Method for predicting functional state in people and animals

FIELD: medicine, diagnostics.

SUBSTANCE: the method deals with monitoring the difference in signals obtained from N pickup units, where N ≥ 2, ECG, pulse, temperature and analysis of the range and variability of their rhythms, nonlinear chaotic fluctuations during the period of registration. During analysis one should detect the values for fractal dimensions of Hirst's index and informational Fischer's index standardized, correspondingly, by the average value during either nocturnal or diurnal period. One should conclude upon improved body state by the normalization of signals' difference of peridiurnal rhythm, increased fractal dimensions, Hirst's index, decreased standardized informational Fischer's index, and one should conclude upon worse physiological or pathophysiological processes according to the opposite alterations. The method enables to widen functional possibilities during diagnostics.

EFFECT: higher accuracy of diagnostics.

3 dwg, 6 ex

 

The invention relates to medicine, in particular to methods of diagnostics of the functional state of a human or animal, and can be used to assess the effectiveness of treatment and/or physical stress.

The known method of diagnostics of the functional state of a human and an animal by daily monitoring of ECG Holter, which is the estimation of the spectrum and variability of heart rhythms, and other diagnostic indicators (see Dabrowski A., Dabrowski B., piotrowicz R. monitoring of ECG. M: Malpractice, 2000 - 208 C.).

However, the known method is used only for the analysis of ECG without calculating the fractal dimension index Hirst and Fisher, which reduces the diagnostic capabilities of the method and does not allow you to diagnose other systems of the body functioning, in addition to the function of the heart.

The technical nature of the closest to the present invention is a method of diagnostics of the functional state of the human and the animal, which consists in reception of electromagnetic waves of excitation of a given organ or part of the biological object, the definition of interval and amplitude parameters of these waves, the formation of their phase and energy characteristics, and basic geometric shapes moving vector of the phase characteristic and defined the e probability density of occurrence of elementary geometric shapes of each kind, which judge the condition of a biological object (see U.S. Pat. Of the Russian Federation No. 2127549, class. And 61 In 10/00 from 13.04.1998 year).

However, this method has limited functionality, as it allows to assess the rhythm tone great vessels, the asymmetry of the flow of paired limbs and head, as well as the daily dynamics of cellular immunity and other physiological functions of the organism.

The technical result is to increase functionality in the diagnosis of various organs and systems in the human or animal with regard to okolomatocnah dynamics of their performance.

This is achieved by the fact that in the method of diagnostics of the functional state of the human and the animal, which, at least in the daily ECG monitoring, and/or heart rate and/or temperature, and/or other recorded signals of physiological processes and the analysis of the spectrum and variability of their rhythms, and/or nonlinear chaotic fluctuations during the registration period, according to the invention under the above analysis determines the performance of the fractal dimension and/or index Hirst, and/or normalized, respectively, by the average value for night or daytime information index Fisher, and about improving the condition of the body is judged by the normalization akoloutheo rhythm, and/or increase fractal razmere and, and/or index Hirst, and/or reduction of the normalized information index Fisher, and about the deterioration of physiological or pathophysiological processes judged by the opposite changes in addition, when the daily monitoring of use N of the respective sensors installed in certain areas of the body, and about the improvement or deterioration of physiological and pathophysiological processes are judged by the same value of the difference signal with N respective sensors, where N≥2 and when the daily monitoring for diagnostics sustainability regulation of functional systems of the organism determine the relationship of heart rate to respiration rate, the first derivative of this relationship before, during, after the test the psycho-emotional or physical stress, and in case of increase after the above load variation amplitude of the oscillation period of the relationship of heart rate to respiration rate, and/or amplitude of the first derivative of this ratio less than 2-fold from baseline, and/or the values of heart rate to respiration rate, not beyond the range of this ratio from 2 to 6, judged on the improvement of self-regulation and optimal loads, and otherwise, the judge reduced the reserves of self-control, and/or excessive load level, and/or the presence of pathology.

Figure 1 and 2 presents daily schedules evaluation of the functional state of the organism on specified indicators to more and less effective treatment, and figure 3 presents the device to realize the inventive method.

The device contains sensors 1...N (where N is from 2 to several tens) of a pulse or other signal, the N-channel amplifier 2, the N-channel logger with 3 solid-state memory, the N-channel ADC 4 and the computer 5 for recording and analysis of the information received. For implementing the inventive method uses standard pulse sensors. Sensor 1 pulse represents the optocoupler (photodiode, led) and may be in the form of suction cups attached to the surface of any part of the body of the patient.

