Apparatus for defrosting of cryogenically preserved bioproduct

FIELD: heat-exchanging equipment used in medicine, in particular, in blood transfusion stations.

SUBSTANCE: apparatus has screened working chamber and cylindrical vessel made from dielectric material and located inside working chamber for rotation by means of electric engine, and temperature sensors connected to control unit. Netted container of dielectric material is provided with openings formed in bottom and wall. Dielectric used has low melting temperature and is adapted for filling of cylindrical vessel, netted container and for surrounding non-metal container filled with bioproduct to be defrosted. Temperature sensors are located inside netted container in the vicinity of non-metal container. Additional emitter with microwave energy source is positioned at opposite side with respect to first emitter and is connected to control unit. Control unit output is coupled to temperature regulator, which is connected to heating members placed inside dielectric material in lower part of cylindrical vessel.

EFFECT: increased efficiency and provision for uniform distribution of temperature through the entire volume of bioproduct under defrosting process.

4 cl, 1 dwg

 

The invention relates to the field of medical equipment and can be used in blood transfusion stations, offices of blood transfusion, surgical and intensive care units in hospitals and clinics, as well as in scientific and medical research institutions.

The known device for thawing cryopreserved product - blood (see Water baths type R-01262-17 and R-201-10. The company's catalog Valtex International Corporation, 1999-2000, 67,70 and utility model U1 20243, class a 61 K 35/14, 27.10.2001). The devices contain a bath with a coolant (water) and heating elements. Thawing of cryopreserved product - blood (or bio) is carried out by heating water heating elements and heat transfer through the water containers with thawed products. To reduce the time defrost is used, the mixing of the water in the tub.

The disadvantages of these devices are long-time defrost and poor device performance.

In recent time for thawing cryopreserved product blood began to use a device that uses microwave energy. A device for thawing cryopreserved product - blood (see US 4503307, class a 61 M 1/03, 05.03.1985), in which the heat transfer is carried out in an active way, by influencing what and thawed product to microwave energy. The device is a metal duct for placing the container with the thawed blood, having a bottom, sides, and the metal cover. The box is mounted on the rotary tray inside the microwave oven. In the lid and bottom box with holes for the passage of microwave radiation. Along holes installed radiation absorbent strips and reflecting it to the container with blood. Holes allow microwave energy to concentrate on the most part of the container with blood, while the edges of the container are protected by a metal box.

A disadvantage of the known device is the low precision temperature control defrosting. The closest device is a device for thawing cryopreserved organic food products in a non-metallic container containing a shielded the working chamber and the cylindrical vessel made of a dielectric material, made with the possibility of rotation from the electric motor, a source of microwave energy emitter, the temperature sensors connected to the control unit (see US 3427422, CL N 05 9/00, 11.02.1969).

A disadvantage of this device is a long time defrost, poor performance and lack of uniformity of temperature on the volume of RA is marivaudage product.

The technical result, which is aimed invention is to eliminate the above disadvantages and create devices that provide high speed defrost when the uniformity of temperature on the volume of thawed organic food products and, thus, ensuring its viability.

This technical result is achieved in that a device for thawing cryopreserved organic food products in a non-metallic container containing a shielded the working chamber and the cylindrical vessel made of a dielectric material, made with the possibility of rotation by an electric motor, a temperature sensor connected to the control unit, the first output of which is connected to a source of microwave energy emitter contains a mesh container with holes in the bottom and walls, installed inside a cylindrical vessel, a dielectric with a low melting point, an additional source of microwave energy emitter and heating elements for heating the dielectric and temperature controller, and the dielectric fills the cylindrical vessel and the mesh container and surrounds a non-metallic container of thawed cryopreserved by the bioproduct, the temperature sensors placed inside catchtag the container near non-metallic container, additional emitter with a source of microwave energy is located on the opposite side of the cylindrical vessel relative to the first emitter and connected to the second output of the control unit, the third output of which is connected to the temperature controller, which is connected to the heating elements installed in the dielectric in the lower part of the cylindrical vessel.

The technical result is also achieved by the fact that the ratio of the area of holes in the bottom of the mesh container to the total area of holes in the walls is at least two to one.

The technical result is also achieved by the fact that as the dielectric used one of dielectrics from a range of paraffin wax, stearin, ceresin.

The drawing shows a schematic diagram of a device for thawing cryopreserved organic food products.

