/or physiologically acceptable salt of compound of the formula (I) wherein R3 means residue of the formula (II): wherein D means -C(O)-; R7 means hydrogen atom (H) or -(C1-C4)-alkyl; R8 means (a) typical residue of amino acid among the group: phenylalanine or homophenylalanine wherein phenyl residue is unsubstituted or substituted with halogen atom; or (b) -(C1-C4)-alkyl wherein alkyl is a linear or branched and (b) 1) mono- or multi-substituted independently of one another with pyrrole residue wherein this residue is unsubstituted or substituted with halogen atom; (b) 2) mono- or bi-substituted independently with residue -S(O)x-R10 wherein x = 0, 1 or 2, or (b) 3) mono- or bi-substituted independently of one another -N(R10)2 wherein R10 means (a) hydrogen atom (H); (b) means -(C1-C6)-alkyl wherein alkyl is unsubstituted or substituted with halogen atom from 1 to 3 times; (c) phenyl wherein phenyl is substituted or substituted with halogen atom from 1 to 3 times; in the case (R10)2 residues R10 have values independently of one another (a), (b), (c); Z means (a) residue of heterocycles group comprising benzothiadizine, pyrrole, pyridine, pyrimidine, pyrazine, imidazole, pyrazole, oxazole, isoxazole, thiazole, isothiazole, tetrazole, oxadiazolone, triazole being heterocycles are unsubstituted or substituted with -NH2=, =O, alkoxycarbonyl or aminocarbonyl from 1 to 3 times, or (b) means -C(O)-R11 wherein R11 means 1. -O-R10 or 2. -N(R10)2; R9 means (a) hydrogen atom (H); (b) means (C1-C6)-alkyl wherein alkyl is unbranched or branched and substituted with phenyl or =O independently of one another from 1 to 3 times; (c) phenyl wherein phenyl is unsubstituted or substituted with halogen atom; R1, R2 and R4 mean hydrogen atom (H); R5 means hydrogen atom (H); R6 means (a) phenyl wherein phenyl is unsubstituted or substituted with -NH2; (b) pyridine, or (c) pyrimidine being pyridine or pyrimidine is unsubstituted or substituted with groups -NH2, -NH-CH3. Compounds of the formula (I) are specific inhibitors of IkB kinase.

EFFECT: valuable biochemical properties of compounds.

3 cl, 3 tbl, 29 ex

FIELD: medicine, pharmacy.

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EFFECT: improved and valuable properties of formulation.

8 cl, 16 tbl, 39 ex

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of adamantane of the general formula:

wherein m = 1 or 2; each R1 represents independently hydrogen atom; A represents C(O)NH or NHC(O); Ar represents the group:

or

wherein X represents a bond, oxygen atom or group CO, (CH2)1-6, CH=, O(CH2)1-6, O(CH2)2-6O, O(CH2)2-3O(CH2)1-3, CR'(OH), NR5, (CH2)1-6NR5, CONR5, S(O)n, S(O)nCH2, CH2S(O)n wherein n = 0, 1 or 2; R' represents hydrogen atom; one of R2 and R3 represents halogen atom, nitro-group, (C1-C6)-alkyl; and another is taken among R2 and R3 and represents hydrogen or halogen atom; either R4 represents 3-9-membered saturated or unsaturated aliphatic heterocyclic ring system comprising one or two nitrogen atoms and oxygen atom optionally being heterocyclic ring system is substituted optionally with one or more substitutes taken independently among hydroxyl atoms, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, -NR6R7, -(CH2)rNR6R7; or R4 represents 3-8-membered saturated carbocyclic ring system substituted with one or more substitutes taken independently among -NR6R7, -(CH2)NR6R7 wherein r = 1; R5 represents hydrogen atom; R6 and R7 each represents independently hydrogen atom or (C1-C6)-alkyl, or (C2-C6)-hydroxyalkyl group eliciting antagonistic effect with respect to R2X7-receptors. Also, invention describes a method for their preparing, pharmaceutical composition comprising thereof, a method for preparing the pharmaceutical composition and their applying in therapy for treatment of rheumatic arthritis and obstructive diseases of respiratory ways.

EFFECT: improved method for preparing and treatment, valuable medicinal properties of compounds.

13 cl, 88 ex

FIELD: medicine.

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EFFECT: accelerated treatment course.

FIELD: organic chemistry and pharmaceutical compositions.

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EFFECT: new effective kinase p38 inhibitors.

23 cl, 6 dwg, 1 tbl, 1 ex

FIELD: medicine.

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EFFECT: higher efficiency of application.

11 cl, 2 ex

FIELD: organic chemistry, steroids, medicine, pharmacy.

