Method for treating iodine-deficient nontoxic goiter
FIELD: medicine, endocrinology.
SUBSTANCE: at the background of applying microdosages of iodine and/or levothyroxine one should conduct electrophoresis with 3%-sodium thiosulfate solution. The latter should be introduced with the help of a cathode placed onto thyroid area, an anode - onto interscapular area. The area of the interlayer corresponds to 5 x 10 cm at current power being 4-8 mA, exposure time being 15-20 min. Seances should be performed either daily or every other day, about 10-12 procedures/course.
EFFECT: higher efficiency of therapy.
The invention relates to medicine, namely to endocrinology, and can be used in the treatment of patients with non-toxic iodine deficiency goiter, caused by the addition of iodine deficiency, environmental pollutants or other toxic factors (medications).
Known surgical method for the treatment of iodine deficiency nontoxic goiter - timearticle or total thyroidectomy .
Disadvantages: postoperative complications (hypoparathyroidism, paresis of the recurrent nerve, the initiation or exacerbation of autoimmune process in the thyroid gland and others), postoperative hypothyroidism, the recurrence of goitre, and contraindications for surgical treatment on the General status.
The closest analogue is the treatment of iodine deficiency non-toxic goiter with iodine and/or levothyroxine .
Disadvantages: lack of effectiveness.
The invention is directed to solution of the problem - improving the efficiency of the method.
These objectives are achieved through the following: on the background of the patients taking non-toxic iodine deficiency goiter trace quantities of iodine and/or levothyroxine in adequate doses electrophoresis with 3% solution of sodium thiosulfate and a cathode in the region of the anterior surface of the neck (i.e. craw) daily or every other day; current 4-8 mA, a duration of 15-20 min, in the course of 10-12 treatments. Location e is Strogov: the cathode region of the thyroid gland, the indifferent electrode on the interscapular region; the area of the strip 5×10 see
The technique of electrophoresis with sodium thiosulfate at the given pathology is used for the first time.
The method is as follows: on the treatment of patients with non-toxic iodine deficiency goiter, including nodular, iodide 100 or iodide 200 and/or levothyroxine adequate individual doses electrophoresis with cathode with a 3% solution of sodium thiosulfate on the region of the thyroid gland, the area of the strip 5×10 cm, the current 4-8 mA, daily or every other day, the exposure time of 15-20 minutes, the course of 10 to 12 treatments; however, the indifferent electrode is placed on the interscapular region.
Examples of specific performance.
Patient C., 30 years old, a nurse. The diagnosis of multinodular non-toxic iodine deficiency goiter grade 2, autres. Complained of discomfort in the neck, the deformation of the neck. Visually and by palpation marked asymmetry of the lobes of the thyroid gland (right contuinue node), the heterogeneity of the consistency of its parenchyma, plotnovato multiple nodules in the right and left parts with a diameter up to 1.5 see an ultrasound of the thyroid gland from 12.05.02 year: the volume of the right lobe of the thyroid gland of 10.7 ml, left to 9.8 ml; isthmus 3 ml; total volume of 20.6 ml of the Echo is reduced. Heterogeneous echostructure; in both lobes are defined by mn the divine nodules without clear rims. Conclusion: iodine-deficient non-toxic Struma of II degree; nodules in both lobes. 28.04.02, the level of TSH 2.9 km mkme/ml, T31.08 ng/ml, T493,6 ng/ml, at-TPO 30 Miu/ml during the year taking levothyroxine at a dose of 50 mg/day. The dynamics of the size of the goiter and size of thyroid nodules clinically and sonography (16.05.03,) is not marked.
The course of electrophoresis from the cathode with a 3% solution of sodium thiosulfate on the region of the thyroid gland, the area of the strip 5×10 cm, the current strength 8 mA, daily, exposure time 20 min, 10 sessions. The indifferent electrode was positioned in the interscapular space. Sessions electrophoresis was well tolerated. After treatment disappeared feeling of tightness in the neck, tumor formation in the neck at external examination is not visible, not detected by palpation; ultrasonographically volume of 18.2 ml, echo is reduced, heterogeneous echostructure, but nodules disappeared. TSH level after treatment 1.5 km mkme/ml
Patient P., 28 years. In 1995 moved timearticle about toxic goiter, and then developed hypoparathyroidism and hypothyroidism. Relapse nontoxic goiter iodine deficiency identified in 6 months. Taking levothyroxine at a dose of 100 µg/day, calcium-D3Nycomed 1 tablet a day at night. In June 2003 he complained of feeling SDA the population in the neck. In addition, complained of infertility for 5 years. Visual and palpation of the study showed the presence of coarse postoperative scar on the anterior surface of the neck, Sanogo with the underlying tissues, asymmetry and deformation of the neck. Scars is determined by the thyroid remnant, dense, heterogeneous texture, size 4×6 see ultrasound of the thyroid gland from 22.08.03 the Volume of the right lobe 11 ml; the form is incorrect, the contours are blurred; the isthmus and the left lobe is not defined. In the thyroid remnant visible two nodes with a diameter of 1.5 and 2.5, see the TSH Level in the blood remaining 9.08, mkme/ml (despite daily dose of 100 mcg eutiroks).
