Tablet with antitumor effect, method for its making and method for treatment of patients with oncological pathology
FIELD: medicine, oncology, chemical-pharmaceutical technology, pharmacology, pharmacy.
SUBSTANCE: tablet eliciting the antitumor effect comprises active dose of aconite alkaloids in the amount 0.0125-0.0375 mg. Invention relates to a method for making tablet with antitumor effect. Method involves treatment suitable carrier taken in the amount corresponding to the content of alkaloids in tablet 0.0125-0.0375 mg with aconite tincture wherein amount of the total content of alkaloids is determined preliminary. Then carrier treated by such manner is dried at temperature 30-35°C, not above, granulated, granules are powdered and tableted. Also, invention relates to a method for treatment of oncological patients that involves prescription to patient 0.5-2 tablets with oncological designation being this treatment is determined individually. Invention can be used in manufacturing medicinal formulations of preparations used for treatment of patients with oncological pathology.
EFFECT: improved method for treatment and making, valuable medicinal properties of tablet.
8 cl, 2 ex
The invention relates to medicine, in particular to pharmacology and Oncology, and can be used in the manufacture of dosage forms of drugs Oncology appointment and in the treatment of patients with oncological pathology.
Currently there is an acute problem of finding adequate means of therapeutic intervention in the field of Oncology. Among therapeutic agents are of particular interest in natural remedies for use in traditional medicine is widespread and often justified due to the achievement of good results.
Among the means of plant origin are well known chaga, celandine, St. John's wort, Hemlock, and the juice of carrot, beet, celery, potato, and others (Danes NI Healing possible. Folk medicine against cancer. ,, "Labyrinth", 1993, s).
Although each of these plants in the form of tincture or juice has a certain biological activity, but it is not enough to achieve sustainable and high treatment outcome.
Among the treatment means Oncology destination known alcoholic tincture of Aconite Jungar, it is used in an amount of from 1 to 9 drops (Danes NI Healing possible. Folk medicine against cancer. ,, "Laurent", 1993, s). Usually when receiving medicinal infusions and the use of 10 g of dry root plants at 0.5 l of a 40%aqueous alcohol. Tincture of Aconite has a sufficiently high efficiency in the treatment of patients with oncological pathology.
However, the dosage form is a tincture of Aconite has significant disadvantages. A drop of the tincture is not defined amount of the active substance, which may be different depending on the quantity of raw materials used and the features of preparation of tinctures. These reasons cause inaccurate dosing tinctures, which in turn, does not allow to estimate and predict therapeutic outcome.
In addition, the need for accurate dosing of Aconite as an active Foundation drop is important because Aconite in doses exceeding a set threshold, is toxic and requires special care in the treatment.
The present invention is the creation of such a dosage form of Aconite, which through accurate dosing of the active component of Aconite achieved high treatment efficiency and eliminates the risk of side effects associated with overdose.
The problem is solved in that the tablet Oncology appointment, according to the invention, contains the alkaloids of Aconite acceptable carrier and a lubricating substance, and an active dose of alkaloids of Aconite is of 0.0125-0,0375 mg.
The authors of the present invention p is tveretina, what existing active substances of Aconite are alkaloids, the number of which depends on the achieved therapeutic effect. When setting the dose of the alkaloids of Aconite in the tablet, the authors were guided, on the one hand, achieving the maximum therapeutic effect when taking the pills, taking into account the complexity of the pathology of age-related characteristics of the organism and others, and on the other hand, the negative impact of a possible excess of the alkaloids of Aconite on the patient's body.
The choice of carrier for the active component of Aconite was carried out on the basis of the following conditions: he must not lose moisture, must yield to the pressing, it should have good flowability required for uniform distribution throughout the mass of the tablet. The specified properties to some extent possess the a lot of accepted in the field of media.
However, among all possible carriers of the most technologically acceptable is the milk sugar, the main advantage of which is a high adsorption, and so forth all the examples are for the media.
As for lubricants, they can also be any of the acceptable in this area substances, however the most suitable because of its lubricating properties and the most easy tabletting mass is calcium stearate, usually in Koli is este to 1% relative to the weight of the tablets.
