Method for prophylaxis of post-operative wound complications and formation of pathological scars

FIELD: medicine.

SUBSTANCE: invention relates to a method for prophylaxis of post-operative complication of wounds and formation of pathological scars using the medicinal therapy. Method involves applying a napkin comprising the following components, mg/cm2: sodium alginate, 6.25; hydrocortisone acetate, 0.4; dimexide, 11.25; mexidol, 0.8; gentamycin, 0.15. Before applying the napkin is wetted and remained on wound for 1-3 days with periodical wetting 2-3 times per 24 h and control of wound region by ultrasonic method at least 3 times in a day and regions with structural damages are detected. Then napkins are applied on these regions with exceeding the surface area by 1-2 cm and with change in 2-3 days for 2-3 weeks. The proposed invention provides enhancing the prophylaxis effectiveness, reducing treatment time and prevents arising complications and pathological scars. Invention can be used for treatment of firearm wounds.

EFFECT: improved method for prophylaxis and treatment of wounds.

1 ex

 

The invention relates to medicine and can be used for treatment of gunshot wounds.

Gunshot wounds are characterized by a number histomorphologically features as in the initial stages of the flow of wound healing and the regeneration of epithelial histogenesis of the skin, connective dermis, adipose hypodermis, musculoskeletal and bone. After a gunshot wound in the tissues within 14-16 days remains expressed heteromorpha, leukocytic infiltration with parametricheskii changes, germination differenes connective tissue elements of the newly formed capillaries and perivascular cells, indicating a protracted course of wound healing compared to pellet injury, inhibition of reparative regeneration due to the extensiveness of the damage and primary infection. The resulting scar tissue is prone to hypertrophy with prevalence of connective tissue elements above the epithelium and in prevocalic tissues.

After the elimination of inflammation in the wound impose a prior-deferred, early or late secondary seams. Given the presence of a primary infection, tissue ischemia in the early postoperative period, a high risk of septic complications violation of epithelization process with the formation of hypertrophies them or keloid scars. Prevention of these undesirable complications and consequences of the wounded with gunshot injuries in the spotlight. In the postoperative period is draining wounds, topical treatment, preventive courses of antibiotic and restorative therapy.

Known way to prevent postoperative complications of wounds and formation of pathological scars, including drug therapy (the Use of the new medical complex with purulent-necrotic complications of combat gunshot wounds”, abstracts of the II International conference “Modern approaches to the development of effective dressing devices, suture materials and polymer implants”, M, - 1995, 149-151 C., prototype)

This method involves the application of physical and chemical asepsis - ultrasonic cavitation (ultrasonic testing) antisepticise mixture: gentamicin, dioxidine, solcoseryl, turrilites (“GDT”)

The disadvantage of this method is that its application requires special equipment and trained personnel. When prevention in a known manner, the formation of the side effects, which themselves can cause complications. For example, ionization of water under the action of ultrasound is not only in microbial cells, but in cells wounds che is owaka with eventual death, what is especially dangerous for gunshot wounds.

In addition, the installation intracranial dialysis tube can exacerbate the suppurative process, to promote the formation of fistulas. After ultrasonic inspection “GDT” the subsequent wound closure is one of the kinds of bands that lengthens the time of ligation, increases the cost of treatment.

The present invention is to remedy these disadvantages, increased efficiency and reduction in terms of prevention through local non-invasive summarizing complex pharmaceuticals) and prevent complications.

To solve this problem in the way to prevent postoperative complications of wounds and formation of pathological scars, including drug therapy, a drug therapy to apply therapeutic napkin containing sodium alginate 6.25 mg/cm2, hydrocortisone acetate 0.4 mg/cm2, dimexide of 11.25 mg/cm2, Mexidol 0.8 mg/cm2, gentamicin 0.15 mg/cm2and before applying the cloth to moisten, to be left in place for 1-3 days, periodically wetting 2-3 times a day, and to control when the wound area using ultrasound at least 3 times a day, to identify areas of structural damage, after which swipe to impose on these areas with excess space at 1-2 cm from Smena is 2-3 days for 2-3 weeks.

