Medicinal plant species for complex therapy of liver and bile- excreting way diseases in chronic intoxications associated with industrial (technogenic) and domestic toxic effects

FIELD: medicine, phytotherapy, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to the development of medicinal species for treatment of liver and bile-excreting way diseases. Agent for treatment and prophylaxis of liver and bile-excreting way diseases in chronic intoxications associated with industrial (technogenic) and domestic toxic effects comprises milk thistle fruits, common immortelle flowers, knot-grass (knotweed) herb, marjoram herb, milfoil herb, motherwort herb, wild rose fruits, flax seeds, alder compound fruits, and fungus Inonotus obliquus taken in the definite ratio of components. Agent is made as a solid formulation (tablet) or syrup. Agent can be milled and packaged in filter-bags. Agent is prepared as dry extract for the following industrial processing. Apart from cholagogue effect the agent elicits antioxidant, expressed membrane-protective, analgesic and anti-inflammatory effects.

EFFECT: valuable medicinal properties of species.

5 cl, 7 tbl


The invention relates to medicine, namely to herbal medicine, and can be used for the prevention and treatment of diseases of the liver and biliary tract.

Known official collection choleretic No. 2 (VFS 42-639-77) (immortelle flowers 40%, yarrow herb 20%, peppermint leaves 20%, the fruits of coriander 20%), has a choleretic, anti-inflammatory and antispasmodic action (Great Russian encyclopedia of medicines. M., “Remedium”, 2001). However, it has several disadvantages, in particular no evidence for hepatopancreatitis and antioxidant properties, which makes them complex therapy to use additional drugs are often synthetic hepatic and antioxidants. It is known that the latter inhibit the immune system (Ball et al., 1986).

The prototype is the drug, "Kars", which is a drug that contains active ingredients, milk Thistle fruit and used in acute hepatitis (toxic) for maintenance therapy in chronic liver diseases and cirrhosis of the liver. Hepatoprotective effect “Kars” explain antioxidant activity, as well as the fact that it stimulates the synthesis of protein, normalizes metabolism of phospholipids (Mashkovsky, “Drugs”, 2000). However, the drug “Cars” has no analgesics is siraudin, lipoic and anti-inflammatory action.

The technical result - getting hepatoprotective agents, possessing in addition choleretic and anti-oxidant actions, expressed lipoic, analgeziruushim and anti-inflammatory properties.

The proposed collection, with trade name “Golden” (the collection) (in the form of herbal teas in filter bags, dry extract, in the form of syrup for special purposes, in pill form), contains immortelle flowers, grass knotweed (knotweed), marjoram, yarrow herb, motherwort herb, fruit, milk Thistle, rose hips, flax seeds, stems alder, chaga in the following ratio, wt.%:

immortelle flowers 1.9

grass knotweed (knotweed) 3.2

herb oregano 6.3

yarrow herb 12.6

motherwort herb 3.2

the fruits of milk Thistle 12.6

rosehips 19

flax seeds 3.2

stems alder 19

chaga 19

Part of the collection includes medicinal plants permitted for use in medical practice (Gasparikova the USSR, 11th edition. Vol. 2 - M., 1990, GOST 21908-93, GOST 1994-93, THE 9700-005-26795008-02).

Antioxidant activity collection set in the course of the research as pharmacological property owned by this collection, is manifested through the songs included in the th composition of the medicinal herbs. In the collection are the fruits of milk Thistle are part of the famous drugs “Kars” and “Zelibor”but the fruit of milk Thistle is not used in the GF, which forced us to write THE 9700-005-26795008-02. Other components of the collection - immortelle flowers, herb oregano, yarrow herb, rose hips have choleretic action (Great Russian encyclopedia of medicines. M., “Remedium”, 2001).

Technology of preparation of the collection lies in the fact that each species of medicinal raw materials that meet the requirements of Gosfarmakapei X and XI edition, is crushed to a size of not more than 7 mm (to filter packets from 0.2 to 2 mm). Then medicinal raw materials are weighed and thoroughly mixed in equal parts to a uniform mixture and take off the dust through a sieve with the hole diameter 0.18 mm, the Raw material is crushed for the manufacture of filter bags pack of 2 g in a special heat sealable porous paper machine ARIZ. For preparing dry extracts and syrups special purpose collection is extracted under vacuum (-0,8 ATM) at a temperature of 65±5°C for 2 hours. The syrup is prepared by saturating the obtained extract the dissolved sugar to the concentration of 60-64%, then the syrup is bottled and pasteurized. To obtain dry extract - 5% liquid extract first concentrated using the mouth of ovci the EMC (installation of a membrane concentration) to the concentration of 18-20%, and then the concentrate is dried by spray drying to 95-97% of dry matter, and tightly Packed at 1000 g for further industrial processing. Solid form (tablets) is prepared from the dried extract and excipients for tablet machines.

