Method for complex therapy of lower limbs' ischemia in patients with diabetes mellitus
FIELD: medicine, endocrinology, physiotherapy.
SUBSTANCE: the present innovation deals with introducing preparations of antioxidant, antiaggregate, antithrombotic and hypolipoedemic action as detralex and sulodexide along with the impact of low-intensity laser radiation (LILR) (at wave length of 0.97 mcm and power of 5-7 W). Moreover, LILR impact should be performed by contact since the 1st d of conservative therapy on projection of the main vessels of lower limbs in, at least, 2 o\points at every of them per 1-2 min/every point, and high-intensity laser radiation (HILR) impact should be carried out by contact-free technique from the distance of 1-3 cm for visually altered part of affected limb's skin in area of trophic disorders up to the border with intact tissue, beginning from toes towards talocrural joint and longitudinally towards knee joint, proximally up to the lower third of femur.
EFFECT: higher efficiency of therapy and decreased traumatism.
1 cl, 2 ex
The invention relates to medicine, namely to endocrinology and physiotherapy, and can be used to treat lower limb ischemia in patients with diabetes mellitus.
Known methods of treatment of vascular complications in diabetes mellitus by diet, medicines: antiplatelet agents, anti-hypertensive drugs, antioxidants, vitamins, and physiotherapeutic methods: UHF, electrophoresis with vasodilators, thermotherapy and others (see Balabolkin M.I. diabetes. M: Medicine, 1994, str-321).
All of the above methods have disadvantages, namely unstable effect.
There is a method of treatment of vascular complications in patients with diabetes mellitus, which consists in intravenous laser irradiation of blood helium-neon laser radiation power at the end of the light guide 2-5 mW, exposure time 30 minutes daily for 7 days (efferent Methods and quantum therapy in clinical practice. Izhevsk, 1995, str).
A significant drawback of this method is the fact that it applies only in the vascular complications of limb, and with other vascular complications (retinopathy, nephropathy, enteropathy, etc. is not applicable.
The known method the treatment of lower limb ischemia in patients with diabetes mellitus, is selected as the closest analogue is, includes conservative therapy involving the administration of drugs with antioxidant and antiplatelet effect combined with the effect of low-intensity laser radiation (see patent RU No. 2169539, IPC 7: A 61 N 5/067, publ. 27.06.2001,).
According to the authors of this method, it is possible to significantly improve the effectiveness of treatment and to prevent side effects.
This method consists in carrying out the preparation of laser therapy for 10-14 days in antioxidants (aevit) and antiplatelet agents (Teledom or chimes), then, continuing therapy with antioxidant and antiplatelet agents, conduct of intravascular laser irradiation of blood (ILIB) for 10-15 minutes, power on the end of the fiber is 0.8-1.5 mW, the treatment course of 8-10 sessions daily or every other day, used helium-neon laser.
However, this method is time-consuming, traumatic enough for this category of patients, requires additional preparation of the patient for the course of therapy, but most importantly, is not efficient enough.
Thus, the technical result for the solution of which this invention is directed, is to increase the effectiveness of treatment of lower limb ischemia in patients with diabetes and reducing its morbidity.
The specified technical result is achieved by those who, in the known method the treatment of lower limb ischemia in patients with diabetes mellitus, combining conservative therapy, which consists in the introduction of drugs with antioxidant and antiplatelet effects, with the effect of low-intensity laser radiation, according to the invention additionally conservative therapy involves intravenous drugs with antiplatelet and lipid-lowering effect, which is used as sulodexide, as a drug with antioxidant and antiplatelet action use Detralex, the effect of low-intensity laser radiation carried out contact with the 1st day of conservative therapy in place of the projections of the main vessels of the lower extremities at least 2 points on each of them for 1-2 minutes on each of the points using a laser with a wavelength of 0,890 μm with a capacity of 20-40 mW and additionally carry out contactless effect of high-intensity laser radiation on the skin of the affected limb, starting with the toes towards the ankle and longitudinally in the direction of the knee joint, proximal to the lower third of the thigh, using radiation with a wavelength of 0.97 μm with a capacity of 5-7 watts in continuous mode, and this impact is my only visually changed portion of the skin in the area of trophic disorders to the border with unmodified cloth.