The method of diagnostics of the functional state of man and animal is at least in the daily ECG monitoring, and/or heart rate and/or temperature, and/or other recorded signals of physiological processes and the analysis of the spectrum and variability of their rhythms, and/or nonlinear chaotic fluctuations during the registration period. CCA is the property of this method is that, when the above analysis determines the performance of the fractal dimension and/or index Hirst, and/or normalized, respectively, by the average value for night or daytime information Fisher index. At the same time improving the condition of the body is judged by the normalization akoloutheo rhythm, and/or increase of the fractal dimension, and/or index Hirst, and/or reduction of the normalized information index Fisher, and about the deterioration of physiological or pathophysiological processes judged by the opposite changes.

Another feature of the method is that when the daily monitoring of use N of the respective sensors installed in certain areas of the body, and about the improvement or deterioration of physiological and pathophysiological processes are judged by the same value of the difference signal with N respective sensors, where N≥2.

In addition, when the daily monitoring for diagnostics sustainability regulation of functional systems of the organism determine the relationship of heart rate to respiration rate, the first derivative of this relationship before, during and after the test psycho-emotional or physical stress. In case of increase after the above load variation amplitude of the oscillation period of the relationship of the pulse frequency to the frequency of respiration is Oia, and/or amplitude of the first derivative of this ratio less than 2-fold from baseline, and/or the values of heart rate to respiration rate, not beyond the range of this ratio from 2 to 6, judged on the improvement of self-regulation and optimal loads, and otherwise, the judge reduced the reserves of self-control, and/or excessive load level, and/or the presence of pathology.

The variation of the amplitude of the oscillation period of mean value varying periods from a minimum to maximum value.

The usefulness of the proposed method is to obtain new information about the condition and disorder of the function of individual organs and body systems change approval rhythms of blood flow and other indicators between symmetric or other comparable areas of the body, reflecting them in physiological and pathological changes.

Example 1. Conducted daily monitoring of ECG Holter device company Meditech (Hungary) in patients (25 men)who have experienced myocardial infarction, prior to the beginning of treatment and after its completion for the sanatorium stage of rehabilitation. In addition to the conventional analysis of variability and spectrum of rhythms of R-R intervals were additionally calculated the performance of the fractal dimension, Hurst index and Fisher. Patients with a successful outcome and treatment laboratory values of the normalization of the blood, reduce cholesterol and atherogenic index, increased tolerance to physical activity according to the Bicycle ergometry, lower functional class severity of the disease, reduce symptoms of painful and painless ischemia, ventricular and supraventricular extrasystoles found a significant increase of the fractal dimension of R-R intervals of the ECG from 0.67±of 0.03 to 0.78±0.04; the increase in the index Hirst with 0,60±0.03 to 0,72±0.05 and the reduction of the index Fisher from 20.4±3.2 to 4.5±1,6. While traditional indicators diagnostics did not show clear changes or even differences were absent. Unlike traditional indicators for daily timetables proposed diagnostic indicators are clearly observed with successful treatment normalization of hronostruktura akoloutheo rhythm (figure 1, 2).

Example 2. Patient S., 42 years. Osteochondrosis of the lumbar spine. Several times a year there are complications in the form of neuritis of the sciatic nerve in the left leg. After another course of treatment with 4 probe pulse, respectively, at the distal and proximal parts of the thigh muscles in the course of the nerve on both legs. Despite the absence of clinical symptoms after treatment fractal dimension and the Hurst index of the rhythms of the velocity of propagation of pulse wave on the left leg were sootvetstvenno 42 and 58% lower than on the right foot, and information Fisher index rhythms pulse wave velocity 2.8 times greater (in size, measured by the product of the amplitude for the duration)than on the right foot. On the left leg there was also no significant colostomy rhythm of these metrics, and colocasia fluctuations had a shorter period (about 40 min)than on the right foot (about 80 minutes).

Example 3. Patient K., 28 years. Pulse sensors installed on the ears. Register using the difference in time of arrival of pulse waves to the sensors of the left and right ear rhythms change the speed of the pulse waves in the vessels of the left and right carotid arteries and arteries of the left and right sides of the head at different functional States. Significant differences between the performance of the fractal dimension at different times of day, under normal quiescent condition and in a state of excitement caused by the conflict at work, the differences in the state before and after physical activity (sports training). Changes in fractal dimension with 78 units 62 units in % was larger than that calculated under the same conditions index voltage Having for mezhpolovyh intervals with heart rate sensors, and other traditional indicators of autonomic imbalance.

