Homeopathic suppository "hemoprost" (variants)

FIELD: medicine, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to the development of new homeopathic suppository that can be used for treatment of prostatitis, hemorrhoid, uterus cervix erosion, endometritis. Invention proposes two variants. By the first variant agent represents suppository comprising the following components, g: propolis, 0.1; sea-buckthorn, 0.2; chestnut homeopathic essences, 0.1; Ginkgo biloba homeopathic essences, 0.1; aloe homeopathic essences, 0.1; milfoil, 0.1; wax, 0.1 and a base. The second variant represents suppository comprising the following components, g: sea-buckthorn, 0.2; propolis, 0.1; rue homeopathic essences, 0.05; Hypericum (Saint-John's-wort), 0.05; Symphytum (comfrey), 0.05; Tambukan curative muddy extract, 0.2; lanolin, 0.15; wax, 0.1, and a base. Proposed suppository elicits an anti-inflammatory regenerating effect and without toxic effect.

EFFECT: valuable medicinal properties of suppository.

15 cl, 4 ex

 

The invention relates to medicine, namely to pharmaceutical production, and for the creation of new homeopathic suppository, which may find application for the treatment of diseases prostatitis, hemorrhoids, cervical erosion, endometritis.

Known medicines for treatment of hemorrhoids and inflammatory diseases of the mucous membranes of the rectum “Anusol”, “Bestial”, “Anesthesiol” (Mashkovsky PPM Medicines. - M.: Medicine, 1986, vol. 1, s, 325, 474, Vol.2, p.84, 404), the main active components which are synthetic substances that has a range of side effects.

In traditional medicine it is known the use of bee products, tinctures and extracts of medicinal plants. For example, “Candles with herb extracts (patent RU No. 2114609), the main active ingredient which are alkaloids, has a number of side effects (dryness of the mucosa in the mouth, dilated pupils).

Closest to the claimed invention achieved by the action are candles containing propolis “Candles rectal containing propolis (patent RU No. 2137468).

Candles have the following composition in grams per candle:

Propolis 0,09

The polyethylene oxide 0,3-0,5

Preservative 0,008-0,01

The basis of water-soluble up to 2,

The disadvantages of this prototype is the presence in the composition of the same active substance, that significantly reduces the range of action of the drug. Recently, a very topical homeopathic medicines, based on the use of drugs in small doses. Homeopathic medicines do not have a toxic effect and will not damage the liver, kidneys and gastrointestinal tract.

Object of the present invention is to provide a homeopathic dosage forms in the form of candles, which will significantly expand the range of anti-inflammatory, regenerating means. The problem is solved in that claimed two options candles used for the treatment of diseases of the mucosa of the rectum and the genitals.

The first version of the medicinal product is a candle that contains propolis (Medmaravis. Medicines, M.: Medicine, 1993 Vol.2 s), sea buckthorn (FS 42-17730-95), homeopathic essences chestnut, homeopathic essences of it-biloba, homeopathic essences of aloe Vera, yarrow, and the basis for the following components in grams per 1 candle mass 2.0,

Propolis 0,1

Sea buckthorn 0,2

Homeopathic essence chestnut 0,1

Ginkgo biloba 0,1

Aloe 0,1

Tysyachelistnik 0,1

Lanolin 0,15,

Wax 0,1

Cocoa butter to 2,

The second option is the Wallpaper candles, contains sea buckthorn (FS 42-17730-95), propolis, homeopathic essences Rue (Homeopathic medicines, guide and manufacturing, Wilmar Schwabe, edited by Whirimako, Moscow, 1967, str);

prescription (Homeopathic medicines, guide and manufacturing, Wilmar Schwabe, edited by Whirimako, Moscow, 1967, str);

Symphytum (Homeopathic medicines, guide and manufacturing, Wilmar Schwabe, edited by Whirimako, Moscow, 1967, str);

extract from mud, Tambukan, the basis for the following components in grams per candle mass of 2 g:

Sea buckthorn 0,2

Propolis 0,1

Homeopathic essences Rue 0,05

Homeopathic essences prescription 0,05

Homeopathic essence of Symphytum 0,05

Extract from mud, Tambukan 0,2

Lanolin 0,15, wax 0,1, cocoa butter to 2,

In homeopathy used homeopathic essences, made from equal parts of juice and 90% ethyl alcohol (Homeopathic medicines, guide and manufacturing, Wilmar Schwabe, edited by Whirimako, Moscow, 1967, p.15-16).

