Method of monitoring functional condition of human

FIELD: medicine; functional medicine.

SUBSTANCE: method in based upon remote irradiation of human body with set of super wide-band electromagnet pulses with duration of 0,2-1,0 ns, repetition rate of 0,05-30,0 MHZ and average density of flow of energy at irradiated part of human body being equal or less than 0,2 mcW/cm2. Modulation component of pulse repetition rate is selected from received reflected signal which pulse repetition rate is determined by heart activity, which is used for forming heart beat rate signal. The latter is used additionally for estimating index of stress which value of index of stress is included into transmitted communication message of mobile phone.

EFFECT: prolonged monitoring of functional condition of human.

3 cl, 2 dwg

 

The invention relates to monitoring the functional state of the person by means of mobile telephony, in particular using mobile phones with extra features.

To assess the functional state of human organism in practice, the use stress level. Under stress the body experiences stress voltage. In everyday life in an urbanized society, people are constantly faced with a continuous stream of stressor effects. In our hyperactive, hyperkinetic world stress leads to numerous reactions types of headaches, muscle tension, dizziness, or insomnia, weight gain, chronic cough, excitement, upset stomach, and shortness of breath. Stress, Selye, is the stress state of the body, any human condition is not stress-free, i.e. it is a "nonspecific (physiological) response of the body against him on any demand" (Selye, Stress without distress. - M.: Progress, 1979). Stress can be caused by major events in our lives: the death of a loved one, divorce, natural disaster, illness or job loss. Stress can be defined daily hectic lifestyle. If chronic stress is not to cope, wasn the cabins serious problems: nervous and somatic diseases. Stress affects physical, emotional and mental state of the individual.

Known methods of objective control of the functional state of a person using a mobile phone with enhanced functionality.

Thus, the method of monitoring the functional state of man, implemented in a mobile phone with GPS receiver and cardiobacterium (US patent No. 6546232, class. And 61 In 5/04, 1998), is that carry out reception and transmission of communication messages, register electrocardiogram and include its parameters in the transmitted communication messages mobile phone. The functional state of the person is judged according to the results of processing electrocardiograma. The mobile phone contains a transmitter, receiver, memory for the target number, four electrodes and two keys on the phone. One of the key activates number emergency telephone number stored in memory. Four electrodes allow the reception of signals from the electrocardiogram (ECG). There is also a device for converting signals, which digitizes the ECG signals and converts them to a form suitable for transmission and feeds them to the transmitter. With this phone, the patient may check your heart rate and send the data to the doctor. For this phone you prig the TB to the chest for 40 seconds and four the sensor will measure the parameters of the heart of man. And then the phone will automatically send the recorded information to the service center where the doctor on duty at any time of the day can analyze it and, if necessary, to call a man an ambulance. If danger to life there, the phone owner can at any time to get the results of the mobile monitoring of the heart.

The main disadvantage of the method implemented in the above-described mobile phone, is the inability to monitor (long-term) monitoring the state of a person is quite difficult to keep for a long time, the phone still in hand. In addition, while monitoring the functional state of the individual is necessary to break away from the main activity.

The known method of monitoring the functional state of man, implemented in a mobile phone (EN 2204887 C1 IPC H 04 M 1/02, 2002), including the reception and transmission of communication messages, the registration of the indicators of the human condition: body temperature, pulse and blood pressure, and the inclusion of these parameters in the transmitted communication messages mobile phone.

The mobile phone according to this patent contains a transceiver block, the block audible indication of a call, a memory unit, a microphone, a telephone, a display, a keyboard, a block selection modes, interface units and a power source that connection is obtained to the controller, two pressure sensor, two temperature sensors and sensor humidity, the first temperature sensor, the first pressure sensor and sensor humidity is installed directly on the surface of the housing of the mobile phone, and the second temperature sensor and the second pressure sensor is installed in a recess in the housing of the mobile phone with touch of finger subscriber, all of the sensors through the respective interface units connected to the controller.

The main disadvantage of this method of monitoring on the basis of this mobile phone is the impossibility of long-term monitoring of control over the human condition. It is almost impossible to sit still for hours for continuous measurement of blood pressure or temperature. Because at the time of removal of the blood pressure in order to reduce artifacts person should be fixed, it is impossible to work actively with the phone keypad and to receive calls for future dialogue. For these reasons, violated the basic function of the phone communication.