Example 4. Patient Z., 63. Registered rhythms of the change of the temperature difference by the method of differential temperature between the sensors, set on the skin projection of the thymus and in the infraclavicular fossa. Found allocative and colostomy rhythms temperature difference, reflecting the level of cellular immunity by production of T-lymphocytes. The temperature increase over the thymus relative to the subclavian basin at night compared to daytime hours correlated with the increase of the fractal dimension and the Hurst index of registered oscillations.

Example 5. In the process of daily monitoring pulse test conducted physical (on the bike) and emotional (computer game) load on two groups of students, young men 18-24 years. Clearly identified 2 types of reactions. For the first type of reaction is characterized by the reduction of fluctuations with the decrease of the ratio of heart rate to respiration rate, PE/BH with the emergence quite correct rhythm. The ratio PE/BH does not go outside the range of 2-6. Used emotional and physical stress improved the functional status of these subjects. Subjectively students with the first type of reaction considered these emotional and physical stress as pleasant.

For students with a second type of reaction is characterized by an increase in the initial state fluctuations relations PE/BH and more frequent outside the range 2-6, which characterizes the instability of the regulation. The amplitude of the change in the response to the first and second derivatives of the relations PE/BH sharply increased, the periods of oscillations also increased. Statistically the second type of reaction correlated with explicit autonomic imbalance (increased tension index on Having to mezhpolovyh intervals). When the test loads these students subjectively perceived discomfort, negative emotions and slow reactions. Normalization of vegetative status contributed to the change of type of reaction from the second to the first type.

Example 6. Conducted daily monitoring of pulse racehorse before training and after achieve higher athletic performance. Calculation of indicators of nonlinear chaotic fluctuations and fractal dimension showed an increase in the fractal dimension is 18% and the condition index, which is determined by the method described in the nearest analogue, 13% as a result of successful training. Analysis of the results of the Desk in arbitrarily taken at 5-minute intervals entries found a big contradiction in their assessments of these indicators. This is due to the presence Kolochava with a period of about 40-100 minutes rhythms with periods of 3-4 hours (figure 1, 2) and random hitting time of diagnosis in different phases of these rhythms. This proves that the use of daily records compared to the 5-minute recordings in the evaluation of the fractal dimension, indicators chaotic not inany fluctuations and other allows to obtain more reliable and accurate information about the condition of the animal or human body.

It should be noted that in different cases, we observed different information content of the above indicators. Therefore, a more objective is the use in the diagnosis of the whole complex of the above indicators.

Thus, the claimed set of essential features, the feature is the use of daily and longer-term monitoring of various recorded signals of physiological processes in addition to the traditional analysis algorithms rhythms and geometric nonlinear analysis of chaotic oscillations, the performance of the fractal dimension, Hurst index, the normalized information Fisher index and the dynamics of the relationship of heart rate to respiration rate, allows to achieve the technical result.

The method of diagnostics of the functional state of the human and the animal, which at least in the daily monitoring of the difference signals taken from the N sensors, where N≥2, ECG, pulse, temperature and analysis of the spectrum and variability of their rhythms nonlinear chaotic fluctuations during the registration period, and when the above analysis determines the performance of the fractal dimension of the Hurst index, and normalized, respectively, by the average value for night or daytime information Indus the KSA Fisher, and about the improvement of the body are judged by normalizing the difference signal akoloutheo rhythm, the increase of the fractal dimension, Hurst index, the decrease of the normalized information index Fisher, and about the deterioration of physiological or pathophysiological processes judged by the opposite changes.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method involves recording rhythmocardiogram. Then, spectral analysis of RR intervalogram components in frequency bandwidth from 0.04 to 0.4 Hz is carried out and information value Z is determined from formula Z=Ahf/Alf, where Ahf is the maximum of high frequency component in bandwidth from 0.14 to 0.4 Hz, Alf is the minimum of high frequency component in bandwidth from 0.04 to 0.14 Hz. Z value being greater than 45 and lower than 14, persons consuming narcotic drugs are detected. Z value being lower than 14, persons consuming sedative drugs like opium, morphine, heroine are detected. Z value being greater than 45, persons consuming psychostimulating drugs like cocaine, amphetamine, efedrone, sydnocarb are detected.

EFFECT: high reliability of screening study data.

4 cl, 6 dwg

FIELD: medicine.

SUBSTANCE: method involves estimating vegetative tonus using cardiointervalography approach and its medication adjustment under cardiointervalography control. The cardiointervalography examination is carried out before applying treatment, in the course of and after the treatment. Each time vegetative tonus increment is estimated on the basis of voltage index. When applying medication adjustment, nootrop group preparations are used that are selected before applying treatment with initial vegetative tonus disorder distinguished by vagotonia or sympathicotonia being taken into account. Preparation or combination of preparations or their doses and application duration is adjusted on basis of vegetative status direction changes obtained from cardiointervalography examination data. The treatment is continued until vegetative status direction change stops towards normotonia.