SUBSTANCE: invention relates to 3-methylene-steroid derivative of the general formula (1):

wherein R1 means hydrogen atom (H), or in common with R3 it forms β-epoxide; or R1 is absent in the presence of 5-10-double bond; R2 means (C1-C5)-alkyl; R3 means βH, βCH3 or in common with R1 it forms β-epoxide; either R3 is absent in the presence of 5-10-double bond; R4 means hydrogen atom, lower alkyl; Y represents [H, H], [OH, H], [OH, (C2-C5)-alkenyl], [OH, (C2-C5)-alkynyl] or (C1-C6)-alkylidene, or =NOR5 wherein R5 means hydrogen atom (H), lower alkyl; dotted lines represent optional double bond. Compound can relate also to its prodrug used for treatment of arthritis and/or autoimmune diseases.

EFFECT: valuable medicinal properties of compounds, improved method for treatment.

38 cl, 1 tbl, 18 ex

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new aminobenzophenones of the formula (I):

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EFFECT: valuable medicinal properties of compounds and composition.

9 cl, 2 sch, 2 tbl, 29 ex

FIELD: medicine, cosmetology.

SUBSTANCE: the suggested wound-healing remedy includes a gel-forming agent, an active substance and distilled (deionized) water. As the active substance it contains Mexidol (2-ethyl 6-methyl 3-oxypyrridine succinate) at the following ratio of components, weight%: gel-forming agent 0.5-5.0, stabilizing agent 0.01-0.8, conservant 0.01-1.0, Mexidol 0.01-10.0, distilled (deionized) water - the rest. The suggested remedy is highly efficient. It is of pronounced wound-healing action in 1, 2 and 3 phases of wound process. It quickly liquidates inflammatory processes, decreases painfulness, edema, considerably improves the state of affected tissues, accelerates reparative-degenerative processes and terms of epithelization. It possesses the wide spectrum of action, manifests pronounced action at treating different skin and mucosal lesions - wounds, fissures, bedsores, trophic ulcers of different genesis, surface burns of 1-3 degree, radiation lesions, it, also, removes skin microlesions that possess the nature of cosmetic defects, moreover, it improves skin structure.

EFFECT: higher efficiency of application.

2 ex

FIELD: medicine, arthrology, pharmacy.

SUBSTANCE: agent comprises glucosamine salt as saccharide, dimethylsulfoxide, ointment base and ibuprofen or nimesulide, or piroxicam, or meloxicam, or diclofenac salt, or indometacin, or ketoprofen as a nonsteroid anti-inflammatory agent. Glucosamine hydrochloride, glucosamine sulfate sodium, potassium or calcium salt is used as glucosamine, and diclofenac potassium or sodium salt is used as diclofenac salt. New ointment shows high perfusion rate of active substances to the articulation zone and enhanced effectiveness. Invention expands assortment of agents used in treatment of articulations.

EFFECT: improved, enhanced and valuable medicinal properties of agent.

2 cl, 14 ex

FIELD: cosmetic industry, cosmetics.

SUBSTANCE: invention relates to a method for preparing a base for cosmetic agents used in skin care. Method for preparing biologically active base for cosmetic agents comprises fermentation of cultures of strains lactobacilli and bifidobacteria in hydrolyzate-milk medium containing lactulose. The ferment of lactobacilli and bifidobacteria in the amount 3-5% of nutrient medium volume is plated and fermented for 6-8 x up to formation of suspension with acidity value = 70°-100° and with titer value 1010 CFU followed by its heating at temperature 80-85°C for 10-15 min and cooling. The content of lactulose in medium is 1.5-2 wt.-%. The base prepared by proposed method provides reducing loss of biologically active substances to minimal value and allows conferring to the base high nutrient activity and producing regenerating, softening, bactericidal and anti-inflammatory effects on skin.

EFFECT: improved preparing method, improved and valuable medicinal and cosmetic properties of base.

2 cl, 1 tbl, 4 ex

FIELD: medicine, dermatology, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an antifungal gel pharmaceutical composition based on ketoconazole and clotrimazole that are derivatives of imidazole. The composition comprises ketoconazole or clotrimazole as an active component, polyethylene glycol-400 (PEG-400) as a solvent, carboxyvinyl polymer as a gel-forming agent, polyethylene glycol as a gel stabilizing agent, organic amine or inorganic bas as a regulator of pH and water taken in the definite ratio of components. The composition is prepared by dissolving active component in PEG-400, dispersing carboxyvinyl polymer in water, successive addition to dispersion propylene glycol as a stabilizing agent and regulator of pH and combination of prepared solution and gel followed by stirring the mixture up to preparing the gel composition with pH 5-7. Invention provides preparing antifungal composition with reduced adverse effect.

EFFECT: improved preparing method, valuable medicinal properties of composition.