This sulodexide is administered in the amount of 600 units/day for the first 14-21 days, then 30-40 days 250 units twice a day to 100.0 ml of physiologic saline, and Detralex administered 3,000 mg on the first day and 1000 mg on the second day until the end of treatment.
The authors experimentally established that it is the combination of conservative therapy, including the administration of the drug with antioxidant and antiplatelet action - Detralex, and the introduction of additional drug that has antiplatelet and lipid-lowering effect, namely, sulodexide, with the effect of low-intensity laser radiation on the claimed area, and high-intensity laser radiation on the claimed area contributes significantly increase the effectiveness of treatment.
Experimentally, the authors found that the use of only low-intensity laser radiation in the infrared range in the complex treatment of these patients can significantly improve the results of treatment. At the heart of pathogenic effect is the stimulation of blood flow in microvessels of the affected limb. Improvement of microcirculation of ischemic tissues contributes to their trophic and reduction of pain syndrome in patients with severe ischemia of the lower extremities. Changes in the microcirculation can serve as important is the second indicator, to verify the influence of laser radiation on tissue. The dynamics of the structural parameters of microcirculation in patients with peripheral occlusive arterial vessels of the lower extremities indicates the systematic stimulation of microcirculation in the above method of laser irradiation.
It was established experimentally that the additional effects of high-intensity laser radiation on the background of the application of the claimed drugs can significantly faster improve microcirculation and blood rheology.
Exposure to high-intensity laser radiation on the claimed area contributes to the warming of the treated tissue to a temperature of 40-50°that results in the first day to the disclosure of existing collaterali, and after 5-7 days to the formation of new blood vessels circulatory channel.
It was established experimentally that the combined effects of low-intensity and high-intensity laser radiation on the claimed area, and the introduction of the proposed drugs improves the transport of substances from the blood into the tissues, reduces the occurrence of hypoxia, a decrease of lymphostasis, reduce swelling, normalizes water-salt balance.
As a result of the treatment significantly increases the rate of volumetric blood flow in astonishment the limbs.
By the end of the first day visually improvement was observed in the affected limb until about mid-thigh, on the 2nd day - to mid calf, on the third day stop.
By the end of treatment angiography revealed an enlarged collateral vessels in the affected limb.
Joint use of drugs Detralex and sulodexide in combination with exposure to laser radiation helps prevent the appearance of free radicals, suppression of the activity system of a compliment, increase lymph flow, increase of oncotic pressure of lymph, and improving the frequency and amplitude of peristalsis lymphatic vessels, inhibition of leukocyte adhesion to the endothelium, prevents their migration into perevalne space and blocks the release of these toxic components, thus has a direct protective effect on microcirculation, provides anticoagulation venous-antithrombotic, antiproliferative, anti-sclerotic and antilipidemics activity.
In addition, and this is also confirmed experimentally, after treatment significantly improves carbohydrate metabolism and normal lipid metabolism, reduces the need for traditional antidiabetic drugs.
The authors experimentally found that the best results are achieved what I exactly when the claimed drug dosages and modes of the laser radiation and that when exposed to declare areas affected limb. The method is as follows. Patients with ischemia of the lower extremities with diabetes appoint conservative therapy, which consists in taking a drug that has antiplatelet and antioxidant - Detralex - 3,000 mg on the first day and second day 1000 mg / day until the end of treatment. Simultaneously with this drug the patient is prescribed a drug that has antiplatelet and lipid-lowering action - sulodexide in the amount of 600 units/day in the first 14-21 day, and then in the next 30-40 days 250 units 2 times per day on 100 ml of physiologic saline intravenously.