EFFECT: enhanced effectiveness in selecting individual treatment course.

3 cl, 3 dwg

FIELD: medicine, cardiology.

SUBSTANCE: one should register rhythmocardiogram, measure current total power in low-frequency and high-frequency areas of dynamic row of cardiointervals. Evaluation of psychophysiological state should be performed by the value of stress index S calculated due to original mathematical formula by taking into account the power of low-frequency and high-frequency constituents of the range of dynamic row of cardiointervals. In case of standard conditions of measurement - the rest lying at one's back position the value of S stress index should be considered to be equal to 1. The method enables to rapidly and noninvasively detect and range human psychophysiological state.

EFFECT: higher accuracy of evaluation.

2 dwg, 1 ex, 2 tbl

The invention relates to medicine, functional diagnostics and can be used to detect autonomic dysfunction and assessment of adaptive mechanisms of the autonomic nervous system (ANS)

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The invention relates to medicine, namely to pediatric cardiology

The invention relates to medicine, particularly cardiology

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FIELD: medicine.

SUBSTANCE: method involves measuring time of sensorimotor response to a stimulus and calculating mean value of parameters of sensorimotor response to a stimulus on a large size people population. When managing an object, parameters of operator sensorimotor response to a sequentially shown stimulus are measured and normalized parameters values of sensorimotor response to a stimulus. Components having identical statistical properties of sensorimotor response parameters are selected as simple components of multi-component stimulus. In managing an object, continuous object management parameter values are additionally measured and their normalized values are calculated. Operator activity is estimated from an integral quality parameter defined as geometrical mean value of normalized parameters of sensorimotor response to a stimulus and normalized continuous object management parameters values.

EFFECT: enhanced accuracy in considering both continuous and discrete process components.

6 cl, 1 deg, 2 tbl

FIELD: medicine.

SUBSTANCE: method involves measuring current values of operator sensory motor response time on multicomponent stimulus, calculating normalized parameter values of sensory motor response to the stimulus, measuring current parameters of object control and recording cardiac rhythm signals. Dynamic series of cardiac intervals is formed from the cardiac rhythm signals. Spectral analysis of the dynamic series of cardiac intervals is applied for calculating operator stress index S. Stress index S value is equal to 1 for statistically mean operator. Integral index Q of operator activity quality is calculated as geometrical mean of normalized parameter values when applied to sensory motor response to stimulus and normalized object control parameter values. Operator activity estimate is obtained from operator activity resource level R determined from relation of R=Q/S.

EFFECT: provided consideration of physiological deviations when estimating operator activity quality.

6 cl, 7 dwg, 2 tbl

FIELD: medicine.

SUBSTANCE: the suggested method is based upon squeezing the artery through the thickness of all tissues with compensating pressure. Moreover, the later should be periodically measured in the range overlapping the desired dynamic constituent of arterial pressure, at period being shorter against duration of cardiac contraction cycle. One should detect the moments of sharp alteration of the first derivative of signal of pulse fluctuations and fix at these moments the values of compensating pressure, according to the values of compensating pressure obtained in every period of compensating pressure during the whole cycle of cardiac contraction, restore continuous curve line due to interpolation to find extreme values of restored curve, which should be considered to be the upper and the lower values of arterial pressure. In case, when there are no sharp alterations of the first derivative of the signal of pulse fluctuations within alteration range of compensating pressure one should increase constant constituent of compensating pressure, then measurements should be repeated.

EFFECT: higher efficiency of detection.

1 cl, 15 dwg, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, physiology.

SUBSTANCE: the present innovation deals with complex evaluating the level of physical working capacity in practically healthy persons above 6 years old of different level of training, who have no restrictions because of their health. It is necessary to perform two loading tests on ultimate keeping the preset intensity of loading by applying the following system of equations: followed by calculating the complex of ergometric values (Imax, I10, I40,I240, I900, a,b,K,LnS,SE) that enables to characterize physical human working capacity within the whole range of acceptable loading and describe individual structure of energy supply of muscular activity. As test loadings one should apply dynamic or static ones, either by applying natural loadings or any other kind of loading equipment and loading devices. The innovation enables to widen functional abilities of the above-mentioned technique due to increased number of informative values at testing.

EFFECT: higher efficiency of evaluation.

3 ex

FIELD: medicine, anesthesiology-resuscitation, traumatology, surgery.

