Drug with membrane-stabilizing efficacy
SUBSTANCE: invention proposes use of polysorb as drug with membrane-stabilizing efficacy supplementing early known antioxidant and sorption properties of this substance.
EFFECT: enabled use of polysorb for monotherapy to treat a large number of diseases.
The invention relates to medicine and can be applied in pharmacology, in particular, refers to drugs used as antioxidant.
Lipid peroxidation is a normal part of oxidative processes constantly occurring in the body. Excessive activation of lipid peroxidation has a damaging effect on the level of subcellular structures. Powerful damaging effect on the cell have a high reactivity of the lipid gidroperekisi, which are formed as a result of lipid peroxidation (LPO) by free radicals.
With dysregulation of processes of free radical lipid peroxidation associated mechanism for the development of many pathological conditions and diseases related to socially significant, including aging, cancer, atherosclerosis, diabetes, Alzheimer's disease.
Not to give free radicals accumulate in the body and prevent the FLOOR can antioxidants. Antioxidants are antioxidants, i.e. substances capable of inhibiting free-radical oxidation processes.
The body has natural antioxidant system enzymes - superoxide dismutase, catalase, peroxidase etc.; macromolecular nonenzymatic components - Suvereto the major proteins; low molecular weight components - thyroxine, female sex hormones, vitamins a, E, K and other
But this system is in a state of oxidative stress is overloaded. It is therefore necessary to compensate for a deficiency of antioxidants from the outside.
As antioxidants of natural origin are used: Tocopherols, ubiquinone, carotenoids, hossipole, sesamol, esters of Gallic acid, quercetin, guaiac and ascorbic acid (see Buldakov A.S., Food additives., C.-P.: Ut, 1996, pp.92).
Some of them, such as Tocopherols, ubiquinone, carotenoids are not soluble in water, making them difficult to use.
Closest to the claimed technical solution and taken as a prototype is widely used in medicine natural hydrophilic, water-soluble antioxidant ascorbic acid (see Captains A.B. Pimenov A.M. antioxidant Carotenoids as modulators of cellular metabolism J. Successes of modern biology. 1996. -T.116. - V.2, s-179.).
The present invention is the expansion of the range of antioxidants.
The problem is solved by applying Polisorb as antioxidant
Polisorb is a drug on the basis of highly dispersed silica. In the aquatic environment on the surface of the microparticles of Polisorb produce large quantities of active groups silox is on, which in the simplified formula look like this:
the covalent bond in this compound is very unstable:
next, the action of H+in the usual way: H2O2+2H+=>2H2O+O2.
Thus, the mechanism of action of Polisorb belongs to the category of antioxidants to“scavengers” (scavenger of free radicals), which cleanse the body of free radicals, restoring them to free inactive ingredients.
Conducted patent research did not reveal identical and similar technical solutions that allows to draw a conclusion about the novelty and inventive step of the claimed technical solution.
The inventive tool is CJSC “Polisorb”, Chelyabinsk under the trademark “Polisorb MP (medical, pills) and represents a high-purity silica, hydrophilic. Applied in the form of a 1-10% aqueous suspension
The study of the antioxidant activity of POLYSORB was carried out by two methods.
Weakly peroxide chemiluminescence (PHL).
Adding hydrogen peroxide to many organic and inorganic substances leads to the development of flash chemiluminescence. The mechanism PHL explained by the reactions resulting from the decomposition of H2About2active Faure is oxygen: BUT +O2 +, HO2 +O2.
The table presents PHL blood serum of rats using POLYSORB.
|Group||No. of animals||% Polisorb in aqueous suspensions||S (sutasoma)||I max (amplitude glow)||St max (duration of the glow)|
|Experimental group (POLYSORB)||1||5||29,14||3,79||0,76|
|The control group||11||-||11,75||1,10||0,64|
The table shows that the maximum amplitude of the outbreak have been reported with the use of POLYSORB that characterizes him as a powerful antioxidant.
2. The study of complementary activity of blood serum (indirect method).
Activation of complement occurs on the basis of proton and electron transfers, depending on the potential difference of the molecules participating immune responses. The use of antioxidants increases the activity of complement due to the directional change of redox potential.