From the first day of taking these drugs the patient is prescribed the effect of low-intensity laser radiation on the projection of the main vessels in the affected limb. This impact exercise contact at least two points of each of the treated vessel for 1-3 minutes on each point. As laser radiation using radiation with a wavelength of 0,890 μm with a capacity of 20-40 mW. Additionally, after a session of laser therapy on the projection of the main vessels in the skin of the affected limb of the patient without contact from a distance of 1-3 cm effect of high-intensity laser radiation, starting from the toes towards the ankle and longitudinally toward the knee su is tabu, proximally to the lower third of the thigh, and is processed only visually affected part of the skin in the area of trophic disorders to the border with unmodified cloth. As laser radiation using radiation with a wavelength of 0.97 μm with a capacity of 5-7 watts in continuous mode.
The method is confirmed by the examples.
Example 1. Patient S. 67 years. He enrolled in the Department of vascular surgery, diagnosed with atherosclerosis obliterans of the lower limbs, occlusion crural artery to the right of the III degree Fantano. Diabetes mellitus, type 2, severe, insulin dependent. Diabetic micro-macroangiopathies.
The Department simultaneously with the achievement of full compensation of carbohydrate metabolism patient were treated by the present method.
Medical therapy included the appointment of the drug Detralex on the first day (3,000 mg (6 tablets on the first day) and 1000 mg (2 tablets) at the second day until the end of treatment and sulodexide 600 per day intravenously per 100 grams. physiologic saline.
From the first day of reception of the above medications the patient has made the processing of the affected limbs laser radiation.
The right limb was handled remotely from a distance of 1 cm high-intensity laser radiation with a wavelength of 0.97 μm 5 watt in the area of the foot (dorsal and plantar areas, IU the finger spacing), the lower third of the leg, processing visually changed portion of the skin in the area of trophic disorders to the border with unmodified fabric and low-intensity laser radiation in contact on space projections of major vessels in 2 points of each of them for 1 minute on each point. Used radiation with a wavelength of 0.89 μm 20 mW. Moreover, low-intensity radiation processed alternately right and left limbs.
The result of therapy on day 12 was a significant subjective improvement with disappearance of all complaints for the receipt.
Objective research methods (laser Doppler plumeria, evaluation of transcutaneous oxygenation) confirmed full normalization of microcirculation left and right, and improvement of microcirculation and tissue trophism right limb on 83,7% of the original (at receipt).
Observation of the patient in the dynamics revealed the preservation of a stable clinical effect within 18 months after the treatment in the hospital.
Example 2. Patient E. 64 years. The diagnosis of atherosclerosis. Stenosis of the iliac artery to the left. Occlusion prednamerennoe artery on the right. Ischemia of the extremities 2A right, 4A on the left. Diabetes.
Medication similar to example 1. From the first day of reception of drugs hurt the have produced the treatment the affected limbs laser radiation.
The right and left limbs were processed remotely from a distance of 3 cm high-intensity laser radiation with a wavelength of 0.97 μm, 7W power in the area of the foot (dorsal and plantar areas, interdigital intervals) lower third of the leg, processing visually changed portion of the skin in the area of trophic disorders to the border with unmodified fabric and low-intensity laser radiation on the locations of the projections of the great arteries 1-2 points each of them for 2 minutes on each point. As a low-intensity laser radiation used radiation with a wavelength of 0.89 microns with a capacity of 40 mW.
At 14 days there was a significant subjective improvement with disappearance of all complaints for the receipt.
Using objective methods of examination confirmed complete normalization of microcirculation to the right and to the left and to the improvement of microcirculation and trophism of the affected limbs in 87.1% of the original (at receipt).
Observation of the patient in the dynamics within 20 months revealed the preservation of a stable clinical effect.
1. The method of complex treatment of lower limb ischemia in patients with diabetes mellitus, combining conservative therapy, which consists in the introduction of drugs with antioxidant and antiplatelet effects, with impacts neither contentionem laser radiation, characterized in that it further conservative therapy involves intravenous drugs with antiplatelet and lipid-lowering effect, which is used as sulodexide, as a drug with antioxidant and antiplatelet effects, use Detralex, the effect of low-intensity laser radiation carried out contact with the 1st day of conservative therapy in place of the projections of the main vessels of the lower extremities at least 2 points on each of them, for 1-2 minutes on each of the points using a laser with a wavelength of 0,890 μm with a capacity of 20-40 mW, and additionally carry out contactless from a distance of 1-3 cm effect of high-intensity laser radiation on the skin of the affected limb, starting with the toes towards the ankle and longitudinally in the direction of the knee joint, proximal to the lower third of the thigh, using a laser with a wavelength of 0.97 μm with a capacity of 5-7 watts in continuous mode, and this impact only on visually changed portion of the skin in the area of trophic disorders to the border with unmodified cloth.
