Tablet with antitumor effect, method for its making (variants) and method for treatment of patients with oncological pathology

FIELD: medicine, oncology, chemical-pharmaceutical industry and technology, pharmacy.

SUBSTANCE: tablet with antitumor effect contains acceptable carrier on which the following mixture of aqueous-alcoholic tinctures is applied: bloody geranium, penny-cress, common cocklebur and European wild ginger. Tablets by mass 1 g including slipping substance contains the following amounts of indicated tinctures as measure for dry matters, g: bloody geranium, 0.015-0.020; penny-cress, 0.011-0.015; common cocklebur, 0.011-0.017, and European wild ginger, 0.024-0.036. Method for preparing tablet involves applying on carrier the mixture of aqueous-alcoholic tinctures of above indicated plants, the following drying the prepared mass, its granulating and tableting. Method for prophylaxis and treatment of oncological patients involves prescription 0.5-2 tablets with oncological designation, tree times per a day and the treatment course is determined individually based on objective data of treatment. Tablet made by claimed methods shows complex properties: it delays tumor growth and metastazing and can be recommended for treatment and prophylaxis of oncological pathology both independently and in combination with chemo-radiation therapy. Invention can be used in technology for making medicinal formulations of preparations with oncological designation and for treatment of patients with oncological pathology of different organs and body systems.

EFFECT: improved for making tablet, valuable medicinal properties of tablet.

7 cl, 4 ex

 

The invention relates to medicine, in particular to pharmacology and Oncology, and can be used in the production technology of medicinal forms of cancer drugs and destination in the treatment of patients with oncological pathology of different organs and body systems.

Cancers are difficult and not solved up to the present time the problem of medicine. In this regard, along with numerous areas of research in this area special attention to the search for an adequate therapeutic agents in Oncology.

Among therapeutic agents occupy a special place of natural remedies of vegetable origin for use in folk medicine justified by effective treatment.

Among the means of plant origin are well known chaga, celandine, St. John's wort, as well as the juice of carrot, beet, celery, potato, and others (Danes NI Healing possible. Folk medicine against cancer. Year: Labyrinth, 1993, s).

Each of these plants in the form of tincture or juice has a certain biological activity, however, it applies only to the individual links of the mechanism of cancer that does not allow to consider them sufficiently effective therapeutic agents.

Well-known drug, for example Portovaya tincture of Aconite Jungar, it has a fairly high antitumor activity, however it is directed only to the correction of some disorders that occur when the specified pathology, in particular reduces the growth of cell mass (Danes NI Healing possible. Folk medicine against cancer. Year: Labyrinth, 1993, s).

Protivoopujolevoe activity has known plant-geranium trovano-red (Lcars roslini: Enciklopedichnih dowdy. Ed. Amerossi - K.: Goals. Ed. UR, 1991, p.101). However, a decoction of the root of this plant also does not provide a robust and reliable treatment results.

The present invention is the creation of a therapeutic drug in a certain dosage form through this combination of components, which gives the drug a high antitumor activity and as a consequence sufficient therapeutic efficacy.

The problem is solved in that the tablet Oncology appointment, according to the invention contains acceptable carrier, which caused a mixture of spirit and water extracts of geranium Gravano red, arucci field, Xanthium strumarium L. and European wild ginger, and 1 g tablet mass, including moving the substance that contains the tinctures in terms of dry matter, g:

geranium Gravano red 0,015-0,020

the field is oleva 0,011-0,015

Xanthium strumarium L. 0,011-0,017

European wild ginger 0,024-being 0.036

The offered tablet Oncology appointment is due to the fact that each component has its specific action aimed at correcting the pathological processes of different systems of the body.

In addition, acting in combination, these components are not only complementary, but enhance the effect of each.

For example, geranium trovano-red, especially its roots, known in medicine as an antitumor agent. In addition, the astringent and anti-inflammatory properties, it is effective in inflammatory bowel disease.

The field the field has hemostatic, diuretic, diaphoretic, astringent, antimicrobial, wound healing properties. In addition, it has a restorative, tonic and detoxifying action, normalizes hormones in both men and women.

Xanthium strumarium L. normalizes the function of the thyroid gland, as it contains significant amounts of iodine, anti-inflammatory effect in diseases of the bronchopulmonary system, normalizes the bowels.

European wild ginger normalizes the stomach, liver and gall bladder, has expectorant effect in the bronchi is Oh, anti-inflammatory properties in diseases of the upper respiratory tract. Its feature is the ability to increase the effects of other components, in particular of Xanthium strumarium L..

As you know, cancer is a process that emerged in the body, disrupts not only one system, but a number of other systems.

Therefore, the choice of herbs for spirit aqueous infusions and due to the fact that they harmoniously affect all body systems, which can be damaging effect of cancer cells and metastasis. In particular, this can be a violation in the broncho-pulmonary, immune, genitourinary system, gastrointestinal tract, biliary tract, endocrine system. At the same time declare a set of components has antitumor and detoxification effect.

As for the amounts of active components supported on a carrier, they are defined based on the required therapeutic dose.