The authors have provided the possibility of introducing a tablet of some inert functional additives, in particular aromatic and/or effervescent components.
The claimed tablet cancer treatment (Aconite) may be of any convenient to use a lot, such as 0.2,
To determine therapeutic action of the claimed tablets experiments were carried out, aimed at studying their impact on tumor growth.
The experiments were conducted on mice, as a model for the study of antitumor activity of the tablets was selected human epidermoid carcinoma, Lewis lung.
In the study used the tablets of Aconite. Because the weight of the mouse is on average 25 g, single dose was 0.05 mg of the alkaloids of Aconite in the tablet. Control animals were injected with distilled water in the same mode.
It was found that the introduction of the proposed drug causes a statistically significant reduction of tumor growth, starting with 21 days of its development.
In General, the drug reduced the rate of tumor growth in 3,49 times (in the control, the average is 0,464 mm/day, and the experience - 0,186 mm/day).
The biggest difference between control and experiment detected on day 36 of the experiment, however, further differences began to decrease, due to the development of necrosis in to ntalnyh animals.
More rapid development of necrotic changes in the tumors of the control animals, indicating the attainment of a new phase of development - decay of the primary tumor, even more confirmed the antitumor activity of the proposed drug.
At the opening of the control mice in some of them metastases in the lungs. At the same time experienced mice visible metastases not detected, which also indicates the pronounced effect of the claimed tablets.
The effectiveness of the treatment of people declare that the tablet will be shown when considering the treatment of cancer patients.
Tablet Aconite is a new dosage form, resistant to light, well kept.
In addition, the set of components of the inventive tablet provides her with prolonging the action.
Another objective of the present invention is to provide such a method of producing tablets Oncology destination where by a particular combination of action and modes to achieve high therapeutic efficacy of tablets when given therapeutically safe dose.
The problem is solved in that a method of manufacturing tablets Oncology appointment, according to the invention, is that the tincture of Aconite, in which pre-determine the amount of alkali is Dov, process acceptable carrier, taken in the quantity corresponding to the achievement of each tablet of 0.0125-0,0375 mg alkaloids, and then the thus treated carrier is dried at a temperature not exceeding 30-35°and granularit. Granules optivault acceptable lubricant, after which they tabletirujut.
As noted above, the main problem when creating the dosage form of Aconite is accurate dosing of alkaloids. In the present method of manufacturing tablets this is achieved, first of all, a preliminary quantification of the amounts of the alkaloids of Aconite in the tincture of Aconite.
Such action is justified, because, knowing the exact content of alkaloids in the tincture, conventional analytical techniques can bring it up to concentrations providing a dose of alkaloids in the resulting tablet in the range of 0.0125-0,0375 mg.
Using these steps, you can apply for tincture Aconite any regional origin, in particular the Carpathian, the activity of which can be adjusted provided by the authors.
It is noticed that during the drying treated with tincture of Aconite with a certain concentration of alkaloids media is quite essential not to exceed the temperature of 30-35°because otherwise are destruct the main processes resulting therapeutic activity tablets Oncology destination drops significantly.
With regard to use of media and lubricants, they choose from acceptable for this purpose substances, however, the authors point out the lactose and calcium stearate, the use of which combination has a greater impact on technology and consumer properties of the tablets.
In addition, another objective of the present invention is to provide a method for treatment of cancer patients, in which, through the selection of dosage and mode of administration of the inventive tablets Oncology appointment achieve a high efficiency of treatment and are excluded adverse reactions of the body of the patient.
The problem is solved because, according to the method of treatment of patients with oncological pathology patient is assigned a day for 0.5 to 2 tablets Oncology appointment according to claim 1, with the course of treatment is determined individually.
Proposed by the authors of this method of treatment the dose pills Aconite selected on the basis of its maximum therapeutic action and taking into account peculiarities of oncological pathologies, age characteristics of the organism and the absence of undesirable side effects.
The course of treatment is determined individually depending on tumor localization and heavy the tee illness.
This method of treatment is suitable for patients who refused for various reasons from chemotherapy, radiation therapy or surgical treatment, and for complex treatment of patients undergoing such treatment.