SUBSTANCE: according to 4-point scale one should evaluate the state of 10 clinical, hemodynamic and instrumental values in patients: patient's skin by detecting its color and moisture; hemodynamic values: heart rate, systolic arterial pressure, central venous pressure, shock index; central nervous system by studying the value of Glasgow scale; respiratory system - the frequency of respiratory movements and blood saturation; cardio-vascular system - myocardial necessity in oxygen. Each value has its own point, moreover, 0 points corresponds to that fact that the index under inspection is within age standard, 1 point - when physiological parameters at rest are different against the standard, but their functions are compensated by organs of one or two systems, 2 points - compensation is kept due to alterations in more than 2 systems and it reaches its peak, 3 points correspond to adaptation failure or affected function of one or several systems, and the sum of points being 0-4 in patients one should diagnose the absence of hemorrhagic shock, at 5-9 points - the severity of hemorrhagic shock corresponds to degree I, at 10-19 points - to degree II, at 20 points and more - to degree III.

EFFECT: higher efficiency and accuracy of diagnostics.

4 ex, 1 tbl

FIELD: medical engineering.

SUBSTANCE: selected reference point in every cardiac cycle on TP-segment. Values of neighboring N=2n+1 reference points also belonging to TP-segment are recorded, n=1,2,…, beginning from the first reference point. Other reference points are set to zero. The central reference point value is left without changes in a group of 2n+1 member. Reference point values of each of n pairs of reference points symmetrically arranged relative to the central reference point are scaled relative to condition Uj=U0Kj, where U0 is the central reference point amplitude, Uj is amplitude of j-th reference point pair, j=1,2,…,n is the number of each reference point pair relative to the central reference point, Kj is the scaling coefficients determined from received signal suppression condition of the first n spectral zones in spectrum. The so formed electrocardiogram signal reference point groups sequence is let pass through lower frequency filter with isoline drift signal being obtained being produced on output. The signal is amplified and subtracted from the initial electrocardiogram signal that is preliminarily delayed for lower frequency filter delay time. Device has the first lower frequency filter, discretization unit and unit for selecting anchor reference points connected in series, as well as subtraction unit, unit for saving N reference points, scaling unit, the second lower frequency filter, amplifier and delay unit. Output of the unit for selecting anchor reference points is connected to the first input of memory unit the second input of which is connected to discretization unit output. Each of N memory unit outputs is connected to one of N inputs of scaling units. Scaling unit output is connected to the second lower frequency filter input which output is connected to amplifier input. Amplifier output is connected to the first input of subtraction unit, the second output of subtraction unit is connected to delay unit output. Its input is connected to output of the first lower frequency filter. Subtraction unit output is the device output.

EFFECT: reliable removal of isoline drift.

2 cl, 8 dwg

FIELD: medicine, cardiology, cardiosurgery.

SUBSTANCE: one should detect risk factors of post-operational lethality in patients with isolated, associative and combined cardiac defects. First, one should detect the presence of functional class of circulation insufficiency being above the 3d, the value for initial fraction of ejection in left ventricle being below 45%, the value of initial pulmonary hypertension being not less than 60 mm mercury column, the concentration of serumal creatinine in pre-operational period being above 102 mcM/l, the time for artificial circulation during operation being above 230 min. At availability of three or more risk factors mentioned the prediction should be considered to be unfavorable. The present innovation enables to evaluate the results of cardiosurgical operations in early post-operational period.

EFFECT: higher accuracy of prediction.

2 ex, 3 tbl

FIELD: medicine, diagnostics.

SUBSTANCE: in schoolchildren one should detect body weight and body length, pulmonary vital capacity, both systolic and diastolic arterial pressure, time for restoring pulse after performing standard loading PWC170. Moreover, one should calculate anthropometric value as body weight/body length, ventilation value as pulmonary vital capacity/body weight, cardiac index, specific working capacity as dynamometry/body weight, reserve value as the time for restoring pulse after loading. Each value should be evaluated in points to summarize them and evaluate health level in a schoolchild according to the sum of points. The innovation suggested enables to objectively evaluate health level in schoolchildren.

EFFECT: higher accuracy of evaluation.

1 dwg, 2 tbl

FIELD: medicine, veterinary science.

SUBSTANCE: the present innovation deals with predicting human or animal immunodeficiency. One should register temperature difference at body surface between the area of subclavian cavity and the area in thymus projection. In case of altered perihourly and peridiurnal rhythms of temperature difference above thymus by 0.4 C and more one should conclude upon normal cell immunity, and in case of lower temperature increase - upon immunodeficiency by T-lymphocytes.

EFFECT: higher efficiency of diagnostics.

2 dwg, 4 ex

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