Closest to the present invention to the technical essence and the achieved result when used and adopted for the prototype is a method of monitoring the functional state of man, implemented in a mobile phone, see the website "http://news.bbc.co.uk/l/hi/technology/2562265.stm". Saturday, 14 December, 2002, 06:25 GMT, "Mobile phone tracks heartbeats. Appendix 1), developed by researchers at the laboratories of Lucent Technologies' Bell. and that remotely irradiated part of the body of a man, takes the reflected signals, modulated by the moving tissues of the body caused by congestive heart activity, allocate the signals of cardiac rhythm, which include in the transmitted communication message mobile phone. This phone connects an additional device that combines the sensor and the antenna and allows to capture respiratory and cardiac activity. To do this, place the phone with an additional device in front of himself. The electromagnetic waves emitted by the antenna of a mobile phone carried by a person, may be reflected from the lungs and heart of a person and again to be caught antenna optional devices. As these bodies are in motion, the frequency of the reflected wave will be slightly altered due to Doppler shift. Heart expanding the frequency increases, it narrows the frequency decreases. The change is of the order of 1 Hertz per billion ("http://www.mcom.ru/news.phtml?id_news=2561″ 12/02/2001, Annex 2). From the received signal are allocated rhythm - and pneumogram. This technology is specific to the location of the continuous signal.

Insufficient the ohms of the prototype method also as analogues, is that it has limited functionality as it is not possible long-term monitoring of human functional state. High power radiation of a mobile phone (for example, Motorola C333 develops output power signal to 1.63 W) during long hours of monitoring environmentally unsafe for humans.

The objective of the invention is the provision of long-term monitoring of the functional state of a person using a mobile phone, they will not interfere with its primary function is communication.

The technical result of the invention is expressed in the creation of the way to ensure long-term environmentally safe monitoring of human functional state by signals of the cardiac rhythm and stress index.

Tasked with achieving the above-mentioned technical result is solved in that in the method of monitoring the functional state of man, namely, that remotely irradiated part of the body of a man, takes the reflected signals, modulated by the moving tissues of the body caused by congestive heart activity, allocate the signals of cardiac rhythm, which include in the transmitted communication message to the mobile phone, the irradiation area of the human body hold sequence sverhdorogom lesnych electromagnetic pulses, from a received reflected signal to produce a modulation component of the pulse repetition rate due to cardiac activity, in which form the signal heart rhythm, heart rhythm signals additionally evaluate the stress index of the person and include its value in the transmitted communication message mobile phone.

The problem is solved also by the fact that irradiation is carried out by a sequence of ultra-wideband electromagnetic pulses of 0.2-1.0 NS, a repetition rate of 0.05-30.0 MHz and the average energy flux density on the irradiated part of the body of man is not more than 0.2 w/cm2.

Irradiation is carried out using ultra-wideband (UWB) radar located outside or inside the mobile phone.

The signals of the cardiac rhythm is the dynamic range of the R-interval, according to the results of spectral analysis which assess the stress index S person of ratio

where LF and HF, respectively, of low-frequency (0.04 to 0.15 Hz) and high frequency (0.15 to 0.4 Hz) components of the spectrum dynamic range of the R-interval;

LFs and HFs, respectively normal values for low and high frequency components of the spectrum dynamic range of the R-interval.

For normal values specification of the spectral power in low frequency (LFs) and high frequency (HFs) regions of the spectrum dynamic range of the R-interval accept the values of the spectral power in low frequency (LF) and high frequency (HF) fields, measured on a large population of people in the standard recording conditions (rest, lying on the back) and averaged over the entire population.

In particular, for normal values of spectral power in low frequency (LFs) and high frequency (HFs) regions of the spectrum dynamic range of the R-interval variation taking values LFs=1170 [MS*MS], HFs=975 [MS*MS].

The novelty of the present invention is the monitoring of the functional status of a person on the stress index, which is assessed according to the signals of heart rhythm derived using UWB radar located outside or inside a mobile phone.

