Agent for treatment of suppurative wound

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to medicinal preparations used for treatment of suppurative wounds. Invention involves applying boric acid (powder) and multi-component ointments on water-soluble base (Laevomecolum or Laevosinum) taken in the ratio 1:10 and used for treatment of suppurative wounds. Invention provides the development of agent exhibiting the expressed antibacterial, dehydrating and necrolytic effect.

EFFECT: valuable medicinal properties of agent.

2 ex

 

The invention relates to medicine, more specifically to medicines for the treatment of purulent wounds,

It is known that multi-component water-soluble ointment base (levsin, levomekol) are widely used for treatment of purulent wounds in the 1st phase of wound healing.

The composition of multicomponent water-soluble ointments basis:

The vegetable "levomekol"Levocin"
Chloramphenicol - 1,0Chloramphenicol - 1,0
Methyluracil - 4,0Methyluracil - 4,0
PEO-400 - 76,0Sulfadimetoksin-4,0
PEO-1500 - 19.0Trimecaine - 4,0
PEO-400 - 16,8
PEO-1500 - 70,2

Osmotically active ointment (levsin, levomekol) have a broad spectrum of action: increase the outflow from the wound, provide for the release of antibiotics from the composition and deep into the tissues, where it breeds germs, effective against most gram-positive and gram-negative bacteria (Escherichia coli, prota)are obezbolivaushee (levsin) and to a certain extent necrolytes have a local immunomodulatory effect.

In the presence of Pseudomonas aeruginosa in wound flora levomekol, levocin little effective is iwny and even in the treatment of wounds by these means attached Pseudomonas flora, weakly expressed nekroliticescoe effect. To overcome this limitation, we have used the following mixture: boric-levonova, boric-levomekol. As a prototype we have taken osmotically active water-soluble ointment base: levomekol, levocin. (Wounds and wound infection. Migukin, Emiconductor).

The purpose of the invention is to develop drugs which have significant antimicrobial, dehydrating, necroticism action.

The tool contains boric acid (powder) and osmotically active water-soluble ointment base (Levsin or Levomekol) in the ratio of 1:10. The combination of these products provides the article concludes that effect.

The choice of boric acid as a component of the mixture was determined by the fact that it is according to the literature not only has a wide spectrum of antibacterial action, but also contributes to the melting of necrotic tissue (Kuzin M.I., Kostyuchenok E.M. Wounds and surgical infection: a Guide for physicians. Ed. 2nd M: Medicine, 1990).

Examples of specific performance method: Example 1. Patient Tacarigua G.S., 61 years old, diagnosis: diabetes of the 2nd type, a severe form. Diabetic foot syndrome. He enrolled in the Department of surgical infection 1st mountains. hospital 22.03.2001.

On the same day produced the opening and drainage of cellulitis lion the th foot, necrectomy. In polaprezinc period wound daily tie-boron-levomekol mixture in the ratio 1:10. The wound was cleansed 9 days from the start of treatment.

Example 2. Sick of Kaurov A.A., 55 years old, diagnosis: diabetes of the 2nd type, a severe form. Carbuncle interscapular area. He enrolled in the Department of surgical infection for 6 days from the onset of the disease 19.03.2001.

After preliminary preoperative preparation for 4-6 hours with the patient under intravenous anesthesia produced by excision of carbuncle back. In the first phase of wound healing wound tie daily boric-levonova mixture in the ratio 1:10. A complete cleansing of the wound occurred on the 7th day from the start of treatment.

Our proposed mixture has a broader spectrum of antibacterial activity and pronounced necroticism effect that significantly reduces the time of the cleansing of wounds, can be used with success in the treatment of purulent wounds in patients with diabetes mellitus, nonhealing wounds, in the treatment of wounds infected with Pseudomonas flora.

Signs, distinctive features of the prototype: the use of boric acid in combination with an osmotically active water-soluble ointments basis Levocin, Levomekol) in the specified value.

For the treatment of purulent wounds, characterized in that it contains Bo the strong acid (powder) and osmotically active water-soluble ointment base (Levomekol or Levsin) in the ratio of 1:10.



 

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