On the background of levothyroxine at a dose of 100 µg/day appointed electrophoresis with cathode solution of 3% sodium thiosulfate, current strength 4 mA, exposure time 15 minutes, every day, in the course of 12 sessions. The procedure was well tolerated. After treatment were unpleasant sensations in the neck. Disappeared cohesion of the scar with the underlying tissues. Sonography (1.10.03 g) volume of the right lobe was 7.5 ml, nodes are not defined. TSH 17.10.03, 3.9 mkme/ml, although the dose of levothyroxine remained the same.
Patient S, 30 years, in February 1998 under preventive examination sonography detected iodine non-toxic Struma of 1 degree (V 21,7 ml) node in the right lobe with a diameter of 8 mm Clinically euthyroid state. Treated irregularly iodides is whether jodthyrox. By the beginning of 2003, the volume of the thyroid gland decreased to 18.0 ml, However, the nodal education with a clear outer contour in the right lobe remained unchanged. Echo node moderately reduced. The TSH level in the blood 2.9 km mkme/ml Appointed electrophoresis with 3% sodium thiosulfate solution, the current is 6 mA, exposure time of 18 min, a total of 12 sessions. The treatment was well tolerated. After a course of physiotherapy treatment of focal lesions in the thyroid gland is not found. TSH 1.44-mkme/ml without the use of thyroid hormones.
Contraindications to the proposed method are absent, except for malignant tumors.
The positive effect of the method is as follows. You know, the thyroid gland is able to Deposit copollutants, drugs and other toxic substances that violate the General and local immunity, causes autoimmune process in thyroid tissue. Not accidentally in recent years has changed the morphology of goiter: if 40 years ago in the thyroid gland was not lymphoid and plasmacytomas infiltration, b-cells, now they are defined in each of the thyroid gland . Due to the content of sulfur in its composition sodium thiosulfate entered using galvanic current in the thyroid parenchyma, binds heavy metals and thereby promotes the removal of chemical pollutants from secovid the second gland. This method can be listed as one of the types of ecological rehabilitation. In addition, sodium thiosulfate is an aid donor (source) sulfhydryl groups, and the enzymes involved in the process of germanophone in the thyroid gland, especially thyroperoxidase contain SH groups. Sodium thiosulfate has anti-inflammatory action, i.e. suppresses aseptic autoimmune inflammation of the thyroid gland.
The proposed method can be used to treat patients with contraindications to medical drugs. The method does not cause addiction and side effects, available, cheap. Courses of this treatment can be repeated after three months or more.
1. Vanushka VA, Kuznetsov NS Medical and economic aspects of surgery nodular goiter // Act. Probl. diseases of the thyroid gland: Mater. 2 the age of three. thyroidologists Congress. - M., 2002. - P.77-81.
2. The consensus. Endemic goiter in children: terminology, diagnosis, prevention and treatment. // Probl. endocrinol. - 1999. No. 6. - P.29-30.
3. Zaitseva N.V., zemlyanova M.A., Kiryanov D.A. Identification of features of formation of iodine deficiency conditions in children exposed to environmental factors of low intensity (for example, Perm oblast) // News. Grew up with. Acad. the honey. Sciences. - M - 2001. No. 6. - P.39-45.
Treatment of iodine deficiency n is toxic goiter by taking micro-doses of iodine and/or levothyroxine, characterized in that it further conduct electrophoresis with 3%sodium thiosulfate solution with the cathode region of the thyroid gland, the anode impose on the interscapular region, the area of the strip 5×10 cm, the current 4-8 mA, daily or every other day, the exposure time of 15-20 min, the rate of 10-12 procedures.
FIELD: medical engineering.
SUBSTANCE: device has reservoir, containing medicament, with electrode fixed therein. The device is to be held with patient hand. Eye-bath end surface designed for making contact with orbit boundary is of oval shape having broad and narrow end approximating orbit form. The narrow eye-bath end is raised above its broad end. The electrode is removable and remountable. The eye-bath is manufactured from flexible biologically neutral thermosetting polymer stable with respect to temperature and medicament action.
EFFECT: improved adjacency to orbit in performing electrophoresis procedures.
SUBSTANCE: method involves dropping 1% midriacyl solution into conjunctival cavity in postoperative period. Then, lidase electrophoresis is applied to orbicular muscle zones. Plaster wetted with Okovidit gel is applied to the lower eyelid.