The invention is illustrated in the drawings, which depict:

figure 1 presents the structural electrical diagram of the device for implementing the method of monitoring the functional state of the person;

figure 2 presents the structural electrical circuit versions of UWB radar.

The use of the communication channel between the mobile phone and UWB radar allows the latter to put in the breast pocket, and mobile phone positioning within the room, if monitoring takes place indoors or in a bag, etc. you Can come up with many different options for comfort and covert monitoring. In the particular case of UWB radar can be mounted in the housing of the mobile phone. In practice the automatic selection of the structural design of a mobile phone depends on the specific application. Implementation of the proposed method does not change. The difference will be that in one case, for monitoring the functional state of the person is put UWB radar outside of the mobile phone and connected with it by channel, opposite the site of the body, is exposed to movements in space due to cardiac activity, the other in front of this place put the mobile phone.

Using UWB radar remotely irradiated part of the body of man sequence ultra-wideband electromagnetic pulses, receive the reflected signals, modulated by the moving tissues of the body caused by congestive heart activity, allocate the modulation component of the frequency pulses, which form the signal heart rhythm, heart rhythm signals additionally evaluate the stress index of the person and include the signal of the heart rate and the value of the stress index in the transmitted communication message mobile phone.

The irradiation area of the body carried out the sequence ultra-wideband electromagnetic pulses of 0.2-1.0 NS, a repetition rate of 0.05-30.0 MHz and the average energy flux density on the irradiated part of the body of man is not more than 0.2 w/cm2.

The signals of the cardiac rhythm is enomichesky a number of cardiac intervals and calculated values of heart rate (HR).

Perform spectral analysis of the dynamic range of the R-interval FFT-based and measure the spectral power of the signal separately in the low-frequency (LF) and high frequency (HF) spectral regions (Attributed R., L. Enochson Applied time series analysis, basic methods. - M.: Mir, 1982, p.52-56). Preliminary measurements for the spectral power in low frequency (LF) and high frequency (HF) conducted on a large population of people in the standard recording conditions (rest, lying on the back), by the above algorithm. The obtained experimental data are averages for the entire population and take over the normal values of the spectral power in low frequency (LFs) and high frequency (HFs). Then carry out current measurements and calculate the stress index S from the relation (1).

The manifestation of stress is associated with activation of the nervous system - stress activity and its decontamination - stress passivity. In standard conditions, the stress is not expressed. Further decrease or increase the level of activation of the nervous system should be accompanied by an increase in stress. Therefore, in standard conditions, the stress index should be equal to unity, while in the other condition, other than standard, the stress index should increase or decrease. This is ensured by the cofactors andwhile factorbinds to the norm of the total capacity, and the cofactornormalizes the value of the stress index to obtain its value at standard conditions, is equal to 1.

Under standard conditions for the average person, the stress index is equal to 1 For a person with a high level of functioning of the cardiovascular system, under standard conditions, the stress index is reduced to 0.1. When the 8-hour intelligent load, the stress index may increase from initial level 1.0-5.0-10.0.

In the particular case as averaged data, you can use the experimental data shown in (Heart Rate Variability Standards of measurement, physiological interpretation, and clinical use.// European Heart Journal. - 1996. - V. 17. - p.354-381), where LFs=1170 [MS*MS], HFs=915 [MS*MS], respectively low and high frequency components of the spectrum dynamic range of the R-interval, obtained in the standard recording conditions (rest, lying on the back) for a large population of people regardless of gender, age and other factors and accept the norm. Thus the expression (1) for an index of stress takes the form

The measured value of the stress index S together with the signals of the cardiac rhythm (including the value is of the heart rate) include in the transmitted communication message mobile phone.

Method for monitoring the functional state of the person can be carried out with the help of the device (see figure 1)containing the associated two-way communication mobile phone 1, channel 4, unit 3 assessment of the stress index and UWB radar 2.

The mobile phone 1 includes a transceiver unit 1.2 connected with the antenna 1.3, microphone 1.4, phone 1.5, 1.6 block an audible indication of a call, the display 1.7, block 1.8 memory, keyboard, 1.9, block 1.10 selection of modes of operation, block 1.11 interface and the power source is 1.12, which is connected to the controller 1.1, the second input/output unit 1.11 interface is a local input/output of the mobile phone.

