Method for production of healthful and therapeutic composition based on plant raw materials

FIELD: chemical and pharmaceutical industry, in particular method for production of healthful and therapeutic composition based on plant raw materials.

SUBSTANCE: claimed method includes separate preparation of fine dispersed powder of at least one plant with crushing degree of 10-200 mum; separate extraction of at least one plant with aqueous ethanol in ratio raw material/extractant from 1:5 to 1:20, respectively; separate preparation and optionally concentration of at least one plant juice followed by blending of obtained powder, extract and juice in ratio of (1-20):(9-90):(9-90), respectively.

EFFECT: new healthful and therapeutic composition with increased content of vitamins, proteins, carbohydrates, flavonoids, etc. and improved action on organism.

4 cl,4 ex, 1 tbl

 

The invention relates to chemical-pharmaceutical industry, namely, to create a therapeutic and prophylactic compositions based on medicinal plants.

We know a lot of compositions based on vegetable raw materials and methods for their preparation. All of them consist in the extraction of biologically active components of various extractants with the possibility of intensification of the process of extracting various physical methods and means. All known methods aimed, as a rule, to extract from a plant of certain biologically active substances to the detriment of other substances of a plant.

A method of obtaining a composition of herbs for the treatment of gynecological diseases at the request of the Russian Federation No. 2001108465, which includes:

a) preparation of a coarse powder of herbs Saraca indica, Emblika officinalis, Terminalia chebula, Terminalia belerica, Zingiber officinale, Cyperus rotundus, Pterocarous santalimus, Beriberis aristata, Cuminum cyminum, Adhatoda vasika, Nelumba nucifera and Piper longum, extraction of specified coarse powder a highly polar solvent, preferably, a sufficient amount of water to obtain decosta, filtering this decoct and collecting a filtrate storage tank, concentrated total filtrate to the state of dry powder;

b) separate cooking coarse powder of herbs Symplocos racemosa, Woodfordia fruticosa and Mangifera indica, the extraction of this coarse is orosco mixture of solvents, includes water and an organic solvent, preferably an alcohol, in a ratio that ranges from 1:9 to 9:1 to obtain an extract, the concentration of the extract;

C) extraction of the juice of the leaves of one or more than one herb selected from the group comprising spinach (Spinacia oleracea), amaranth (able to provide spp.), Egyptian clover (Trifolium alaxandrum) and Chinese Vigna (Vigna sinensiss), and separation of the protein in a suitable way, preferably by heating of the juice at a temperature of 40-100°followed by filtration and drying the coagulate with the aim of obtaining plant coagulate, blend of extracts obtained in stages a) and b), and plant coagulate obtained in stage C) with the aim of obtaining herbal composition of the present invention.

As is known, biologically active substances included in the composition of plants depending on their nature, are extracted by different extractants (water, alcohol, oil etc). In addition, there are such substances are better preserved in the dried plant as other ways to retrieve their ruin. It is also known that in the most intact, biologically active substances contained in the freshly prepared juice.

In connection with a variety of biologically active substances there is no single way to save in the end is the product all substances of the living plants. Therefore, any of the known methods of preparation of compositions based on vegetable raw materials has its drawbacks, as extracts from plant material only certain types of biologically active substances. However, there is a need for industrial manufacturing of such products, in particular biologically active additives to food, which would be preserved as much as possible of biologically active substances of the original plant materials.

The task of the group of inventions is the creation of new products and the development of a retrieval method that allows you to migrate in the final product as much as possible of biologically active substances from the original plant materials.

The technical result - obtaining a new product that preserves the most unaltered whole complex of biologically active substances of the raw materials, i.e. the product of the approximate composition to a live plant and suitable for long term storage.

The problem is solved in that the received curative-preventive composition, characterized in that it is a mixture of powder, aqueous-alcoholic extract and the juice of one, or more than one plant, the ratio of powder, extract and juice is (1-20):(9-90):(9-90), respectively, and the crushing of the powder is and is 10-200 μm, and characterized in that it is made in the form of a solution, powder, tablets or capsules.

The task is solved in that a method for obtaining compositions based on vegetable raw materials, including the preparation of a fine powder of one or more than one plant with grinding 10-200 μm; separate extraction of one or more than one plant water ethanol at the ratio of raw material:extractant from 1:5 to 1:20, respectively; separate cooking and, optionally, the preservation of the juice of one, or more than one plant; followed by mixing the resulting powder, extract and juice in the ratio (1-20):(9-90):(9-90), respectively.

In addition, to solve the problem, the resulting composition may insist 1 30 days, then filter and dispensed into vials or obtained composition can be concentrated and dried, then capsulerebel or tablet.

The closest analogue (prototype) of the prior art could not be detected. The difference of the proposed method from the above-described method according to the proposal of the Russian Federation No. 2001108465 is that

- similar at different stages take different herbs and is extracted from them in different ways specified BAS, and the proposed method at all stages of processing are subjected to the same type of plant (or the same kinds of age what th) to extract the different ways the whole complex of active substances of a plant;

- there is also a stage of preparation of fine powder of one or more than one plant, which is then mixed with other components, while in the similar prepare a coarse powder of the herbs, which are then subjected to extraction;

in similar leaf juice of one or more than one herb is subjected to coagulation and subsequent drying, in our method uses either freshly cooked or canned juice, keeping all components of the feedstock, in particular vitamins.