The significance of these characteristics is confirmed by the fact that the local summarize the necessary PL to the wound reduces the risk of unwanted effects and complications (allergies, potential toxic effects and so on)that can develop in the systemic use of these drugs. The creation of the hearth injury (gunshot wound) required concentration protivoekssudativnym, antihistamines, antimicrobials and antioxidants through the use of appropriate medical wipes helps to normalize course of wound process, creates conditions for wound healing at the optimum time with the formation of normotrophic scars.

We offer anti-inflammatory napkin to treat wounds on the stage of formation of the scar consists of atraumatic hydrophilic base coated with a mixture of PL: the gel of sodium alginate 6.25 mg/cm2, hydrocortisone acetate 0.4 mg/cm2, dimexide of 11.25 mg/cm2, gentamicin 0.15 mg/cm2.

The proposed combination of drugs improves microcirculation, stimulates regenerative processes in the wounds. The combination of all these qualities provides a napkin broad indications for use in the treatment of gunshot wounds and their consequences as prevention is the first tool in the postoperative period after imposition of secondary sutures, to care for hypertrophic scars during their maturation, as well as for the treatment of wounds, when there is a risk of formation of keloid zone. Monitoring of the wound area using ultrasound allows to determine its status and to put napkins in the appropriate places.

The method is as follows.

On sutured secondary sutures the wound or pathological scar tissue, a visible inflammatory and degenerative changes in 24-72 hours impose anti-inflammatory therapeutic napkin containing gel of sodium alginate 6.25 mg/cm2, hydrocortisone acetate 0.4 mg/cm2, dimexide of 11.25 mg/cm2, gentamicin 0.15 mg/cm2. Technology of production of cloth similar to that used for the production of napkins “Kreteks” (Oltarzhevsky N “Theoretical fundamentals and technology of obtaining medical textile materials with tailored properties”. Abstract. Diss. doctor of technical Sciences, St. Petersburg., 1996, p.3-44), and consists in printing on textile-based compositions containing biocompatible polymer is sodium alginate in the form of a gel and dispersed therein the above-mentioned drugs. Moreover, the feature of the manufacturing process wipes is that, in the composition it is possible to enter essentially any medications on a process diagram. After NAS is the basis of a viscous composition on a textile basis, drying and sterilization is obtained medical napkin with prolonged (up to 2-3 days) anti-inflammatory action. Moreover, before applying a cloth moistened, which ensures penetration of drugs, and leave in place for 1-3 days, periodically wetting 2-3 times a day, constantly maintaining a uniform penetration of drugs.

Then the wound area at least 3 times a day (2, 4, 6 days) depending on the characteristics of the course of wound healing and scar-tissue formation control ultrasound and determine the area of structural damage, swelling, presence and rasprostranennosti destructive degenerative changes, excessive accumulation of fluid and its density. Then the cloth is put on zainteresovannoy area so that it overlaps the wound and the whole area of pathological changes prevocalic tissues with capture at least 1-2 cm, which is associated with the penetration depth of drugs and napkins into the underlying soft tissue. This towel are changed every 2-3 days to restore the structure of the tissues in the wound and around it with the formation of normotrophic scar in the damaged area, setbacks, signs of lymphoid swelling and destruction. The course of treatment is 2-3 weeks.

Example 1.