2. The method of complex treatment of lower limb ischemia in patients with diabetes mellitus according to claim 1, characterized in that the sulodexide designate is Alceste 600 units/day for the first 14-21 days then 30-40 days 250 units twice a day to 100.0 ml of physiologic saline, and Detralex administered 3,000 mg on the first day and 1000 mg on the second day until the end of treatment.
FIELD: medicine, obstetrics.
SUBSTANCE: the present innovation deals with treating light-degree gestosis. One should perform percutaneous laser irradiation of renal area at pregnancy terms being 30-33 wk at impulse power of 10 W and frequency of impulse sequence of 80 Hz. Laserotherapy course consists of about 7-10 procedures to be carried out daily. The method enables to interrupt gestosis symptomatology after therapy, decrease the risk for the development of severe forms of the present complication at terms of mature pregnancy and necessity in medicinal therapy and, also, achieve better perinatal results, that is, to increase the number of healthy babies born.
EFFECT: higher efficiency of therapy.
SUBSTANCE: the present innovation deals with treating cerebral diseases, Parkinson's disease being among them. One should measure biochemical and immunological blood values of a patient, the values of MAO-B thrombocytes activity, the values of erythrocytes activity, Cu/Zn - TFD, the level of neuromediators of glutamate and taurine in blood plasma and circulating immune complexes (CIC) in blood serum. To perform the impact with laser irradiation it is necessary to choose the patients with all, several or only one value in ranges given below: MAO-B 90-250 nM/mg or MAO-B 0-47 nM/mg, at the norm of 73+7 nM/mg, Cu/Zn - TFD 1.2-2.5 U/mg or Cu/Zn - TFD 0-0.8 U/mg, at the norm of 1.5 ± 0.05 U/mg, CIC low-molecular fractions 100-300 c.u., at the norm of 80 ± 5.0 c.u., CIC average-molecular fractions 48-150 c.u., at the norm of 39 ± 2 c.u., affected ratio of glutamate to taurine. Impact should be carried out intravenously with the help of a light guide at the power at its end being 1 mW and wave length of 632.8 daily for 5 d, every seance lasts for 20 min, then medicinal therapy should be fulfilled without laser impact by repeating the course of laser irradiation in a year. The method enables to increase the quality in treating Parkinson's disease due to stimulating the system of antiradical tissue protection, increased protective body reserves and correction of immune disorders.
EFFECT: higher efficiency of therapy.
FIELD: medicine, gynecology, oncology.
SUBSTANCE: the present innovation deals with treating pre-cancer pathology of uterine cervix in women with either bacterial or viral infection. One should affect the tissues of uterine cervix with low-intensity infrared radiation of semiconductor laser at wave length being 0.89 nm, frequency of 80 Hz, power of 6 W. Simultaneously, one should perform hypervenous blood photomodification in projection area of left elbow vein and sternum, per 2.5 min for every area. Hypervenous blood photomodification should be carried out with the help of a matrix emitter MLOK-6. Laser impact should be fulfilled due to application of "Mustang-bio" apparatus, emitting head LO-2 and a gynecological headpiece G-1.
EFFECT: higher efficiency of therapy.
2 cl, 1 ex, 1 tbl
FIELD: medicine, surgery.
SUBSTANCE: one should introduce solution "Rheamberin 1.5%"intravenously with infusomates at the dosage of 5 ml/kg/d during the next 5 d. Then, 1-2 h later, one should infuse intravenously "Dalargin" at 30 mg/kg/d dissolved in 60 ml 0.9% sodium chloride at the rate of 120 ml/h for 5 d. Additionally, 4-5 h after "Dalargin" injection it is necessary to perform daily intravenous He-Ne laser irradiation of blood beginning since the first day at wave length being 0.63 mcm, power 1 mW, exposure 50-60 min, course lasts for 5 d. The method enables to interrupt intestinal paresis in case of vertebral traumas and wounds in earlier terms.