Some signs invented method is known, for example, in patent No. 2192272 known addition of seaweed extract powdered air-dried algae. However, the claimed therapeutic agent, the method of its production are not derived explicitly from known modern technology and only the combination of all the characteristics of this method with inherent characteristics, temporal, and technological parameters, allows to solve the problem and retrieve the specified technical result, namely to obtain a brand new product that preserves the most unaltered whole complex of biologically active substances of the raw materials, i.e. the proposed solutions are not obvious to a person skilled and inventive.

So what Braz, from the above it is seen that the proposed group of inventions combined to form a single inventive concept, the second invention is intended to obtain the first. Both inventions solve the same task with achieving the same technical result. It is found experimentally that as a result of this, claimed as the invention of the technology is possible in a maximum degree of extraction of biologically active substances (BAS).

In more detail the proposed method is illustrated by examples.

EXAMPLE 1.

a) 100 g dried to a residual moisture content of 10-14% grass and flowers of Echinacea crush on Karmatronic, and then a hammer mill to a particle size of less than 200 microns. Get 90 grams of powder with a particle size of from 10 to 200 μm. The total content of derivatives oksikorichnye acids in terms of tikolevu acid - 2,1%.

b) Dry grass and flowers of Echinacea in the amount of 100 g pre-chopped Karmatronic, extracted with aqueous alcohol (40%vol.) in the amount of 1050 g (the ratio of grass and extractant 1:10,5). The extract is separated from the solid phase in the centrifuge. Get 1000 g of extract. The total content of oksikorichnye acids in terms of tikolevu acid is not less than 0.15%.

c) From 100 g of fresh grass and flowers of Echinacea press in a known manner juice of Echinacea in the amount of 50, When n is needed to temporarily store the juice canned ethanol in the amount of 20% by weight of the juice. The total content of derivatives oksikorichnye acids in terms of tikolevu acid is not less than 0.4%.

d) the Intermediate products obtained in stages a), b) and (C)are mixed in required in the recipe proportions, for example, in the ratio 20:10:70 and receive the product with the total content of derivatives oksikorichnye acids in terms of tikolevu acid is not less than 0,88%. Alcohol content not less than 20%.

EXAMPLE 2.

a) 100 g dried to a residual moisture content of 10-14% grass and red clover blossoms crushed on Karmatronic, and then a hammer mill to a particle size of less than 200 microns. Get 90 grams of powder with a particle size of from 10 to 200 μm. The content of total flavonoids rutin - 1,0-1,2%, crude protein - not less than 5.0%, nitrogen-free extractives - not less than 10%of the carotenoids is not less than 5 mg %.

b) the Dry grass and the flowers of red clover in the amount of 100 g pre-chopped Karmatronic, extracted in alcohol (about 40. %) in an amount of 1050 g (the ratio of grass and extractant 1:10,5). The extract is separated from the solid phase in the centrifuge. Get 1000 g of extract. The content of total flavonoids rutin - not less than 0.05%, nitrogen-free extractive substances is not less than 3.8 percent, carotenoids is not less than 2 mg % (soluble proteins in the grass there).

c) From 100 g of fresh grass and clover blossoms CR is red wring out the juice in the amount of 60 g If necessary, temporary storage of the canned juice 96% ethanol in the amount of 20% by weight of the juice. The content of total flavonoids rutin - not less than 2.0%, crude protein - not less than 8.5%, nitrogen-free extractives - not less than 23,5%, carotenoids is not less than 8.0 mg %.

d) the Intermediate products obtained in stages a), b) and (C)are mixed in required in the recipe ratios (for example, in the ratio 10:40:50) and get the product with the total content of flavonoids rutin - not less than 1.1%, crude protein - not less than 4.1 per cent, of nitrogen-free extractives - not less than 12,4%, carotenoids is not less than 5.0 mg %. Alcohol content not less than 20%.

EXAMPLE 3.

a) 100 g dried to a residual moisture content of 10-14% of burdock roots are crushed on Karmatronic, and then a hammer mill to a particle size of less than 200 microns. Get 90 grams of powder with a particle size of from 10 to 200 μm. The content of fructosans and fructoside in terms of inulin at least 8%.

b) Dry roots of burdock in the amount of 100 g shredded in a hammer mill, placed in a mixer and extracted with alcohol (about 40. %) in an amount of 1050 g (the ratio of roots and extractant 1:10,5) for 5 days. The extract is separated from the solid phase in the centrifuge. Get 1000 g of extract. The dry matter content of not less than 3%, fructosans and fructoside in terms of inul the n - not less than 1%.

c) From 100 g of fresh burdock industrial centrifuge wring out the juice in the amount of 70, If necessary, temporary storage of the canned juice 20% ethanol in the amount of 20% by weight of the juice, the mixture is well stirred and poured into containers for storage. The dry residue in the juice - not less than 12%. The content of fructosans and fructoside in terms of inulin - not less than 2%.

d) the Intermediate products obtained in stages a), b) and (C)are mixed in required in the recipe ratios (for example, in the ratio 10:30:60) and receive the product with the content of fructosans and fructoside in terms of inulin - not less than 3.7%. Alcohol content not less than 20%.