Device for thawing cryopreserved bio contains shielded the working chamber 1 and the cylindrical vessel 2 of a dielectric material made with the possibility of rotation by an electric motor 3, two sources of microwave energy with 4 emitters 5, the temperature sensors 6, connected to the control unit 7, a mesh container 8 of dielectric material with holes in the bottom and walls, installed inside a cylindrical Souda, the insulator 9 with a low melting point, the heating elements 10 for heating the dielectric and temperature controller 11, and the dielectric fills the cylindrical vessel and the mesh container and surrounds a non-metallic container 12 with thawed cryopreserved by the bioproduct, the temperature sensors placed inside the mesh container near non-metallic container. The first emitter with a source of microwave energy connected to the first output control unit, additional emitter with a source of microwave energy is on the opposite side of the cylindrical vessel relative to the first emitter and connected to the second output of the control unit, the third output of which is connected to the temperature controller, which is connected to the heating elements installed in the dielectric in the lower part of the cylindrical vessel.

The operation of the device for thawing cryopreserved bio is as follows.

Cryopreserved product can be frozen blood plasma, human organ or tissue, placed in a non-metallic container 12. The device allows you to put in mesh container 8 are either one or several non-metallic containers 12.

Non-metallic container 12 with defrosted cryomancer is a new bioproduct is placed in the dielectric, which fills the cylindrical vessel 2 and the mesh container 8. The dielectric is selected from a range of products that have a low melting point, for example, from a number - paraffin, stearin, ceresin.

Include electric power control unit 7, which respectively includes a motor 3, providing circulation of the dielectric cylindrical vessel 2 (connection not shown). When this dielectric penetrates through the holes in the bottom and walls of mesh container, washing non-metallic container 12 with thawed cryopreserved by bioproduct. Experiments have shown that the best results washer nonmetallic container when choosing a dielectric from a number - paraffin, stearin, ceresin are obtained when the ratio of the square holes in the bottom of the mesh container to the total area of holes in the walls, at least two to one.

The control unit 7 at the same time includes two sources of microwave energy with 4 emitters 5, which provide a rapid dielectric heating. The location of emitters of microwave energy on opposite sides of the cylindrical vessel allows to provide a more uniform heating of the dielectric that is located inside of the cylindrical vessel 2. The radiation power, as well as temperature setpoint defrost, depending the spine of the characteristics of thawed cryopreserved product, set by the control unit.

The device uses a property of a dielectric with a low melting point when heated to have a plot with a constant temperature. During heating of the dielectric on the plot of the phase transition temperature is kept constant.

When the temperature measured by the sensors 10, the setting range, the control unit enables or disables the temperature controller 11, which respectively includes heating elements.

Heating system - cooling can be performed in a unit of a semiconductor thermopile (elements Pelite), providing heating and cooling depending on the polarity of the supplied voltage to them. The temperature controller can be either stationary or analog. The control unit may be performed on the elements of logic or microprocessor and can be synthesized using methods known before the priority date of the invention, see Stalin CENTURIES and other digital devices Design on single-chip microcontroller, M., Energoatomizdat, 1990. Actually this block is executed on the microprocessor of the type AT 89S 8252 ATMEL, see Catalog “Microcon” Electronic components for developers, Moscow, publishing house of Microcon, No. 2, 2002, p.9-10.

The simultaneous use of a dielectric with a low melting point p and the heat, uniform mixing of the dielectric by its passage during rotation of the cylindrical vessel through the holes in the mesh container and placing of sources of microwave energy on two sides allow for high-speed thawing with the uniformity of temperature on the volume of thawed organic food products and, thus, to ensure its viability.

1. Device for thawing cryopreserved organic food products in a non-metallic container containing a shielded the working chamber and the cylindrical vessel made of a dielectric material, made with the possibility of rotation by an electric motor, a temperature sensor connected to the control unit, which is connected to a source of microwave energy emitter, characterized in that it contains a mesh container with holes in the bottom and walls, installed inside a cylindrical vessel, a dielectric with a low melting point, an additional source of microwave energy emitter and heating elements for heating the dielectric and temperature controller, and the dielectric fills the cylindrical vessel and the mesh container and surrounds non-metallic container of thawed cryopreserved by the bioproduct, the temperature sensors placed inside the mesh is on the container near non-metallic container, additional emitter with a source of microwave energy is located on the opposite side of the cylindrical vessel relative to the first emitter and connected to the control unit, the output of which is connected to the temperature controller, which is connected to the heating elements installed in the dielectric in the lower part of the cylindrical vessel.

2. The device according to claim 1, characterized in that the ratio of the area of holes in the bottom of the mesh container to the total area of holes in the walls is at least 2:1.

3. The device according to claim 1, characterized in that the dielectric is applied to one of the dielectrics of a range of paraffin wax, stearin, ceresin.



 

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