EFFECT: higher efficiency of therapy.
FIELD: medicine, gastroenterology.
SUBSTANCE: laser therapy should be prescribed at differentiated mode. In case of primarily detected pathology or disease duration for under 10 years or rarely relapsing form and availability of pronounced pain syndrome cutaneous impact should be performed at wave length of 0.89 mcm, impulse power of 5-7 W, impulse frequency of 80-150 Hz, by contact-stable technique for standard fields of impact, impact time being 64-128 sec/field, about 10-12 procedures/course. In case of disease duration being above 10 years in elderly groups, at pronounced astheno-autonomic syndrome and at no or unpronounced pain syndrome one should conduct intravenous laser impact at wave length of 0.63 mcm, radiation power at the edge of a disposable intravenous light guide being 1-1.5 mW, duration of procedure being 20 min, 7 procedures/course. Combined method deals with daily successive intravenous and cutaneous impact according to the above-mentioned technique - in case of disease duration above 10 years, frequently relapsing form, availability of multiple or combined ulcers and availability of two or more parallel diseases. The method enables to decrease terms of hospitalization, decrease frequency of exacerbations and prolong remission period.
EFFECT: higher efficiency of therapy.
1 dwg, 2 ex, 2 tbl
FIELD: medicine, gynecology.
SUBSTANCE: one should perform surgical destruction of endometrioidal heterotopias, antibioticotherapy followed by hormone-modulating therapy. Moreover, it is necessary to irradiate blood through a monofilamentous quartz light guide introduced into patient's elbow vein with the help of He-Ne laser at wave length being 628 nm at 15 min duration during the first 5 procedures and for 30 min during 2 last procedures followed by prescribing GnRH agonists for 7 d at the background of antibioticotherapy, intake of analgetics and vobenzyme beginning since the 1st postoperative day.
EFFECT: higher efficiency of therapy.
SUBSTANCE: method involves detecting pathological changes and setting diagnosis. Biologically active points corresponding to the disease and points or zones of Zakharyin-Gedda with low electric resistance are determined. Constant action is first applied to them with DC intensity of 1-10 mcA. Electric stimulation intensity is increased to reach sensory response of a patient. Then, magnetic infrared laser therapy is applied.
EFFECT: enhanced effectiveness of treatment; accelerated treatment course.
SUBSTANCE: method involves introducing 0.1-2% aqueous solution of photosensibilizer agent of chlorine series. After accomplishing enucleation, scanning laser radiation of muscle funnel cavity is carried out. Muscle funnel cavity tamponade is done with two implant components. The implant is manufactured from carbon felt impregnated with photosensibilizing gel based on hyaluronic acid viscoelastic. The gel has 0.1-1 % by mass of photosensibilizer of chlorine series. The first implant component is placed at the beginning. Scanning laser radiation of muscle funnel cavity with the first implant component being arranged therein, is carried out during 2-4 min after 15-30 min long exposure away from light action. The second implant component is placed. Scanning laser radiation of muscle funnel cavity after 15-30 min long exposure away from light action is carried out in the same mode. Muscles are sutured. Soft tissues are sutured layer-by-layer. The postoperative space is drained. Sutures are placed on conjunctiva. Eye prosthesis is set and eyelids are sutured to each other. Photosensibilizer agent of chlorine series is repeatedly introduced into cubital vein of one of the arms. 5-15 min later, intravenous laser radiation treatment of blood is carried out via laser light guide introduced into cubital vein of one of the other arm, during 10-45 min with total power of 20-50 mW.
EFFECT: enhanced effectiveness of treatment; excluded soft tissue deformity in orbital region; reduced implant rejection and carcinoma cells metastasis and dissemination risk.