UWB radar 2 (see figure 2) contains the generator 2.1, the output of which is connected to the input of the transmitting antenna 2.3 through the first driver 2.2 a short pulse and the first input of the time discriminator 2.9 through serially connected across the delay line 2.4 and the second shaper 2.5 short pulse. The output of the receiving antenna 2.10 connected to the input of the microcontroller 2.6 connected in series through a time discriminator 2.9, integrated amplifier 2.8, analog-to-digital Converter 2.7. The first and second outputs of the microcontroller 2.6 respectively connected to the input of the generator 2.1 and the second input of the delay line 2.4. The third output bus of the microcontroller 2.6 is output bus the current radar 2.

The implementation choice of the communication channel 4 does not affect the implementation of the proposed method. Implementation of the communication channel 4 in the form of a wired connection, you can simplify transceiver amplifier of the communication channel. The use of electromagnetic communication channel increases the ease of use, comfort in the implementation of the proposed method.

UWB radar 2 is designed for remote registration of parameters of cardiac activity. Contactless method of measuring parameters of cardiac activity based on the measurement of the acceleration of the movement of the human heart. The measurement is carried out radar method. The method is based on the ability of electromagnetic waves partially reflected from the interface of two media and to penetrate the environment. For transmission of electromagnetic energy selected UWB signal with a duration of 0.2-1.0 NS. This signal allows you to:

to increase the resolving power of the radar, separately to measure the movement of the chest and heart;

to reduce the minimum distance at which measurements are made;

to reduce the spectral power density of the radiated signal and the level of electromagnetic radiation acting on the pilot;

to reduce the dimensions of the radar;

to increase the protection of radar from external interference and to increase the reliability of the measurements.

Generator 2.1 with a controllable frequency is th pulse produces rectangular pulses with a frequency of 0.05-30 MHz. These pulses arrive at the first shaper 2.2 short pulse in the delay line 2.4. The pulses from the output of the first driver 2.2 short pulse received in the transmitting antenna 2.3 shock and excite her.

The radiated pulses of electromagnetic field reflected from the moving surfaces of the chest and heart of the examinee. When this occurs, the modulation of the pulse repetition frequency with a nonlinear dependence of the repetition rate of the pulses from the speed of movement of body parts.

To eliminate the interfering signals in the receiving channel formed time Windows that open receiver in the time of arrival of the signal reflected from an object at a certain distance. This task as part of UWB radar 2 performs strobing time discriminator 2.9. It consists of high-speed electronic keys. The switching time is on the order of 200-300 PS. Moments Gating is determined by the delay control signal in software-controlled delay line 2.1.4. The rest of the time the receive path is closed. Adopted in the Windows of the signals are detected and amplified in the integrated 2.8 amplifier, the output of which is allocated a signal that carries information about the movement of the chest and heart of a person.

The Gating device consists of a software-controlled delay line 2.4 and second formirovanie the 2.5 short pulse. The delay time is set by the microcontroller 2.6, is determined by the distance to the individual. The time constant of the integrating amplifier 2.8 is selected depending on the bandwidth of the useful signal. The accumulation of the pulses reduces the radiated mean power of UWB radar 2 and to increase the signal-to-noise ratio at the input of the amplifier 2.8.

Selected and amplified low frequency signal proportional to the frequency of breathing and heartbeat, enters the analog-to-digital Converter 2.7.

The microcontroller 2.6 controls the operation of UWB radar 2, monitors the status of major units, carries out the selection of moving targets and provides the output data for further processing to the input unit 3 assessment of the stress index.

To the input unit 3 assessment of the stress index is supplied in digital form the signal that carries information about the movement of the chest and heart.

Unit 3 performs digital filtering selection signal of the cardiac rhythm, the selection of extrema of the signal of the cardiac rhythm (in the processing of the electrocardiogram, a similar operation is the selection of the R-wave), the measurement of the duration of the R-interval as the time interval between the extrema of the signal of the motion of the heart (pulse interval) (in processing the electrocardiogram similar operation is a measurement of the duration of RR-intervals). On BA the f values of the R-interval form the dynamic range of the R-interval, which is spline-interpolation. Thanks spline interpolation gain values of the R-interval equal intervals of time.