EFFECT: accelerated treatment course.
SUBSTANCE: method involves placing active electrode like metal conductor in canal and passive electrode on body surface zone and applying DC action. The metal conductor is coated with dielectric layer spread to its working part. The working part is brought close to impassable area through badly or well-passable zones of the root canal. Gap filled with electrolyte is left between the impassable area and electrode end. The active electrode is connected to electric current source plus terminal and the passive one to minus terminal.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: method involves introducing oxybutinine solution into the urinary bladder via catheter in the amount of 5-10 mg per 20-30ml of sterile water once a day. Electrophoresis is concurrently carried out on the urinary bladder projection region using current intensity of 0.02-0.04 mA/cm2 during 15-20 min. The total treatment course is 10-12 daily procedures long.
EFFECT: enhanced effectiveness of treatment.
FIELD: medicine, juvenile surgery.
SUBSTANCE: the method is characterized by the fact that 3 wk before surgical dissection of adhesions due to laparoscopy one should prescribe bifiform per 1 capsule and Hilak-Forte per 10-15 drops thrice daily. Moreover, 7 d before surgical interference it is necessary to conduct 7 seances of electrophoresis with irucsol and prescribe smekta sorbent per 1 packet thrice daily. Then comes laparoscopic dissection of adhesions, and after surgical interference one should perform electrophoresis with irucsol for 7 d. After appearance of intestinal peristaltics it is necessary to apply smekta per 1 packet thrice daily for 7 d. Since the 8th after operation one should prescribe bifiform per 1 capsule and Hilak-Forte per 10-15 drops thrice daily for 1 mo. Then 1 mo after laparoscopy one should prescribe electrophoresis with collalysine up to 8-10 procedures at simultaneous abdominal massage and curative-physical culture complex for 8-10 d. The method enables to obtain antiadhesive effect in 92% cases of surgical dissection of adhesions due to complex impact upon pathogenesis of adhesive disease, at decreased number of relapses.
EFFECT: higher efficiency of therapy.
FIELD: medical engineering.
SUBSTANCE: device has container for keeping product to be applied, dosing unit for distributing the product, power supply element placed near the dosing unit. The dosing unit is designed as rotating element and is apiece of felt. Container walls are flexible. The dosing unit is manufactured from electric conducting material and connected to the power supply element.
EFFECT: enhanced effectiveness in carrying out viscous product iontophoresis.
8 cl, 7 dwg
FIELD: animal science.
SUBSTANCE: one should supplement the diet with microelements. Prophylaxis should be performed during stable and pasture keeping by cycles consisting of 30-60-d-long introduction of microelements and 30-60-d-long interval. Microelements should be added into the diet in their easily digestible form daily as aqueous solution at the quantity of (mg/kg body weight): cobalt chloride 0.02-0.5 mg; manganese chloride 0.05-1.0 mg; potassium iodide 0.002-0.02 mg; water - up to 1 ml. The method enables to prevent urinary losses of biologically valuable substances necessary for animals, increase protein synthesis and assimilation of microelements out of fodders, normalize blood composition and activity of cardio-vascular system, enhance deposition of calcium and phosphorus in bony tissue, increase musculature tonicity, improve total body state and productivity.
EFFECT: higher efficiency of prophylaxis.
FIELD: veterinary science.
SUBSTANCE: invention relates to methods for preparing chemotherapeutic preparation comprising biologically active iodine. Method for preparing bismuth iodide sulfamide is carried out by addition of bismuth basic nitrate to potassium iodide an aqueous solution and heating the reaction mass in acid medium up to 75-80oC. Then streptocide is added and heating is continued up to 100-105oC, kept at this temperature up to the melt formation followed by cooling and grinding. Method provides preparing the end product with the content of elemental iodine 10.8-11.0% by the wasteless technology for a single stage.
EFFECT: improved preparing method.
FIELD: sanitary and hygienic materials.
SUBSTANCE: water-based disinfecting composition contains water-soluble cyclodextrin-iodine inclusion complex and/or derivatives thereof, iodine, iodide ion source, organic solvent, and, if necessary, surfactant and/or functional additive, all in specified proportions. Agent possesses wide spectrum of antimicrobial effects at low concentrations. It does not irritates skin, shows no toxicity, and is stable upon storage within a wide temperature range.
EFFECT: increased choice of high-efficiency disinfecting agents.
19 cl, 2 tbl
FIELD: poultry science.
SUBSTANCE: one should daily introduce sodium selenite into chickens' diet at the quantity of 1.5 mg selenium/kg feedstuff. The method enables to decrease the content of lead in muscular tissue by 69.8-78.4%, in bones - by 74.4%.
EFFECT: higher efficiency of lead withdrawal.