The invention is illustrated by examples of specific performance.
Crushed roots of Aconite Junggar pour a 40-degree alcohol based obtain 3% tincture. Insist in a dark place for 14 days.
The resulting infusion analyze known method, such as potentiometric titration of 0.01 N hydrochloric acid. The quantitative analysis suggests that 3% tincture is 0.03% alkaloids, a determinant of activity in the treatment of oncological pathologies, in 1 l of tincture is 0.3 g (300 mg) alkaloids of Aconite.
A simple calculation shows that to obtain tablets weighing 0.2 g containing alkaloids 0,0124 mg should 4.8 kg, for example, tablet mass to handle 1 l tinctures with content 0.3 g of alkaloids.
The obtained wet mass is dried at a temperature of 30-35°dried mass is passed through a sieve with holes of 2 mm, as a result of this processing gain granulate, which is subjected to dusting with calcium stearate.
Then the resulting mass tabletirujut on a rotary press and get the tablets weighing 0.2 g, for this example, the composition tablets next, mg:
The alkaloids of Aconite of 0.0125
Milk sugar 197,9875
Calcium stearate 2,0000
Patient L., 1973 birth in March 2000, he suffered a viral infection, in may there was a sudden pain in the chest, weakness, shortness of breath. Conducted radiography of the chest, signs of a lesion (hydrophilic tumor) varnishing mediastinum. The dimensions of education of 3.5×3,5 see the Patient refused diagnostic puncture, radiation therapy, chemotherapy, and surgery. Tumor growth continued, so I decided to spend treatment tablets Aconite. The patient took 2 tablets (dose of 0.0125 mg alkaloids per tablet) 3 times a day for 20-30 minutes before eating. The treatment lasted 3 months, after 2-3 weeks of being sick has improved significantly decreased weakness, virtually disappeared shortness of breath.
When radiography is conducted after three months of treatment, found no signs of a lesion.
We offer drug treated 7 patients with stage 3-4 of ecoprocess who refused chemo treatment, including 3 patients with lung cancer, 4 with prostate cancer.
The first group of patients, life expectancy ranged from 1.5 to 3.5 years, in the second group of patients - from 3 to 5 years.
In addition, a survey was conducted and the treatment of 40 patients with malignant tumors of different localization (mainly squamous cell carcinoma)who received radiation therapy.
Treatment was performed with tablets, the dose of alkaloids which treatment was chosen depending on the condition of the patient.
Studies have shown that the total radiation reactions (headaches, nausea, changes in blood) in patients who took the pill, was missing.
Thus, the claimed tablets Oncology appointment showed high treatment efficiency. The method of manufacture of such tablets is quite simple and provides accurate dose of the active component of Aconite - the amount of alkaloids, which is very essential to achieve reliable therapeutic effect.
The ability to control the precise therapeutic dose in tablet allows the use of raw materials (monkshood), growing in every region, including in the Carpathians.
Studies on patients with oncological pathology showed promising treatment by the claimed method.
1. Tablet antitumor activity, characterized in that it contains the alkaloids of Aconite acceptable carriers and grease, and an active dose of alkaloids of Aconite is of 0.0125-0,0375 mg.
2. The tablet according to claim 1, great is the rpm die, that as the carrier contains milk sugar.
3. The tablet according to claim 1 or 2, characterized in that the lubricant contains calcium stearate.
4. The tablet according to claim 1 or 2, or 3, characterized in that it further comprises aromatic and/or effervescent components.
5. Method of preparation tablets antitumor activity, characterized in that the tincture of Aconite, in which pre-determine the amount of alkaloids, process acceptable carrier, taken in the quantity corresponding to the achievement of each tablet of 0.0125-0,0375 mg alkaloids, and then the thus treated carrier is dried at a temperature no higher than 30-35°and granularit, granules optivault acceptable lubricant, after which they tabletirujut.
6. The method according to claim 1, characterized in that as an acceptable media use milk sugar.
7. The method according to claim 1 or 2, characterized in that the lubricant used calcium stearate.
8. The method of treatment of patients with oncological pathology, characterized in that the patient is prescribed 3 times a day at 0.5 to 2 tablets antitumor activity according to claim 1, with the course of treatment is determined individually.
FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to new compounds - pluraflavines of the formula (I): wherein R1 represents sugar group of the formula: ; R2 represents -COOH or -CH2-O-(R7)m wherein R7 represents sugar group of the formula: ; R3 is taken among the groups: and , and to all its stereochemical forms and mixtures of indicated forms in any ratio, and to their physiologically acceptable salts; R5 means hydrogen atom; R4 and R6 represent in common group -X2 with a double bond wherein X2 means oxygen atom (O); R8 and R10 represent in common group -X2 with a double bond wherein X2 means oxygen atom (O), and m = n = 1, and to all its stereochemical forms and mixtures of indicated forms in any ratio and to its physiologically acceptable salts. Invention relates to a method for preparing these compounds from culture of microorganism actinomycetes HAG 003959, DSM 12931 by fermentation, to the strain Actinomycetales HAG 003959, DSM 12931 used for preparing compounds of the formula (I) and to pharmaceutical composition inhibiting transcriptase activity and eliciting cytotoxic effect based on above said compounds. Compounds of the formula (I) are used as medicinal agents, for example, as antitumor agents.
EFFECT: improved method for preparing, valuable medicinal properties of compounds and composition.
19 cl, 3 tbl, 12 ex
FIELD: medicine, oncology.
SUBSTANCE: the present innovation deals with inhibiting the growth of host's cerebral tumors. It deals with introducing therapeutically efficient quantity of integrin αv antagonists being cyclo(Arg-Gly-Asp-D-Phe-[N-Me]-Val). The innovation enables to considerably inhibit cerebral oncogenesis in vivo, moreover, despite antiangiogenesis, due to induction of direct lethality of tumor cells.
EFFECT: higher efficiency of inhibition.
9 dwg, 2 tbl
FIELD: medicine, oncology.
SUBSTANCE: invention relates to a method for assay of efficacy on post-operative intrathecal chemotherapy of patients with intracerebral malignant tumors. Method involves determination of total protein level in cerebrospinal fluid before and after carrying out chemotherapy in autoliquor. Increase of the level of total protein by 5.6-6.3 times indicates on effectiveness of the post-operative chemotherapy. Method provides the objective evaluating dynamic of cytolysis of tumor cells that is the reliable method for estimation of efficacy of indicated treatment.
EFFECT: enhanced and improved method for treatment.
FIELD: experimental medicine, oncology, biology.
SUBSTANCE: invention relates to a method for inhibition of tumor growth using radiation therapy as ionizing radiation with additional administration of mixture of octa-4,5-carboxyphthalocyanine sodium cobalt salt or oxocobalamine with sodium ascorbate in the ratio = (1:10)-(1:30). Method of combined using irradiation and indicated mixture of substances provides enhancing the effectiveness of anti-tumor treatment resulting to 70-100% recovery of experimental animals and reducing radiation loading and toxicity.
EFFECT: improved method for inhibition.
2 tbl, 3 dwg, 3 ex
FIELD: medicine, oncology.