Both the claimed dosage forms aimed at solving the same problems - increased bioavailability and increase homeopati the definition anti-inflammatory, regenerating means, used to treat prostatitis and lesions of the mucous membrane of the rectum, and genitals.

Received suppositories should have the following physicochemical characteristics:

The full deformation of not more than 15 minutes

The melting temperature not above 35°

The acid number of not more than 5.0 mg KOH

Example 1

The composition in grams per 1 candle weighing 2.0 g:

Propolis 0.1 g,

Sea buckthorn 0,1,

Homeopathic essence chestnut 0,1

Homeopathic essence gingko-biloba 0,15

Homeopathic essence aloe 0,15,

Homeopathic essence yarrow 0,1

Lanolin 0,13,

Wax 0,12

Cocoa butter to 2.

Suppositories are prepared by the method of pouring. Homeopathic essences chestnut 0.1 g, aloe 0.15 g, Ginkgo-biloba 0.15 g, yarrow 0.1 g triturated with anhydrous lanolin. Then with the molten base pounded 0.1 g of propolis and 0.12 g of wax. The resulting mixture together and added sea buckthorn oil in the amount of 1.15 g at a temperature of from 28 to 31°C, the mixture is thoroughly mixed until a homogeneous mass.

Suppositories are prepared by the method of splashing in a special metal or plastic forms.

The full deformation 6,36

Melting point 30,8

Acid number of 2.26

Example 2

Propolis 0.1 g oil, sea buckthorn oil 0.2 g, Homeo eticeskaja essence chestnut 0.1 g, homeopathic essence Ginkgo-biloba 0.1 g, homeopathic essence yarrow 0.1 g, homeopathic essence aloe 0.1 g, anhydrous lanolin 0.15 g, wax 0.1 g, cocoa butter, 1,05,

Suppositories prepared as follows. Homeopathic essences chestnut 0.1 g, aloe 0.1 g, Ginkgo-biloba 0.1 g of yarrow in an amount of 0.1 g ground with 0.15 g of lanolin with the purpose of emulsification, and then with the molten base of cocoa butter 1.05 g grind 0.1 g of propolis and 0.1 g of wax. Then at a temperature of from 28 to 31°pound received until smooth, then add 0.2 g of sea buckthorn oil. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

The full deformation are 5.36

Melting point 30,8

Acid number of 2.26

Example 3. Part 1 spark a mass of 2 g:

Sea buckthorn oil 0.2 g, propolis 0.1 g, homeopathic essences Rue 0.05 g, homeopathic essences prescription 0.05 g, homeopathic essence of Symphytum 0.05 g, extract from mud, Tambukan 0.2 g, lanolin 0,15, wax 0.1 cocoa butter to 1.1,

Homeopathic essences Rue 0.05 g, hyperium 0.05 g, Symphytum 0.05 g triturated with 0.15 g of lanolin with the purpose of emulsification. Then mix with melted cocoa butter 1.1 g wax 0.1 and propolis in an amount of 0.1, and then at a temperature of from 28 to 31°grow With the with the resulting composition to obtain a homogeneous mass, then add 0.2 g of sea buckthorn oil and 0.2 g of the extract of Tambukan dirt. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

The full deformation are 5.36

Melting point 30,8

Acid number of 2.26

Example 4

The composition in grams per candle mass 2,

Sea buckthorn 0,1

Propolis 0,2

Homeopathic essence Rue 0,05

Homeopathic essences prescription 0,05

Homeopathic essence of Symphytum 0,05

Extract from mud, Tambukan 0,2

Lanolin anhydrous 0,2

Wax 0,2

Cocoa butter is the rest

Suppositories are prepared as follows.