EXAMPLE 4.

a) 100 g dried to a residual moisture content of 10-14% grass and flowers of Echinacea mixed with 100 g of burdock roots, dried to the same moisture content and milled on Karmatronic, and then a hammer mill to a particle size of less than 200 microns. Get 180 grams of powder with a particle size of from 10 to 200 μm. The total content of derivatives oksikorichnye acids in terms of tikolevu acid is 1.0%, the content of inulin - 19%.

b) Dry grass and flowers of Echinacea and dried burdock root in the amount of 100 g pre-chopped Karmatronic, extracted with aqueous alcohol (40%vol.) in the amount of 1050 g (the ratio of grass and extractant 1:10,5). extrac is separated from the solid phase in the centrifuge, get 1000 g of extract. The total content of oksikorichnye acids in terms of tikolevu acid is not less than 0.08%, the content of inulin - not less than 0.5%.

c) 100 g of a mixture of freshly picked herbs and flowers of Echinacea and freshly harvested roots of burdock in the centrifuge wring out the juice in the amount of 60, If necessary, temporary storage of the canned juice ethanol in the amount of 20% by weight of the juice. The total content of derivatives oksikorichnye acids in terms of tikolevu acid is not less than 0.2%, the content of extractives (dry residue) is not less than 10%.

d) the Intermediate products obtained in stages a), b) and (C)are mixed in a ratio of 20:10:70 (in different ratios) and get the product with the total content of derivatives oksikorichnye acids is not less than 0.5%, the content of inulin - not less than 8%, the alcohol content is not less than 20%.

Obtained in examples 1-4 song:

a) use as a finished product (pre-Packed, Packed);

b) insist 1 30 days, filtered and the filtered liquid is used as the finished product (pre-Packed, Packed);

C) is dried to a residual moisture content of not more than 14% (if necessary, in a known manner tabletirujut or capsulebuy and pack) and used as a finished product either in powder form or in the form of tablets or capsules.

P is obtained in the described way the products are different, than products obtained by known preparation, in particular tincture obtained by the technology of herbal preparations.

In combination with one product different way of processing types of the same plant (the same plant) suddenly received a synergistic effect, i.e. the enhanced activity of the product obtained invented method, in comparison with the product obtained by conventional technology (for example, the technology of galenical preparations). In addition, all received new way foods retain more vitamins, proteins, carbohydrates, flavonoids, organic acids, carotenoids and other bioactive substances, which also contributes to their positive effects on the body. Table 1 provides a comparison of the new invented products and products produced by the applicant in the traditional way (technology galenical preparations).

Table 1.
burdock extract, fructose and fructose in terms of inulin, wt.%Echinacea extract, oksikorichnye acid in terms of tikolevu acid, wt.%the clover extract, flavonoids rutin, wt.%
received the first traditional method according to the inventionobtained in the traditional wayaccording to the inventionobtained in the traditional wayaccording to the invention
at least 1.0no less

3,7
not less than 0.15not less 0,88not less than 0.05not less than 1.1

Table 2 shows therapeutic efficacy of the products (products)obtained invented method, in comparison with the products (products)obtained in the traditional way.

Table 2.
burdock extract in the treatment of cancerextract of clover, hypolipidemic effect on 20 patients with CHD
obtained in the traditional wayaccording to the invention (BAA "Retain")obtained in the traditional wayaccording to the invention (BAA "Heteroclitic Forte")
The effect is not observedThe effect is confirmed by clinical studiesReducing the level of cholesterol in the blood to normal in 42% of patientsReducing the level of cholesterol in the blood to normal in 68% of patients

In General, given the novelty and non-obviousness of the invention, which is responsible for all General and particular features of the invention, and also indicated the feasibility of the invention and the achievement of invention tasks, the claimed group of inventions meets all the requirements of the inventions.

1. The way to obtain therapeutic and prophylactic compositions based on vegetable raw materials, including the preparation of a fine powder of one or more than one plant with grinding 10-200 μm; separate extraction of one or more than one plant water ethanol at the ratio of raw material:extractant from 1:5 to 1:20, respectively; separate cooking and, optionally, the preservation of the juice of one, or more than one plant, followed by mixing the resulting powder, extract and juice in the ratio (1-20):(9-90):(9-90), respectively.

2. The method according to claim 1, characterized in that the obtained composition insist 1 30 days, then filtered and poured into consumer packaging.

3. The method according to claim 1 or 2, characterized in that the resulting composition is concentrated and dried.

4. The method according to claim 3, characterized in that the obtained composition tabletirujut and capsulebuy.



 

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