The values of the samples of the R-interval equal intervals of time required for the spectral analysis of the dynamic range of the R-interval using the fast Fourier transform (FFT). On the basis of spectral analysis of the dynamic range of the R-interval measure of the spectral power of the signal separately in the low-frequency (LF) and high frequency (HF) fields.

In block 3, the evaluation of the stress index contains measurement data for the spectral power in low frequency (LF) and high frequency (HF) fields, conducted on a large population of people in the standard recording conditions (rest, lying on the back) and averaged over the entire population. Then calculate the stress index S from the relation (1).

In General, the device for implementing the method works as follows.

The mobile phone 1 is used as intended. If the individual needs to monitor its own functional status, it with keyboard 1.9 and block 1.10 selection of the operating modes via the interface unit 1.11, channel 4 and unit 3 includes the operational status of UWB radar 2. A signal with information about the parameters of cardiac activity coming from the UWB radar is processed in b is the eye 3 to receive the signal of the cardiac rhythm and stress index and converted to a form convenient for processing by controller 1.1, which display 1.7 displays information about the functional state of a person and includes the signals of heart rate and index values of stress and heart rate in the transmitted communication message mobile phone.

When placing UWB radar inside the latest cellphone is usually placed in the breast pocket in front of the heart. Although other variants of placement of the mobile phone relative to the body. All these options should be capturing the receiving and transmitting antennas of the body with movements from cardiac activity. The procedure of the proposed method remains the same regardless of the type of mobile phone.

It should be noted that the average energy flux density created by the radiation of UWB radar 2 on the irradiated part of the body is not more than 0.2 w/cm2that is significantly less sanitary standards for electromagnetic radiation. Average radiation power of UWB radar 2 is not more than 50 w. This amount of radiation is less than 3.3*104than the radiation of the mobile phone (mobile phone Motorola S develops output power signal to 1.63 W) in the transmission of communication messages.

The low value of the average flux density e is ergie, created by the radiation of UWB radar 2, allows for long-term environmentally safe monitoring of the functional state of the person.

The proposed method of monitoring the functional status of a person can be used when working on the simulator in the laboratory and clinic, as well as at home. In the field of aviation with the proposed method it is possible to carry out constant monitoring of the pilot as in real flight, and when running on the simulator, and to collect statistics of the main parameters of its functional state.

1. Method for monitoring the functional state of man, namely, that remotely irradiated part of the body of a man, takes the reflected signals, modulated by the moving tissues of the body caused by congestive heart activity, allocate the signals of cardiac rhythm, which include in the transmitted communication message mobile phone, characterized in that the irradiation area of the human body hold sequence ultra-wideband electromagnetic pulses with a duration of 0.2-1.0 NS, the repetition rate of 0.05-30,0 MHz and the average energy flux density on the irradiated part of the body of man is not more than 0.2 w/cm2from the received reflected signal to produce a modulation component of the repetition rate is mulsow, due to cardiac activity, in which form the signal heart rhythm, heart rhythm signals additionally evaluate the stress index of the person and include its value in the transmitted communication message mobile phone.

2. The method according to claim 1, characterized in that the irradiation is carried out using ultra-wideband radar, located outside or inside the mobile phone.

3. The method according to claim 1, characterized in that it signals cardiac rhythm dynamic range of the R-interval, according to the results of spectral analysis which assess the stress index S person of ratio

where LF and HF, respectively, low frequency (0.04 to 0.15 Hz) and high frequency (0.15 to 0.4 Hz) components of power spectrum dynamic range of the R-interval,

and under standard measurement conditions (rest, lying on the back) the value of the stress index S for the average operator is considered equal to 1.



 

Same patents:

FIELD: medicine; professional diseases; labor hygiene.