SUBSTANCE: method involves introducing 0.1-1% aqueous solution of photosensibilizer agent of porphyrin or hematoporphyrin series belonging to Photohem or Photophryne group at a dose of 2.5-5.0 mg/kg. After accomplishing enucleation, scanning laser radiation of muscle funnel cavity is carried out. Muscle funnel cavity tamponade is done with two implant components. The implant is manufactured from carbon felt impregnated with photosensibilizing gel based on hyaluronic acid viscoelastic from chealon, viscoate or hyatulon group. The gel has 0.1-1 % by mass of photosensibilizer of porphyrin or hematoporphyrin series belonging to Photohem or Photophryne group. The first implant component is placed at the beginning. Scanning laser radiation of muscle funnel cavity with the first implant component being arranged in it, is carried out during 2-4 min after 15-30 min long exposure away from light action. The second implant component is placed. Scanning laser radiation of muscle funnel cavity after 15-30 min long exposure away from light action is carried out in the same mode. Direct muscles are sutured. Soft tissues are sutured layer-by-layer. The postoperative space is drained. Laser light guide is introduced into cubital vein immediately after enucleation. Intravenous laser radiation treatment of blood is carried out during 10-45 min with total power of 20-50 mW.
EFFECT: enhanced effectiveness of treatment; excluded soft tissue deformity in orbital region; reduced implant rejection and carcinoma cells dissemination risk.
SUBSTANCE: method involves carrying out vitrectomy, retinotomy, exposing the intraocular neoplasm, surgically removing the intraocular neoplasm, smoothing retina with perfluororganic compound and substituting the perfluororganic compound with silicon oil. After having removed the perfluororganic compound, 10% ozonized Perfluoran emulsion having ozone concentration of 2-4 mg/l is intravenously introduced. Photosensibilizer agent is introduced into cubital vein of the same arm during 5-10 min. Intravenous laser radiation treatment of blood in 5-15 min after beginning photosensibilizer agent injection with wavelength corresponding to maximum light absorption value characteristic of the photosensibilizer agent within 10-45 min under radiation power required for activating photochemical process. Smoothing retina with perfluororganic compound being completed, separating endoscopic laser coagulation of retinotomy region is carried out with diode laser. 1-3 months later, ozonized Perfluoran emulsion, photosensibilizer agent and intravenous laser radiation treatment are repeatedly applied.
EFFECT: enhanced effectiveness of treatment; reduced risk of tumor cell dissemination.
FIELD: veterinary science.
SUBSTANCE: treatment should be carried out with an extract of walnuts of milk-wax maturity upon kerosene at addition of propolis and pollen perorally as compresses for 2-3 h followed by treating affected surface with mustard-gourd oil named "Volgogradskoe"; moreover, one should introduce perorally per 7-8 ml extract/5 ml liquid for milking twice daily. The present innovation enables to perform valuable body sanitation in more shortened period of time due to activation of immune system and restoration of metabolic body processes.
EFFECT: higher efficiency of therapy.
1 cl, 1 ex
SUBSTANCE: the present innovation deals with the ways for body purification and detoxication with the help of products of plant origin. The method includes preliminary period at additional survey for the presence of parasites followed by body purification due to curative starvation: during the first day a patient should apply nocturnal purifying enema, next morning - saline purgative preparation, then during the second and next day of starvation it is prescribed the intake of not less than 1-1.5 l water at daily application of purifying enemas for the whole period of starvation, and restorative period at applying juice-fruit-vegetable diet. Moreover, at the background of starvation, one should perform hepatic purification and that of gastro-intestinal tract along with body disinfection and withdrawal of parasites: at 7 p.m. during the 1st d of starvation a patient should apply 150 mg decaris, daily since the 1st d to the 7th d of starvation it is necessary to use decoctions of cholagogue, diuretic and antiparasitic herbal species. Since the 4th d of starvation one should add the intake of garlic decoction based upon milk, on the 3d, 5th, 7th d of starvation it is necessary to fulfill hepatic tubing at 7 p.m. after the intake of natural apple juice at 4 p.m., moreover, on the 3d d of starvation tubing should be conducted after the intake of vegetable oil in lemon juice, 4 times, on the 5th d - after the intake of cholagogue species, 4 times, on the 7th d - after the intake of purgative species with sorbitol. During the 1st d of starvation end one should perform parasitic disinfection due to the intake of acid milk whey to one's empty stomach, in 30-40 min -herring without bread, in 2 h - a glass of warm, sweet milk and application of purifying enema in 6-8 h. The method provides simultaneous restoration of affected body metabolism, hepatic purification and that of gastro-intestinal tract followed by withdrawal of parasites.