To prepare aqueous extract at 4.0 g collection pour 200 ml of purified water at room temperature, insist in infundere apparatus for 15 minutes, then cooled at room temperature for 45 min; filter, wring out plant material and add water to the required volume of extract. When an infusion of filter bags (2 g) you must place the filter pack into the Cup, pour 200 ml boiling water, cover and let stand 10-15 minutes dry Extract is suggested for further industrial processing. Syrup special purpose prepares the drink by adding 20-30 ml of syrup in boiled water or tea. Dosage tablets 0.1 g of dry extract per tablet.

The collection action was studied on a painkiller (analgesic) effect on white weinbrenner rats on the model of acetic cramps”, which was induced by single intraperitoneal introduction of 1 ml of 1% acetic acid, was registered the time of their occurrence within 15 minutes. As the comparison drug used analgin of nutrigenomics is about 50 mg/kg In the control group pain syndrome manifested through 4.5 min, the collection was delayed manifestation of pain syndrome of 7.8 min, and analgin of 9.8 minutes Thus, the analgesic action of collecting comparable with the action of dipyrone (PL. 1).

Anti-inflammatory activity collection was tested for antitumor action in the development of carragenine inflammation logged largest emerging swelling on the white weinbrenner rats (table. 2). Drug comparison ortofen reduced exudation by 63.7%, collection of 23.9% from the control.

Lipoic activity collection was shown in a model of acute poisoning with carbon tetrachloride. In the integral test assessed the microviscosity of membranes on the mobility of the fluorescent probe pyrene in erythrocyte membranes (table. 3). The structure of membranes in the pathogenesis of most pathological conditions is violated due to the intensification of lipid peroxidation, in the process in which hydrophobic fatty acid residues of lipids formed hydroperoxide group. The interaction of these groups with other polar structures of membranes increases microviscosity cellular and subcellular membranes, which, consequently, leads to disruption of intracellular metabolism. As can be seen from table 3, the collection in its action took an intermediate position between con the role (intact animals) and untreated. Thus, the collection has a certain lipoic action.

Hepatoprotective activity of the collection has been evaluated in 2 models:

Toxic hepatitis caused daily for 4 days subcutaneous injection of 50% of carbon tetrachloride. The collection was introduced within 4 days, 15 minutes and 2 hours after poisoning. As the comparison drug used hepatoprotector “Zelibor in a dose of 5 mg/kg In the serum was determined by the activity of alanine aminotransferase, aspartate-aminotransferase elevated which indicates damage of the membranes of hepatocytes, and ran thymol turbidity test. Treatment collection resulted in improved biochemical indices and comparable to the reference product “Zelibor” (PL. 4).

In untreated animals with toxic hepatitis increased activity of Alt in 15.1 times, the activity of AST - 10.2 times, thymol test was increased in 7 times. Treatment collection and Siliborum” reduced accordingly, the activity of Alat - 10,56 and 3.9 times, the activity of AST was 5.2 and 2.1 times, reduced the severity of thymol samples whose values exceeded the normal levels in 3.6 and 1.7 times, respectively.

High values of thymol turbidity tests indicate disruption of the functioning of hepatocytes (liver parenchyma). Elevated levels of Alt and AST ascertain the damage to liver cells is K. Pharmacological action of gathering, leading to improvement of biochemical parameters, comparable to the “Siliborum”, allows to make a conclusion about the presence of hepatoprotective activity.

In the second model of acute toxic hepatitis caused by industrial toxicant from the group of hydrazine derivatives. As Comparators served medicines “Kars”, “Heptral” and “Essentiale”. These drugs and the collection was introduced animals. a day and an hour before hepatotoxicant. Recorded survival of animals by days (up to 14 days). Under the action of LD50the toxicant on the 4 day survival of mice was using drugs “Kars” - 100%of fee - 83%, “Heptral” - 66%, “Essentiale” - 50% (Table. 5). As can be seen from table 5, the collection was superior to the known pharmacopoeial hepatoprotectors, “Heptral” and “Essentiale” and was close to the action “Kars”.

More “hard” conditions (“2LD50the toxicant) 4 day survival rate was “Kars” - 53%, collection of 46% (table. 6).

Thus, the collection has hepatoprotective activity.

The antioxidant activity of the collection was estimated by chemiluminescence in vitro and in vivo (Farkhutdinov, Lihovsky, 1995). At a dose of 0.1 mg/ml collecting inhibited more than 50% of free-radical reactions in the system generation of active forms of oxygen in the system per kanogo lipid oxidation in a dose of 1 mg/ml On the illumination of the whole blood, predominantly neutrophilic granulocytes, the collection had a stimulating effect. Generation biooxidation increased by 25.9% (table. 7). It is known that Lomonosovskaya chemiluminescence of neutrophils is closely connected with the myeloperoxidase system and determines bactericidal activity (Horan et al., 1982). Synthetic antioxidant Mexidol, in contrast, suppresses the glow of phagocytes.