SUBSTANCE: method can be used in avionics, space and naval medicine for determining of professional suitability of people being subject to influence of different accelerations. Labyrinth asymmetry is calculated by means of nystagmography at bi-thermal caloric test by relation of LAF=[(Rt+Rc)-(Lt+Lc)]:[(Rt+Rc+Lt+Lc)]100%, where LAF is labyrinth asymmetry factor, Rt and Lt is intensity of nystagmic reaction (in %) at thermal stimulation of right and left ears correspondingly, Rc and Lc is intensity of nystagmic reaction at cold stimulation of right and left ears correspondingly. Otolith asymmetry is determined by means of indirect otolythometry at registration of reflex of eyeball counter-rotation (REC) when patient lies on the right side and then on the left side. Otolithic asymmetry is calculated by relation of OA=(R-L):(R+L)x100%, where OA is otolithic asymmetry factor, R and L is intensity of eyeball counter-rotation REC(in º) at inclination to the direction of right and left eras correspondingly. Pupillary reflex PR is calculated additionally by relation of PR=[(Sd-Sl):(Sd+Sl)]%, where Sd and Sl are areas of pupils in darkness and at light stimulation correspondingly. Value of labyrinth asymmetry is assumed to be standard if it is lower than 10% and 15% for otolithic symmetry. For papillary reflex those values are assumed to be equal to 30-40%. In case all three factors are present, the professional suitability is declared. If at least one factor doesn't correspond to standard value, the patient should be judged as belonging to group of risk. In case two or all three factors do not correspond to standard values, the profession unsuitability is declared.

EFFECT: improved precision.

3 ex

FIELD: medicine.

SUBSTANCE: method involves measuring signal intensity in three mutually perpendicular planes and applying standard T1 and T2 protocols of magnetic resonance study. Basic image-building parameters are set in addition to standard T2 protocol like interval repetition time equal to 5000 ms, echo time 102 ms, slice thickness 4 mm, the number of slices 6 and time required for producing single image 5 min corresponding to optimum time for building an image.

EFFECT: high accuracy of diagnosis.

4 dwg

FIELD: medicine.

SUBSTANCE: method involves determining injured vertebra body contrast on sagittal T2-weighted magnetic resonance tomogram using a formula of C=(Ia+Ib)/(Ia+Ib). Axial unloading time corresponding to vertebra body marrow edema duration is determining from formula T=C/Inc. Daily contrast drop index Inc is taken to be equal to 0.0025 in superior thoracic vertebra cases. The value is equal to 0.0023 in medial thoracic vertebra cases and to 0.0022 in inferior thoracic vertebra cases. C is the injured vertebra contrast; Ia is the injured vertebra body signal intensity; Ib is the adjacent intact vertebra body signal intensity; T is the vertebral column axial unloading time corresponding to vertebra body marrow edema duration; Inc is the daily injured vertebra contrast drop index.

EFFECT: high accuracy in determining axial unloading time.

1 tbl

FIELD: medicine, reflexodiagnostics.

SUBSTANCE: one should measure the values for the potentials of auricular biologically active points: one should study biologically active auricular points (AP) 51, 55 to calculate average value. According to the obtained values in points of right and left ears one diagnosed stress state. The innovation shortens duration and labor capacity of diagnostics performed.

EFFECT: higher accuracy of diagnostics.

1 dwg, 3 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: method involves measuring specific electric resistance of biological tissue using electrode device to estimate edema degree from specific electric resistance variation pattern. Canal is built before taking measurements in biological tissue to place and fix there an electrode unit. The canal is formed by creating organ wall fold and fixing the edges. The electrode unit has rope composed of four flexible current-conducting wires, each being connected in series to four biologically inert ring-shaped electrodes mounted on the rope. External wires are current-operating wires and internal ones are measuring wires. Distance between current-operating electrodes is 2-4 times as large as examination depth. Distance between measuring electrodes is not greater than 1/3 of the distance separating the current-operating ones.

EFFECT: enhanced effectiveness of monitoring.

2 cl, 3 dwg

FIELD: medical engineering.

SUBSTANCE: device has divider, comparison unit, oscillator, acoustic radiator, controllable current source, stable constant voltage source, perspiration equivalent unit, key member, illumination source, conductivity transducer having two electrodes, the first commutator, delay unit, trigger, inverter, discharge unit, the second commutator and feeding voltage availability indicator unit. The first delay unit inputs and the first commutator inputs are connected to comparison unit output. The first commutator input is connected to the first oscillator input which delay unit, trigger and inverter are connected in series. Inverter output is connected to the second input of the first and the second commutator. The first input of the second commutator is connected to the other conductivity transducer electrode and its output is connected to device body via resistor.