EFFECT: higher efficiency of body healing.
6cl, 2 ex, 1 tbl
FIELD: medicine, urology.
SUBSTANCE: at the background of curative starvation a patient should be prescribed for peroral intake of 100 ml tincture or 1 teaspoon tincture out of bees twice daily in the morning and in the evening, and, also, 200 ml hempseed decoction based upon milk twice daily in the morning and in the evening at the course of 5 d. On the 3d, 5th, 7th d of starvation one should perform hepatic and biliary ductal purification at 7 p.m. at the intake of 250 ml natural apple juice at 4 p.m., since the 1st to the 7th d of starvation one should daily apply enemas: in the morning - purifying enema with juice of 1 lemon, in the daytime - curative enema with Artemisia decoction. One should daily perform rectal prostatic massage followed by applying microenemas with 30 ml composition containing the tincture of Sophora, oil of wheat germs, decoction of medicinal plant of antiphlogistic action taken at weight ratio of 1:0.5:2, correspondingly, at the course of 10 d long. Duration of curative starvation lasts for 7 d, not less. The method provides shortened terms of therapy due to simultaneous normalization of body metabolic processes, purification of organs against bacteria and parasites.
EFFECT: decreased body allergization.
6 cl, 2 ex
FIELD: chemical technology.
SUBSTANCE: invention relates to a method for preparing biologically active sum of triterpene acids from fir wood greens. Method for preparing biologically active sum of triterpene acids from dried and milled fir wood green involves double extraction with organic solvent - isopropyl alcohol by infusion with raw in the definite conditions followed by treatment of extract with alkali agent an aqueous solution, acidification of an aqueous-alkaline extract and isolation the end product from its. Method provides effective enhancing the yield of biologically active sum of triterpene acids and to simplify the technological process.
EFFECT: improved method for preparing.
1 tbl, 4 ex
FIELD: pharmaceutical industry and technology.
SUBSTANCE: invention relates to methods for extraction of plant raw. Invention relates to a method for extraction being mainly the plant raw that involves milling the raw, extraction of raw with liquid and separation of the end product. Extraction and separation of phases are carried out by feeding dispersed gaseous flow to the high-gradient mass-exchange field taken in the definite ratio gas-liquid. High-gradient field is created by rotor-pulsation device and extraction of raw is carried out with purified water or ethyl alcohol, or purified water with addition of 25% solution of NH3. Method enhances effectively the yield of dry soluble substance in extract and percent of separating grist particles from extract.
EFFECT: improved method for extraction.
5 cl, 1 dwg, 3 ex
FIELD: pharmaceutical industry and technology, pharmacy.
SUBSTANCE: invention relates to the improved method for preparing dihydroquercitin. Invention involves preliminary separation of volatile nonpolar compounds with steam at rapid change of pressure from 0.1 to 0.3 MPa in reactor carried out before extraction stage and with reduced time of raw extraction being without milling wood under conditions of mild mechanical-chemical effect and without destruction of wood occurring in rapid change of pressure from 0.1 to 0.5 MPa using mixture of polar solvent with water or their mixtures as an extractant. Invention reduces extraction time in intensifying and optimization of the process of dihydroquercitin that provides reducing total time of process from 60-75 min to 7-9 min and to simplify technology in carrying out the process without milling wood.
EFFECT: improved method for preparing.
FIELD: medicine, infectious diseases, phytotherapy.
