Method for estimating osteogenesis intensity

FIELD: medicine.

SUBSTANCE: method involves applying computer-aided processing of general plan survey X-ray films with one or several zones of interest being detected on digitalized image corresponding to the number of osteogenesis foci. Quantitative osteogenesis intensity estimate is obtained by applying test grid and interpreting ratio of areas corresponding to distraction regenerate mineralization degree. Boundaries are determined in each zone of interest for delimiting intensity ranges characterizing tissue mineralization degrees at osteogenesis stages and reference points are marked. The first reference point is selected on proximal bone fragment end turned to diastasis. Lower boundary line of the proximal test grid, composed of parallel lines being perpendicular to long bone axis, is superposed with the first reference point. The second one is selected on distal bone fragment end turned to diastasis and the upper line of the distal test grid is superposed with it. Every region belonging to a zone of interest confined by neighboring test grid lines is segmented within the scope of established boundaries into intensity ranges and intensity range area shares in the total area of each region belonging to zone of interest. The intensity range area share proportions are used for estimating osteogenesis intensity.

EFFECT: wide range of functional applications.

11 dwg

 

The invention relates to medicine, namely to traumatology and orthopedics, and can be used to assess the status or current bone formation in patients and experimental research works.

Known "Method of distraction osteosynthesis", involving the assessment of the intensity of bone formation by roentgenometry connective tissue layer formed bone regeneration (RF Patent No. 2102022 published 20.01.98, Bulletin No. 2).

However, this method is applicable for a particular case - distraction osteogenesis and does not allow to assess bone formation in regenerating or growing in the osteogenesis of bone.

The known method stereological assessment of distraction osteogenesis, in which carry out computer processing review of radiographs, there is a digitized image of one or more zones of interest, according to the number of foci of bone formation, and using a test grid, get a quantitative assessment of the intensity of bone formation by the ratio of areas, reflecting the degree of mineralization of the distraction regenerate (RF Patent No. 2165243 published 20.04.2001, bull. No. 11).

However, obtained with the help of this method the results are not reflective of the intensity of the regeneration process to the local tissue.

The task of the invention is to increase the information content and the expansion of the scope of method study bone formation.

This task is solved in that in the method of estimating the intensity of bone formation by computer processing review of radiographs, the selection on the digitized image of the one or more zones of interest, according to the number of foci of bone formation, and using a test grid, obtaining a quantitative assessment of the intensity of bone formation by the ratio of the areas. reflecting the degree of mineralization of the distraction regenerate, for each zone of interest define the boundaries of the ranges of intensities, reflecting the degree of mineralization of the tissue on the stages of bone formation, and identifying a reference point, the first point is chosen on facing the diastasis end of the proximal bone fragment and combined with her extreme line proximal the test grating consisting of parallel lines perpendicular to the long axis of the bone, and the second anchor point is chosen on facing the diastasis end of the distal bone fragment and combined with her extreme upper distal line of the test grating, each area of interest, limited adjacent lines of the test gratings, segments according to the established boundaries the ranges of intensity and Radelet share space ranges of intensities in the total area of each area of interest, the ratios of the areas of the ranges of intensities assess the intensity of bone formation.

The invention is illustrated by the description, an example of practical use and illustrative material, which shows:

figure 1 - initial radiograph of the bone;

Figure 2 radiograph of the bone with contoured area of interest;

figure 3 radiograph of defined reference points;

figure 4 - integerrima with the test grid on the proximal fragment;

5 is a radiograph of the test gratings on both fragments;

6 is a radiograph with the combined test gratings;

Fig.7 - radiograph with the area of interest, separated by lines of the test grating on the land;

Fig - table space distribution of test levels of the distraction regenerate by band intensity (mineralization);

figure 9 is a graphical representation of the ratio of the area of the ranges of intensities, reflecting the degree of mineralization of the distraction regenerate and bone fragments on the 14th day of distraction;

Figure 10 - graph of ratio of area proportions-ranges of intensities. reflecting the degree of mineralization in the selected area of interest on the 14th day of distraction:

11 is a chart of the ratio of area proportions ranges intensive gene. reflecting the degree of mineralization of distrac the ion regenerate on the 14th day of distraction.

The method is as follows.

On the digitized images, review x-rays emit one or more zones of interest according to the number of foci of bone formation.

In each zone of interest outline control points, which serve as a guide for applying the test grating consisting of parallel lines perpendicular to the long axis of the bone. Thus take into account that the fragments of bone at different stages to converge (when compression in the treatment of a fracture) or away from each other (when the distraction osteosynthesis). Therefore, the first anchor point is chosen on facing the diastasis end of the proximal bone fragment and combine extreme bottom line proximal the test grating.