EFFECT: reduced current intensity passing through patient skin; excluded negative influence upon skin during prolonged operation time on patient arm during hypoglycemia attack; low power consumption.

2 cl, 4 dwg

FIELD: medical engineering.

SUBSTANCE: device has divider, comparison unit, oscillator, acoustic radiator, controllable current source, stable constant voltage source, perspiration equivalent unit, key member, illumination source, conductivity transducer having two electrodes, the first commutator, delay unit, trigger, inverter, discharge unit, the second commutator and feeding voltage availability indicator unit. The first delay unit inputs and the first commutator inputs are connected to comparison unit output. The first commutator input is connected to the first oscillator input which delay unit, trigger and inverter are connected in series. Inverter output is connected to the second input of the first and the second commutator. The first input of the second commutator is connected to the other conductivity transducer electrode and its output is connected to device body via resistor.

EFFECT: reduced current intensity passing through patient skin; excluded negative influence upon skin during prolonged operation time on patient arm during hypoglycemia attack; low power consumption.

2 cl, 4 dwg

FIELD: medicine.

SUBSTANCE: method involves carrying out clinical and diagnostic examination and additionally measuring latent period of III peak on invoked potential curve from acoustic invoked stem potentials. Cerebral stem injuries are determined from neuromuscular electrodiagnostic data. Latent period III peak value being above or below a norm and injured medial cerebral stem region allover the stem thickness or totally injured lateral and caudal stem regions or all said regions injury taking place, high intraoperation trigeminocardial reflex risk degree is diagnosed in patients suffering from vestibular neuroschwannoma. Latent period III peak value being above or below a norm and no injuries of cerebral stem or latent period III peak value corresponding to norm and totally injured lateral and caudal stem regions at the same time or only medial cerebral stem regions taking place, moderate risk degree is diagnosed. Normal latent period III peak value and no injuries of cerebral stem being the case, low risk degree is to be diagnosed.

EFFECT: high accuracy of diagnosis.

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychotherapy.

SUBSTANCE: the method deals with correcting neurological and psychopathological disorders with anxiety-phobic symptomatics due to individual trainings. The method includes evaluation of body reaction to stimulating signals, seances of individual training performed due to the impact of two quasiantipodal stimulating signals of similar physical modality applied in time of sporadic character, and as a signal one should present biological feedback for the altered value of physiological parameter adequately reflecting body reaction to the impact of stimulating signal. At the first stage of training it is necessary to achieve body adaptation to the impact of quasiantipodal stimulating signals, at the second stage it is necessary to obtain conditional reflex for one out of stimulating signals, for this purpose one should accompany this stimulating signal with discomfort impact, during the third stage, finally, due to volitional efforts one should suppress body reaction to stimulating signal. The devise suggested contains successively connected a transformer of physiological parameter into electric signal and a bioamplifier, an analysis and control block with a connected block to present the signals of biological feedback, a block for presenting discomfort impact, an indication block and that of forming and presenting quasiantipodal stimulating signals. The innovation enables to have skills to control one's emotions, decrease sensitivity threshold to environmental impacts and learn to how behave during stress situations.

EFFECT: higher efficiency of training.

15 cl, 8 dwg

FIELD: medicine; cardiology.

SUBSTANCE: electrocardiogram of patients suffering from arterial hypertension is subject to twenty-four-hours monitoring. Spectral analysis of variability of heart beating is carried out. Very low frequency, low frequency and high frequency wave components are selected. General, day and night strength of wave components of heart beating is determined. Any factor is estimated according to the data taken from the spreadsheet. Generalized factor Z is calculated by original mathematical relation. Value of Z is used for judging on level of influence of hormones of adrenal gland onto pace-maker activity of sinus node.

EFFECT: comfort at usage; higher efficiency at non-invasive application.

2 ex, 2 tbl

FIELD: medicine; cardiology.

SUBSTANCE: electrocardiogram of patients with arterial hypertension is subject to twenty-four-hours monitoring. Spectral analysis of variability of heart beating is conducted and low-frequency, very low frequency and high frequency wave components of heart beating are selected. Strength of wave components of heart beating is determined as general, day and night ones. Generalized factor W is calculated by original relation. Value of W is used for diagnosing absence or presence of hormone-active hyper-plastic process of adrenal glands.