SUBSTANCE: method involves surgery treatment and chemotherapy. In preoperative period 150 ml of blood is taken off in patients, blood is centrifuged for separating for plasma and formed elements. Standard dose of cytostatic agent is separated and placed into the first flask with 20-40 ml of autoplasma and remained plasma part and formed elements are placed into the second flask. Flasks are incubated separately for 40 min at 37°C followed by carrying out a procedure when blood incubated with the chemopreparation from the second flask is administrated by intravenous route by drops. After removing tumor its bed in infiltrated with autoplasma incubated with the chemopreparation from the first flask or autoplasma with the chemopreparation are added in blood vessels in zone of regional blood supply of tumor. Method provides reducing frequency of topical relapses and alienated metastasis after surgery treatment of solid tumors and shows low toxicity. Invention can be used in the complex cancer treatment, in particular, regionally distributed cancer in large intestine and mammary glands.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: the method deals with 2 courses of polychemotherapy at the first stage due to regional intra-arterial introduction of cisplatin at the dosage of 100 mg/m2 during the first day of every course and 6-h-long intra-arterial infusion of 5-fluorouracil at total dose of 750 mg/m2 in the morning since the 2nd to the 6th d of every course. Chemotherapy should be performed at the background of total magnetotherapy at frequency of magnetic field being 98-112 Hz, intensity of 25-30 oersted, duration of every seance being 30 min, the number of seances corresponds to the duration of chemotherapeutic courses. At the second stage in 2-3 wk after finishing chemotherapy it is necessary to conduct the course of distance radiation therapy (DRT) at multifractioning the dosage by SFD being 1.2 Gy twice daily 5 times weekly up to TFD being equivalent to TDF (time-dosage-fraction) of 62-70 Gy onto primary focus and 40-46 Gy onto areas of regional lymph outflow. As modifiers one should apply cisplatin during the first 2 wk of radiation therapy, hyperbaric oxygenation during the first 10 d of radiation therapy and total magnetotherapy since the 11th d of DRT course till its ending. At the third stage in case of residual metastases in lymph nodes of patient's neck in 2-3 wk after the end of radiation therapy one should conduct operative interference in lymph outflow pathways. The method enables to decrease toxicity of chemo-and radiation therapy due to decreased radiation reactions, stimulation of immune system and improved microcirculation.
EFFECT: higher efficiency of therapy.
FIELD: organic chemistry, medicine, oncology.
SUBSTANCE: invention relates to new glycosides of indolo[2,3-a]-pyrrolo[3,4-c]carbazol-5,7-diones of the general formula (1)
wherein: -R1 means residue of mono- or disaccharide in pyranose form taken among the group: D-Rib, L-Ara, D-Xyl, D-Gal, D-Glc, D-Lac; -R2 means hydrogen atom, methyl group or residue of mono- or disaccharide; -R3 means hydrogen atom, hydroxyl group, amino-group or formamido-group; each -X1 and -X2 means independently of one another hydrogen atom or bromine atom under condition that they can't mean hydrogen atom simultaneously and under condition also that if R1 means disaccharide residue then R2 differs from hydrogen atom. Prepared derivatives show, in particular, cytotoxic and antitumor activity against melanoma B16 and Ehrlich tumor.
EFFECT: valuable medicinal properties of derivatives.
3 cl, 3 tbl, 2 dwg, 8 ex
FIELD: chemistry of peptides, medicine, oncology, pharmaceutical chemistry.
SUBSTANCE: invention relates to the development of medicinal agent of peptide nature eliciting an antitumor effect and can be used in treatment of endocrine and hormone-dependent tumors. Agent represents peptide of the general formula: . Invention provides enhancement of the therapeutic effect and reducing toxicity.
EFFECT: valuable medicinal properties of agent.
3 cl, 4 tbl, 2 ex
FIELD: biochemistry, medicine, pharmacy.
SUBSTANCE: leaves of Mikania micrantha, Mikania scandens and Mikania cordata are milled and dries and a solvent - toluene, ethyl acetate, their mixture, mixture of toluene with acetone, mixture of ethyl acetate with heptane or mixture of heptane with acetone is added in the ratio (7:3)-(3:7), mixture is filtered and concentrated up to 2.5-10% as measure for dry extract. Then extract is contacted with a mixture containing 10-50% of methanol or ethanol in water, an aqueous-alcoholic phase is washed out with n-hexane or heptane and alcohol is removed. An aqueous phase is extracted with ethyl acetate, prepared phase is dried, solvents are evaporated and dry extracted is purified. Dry extract prepared from leaves is dissolved in ethyl acetate and hydrogenated at 10-35°C in the presence of hydrogenation catalyst under pressure 1-2 atm. After hydrogenation dihydromikanolid is crystallized. Mikanolid and dihydromikanolid are used for treatment proliferative diseases and parasitic diseases. Also, invention relates to a medicinal agent containing above indicated vegetable extract. Invention provides realization of indicated designation.
EFFECT: valuable properties of agents.
12 cl, 3 tbl, 3 ex
FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to pharmaceutical composition comprising the known antibiotic eliciting an antitumor activity and derivative of hydroxamic acid of the formula (1) wherein the weight ratio of two active agents is (1:50)-(50:1), respectively. The composition reduces adverse effects and elicits the enhanced antitumor effect.