The carrier may be any appropriate to the field of media, with the ability to absorb the above-mentioned mixture of herbal extracts, when not to be too hygroscopic. In addition, the media should be well to give the drying at a temperature not exceeding 35°C, because at higher temperatures may deteriorate active in the substances supported on a carrier. Such carriers can be, for example, magnesium carbonate, lactose, calcium phosphate or mixtures thereof, and others

Sliding substances can be those that provide the necessary technological characteristics of the resulting tablets, for example stearic acid or its salts of magnesium, calcium, talc and other

The claimed tablet meets the requirements of the State pharmacological Committee of Ukraine. Its medicinal properties will be confirmed by the examples of the treatment of oncological diseases.

Another object of the invention is to provide a method for obtaining tablets Oncology appointment by the selection of actions and modes in combination with the properties of the original components, which results in high therapeutic efficacy of tablets when given therapeutically safe dose.

The method of obtaining tablets Oncology destination presents options, the implementation of which get the tablet with the desired properties.

The problem is solved in that in the method of producing tablets Oncology appointment acceptable carrier put a mixture of spirit and water extracts of geranium Gravano red, arucci field, Xanthium strumarium L., European wild ginger, taken in amounts corresponding to the composition of the dry the substances infusions of 1 g pills g:

geranium Gravano red 0,015-0,020

the field the field to 0.011-0,015

Xanthium strumarium L. 0,011-0,017

European wild ginger 0,024-being 0.036

The above treatment is carried out Paladino, the resulting mass after each stage of the coating is dried at a temperature not exceeding 35°C, after which the dried mass granularit, granules optivault moving substance and tabletirujut.

In this way the treatment is carried out Paladino portions of a mixture of tinctures, to ensure a gradual and uniform saturation of the carrier of active substances tinctures. Drying temperature treated with a mixture of tinctures media should not exceed 35°C, because at higher temperatures possible decomposition of biologically active components of infusions.

To perform the described method may use any acceptable carriers and moving substances.

The following variant of the method provides for applying to the medium a mixture of spirit and water extracts of the above herbs, pre-evaporated to a moisture content of from 10 to 30%, after this treatment, the resulting mass is dried at a temperature not exceeding 35°C, followed by granulation, coating granules moving substance and tableting.

And another option way to obtain tablets Oncology appointment is, to the which involves a preliminary drying of the mixture of spirit and water extracts of the above herbs to 0.5-2% moisture, mixing the media with the obtained dry mass, add a moving substance and tableting.

In this case, among acceptable carriers, it is advisable to use, for example, microcrystalline cellulose or Aerosil, because, for example, the first helps to ensure a good technological characteristics of tablets by direct compression, the necessary fluidity and raspadaemosti in the gastrointestinal tract.

The advantages of using Aerosil how media lies in its ability to regulate moisture in the dried mixture of tinctures and give tableting mass flow as required.

Each of the proposed options for the way to obtain tablets Oncology destination has its own specific features. Select one of the offered choices may depend on the technological possibilities of production and the availability of appropriate equipment. However, each of these variants of the proposed method ensures obtaining tablets containing the necessary therapeutic dose, appropriate to the requirements of HFCs.

In addition, another objective of the present invention is to provide a method for treatment of cancer patients, in which, through the selection of dosing tablets Oncology appointment and mode of admission is a high degree of efficiency the spine treatment.

The problem is solved in that in the method of prevention and treatment of patients with oncological pathology according to the invention the patient is prescribed at 0.5 to 2 tablets Oncology appointments three times a day, and the course of treatment is determined individually according to the objective results of the treatment.

Daily dose of the claimed tablets cancer assignments and the course of treatment is defined by the authors on the basis of the maximum therapeutic action based on the tumor location, extent of injury, the age characteristics of the organism, concomitant treatment.

This method of treatment is suitable for patients who refused for various reasons from chemotherapy, radiation therapy or surgery, and for complex treatment of patients undergoing such treatment.

According to the proposed method were treated 7 patients with 3-4 stages of the cancer process, refused chemo treatment, including 3 patients with lung cancer, 4 - prostate cancer.

In patients with lung cancer life expectancy after treatment ranged from 1.5 to 3.5 years, in patients with prostate cancer from 3 to 5 years.

Conducted research and treatment of 40 patients with malignant tumors of different localization showed that the total radiation reactions (headaches, nausea, edit the deposits in the blood) was absent in patients that along with radiation therapy took the claimed tablets in the amount of 0.5-2 pieces per day.

The invention is illustrated by examples of specific performance.

Example 1

For the preparation of the claimed tablets Oncology appointment take a 40%spirit aqueous solution and prepare a 20%tincture geranium trovano-red, 15%tincture of arucci field, a 10%tincture of Xanthium strumarium L., 10%tincture of European wild ginger. The resulting tincture is mixed in the ratio 1:1:1:1,5. Receive 4.5 l of a mixture of tinctures, as the carrier take the milk sugar in a quantity calculated to obtain 1 g tablets of dry substances, tinctures, g:

geranium Gravano red 0,017

the field field 0,013

Xanthium strumarium L. 0,015

European wild ginger 0,030

The number of media is 2 kg less dry matter and moving substance.