SUBSTANCE: method involves preparing, specific and rehabilitation steps of therapy. On the preparing step method involves using plant saltwort an aqueous infusion prepared by the definite manner and in the definite regimen followed by using milk thistle powder. On the specific step method involves using aspen bark 6% tincture in cognac in the dose 1 spoon, 2 times per a day for 1 month as an anthelminthic agent and tubing is carried out simultaneously, once per a week. On the rehabilitation step method involves using an aqueous infusion prepared by addition of 500 ml of boiling water to 1/2 glass of unpeeled oat seeds and by 15 g of dried apricots, raisin and honey and this infusion is used by the definite schedule. Then method involves using field artichoke leaves juice fresh extract as chofitol tablets by the definite schedule. Invention promotes to the complete healing body due to the complete sanitation of all organs and systems and recover of all its functions also. Invention can be used for treatment of chronic opisthorchiasis.
EFFECT: enhanced method for treatment.
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention elates to development of agent on the natural base used for recovery therapy. Agent for recovery therapy comprises bee bread, chitosan wild rose fruits powder, Fucus powder and a filling agent in the following ratio of components, wt.-%: bee bread, 30-50; chitosan, 9-15; wild rose fruits powder, 10-16.7; Fucus powder, 10-16.7, and filling agent, the balance. Agent is made as a tablet with mass 0.5 g or as a capsule with mass 0.3 g. Agent promotes to optimal function and full-value nutrition of human organs and tissues at the cellular level and normalizes metabolic processes also.
EFFECT: valuable medicinal and biochemical properties of agent.
SUBSTANCE: the present innovation deals with non medicinal body sanitation and could be applied to purify one's body against toxins due to the intake of cholagogue species and application of thermal procedures as daily baths and sauna. Moreover, purification should be conducted at salt-free vegetarian diet. Decoctions of cholagogue species should be prescribed a half hour before meals, for baths one should use brine sodium-chloride mineral water at bromine and iodine ions content, as for sauna it should be prescribed on the 1st, 2nd and 3d d. Moreover, additionally it is useful to prescribe abdominal massage on the 2nd, 3d and 4th d, intestinal enemas with herbal decoctions after breakfast on the 2nd, 3d and 4th d, after lunch on the 1st, 2nd and 3d d and tubing on the 4th d along with a honey-juice diet. On the 5th d after breakfast one should perform 2 intestinal enemas at 15-20-min-long interval. Course lasts for 6 d. The method could be supplemented with daily seances of phytoaromatherapy, spinal massage, training in swimming pool and curative physical culture. The method to normalize body functions due to restoring metabolism with natural factors at minimal quantity of contraindications.
EFFECT: higher efficiency of body purification.
4 cl, 3 ex
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to the development of agent for protection of body against effect of different factors of environment. The sanitation-prophylactic agent comprises the following components: bee wax, propolis, quartz sand and an alcoholic extract of medicinal vegetable raw consisting of sage, Saint-John's-wort, common wormwood, arborescent aloe, common immortelle, oak bark, mushroom Inonotus obliquus, peppermint and lovage. All components are enclosed into capsule that is opened from one side. Also, invention proposes a method for preparing sanitation-prophylactic agent that involves mixing components of agent, boiling and pouring into capsule. Agent is poured into capsule in two tightly adjoining layers being a layer containing a mixture of bee wax and sand is poured firstly followed by its cooling and applying a spiral picture by pressing in by deepness 0.5 mm and then the second layer containing a mixture of bee wax, propolis and alcoholic extract of medicinal vegetable raw is poured being height of the second layer is lower of upper rim of capsule by 1 mm. Thickness of each layer is 2-2.5 mm. Applying the capsule-enclosed agent provides protection of the human body against effect of environment factors being without effect on vitally important processes in the human body. Agent enhances working ability, improves sleep and reduces petulance.
EFFECT: improved method for preparing, valuable medicinal properties of agent.
4 cl, 1 tbl, 3 ex
FIELD: analytical methods in medicine.
SUBSTANCE: invention concerns hematological procedures and, in particular, can be used in heparin treatment practice. Method of invention is based on measuring rate of thrombin-mediated hydrolysis of a chromogenic substrate, thrombin having activity 0.5-0.6 unit/ml and chromogenic substrate being z-Ala0Ala-Arg-pNA·HBr.
EFFECT: extended assortment of home reagents, simplified preparation procedure, and increased sensitivity of method.
1 dwg, 3 tbl, 2 ex