Patient K., 29 years passedst what s mine explosive wounds of the lower extremities. Atopiceski false joint, chronic osteomyelitis of the right femur, active form, aggravation. Post-traumatic neuropathy of the right sciatic nerve. Extensive izjazvlenija hypertrophic scars of the knee joints and the back surface of the right thigh, the right ankle and right heel region. The patient was performed necrsequestrectomy. Resection of false joint, the right femur osteosynthesis rod device for external fixation. After excision of the pathological granulations, remove, sequester, the treatment of wounds outer surface of the right thigh on her after 14 days superimposed secondary seams. After surgery, the wound is closed with stitches hydrated offer napkins, blocking not less than 2 cm on both sides. In the subsequent change of cloths produced once in 2 days, controlling the course of the wound process clinically, visually and by ultrasound conducted at 2, 4, 6 days after surgery. In the rear-outer thigh at a distance of 5 cm from the wound diagnosed with excessive fluid accumulation, swelling of the soft tissues with the violation of their structure. Performed biopsy of the lesion accumulation of fluid received 15 ml of serous content. The wound and the area of destructive changes with lymph edema closed offer napkins with what revisionism its square is 2 cm This wipes watered 2 times a day, changing every 2 days for 10 days. At 8 days after surgery inflammation cropped, the wound healed with education magkoelasticna scar, the sutures were removed on day 15 after the secondary surgical treatment. To care for hypertrophic scars on both knees, right ankle and right heel region, edema of inflammation in this area have used wipes anti-inflammatory on the above scheme. The inflammation regressed within 2 weeks from the start of treatment and preventive measures.

The use of this invention will increase the effectiveness of prevention, reduce the time of treatment prevents complications and pathological scars.

The way to prevent postoperative complications of wounds and formation of pathological scars, including drug therapy, characterized in that the quality of drug therapy therapeutic use cloth containing sodium alginate 6.25 mg/cm2, hydrocortisone acetate 0.4 mg/cm2, dimexide of 11.25 mg/cm2, Mexidol 0.8 mg/cm2, gentamicin 0.15 mg/cm2and before applying the cloth moisturizing, leave in place for 1-3 days, periodically wetting 2-3 times a day, and control while the wound area using ultrasound at m is PE 3 times a day, identify areas of structural damage, after which the cloth put on these areas with excess space at 1-2 cm from the change in 2-3 days for 2-3 weeks.



 

Same patents:

FIELD: medical engineering.

SUBSTANCE: material has base containing substance of therapeutic activity like acetylsalicylic acid covering base surface as monolayer with coverage degree being equal to 20- 30%. Base material is polypropylene or polyamide. Articles like surgical swaddling cloths and suture threads are manufactured from the material.

EFFECT: wide range of functional applications; reduced risk of adverse side effects.

6 cl, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: means is composed of spherical and close-to-spherical 500-3000 mcm large microgranules. Microgranule matrix has at least one cross-linked polymer and fillers. The cross-linked polymer is taken as sodium alginate, or gelatin, or pectin, or carraginan, or agar-agar, or sodium salt of carboxycellulose, or copolymer of acrylic acid and butylacrylate, or their mixtures. The fillers are hyperosmolar, antiseptic, anesthetic and, when required, antioxidant compounds. Method involves placing microgranules into pyoinflammatory lesion focus through postoperative or fresh wound. Wound cavity space is filled with microgranules to not more than one-half of its volume. Then the wound is drained and covered with antiseptic bandage. The granules and bandage are changed once a day during 2-3 days.

EFFECT: enhanced effectiveness of treatment; prolonged drug concentration support in wound.

6 cl,1 tbl

The invention relates to medicine, namely to new medications intended for the treatment of wound surfaces, and methods for their preparation

Rescue blanket // 2210389
The invention relates to pharmaceutical industry and relates to medical devices, in particular materials that are used as antiseptic coating for wounds of various etiologies, means of transportation to transfer patients in emergency, protective burns funds and auxiliary funds in cases of explosion and fire hazard

The invention relates to medicine, namely to the device for insertion through the skin of the two active principles are (I and II), contains two sections (a and b), from which section a contains a basis, including the active principle I, section b contains a basis, including the active principle II, and both bases covered with protective films a and a', respectively, which may be the same or different in nature

The invention relates to medicine and can most effectively be used to treat wounds, burns, ulcers, bedsores, treatment pustular and trophic lesions of the skin and subcutaneous tissue, frostbite, and first aid with prolonged therapeutic effect

The invention relates to medicine, namely to the adhesive polymer matrix applied to the device for percutaneous introduction of progestogenic, and this matrix is composed of a single layer (2) or the following sequential layers: if necessary, layer (1), called anchoring, formed of silicone polymer; a layer (2) formed of silicone polymer enriched Trimegestone and/or one or more pharmaceutically acceptable derivatives and, if necessary, a plasticizer; if necessary, the layer (3), called adhesive formed of silicone polymer

The invention relates to medicine, namely to devices and devices for leading drugs in the wound cavity, for the treatment of proctologic (hemorrhoids, proctitis, fissures) and vaginal (Kolpa) diseases

Hemostatic bandage // 2200583
The invention relates to medicine, specifically to dressing tools used to stop the capillary, diffuse parenchymal hemorrhage, used for closing the bleeding wounds

FIELD: medicine; medical engineering.