Then choose the second anchor point on facing the diastasis end of the distal bone fragment and combined with her extreme upper distal line of the test grating.

After that, both of the test grating gradually completed equals the number of steps from the reference points in the direction of diastasis towards each other as long as the distance between the extreme lines of the gratings will not be less than twice the step (understanding under step the distance between the lines of the test grating). This method of combining test gratings with the image area of interest allows standardized, is operatiu test levels. For the zero line of the test grating accept those that are aligned with the anchor points at the proximal and distal bone fragments. This gives you the opportunity to select for the analysis of comparable areas in reseating radiographs, even in cases when the height of the diastasis between the bone fragments is changed.

After this, taking into account the intensity of a particular x-ray image sets the boundaries of the ranges of the intensity of the investigated area of interest, while highlighting areas of medium (shadow bone medullary canal) and high (shadow cortical plates) degree of rentgencontrastnoe, as well as the portions that correspond to the intensity of the image of the shadow of soft tissue. The degree of intensity of the image of each of the following sections and their corresponding boundary values are expressed in arbitrary units of intensity, which when using appropriate software (for example, a set of specialized programs for hardware-software complex "Dimorph", Moscow, Russia)are set automatically.

Using these boundary values of the intensity image, each test level (area of interest, limited adjacent lines of the test grating segments on the ranges of intensity. Receiving the hydrated digital material process and bring in the table, on the basis of which determine the proportion of the squares of the ranges of intensities in the area of each of the investigated area and hearth bone formation in the whole.

To simplify the analysis of digital material and clarity of the process of bone formation, on the basis of data tables can be constructed graphs that characterize the area of interest and each of its sections.

Practical implementation of the method is illustrated by the following example.

Dog No. 1191, age at the time of surgery 2 years, were lengthening of the right tibia. Examined the radiographs of the operated limb on the 14 days of distraction.

The x-ray image entered in the computer memory using a camera or scanner. Made of geometrical and optical calibration image. In interactive mode, the highlighted area of interest distraction regenerate and adjacent the ends of fragments of the tibia).

The histogram of the intensities in the image area of interest was defined border ranges, reflecting the degree of mineralization of the tissue on the stages of bone formation. On the same image set of reference points on the ends of the proximal and distal fragments belieberboy bones. On each of the bone fragments imposed on the test grating of parallel lines perpendicular to the long axis of the bone, so that the x extreme facing the diastasis, lines are aligned with the corresponding anchor points.

After that, both of the test grating was gradually added to equal the number of lines in the direction of diastasis towards each other as long as the distance between their extreme lines was not less than double step. Combined with the reference line points of the test grating was defined as zero and correspondingly numbered test levels (the zone of interest, limited adjacent lines of the test grating.

Then each level has planimetrically and segmented by intensity, using previously established boundary values of the ranges. The digital material is made in the table on the basis of which identified the percentage of the areas of ranges in the total area of each test level and areas of interest in General. The results of the calculations are shown in graph 1.

The study of a digitized image of this landmark x-rays allowed us to obtain a quantitative assessment of lesion of bone formation. The analysis of the received digital data has shown that in this case was active osteogenesis, as evidenced by the ratios of the areas of the ranges of intensities, reflecting the degree of mineralization of the distraction regenerate. Share remineralizing component in Piazza di is stasis (the distraction regenerate) was 24%, brackish - 34%, moderately mineralized - 42%, saline - 0%. The total area of the zone of interest, comprising in addition to regenerate and prioralye areas of bone fragments, the share remineralizing component - 9%, brackish -15%, moderately mineralized - 65%, saline - 11%.

Using the proposed method provides a more informative and objectivity of research results hearth bone formation.

The method of estimating the intensity of bone formation by computer processing review of radiographs, the selection on the digitized image of the one or more zones of interest, according to the number of foci of bone formation, and using a test grid, obtaining a quantitative assessment of the intensity of bone formation by the ratio of areas, reflecting the degree of mineralization of the distraction regenerate, characterized in that for each zone of interest define the boundaries of the ranges of intensities, reflecting the degree of mineralization of the tissue on the stages of bone formation and outline control points, with the first anchor point is chosen on facing the diastasis end of the proximal bone fragment and combined with her extreme bottom line proximal the test grating consisting of parallel lines perpendicular to lengths of the second axis of the bone, and the second anchor point is chosen on facing the diastasis end of the distal bone fragment and combined with her extreme upper distal line of the test grating, each area of interest, limited adjacent lines of the test gratings, segments according to the established bounds on the ranges of intensity and determine the proportion of the squares of the ranges of intensities in the total area of each area of interest, the ratio of area proportions ranges of intensities assess the intensity of bone formation.



 

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