EFFECT: improved valuable medicinal properties of composition.
4 cl, 1 tbl, 5 ex
SUBSTANCE: invention relates to films for in-mouth application containing cosmetic or pharmaceutical substances. Film comprises at least one water-soluble polymer such as pullulan, pharmaceutically active agent, and ion-exchange resin as taste masking agents containing divinylbenzene-crosslinked polystyrene. Preparation procedure: water-soluble ingredients are dissolved in water; water-soluble film-forming agent is mixed with one stabilizer to form film-forming mixture; the latter is combined with above aqueous solution and resulting mixture is stirred to form gel; gel is mixed with oil blend to give homogenous gel, which is poured onto support and dried to form desired film.
EFFECT: achieved good masking of agent taste and good-quality appearance.
28 cl, 7 tbl, 7 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to the solid medicinal formulation comprising chondroitin sulfate. The proposed medicinal formulation comprises 250 mg of chondroitin sulfate as an active component, filling agent, binding agent, antifriction substances and can comprise a solubilizing agent additionally. Pharmaceutical composition is made as a tablet. Invention provides development of the preparation for oral administration with the less amount of active substance and with indices satisfying requirements of the State Pharmacopoeia.
EFFECT: improved and valuable properties of formulation.
8 cl, 16 tbl, 39 ex
FIELD: medicine, pharmacology, pharmacy.
SUBSTANCE: antiviral agent comprises aciclovir as an active substance and special additives wherein agent comprises potato starch, talc, stearic acid or stearates as special additives taken in the definite ratio of components. Antiviral agent is made as a tablet. Also, invention relates to a simple method for preparing an antiviral agent and invention provides rapid release of active component. Invention can be used for treatment of skin and mucosa viral diseases induced by herpes simplex virus or herpes zoster virus, and for prophylaxis of these diseases in patients with damage of the immune system.
EFFECT: improved method for preparing, valuable medicinal properties of agent.
4 cl, 1 tbl
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to producing a medicinal preparation with analgesic, antipyretic and anti-inflammatory effect. The preparation is made as a tablet comprising a core containing ibuprofen as an active substance wherein a core is covered by envelope masking taste of the preparation. Core comprises potato starch and calcium stearate as special additives, and envelope comprises sugar, magnesium basic carbonate, polyvinylpyrrolidone, aerosil, talc, titanium dioxide, gelatin, vanillin, dye acid red and bee wax. Invention provides the necessary quality and necessary therapeutic effect of tablets due to rapid release of active substance from the tablet core wherein the core decomposition is 7-8 min and that in dissolving and 92-94% of active component transfers to medium in 45 min.
EFFECT: improved method for preparing, improved and valuable medicinal and pharmaceutical properties of preparation.
4 cl, 1 tbl, 5 ex
FIELD: medicine, gastroenterology, pharmacy.
SUBSTANCE: invention relates to a solid composition eliciting with an anti-ulcer activity and to a method for its preparing. Pharmaceutical composition consists of a core containing famotidine as an active component and starch, aerosil, stearic acid salt as accessory inert substances wherein a core is covered by polymeric envelope. Core comprises glucose and stearic acid as an accessory inert substance and magnesium stearate as a stearic acid salt. Polymeric envelope comprises oxypropylmethylcellulose, propylene glycol, castor oil, talc and titanium dioxide taken in the definite ratio of all components in the composition. Method for preparing pharmaceutical composition involves preparing raw, mixing therapeutically effective amount of famotidine with glucose and starch, moistening the mixture with starch paste, granulation, drying wetted granulate, repeated granulation, powdering dry granules, tableting and applying polymeric envelope containing oxypropylmethylcellulose on prepared cores with addition of titanium dioxide, propylene glycol, castor oil and talc. Invention provides enhancement of degradability, solubility and stability in storing.
EFFECT: improved method for preparing, valuable pharmaceutical properties of composition.