SUBSTANCE: means is composed of spherical and close-to-spherical 500-3000 mcm large microgranules. Microgranule matrix has at least one cross-linked polymer and fillers. The cross-linked polymer is taken as sodium alginate, or gelatin, or pectin, or carraginan, or agar-agar, or sodium salt of carboxycellulose, or copolymer of acrylic acid and butylacrylate, or their mixtures. The fillers are hyperosmolar, antiseptic, anesthetic and, when required, antioxidant compounds. Method involves placing microgranules into pyoinflammatory lesion focus through postoperative or fresh wound. Wound cavity space is filled with microgranules to not more than one-half of its volume. Then the wound is drained and covered with antiseptic bandage. The granules and bandage are changed once a day during 2-3 days.

EFFECT: enhanced effectiveness of treatment; prolonged drug concentration support in wound.

6 cl,1 tbl

FIELD: medical engineering.

SUBSTANCE: material has base containing substance of therapeutic activity like acetylsalicylic acid covering base surface as monolayer with coverage degree being equal to 20- 30%. Base material is polypropylene or polyamide. Articles like surgical swaddling cloths and suture threads are manufactured from the material.

EFFECT: wide range of functional applications; reduced risk of adverse side effects.

6 cl, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to a method for prophylaxis of post-operative complication of wounds and formation of pathological scars using the medicinal therapy. Method involves applying a napkin comprising the following components, mg/cm2: sodium alginate, 6.25; hydrocortisone acetate, 0.4; dimexide, 11.25; mexidol, 0.8; gentamycin, 0.15. Before applying the napkin is wetted and remained on wound for 1-3 days with periodical wetting 2-3 times per 24 h and control of wound region by ultrasonic method at least 3 times in a day and regions with structural damages are detected. Then napkins are applied on these regions with exceeding the surface area by 1-2 cm and with change in 2-3 days for 2-3 weeks. The proposed invention provides enhancing the prophylaxis effectiveness, reducing treatment time and prevents arising complications and pathological scars. Invention can be used for treatment of firearm wounds.

EFFECT: improved method for prophylaxis and treatment of wounds.

1 ex

FIELD: chemico-pharmaceutical industry.

SUBSTANCE: the method deals with controlling the flow of penetrants through easily adaptable semi-permeable porous barrier, it, also, deals with a plaster containing penetrants suspended in polar liquid in the form of liquid drops, moreover, it refers to the set containing the composition including penetrants dispersed in polar liquid and, also, the way of introducing the composition containing penetrants dispersed in polar liquid into the body of mammals or plants. The innovation enables to obtain medicinal form at controlled release of active substance and its application as a plaster to introduce medicinal preparation.

EFFECT: higher efficiency.

92 cl, 14 dwg, 4 tbl

FIELD: medicine, in particular, production of medicinal and hygienic diapers used, for example, for applying of liquid protective or medicinal preparations onto skin surface.

SUBSTANCE: method involves preliminarily preparing blank by extending several layers of gauze of desirable width; longitudinally placing gauze in layer-by-layer manner and cutting; performing additional placing of gauze in layer-by-layer manner in transverse direction; processing by sterilizing and/or impregnating with protective or medicinal preparations.

EFFECT: provision for producing of diapers ensuring impregnation thereof with sufficient amounts of medicinal preparations, such as liquid protective and medicinal means, and convenient usage for treatment of skin surfaces.

4 cl, 2 dwg

Dressing material // 2270646

FIELD: medicine, in particular dressing materials based on polymeric hydrogel coats.