2 cl, 1 tbl, 11 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to curative ointments with anti-inflammatory effect and with biostimulating properties for treatment of burns, suppurative and infected wounds of different etiology and to a method for treatment above said diseases using the ointment said. The proposed ointment comprising bee wax and greasy basis comprises colophony additionally. As greasy basis the ointment comprises butter and vegetable oil in the following ratio of components, wt.-%: bee wax, 20-30; butter, 30-40; vegetable oil, 15-25; colophony, 15-25. Method involves applying ointment by thin layer 0.5-3 mm on dense cotton fabric, its applying to damaged site, keeping and removing ointment with change of bandage 1-3 times per 24 h for 3-14 days. Method provides enhancing the therapeutic effectiveness of ointment due to significant acceleration the healing process of suppurative wounds and insidious furuncles being the ointment doesn't cause irritating effect.

EFFECT: improved and valuable medicinal properties of ointment.

2 cl, 4 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to medicinal preparations used for treatment of suppurative wounds. Invention involves applying boric acid (powder) and multi-component ointments on water-soluble base (Laevomecolum or Laevosinum) taken in the ratio 1:10 and used for treatment of suppurative wounds. Invention provides the development of agent exhibiting the expressed antibacterial, dehydrating and necrolytic effect.

EFFECT: valuable medicinal properties of agent.

2 ex

FIELD: medicine, in particular homoeopathic ointment for treatment of hemorrhoids, dermatitis and rhinitis.

SUBSTANCE: claimed ointment includes Calendula D 1, Hamamelis D 1, Aesculus D 1, and menthol as active ingredients and zinc oxide and vaseline as ointment base in specific ratio. Ointment of present invention makes it possible to improve microcirculation and cell respiration in tissues, to reduce venous engorgement, to increase immunity, to stimulate regeneration processes.

EFFECT: ointment for treatment of hemorrhoids, dermatitis and rhinitis of improved effect.

1 tbl

FIELD: medicine.

SUBSTANCE: the present innovation deals with preparing ointments to be applied at treating both surface and deeply penetrating cutaneous burns and other skin diseases, as well. Composition of the suggested ointment includes, weight%: 45…67% food sunflower oil, 15…37% food olive oil, 1…2% Calendulae officinalis extract, 0.8…1.8% labdanum, 2.5…8% colophony, 6.5…11.5% white bee wax, 0.7…1.8% the main bismuth gallate and 0.7…1.8% camphor. The suggested ointment is highly efficient for rapid and successful treatment of burns III and IV degree. It should be also applied for treating shin's ulcer and, also, in gynecology - for treating inflammation of uterine cervix.

EFFECT: higher efficiency of therapy.

4 ex

FIELD: pharmaceutics.

SUBSTANCE: the present innovation deals with cryoprotective ointment containing recombinant interferon-α2. The suggested cryoprotective ointment contains recombinant interferon-α2, glycerol, polyethylene glycol 300-6000, polyglucin, buffered 0.02%-Trilon B solution at pH of 5.5-7.0 and ointment foundation at a certain content of components per 1.0 g ointment. Additionally, cryoprotective ointment could contain glycine 3,7-bis(dimethylamino)phenothiazonium chloride, dry immunoglobulin preparation or dry immunoglobulin preparation for enteral application. Ointment foundation of cryoprotective ointment could contain water-free lanolin, Vaseline and Vaseline oil, at the following ratio of components: 2.5;3.5:1 - 6.5:0.5:1. The innovation provides maximal safety of recombinant interferon-α2 activity in cryoprotective ointment at multiple alteration of positive and negative environmental temperature and at keeping cryoprotective ointment under these conditions.

EFFECT: higher efficiency of application.

8 cl, 8 ex

FIELD: pharmaceutics.

SUBSTANCE: the suggested composition has got viscosity being below of about 15000 cP and pH being approximately 3.0-9.0 for treating human skin diseases. He suggested composition consists of (a) therapeutically efficient quantity of, at least, one compound being useful in treating the above-mentioned disease; (b) pharmaceutically acceptable, partially bound polymer of polyacrylic acid being compatible with the compound; (c) not obligatory, a solvent being mixed with water, (d) not obligatory, a conserving agent, (e) not obligatory, a component of butyric phase and acceptable surface-active substance, and (f) water. The suggested composition is useful to treat inflammatory skin disease, acne or acne erythematosa. The composition of low viscosity has got its advantage in the fact that it is applied more accurately when in contact with a container that doses the composition in the form of drops.

EFFECT: higher efficiency of application.

23 cl, 15 ex, 19 tbl

FIELD: medicine.

SUBSTANCE: composition has sulfated glycosaminoglycanes in physiologic saline of sodium salts. Sodium salt of keratan sulfate and sodium salt of chondroitin sulfate are taken as the sulfated glycosaminoglycanes in known ingredients proportion.

EFFECT: enhanced effectiveness of treatment; reduced glycosaminoglycanes consumption.

5 cl

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