3 cl, 1 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to medicinal formulations. Tablet consists of a mixture of medicinal agents and accessory substances and made with internal cavity filled with air. Cavity can involve isolated cells and the reduced specific weight of tablet is less 1 g/cm3. Invention provides enhanced effectiveness and safety of orally ingested tableted medicinal agents and safety of dissolving process and absorption of medicinal agent in stomach.
EFFECT: improved and valuable properties of tablet.
FIELD: pharmaceutical industry.
SUBSTANCE: pharmaceutical composition exhibiting neotropical, antiepileptic, sedative, and antistress activities, normalizing metabolic processes in body, contains aminoacetic acid and pharmaceutically acceptable carrier constituted by mixture of sorbitol and crosslinked carboxymethylcellulose sodium salt at weight ratio between 1:1 and 1:3 with additive selected from vinylpyrrolidone/vinyl acetate, stearic acid, stearic acid sodium salt, and mixtures thereof.
EFFECT: increased bioavailability and active component release velocity.
2 cl, 1 tbl
FIELD: pharmaceutics, medicine.
SUBSTANCE: the present innovation deals with cardiotherapy for treating and preventing coronary deficiency. The preparation is designed as a plate (film) consisted of three layers, each of them is manufactured out of co-polymer of vinyl pyrrolidone, acrylamide and nitroglycerin-containing ethylacrylate; moreover, internal layer additionally contains solid fat - cacao oil, and weight ratio for the sum of external layers to internal corresponds to 1 : 1. The suggested preparation could additionally contain brilliant green dyestuff. The preparation should be manufactured out of pre-obtained mixture of nitroglycerin and copolymer in solution of alcohol and water followed by layer-by-layer forming three-layer film due to spreading the mixture onto solid bottom plate and drying at 30-50 C. The innovation provides higher adhesion to gingival mucosal surface, decreased side action, improved bioavailability and stability of therapeutic effect.
EFFECT: higher efficiency of therapy.
3 cl, 3 ex
FIELD: pharmaceutical industry, medicine.
SUBSTANCE: invention relates to peroral immediate-released drug in solid form, containing low molecular thrombin inhibitor based on peptide with pH-depending solubility. Claimed drug has size particle less than 300 mum and contains combination of microcrystal cellulose and sodium glycolate starch in amount of more than 35 mass % (calculates as preparation mass).
EFFECT: drug with reduced dependence of thrombin inhibitor dissolution from pH and increased releasing rate from tablet.
17 cl, 3 ex, 3 dwg
FIELD: medicinal industry.
SUBSTANCE: the present innovation deals with manufacturing medicinal preparation containing drotaverin hydrochloride to be applied for interrupting spasms of smooth musculature. Mass for tableting should be prepared due to mixing the powder of drotaverin hydrochloride with that of dyed granulate at the ratio of 1:3 to 2:1. One should obtain the dyed granulate by moisturizing inert pharmaceutical filler with binder's solution dyed with quinoline yellow dyestuff. Then comes drying up to 0.1-2.5% followed by granulation and tableting. The innovation enables to obtain tablets of drotaverin hydrochloride upon industrial equipment at its degradability being below 15 min, being stable during manufacturing and at storage. Quality of tablets meets all the requirements of pharmacopoeic article.
EFFECT: higher efficiency of manufacturing.
2 cl, 4 ex, 3 tbl
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to curative ointments with anti-inflammatory effect and with biostimulating properties for treatment of burns, suppurative and infected wounds of different etiology and to a method for treatment above said diseases using the ointment said. The proposed ointment comprising bee wax and greasy basis comprises colophony additionally. As greasy basis the ointment comprises butter and vegetable oil in the following ratio of components, wt.-%: bee wax, 20-30; butter, 30-40; vegetable oil, 15-25; colophony, 15-25. Method involves applying ointment by thin layer 0.5-3 mm on dense cotton fabric, its applying to damaged site, keeping and removing ointment with change of bandage 1-3 times per 24 h for 3-14 days. Method provides enhancing the therapeutic effectiveness of ointment due to significant acceleration the healing process of suppurative wounds and insidious furuncles being the ointment doesn't cause irritating effect.
EFFECT: improved and valuable medicinal properties of ointment.
2 cl, 4 ex