The collection was also used in complex therapy with drugs in the rehabilitation of persons exposed to industrial hazards. So for a group of 34 people in the functional state of the autonomic nervous system was prevailing in the original vegetative tone agatonikiiski signs, impaired microcirculation extravascular character. It also reduced the indicators of spontaneous and stimulated chemiluminescence of whole blood.

Table 1.

Analgiziruyuschee a collection action
The name of the collectionThe time of onset of pain, minThe number of writhing
“Analgin” (drug comparison)9,8±,8* 10,7±0,9*
* Differences with the control group statistically significant.
Table 2.

Antioxidative a collection action on the model carragenine inflammation.
The name of the collectionThe amount of swelling after 3 h %The amount of swelling after 24 h, %
“Ortofen” (drug comparison)19,8±0,9*22,7±1,0*
* Differences with the control group statistically significant.

Table 3.

Effects of drugs on the characteristics of microviscosity membranes of erythrocytes in rats poisoned by carbon tetrachloride
Control68,1±4,737,3±3,0 0,55□
* Differences with the control group statistically significant.

□ Differences with untreated group statistically significant.
Table 4.

Hepatoprotective activity fee (1 model)
Group nameThe activity of Alat, µm/h·mlThe activity of AST, µm/h·mlThymol test, Rel. units
Collectionof 2.51±0,24*1,72±0,32*7,6±0,6*
Zelibor (drug comparison)0,93±0,22*0,68±0,40*3,6±0,4*
Control (untreated)3,62±0,293,36±0,3514,6±0,1
* Differences with the control group statistically significant.

Table 5.

The impact of collection on the survival of mice with acute toxicosis (including steatosis) in the administration of the dose LD50the% protection
Medication1 days4 daysQualitative assessment of medication
Collection8383Activity: expressed
Essentiale5050not effective
Table 6

The impact of collection on the survival of white mice 2LD50the toxicant, %
Medication1 days4 days

Table 7.

The influence of different concentrations of collection on the chemiluminescence model systems (in$)
HerbalConcentration, mg/mlThe system generating ROSThe system, initiating the FLOORThe system of phagocytes whole blood
SS% of controlSS% of controlSS% of control
Control014,08±0,03100,0034,91±1,40100,00 100,00
* P<0,05.

At the beginning of treatment for removal of perivascular edema was administered aminophylline tablets of 0.15 for 10 days, then piracetam intramuscular injection of 5 ml of 20% solution for 10 days, then in capsules 0.4-0.8 2 times a day up to 1 month. In the future, within 20 days of the prescribed fee in the form of a 2% aqueous extract of 200-300 ml per day.

After 1 year of treatment, consisting of prescribed medication, showed improvement of microcirculation, the tendency to normalization of blood chemiluminescence, more pronounced in regard to spontaneous luminescence. After a course with the use of data collection changes grew more pronounced was the effect of the normalization of the functional reserve faguoqitirute blood cells - differences between indicators setosum stimulated and spontaneous chemiluminescence of whole blood. In 90.3% of patients noted this trend. Immunological indicators also improved - increased the number of T-lymphocytes, including helper-inductors, changed immunoregulatory index by reducing the content of suppressor-cytotoxic cells.

In General, the use of the collection in the complex therapy with drugs had a positive effect on circulation, Central nervous system, free radical Oka the field. The obtained results allow to recommend the collection for the treatment of persons exposed to industrial hazards, as well as in connection with a negative influence on the body most of the workers are functional sub-optimal state, which can be considered as predvoleny.

Thus, the proposed collection may be used in the treatment of diseases of the liver and biliary tract, as well as prevention of chronic intoxications associated with production (man-made) and household toxic effects.

1. For the treatment and prevention of diseases of the liver and biliary tract in chronic intoxications associated with production (man-made) and household toxic effects, containing fruits, milk Thistle, characterized in that it additionally contains immortelle flowers, grass knotweed (knotweed), marjoram, yarrow herb, motherwort herb, fruit trees, flax seeds, stems alder, chaga, in the following ratio, wt.%:

Immortelle flowers 1,9

Grass knotweed (knotweed) 3,2

Herb oregano 6,3

Yarrow herb 12,6

Motherwort herb 3,2

The fruits of milk Thistle 12,6

Rosehips 19,0

Flax seeds 3,2

Stems alder 19,0

Chaga 19,0

2. The tool according to claim 1, characterized in that it is made in the form of solid forms (tablets).

3. The tool according to claim 1, characterized in that it is made in the form of syrup.

4. The tool according to claim 1, characterized in that it is shredded and packaged in filter bags.

5. The tool according to claim 1, characterized in that it is made in the form of a dry extract for further industrial processing.


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6cl, 2 ex, 1 tbl

FIELD: medicine, cardiology, phytotherapy, pharmacy.

SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.

EFFECT: valuable medicinal properties of supplement.

1 ex