SUBSTANCE: dressing material contains polymer film with polymeric hydrogel layered on the surface thereof. Said film is made of biocompatible optically transparent polymer having open holes with diameter of D = 0.01-3.0 mum and density of N = (103-109) 1/cm2, and polymeric hydrogel contains chitosan hydrogel. Dressing material of present invention prevents microorganism infiltration into wound and may be easily attached to wound surface.

EFFECT: improved dressing material with bacteriostatic action.

24 cl, 4 dwg, 8 ex

FIELD: medical engineering.

SUBSTANCE: device has textile cotton stockinet of 110-210 g/m2 saturated with aqueous solution of polyethylene glycols having molecular weight of 200-2000 and antiseptic and anesthetic drugs. Substrate bears polyethylene glycols 10-50 mg/cm2; antiseptics 0.03-1.0 mg/cm2; anesthetics 0.05-1.2 mg/cm2. Sorption layer is produced above the treatment layer, the former being fabricated from nonwoven fabric to secure bandage sorption power at the level of 10g/g. Textile drug carrier is optionally cotton gauze of 150-250 g/m2 and mesh dimensions of at least 1.5x1.5 mm. Chlorhexidine, Furagin, Iodopironum, povidone-iodine, Quinosol, or Dioxidine are taken as the antiseptic drugs. Lidocaine, Dicaine, Anylocine, and Trimecaine are taken as the anesthetic drugs. Fabric perforation is produced as through canals which total area makes up 20-40% of the whole treatment layer area.

EFFECT: improved sorption and atraumatic features.

5 cl, 1 tbl

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to porous spongy cellulose material for its using in treatment of wounds and/or burns. Cellulose material comprises zinc, copper, selenium and/or iron bound with the matrix material and/or absorbed on its in the amount providing granulation and revascularization processes of the wound base wherein the amount of zinc, copper, selenium and/or iron is at least 0.1 mcg/g of dry material. The porous spongy cellulose material is effective by consumptions for its preparing and can be used easily in treatment of wounds and/or burns.

EFFECT: enhanced effectiveness and valuable medicinal properties of material.

12 cl, 3 ex

FIELD: medicine, in particular gynecology.

SUBSTANCE: claimed filler contains 1 % hydrogel of chitosan with molecular mass of 300-700 kDa and deacetylation ratio of at least 89 %, as well as metronidazole and dioxydine; and 1 l of composition contains (g): dry chitosan chlorohydrate 10; metronidazole 1.250-1.665; dioxydine 2.5; and balance: distilled water. Method for filler production includes stirring of 10 g dry chitosan chlorohydrate in 300 ml of distilled water heated up to 50°C for 20-30 min until full dissolution. Then gradually under intense agitation 250-333 ml of metronidazole for intravenous injection is added, mixture is thoroughly stirred for 5 min, further gradually under intense agitation 250 ml of 1% dioxydine solution is added, mixture is thoroughly stirred for 10 min and packed in container made of dark glass or plastics for storage. Methods for treatment of female genitals diseases by using absorbent articles containing filler of present invention also are disclosed.

EFFECT: non-toxic filler with prolonged antiinflammation and antibacterial effects.

3 cl, 3 tbl

Absorbing product // 2287349

FIELD: medicine, hygiene.

SUBSTANCE: the present innovation deals with an absorbing product chosen out of the group consisted of a hygienic shield and a protective product indicated to be applied between large and small pudendal lips and in case of menstruations, moreover, it is useful to introduce pharmaceutical substance. The latter is efficient for treating, weakening and/or preventing pre-menstrual syndrome. The product consisted of an absorbing body and has got, as a rule, prolonged shape. The product has got the first surface facing the consumer, and the second surface which should face opposite side. The first surface is, at least, partially covered with therapeutic system for transdermal injection that contains a compound being efficient for treating and/or preventing pre-menstrual syndrome, moreover, while applying the present product it occurs the transdermal introduction of the consumer's compound for the user in modified product.

EFFECT: higher efficiency.

6 cl, 5 ex, 2 tbl

Up!