Processing media carried out in stages, each time processing media 200-500 ml of a mixture of tinctures and drying the treated medium at a temperature not exceeding 35°C to a moisture content of 1-5%.

After this the resulting product granularit, granules optivault moving substance, such as calcium stearate in the amount of 1% by weight of the tablet, i.e. 0,02 kg Then the obtained granules tabletirujut.

Example 2

This example differs from the previous one by the fact that predommantly media (milk sugar) the mixture of extracts of medicinal herbs is evaporated in a vacuum rotary installation at a temperature not exceeding 35° C to a residual moisture content of 10-30%.

Then the media and the resulting thick extract is stirred, and the resulting mass is dried at a temperature not exceeding 35°C to a residual moisture content of 1-5%. The resulting product granularit, granules optivault, such as magnesium stearate, then tabletirujut.

Example 3

This example differs from the previous examples 1 and 2 in that the mixture of tinctures of herbs evaporated to obtain a dry residue with a moisture content of 0.5-2%, after which the dry residue is mixed with microcrystalline cellulose, and then as a moving substance to add, for example, Aerosil, mix and tabletirujut. The number of recovered components corresponds to example 1.

Example 4

Patient K., 58 years old, was admitted for treatment at the Main military clinical hospital of the Ministry of defense of Ukraine with a diagnosis of gastric cancer with metastasis to the liver, resulting in pain in the right hypochondrium, bowel, General weakness.

At the time of examination, the patient was observed cachexia and yellowness of the skin.

The patient was assigned to the claimed preparation in the form of tablets: 2 tablets three times a day.

During 10 days of treatment disappeared yellowness of the skin, pain in the intestines, in the right hypochondrium, the patient started to gain weight. Disappeared weakness, began to appear Ave is Liv forces. Normalized blood counts.

Thus, the claimed tablet Oncology destination possesses a number of characteristics that determine the delay of tumor growth and metastasis. The drug can be recommended for the treatment and prevention of cancer, both alone and in combination with conventional treatment regimens, including chemotherapy and radiation therapy.

1. Tablet antitumor activity, characterized in that it contains acceptable carrier, which caused a mixture of spirit and water extracts of geranium blood-red, arucci field, Xanthium strumarium L. and European wild ginger, and 1 gram tablets, including the moving substance, contains the following quantities of these tinctures in terms of dry matter, g:

Geranium blood red 0,015-0,020

The field the field to 0.011-0,015

Xanthium strumarium L. 0,011-0,017

European wild ginger 0,024-being 0.036

2. The method of obtaining tablets antitumor activity, wherein the acceptable carrier is applied a mixture of spirit and water extracts of geranium blood-red, arucci field, Xanthium strumarium L. and European wild ginger, taken in amounts corresponding to the composition of the dry matter infusions of 1 g tablet, g:

Geranium blood red 0,015-0,020

The field the field to 0.011-0,015

D is Michnik ordinary 0,011-0,017

European wild ginger 0,024-being 0.036

moreover, the above treatment is carried out Paladino, the resulting mass is dried at a temperature not exceeding 35°C, after which the dried mass granularit, granules optivault moving substance and their tabletirujut.

3. The method of obtaining tablets antitumor activity, wherein the acceptable carrier is applied a mixture of spirit and water extracts of geranium blood-red, arucci field, Xanthium strumarium L. and European wild ginger, taken in amounts corresponding to the composition of the dry matter infusions of 1 g tablet, g:

Geranium blood red 0,015-0,020

The field the field to 0.011-0,015

Xanthium strumarium L. 0,011-0,017

European wild ginger 0,024-being 0.036

with this mixture before application to the carrier is evaporated to a residual content of moisture from 10 to 30%, then the resulting mass is dried at a temperature not exceeding 35°dried mass granularit, granules optivault moving substance and their tabletirujut.

4. The method of obtaining tablets antitumor activity, wherein the acceptable carrier is applied dried to a moisture content of 0.5-2.0% of a mixture of spirit and water extracts of geranium blood-red, arucci field, Xanthium strumarium L. and European wild ginger, taken to the icestar, the appropriate composition of dry matter infusions of 1 g tablet, g:

Geranium blood red 0,015-0,020

The field the field to 0.011-0,015

Xanthium strumarium L. 0,011-0,017

European wild ginger 0,024-being 0.036

after which the formed mass is added acceptable the moving substance and weight tabletirujut.

5. The method according to claim 4, characterized in that as the carrier is used microcrystalline cellulose.

6. The method according to claim 4, characterized in that the quality of media use are presented.

7. Method of prevention and treatment of patients with oncological pathology, wherein the patient is administered 0.5 to 2.0 tablet antitumor activity according to claim 1 three times a day, and the course of treatment is prescribed individually depending on objective outcomes.



 

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17 cl, 3 ex, 3 dwg

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EFFECT: improved method for treatment and making, valuable medicinal properties of tablet.

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