EFFECT: screening testing at out-patient conditions.

2 ex, 2 tbl

FIELD: medicine, diagnostics.

SUBSTANCE: the method deals with monitoring the difference in signals obtained from N pickup units, where N ≥ 2, ECG, pulse, temperature and analysis of the range and variability of their rhythms, nonlinear chaotic fluctuations during the period of registration. During analysis one should detect the values for fractal dimensions of Hirst's index and informational Fischer's index standardized, correspondingly, by the average value during either nocturnal or diurnal period. One should conclude upon improved body state by the normalization of signals' difference of peridiurnal rhythm, increased fractal dimensions, Hirst's index, decreased standardized informational Fischer's index, and one should conclude upon worse physiological or pathophysiological processes according to the opposite alterations. The method enables to widen functional possibilities during diagnostics.

EFFECT: higher accuracy of diagnostics.

3 dwg, 6 ex

FIELD: medicine.

SUBSTANCE: method involves recording rhythmocardiogram. Then, spectral analysis of RR intervalogram components in frequency bandwidth from 0.04 to 0.4 Hz is carried out and information value Z is determined from formula Z=Ahf/Alf, where Ahf is the maximum of high frequency component in bandwidth from 0.14 to 0.4 Hz, Alf is the minimum of high frequency component in bandwidth from 0.04 to 0.14 Hz. Z value being greater than 45 and lower than 14, persons consuming narcotic drugs are detected. Z value being lower than 14, persons consuming sedative drugs like opium, morphine, heroine are detected. Z value being greater than 45, persons consuming psychostimulating drugs like cocaine, amphetamine, efedrone, sydnocarb are detected.

EFFECT: high reliability of screening study data.

4 cl, 6 dwg

FIELD: medicine.

SUBSTANCE: method involves estimating vegetative tonus using cardiointervalography approach and its medication adjustment under cardiointervalography control. The cardiointervalography examination is carried out before applying treatment, in the course of and after the treatment. Each time vegetative tonus increment is estimated on the basis of voltage index. When applying medication adjustment, nootrop group preparations are used that are selected before applying treatment with initial vegetative tonus disorder distinguished by vagotonia or sympathicotonia being taken into account. Preparation or combination of preparations or their doses and application duration is adjusted on basis of vegetative status direction changes obtained from cardiointervalography examination data. The treatment is continued until vegetative status direction change stops towards normotonia.

EFFECT: enhanced effectiveness in selecting individual treatment course.

3 cl, 3 dwg

FIELD: medicine, cardiology.

SUBSTANCE: one should register rhythmocardiogram, measure current total power in low-frequency and high-frequency areas of dynamic row of cardiointervals. Evaluation of psychophysiological state should be performed by the value of stress index S calculated due to original mathematical formula by taking into account the power of low-frequency and high-frequency constituents of the range of dynamic row of cardiointervals. In case of standard conditions of measurement - the rest lying at one's back position the value of S stress index should be considered to be equal to 1. The method enables to rapidly and noninvasively detect and range human psychophysiological state.

EFFECT: higher accuracy of evaluation.

2 dwg, 1 ex, 2 tbl

The invention relates to medicine, functional diagnostics and can be used to detect autonomic dysfunction and assessment of adaptive mechanisms of the autonomic nervous system (ANS)

The invention relates to medicine, namely to identify informative parameters of ST-segment electrocardiograma, namely the displacement, slope, shape, deviation of the peak ST-segment from its center, and combinations of these parameters, and can be used to analyze changes in ST-segment electrocardiogram (EX) to detect abnormalities in the early stages of heart disease

The invention relates to medicine, namely to pediatric cardiology

The invention relates to medicine, particularly cardiology

FIELD: medicine, cardiology.

SUBSTANCE: one should conduct the performance of home birds, control heart rate and objective survey of a patients being the member of intensive therapy. Moreover, additionally in patient's blood serum one should determine efficient albumin concentration, detect the volume of diuresis and at its 30-35 g/l. One should detect efficient development of cardiogenic shock.

EFFECT: higher accuracy of prediction.

3 ex, 1 tbl

Up!