Homeopathic essences Rue, prescription, Symphytum in the amount of 0.15 g triturated with 0.15 g of lanolin with the purpose of emulsification. Then with the molten base (cocoa butter 1.1 g) is mixed wax 0.1 g and 0.2 g of propolis. The mixture is ground between themselves until smooth and add 0.1 g of sea buckthorn oil and 0.2 g of the extract of Tambukan dirt. Suppositories are prepared by the method of splashing in a special metal or plastic forms.

The full deformation of 7.36

The melting temperature of 31.8

Acid number of 2.28

Experimentally it was found that the candle composition No. 2 and No. 3 most stable. Received suppositories meet the requirements of the global Fund XI (2), s article is Thiey “suppositories”).

Therapeutic activity of the proposed suppositories was investigated by sexologists and andrologists Caucasian Mineral Waters, and Stavropol. The study included 60 patients (30 in the main and control groups) with a diagnosis of “chronic prostatitis”. Distributed patient groups by random sampling. When retractile palpation of the prostate gland tenderness was noted in all patients of the main group, the change in the consistency of the gland was diagnosed in 18 (60%) patients, the heterogeneity of its in 16 (53.3 percent), 6 (20%) - extended painful seminal vesicles. All surveyed diagnosed chronic diffuse prostatitis.

Bacteriological examination of the prostate gland secretion in 24 (80%) patients and 26 (86.6 per cent) of the control group, the growth of pathogenic organisms were not identified. In other patients found the growth of opportunistic microorganisms.

Patients primary 1st and 2nd groups were used rectal suppositories 1 time per day during the entire study period.

Patients in both groups the severity of pain as a result of treatment has decreased. Marked statically significant reduction in the severity of disorders of sexual function after therapy. The results indicate a fairly high therapeutic the effectiveness of the study drug.

Thus, the proposed homeopathic candles, possessing anti-inflammatory, regenerating effect, take precedence over the prototype, due to the broader spectrum of action and homeopathic effect, which gives the possibility of reducing the risk of toxic action.

1. Homeopathic suppositories for treatment of prostatitis and lesions of the mucous membrane of the rectum, sex organs, containing propolis, an excipient and a base, characterized in that it further contains sea buckthorn oil, homeopathic essence chestnut, homeopathic essence Ginkgo-biloba, homeopathic essence aloe, homeopathic essence yarrow, as excipients anhydrous lanolin, wax, in grams per candle by weight of 2 g:

Propolis 0,1

Sea buckthorn 0,2

Homeopathic essences chestnut 0,1

Homeopathic essences Ginkgo biloba 0,1

Homeopathic essences of aloe 0,1

Homeopathic essence yarrow 0,1

Lanolin anhydrous 0,15

Beeswax 0,1

The basis of the Rest

2. Homeopathic suppositories for treatment of prostatitis and lesions of the mucous membrane of the rectum, sex organs containing propolis, excipients and the base, wherein Ni is sustained fashion contains sea buckthorn oil, homeopathic essence Rue, homeopathic essences prescription, homeopathic essences prescription, homeopathic essence of Symphytum extract of Tambukan dirt, as excipients anhydrous lanolin, wax,, 1 candle mass 2,

Sea buckthorn oil 0,2

Propolis 0,1

Homeopathic essence Rue 0,05

Homeopathic essences prescription 0,05

Homeopathic essence of Symphytum 0,05

Extract from Tambukan mud 0,2

Lanolin anhydrous 0,15

Beeswax 0,1

The basis of the Rest

3. Homeopathic suppositories for treatment of prostatitis and lesions of the mucous membrane of the rectum, sex organs according to claims 1 and 2, characterized in that is used as a base of cocoa butter or tallow type a and b, or hydrogenated fat, or superin-m”.



 

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