The activity of complement was determined by recording the time constant lysis of sheep erythrocytes. The initial activity of complement amounted to 6.4% When using POLYSORB in a daily dose of 150 mg/kg of body weight constant was 8.3%
The dosage of POLYSORB can vary widely without any negative side effects. The harmlessness of POLYSORB were studied on animals Institute of surface chemistry of NAS of Ukraine. It is established that at which the base introduction 10 times therapeutic dose (1.0 g/kg) did not register any deviations from the indices of metabolism, hematological parameters of blood and immune system. The long introduction of POLYSORB in doses of 0.1, to 0.33 and 1.0 g/kg total protein content was not significantly changed in any series of experiments. The introduction of POLYSORB up to 90 days at a dose of 0.1 and 0.33 g/kg has no effect on the indices of nonspecific protection and immunity. None of the tested doses POLYSORB has no teratogenic, embryotoxic and teratogenic action.
Therefore, pharmacological tool POLYSORB can be used as an antioxidant long courses and, if necessary, in large doses, without toxic effects on the body.
In addition, it is known that in the pathogenesis of a large number of diseases are important syndrome of endogenous intoxication and violation of redox processes. Also proved the effectiveness of the joint application of chelators and antioxidants. High sorption activity of POLYSORB, its adaptogenic, anti-allergic, antioxidant, membrane-stabilizing effect mutually enhance the effects on the body and allow the use of POLYSORB as monotherapy instead of using multiple drugs. The result is a reduction in the number of drugs used and how sledstvennaya frequency is oznacevanje side effects.
The use of Polisorb as a means of membrane-stabilizing effect.
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to biologically active compounds. Agent represents 3,6-dioxocyclohexa-1,4-diene-1,2,4,5-tetrasulfonate sodium. The new agent elicits antioxidant properties and therefore it can be used in food industry, in pharmaceutical compositions and cosmetic products. Also, the new agent elicits antiviral activity owing to it can be used as both the independent medicinal agent and in compositions with other preparations used for treatment of viral infections.
EFFECT: expanded assortment of medicinal agents and antioxidants, realization of indicated prescription.
1 tbl, 8 dwg
FIELD: medicine, in particular disinfectant for domestic and industrial compartments, surfaces, tools, transport.
SUBSTANCE: claimed composition contains mixture of tetramethylenediethylene tetramine with silver ninrate, stabilizer and silica gel. Tetramethylenediethylene tetramine is obtained by reaction of at 50-70°C for 60-80 min in absence of alkali, then formed solution is cooled to 18-20°C for 12-18 h.
EFFECT: disinfectant with improved quality, higher bactericide and virulicide action; method with increased yield.
2 cl, 4 tbl, 6 ex
FIELD: veterinary science.
SUBSTANCE: about 20-25 d before calving one should introduce intramuscularly 0.5%-sodium selenite solution for cows at the dosage of 10 ml. Twice before and twice after calving at 10-d-long interval - tetravit at the dosage of 10 ml at the content of 50000 IU vitamin A, 25000 IU vitamin D, 20 mg vitamin E and 5 mg vitamin F per 1 ml. Succinic acid should be introduced 20-25 d both before and after calving at the dosage of 1.0 g. The method provides efficient correction of the main values of homeostasis in cows after calving.
EFFECT: higher efficiency of normalization.
2 ex, 4 tbl
FIELD: ecology, medicine, toxicology, experimental biology.
SUBSTANCE: the present innovation deals with studying the mechanisms to withdraw heavy metals, cadmium, in particular, out of the body in animals and preventing intoxication due to introducing zeolite irlite-1 as 6%-suspension through the probe into animal's stomach at the quantity of 2.5% against body weight simultaneously with daily introduction of cadmium sulfate solution either subcutaneously or through the probe into animal's stomach at the dosage of 0.5 mg/kg.
EFFECT: higher efficiency of prophylaxis.
2 ex, 4 tbl
FIELD: ecology, medicine, toxicology, experimental biology.
SUBSTANCE: the innovation deals with introducing zeolite irlite-1 as 6%-suspension at the quantity of 2.5% against body weight. The method provides withdrawing cobalt out of the body in experimental animals in case of acute intoxication.
EFFECT: higher prophylaxis of intoxication.
2 dwg, 1 ex, 2 tbl
FIELD: medicine, neurology, traumatology, neurosurgery.
SUBSTANCE: the present innovation deals with treating acute craniocerebral traumas (CCT). Since the first hours of therapy it is necessary to perform intravenous drop injection of 2-ethyl-6-methyl-3-hydroxypyridine succinate per 200 mg twice daily in case of severe degree of disease and per 200 mg once daily in case of average and light degrees of the trauma. The method provides detoxication effect in acute period of CCT due to recently established antitoxic action of the preparation suggested , that is accelerated degradation and withdrawal of toxic metabolites out of cerebrospinal liquid.
EFFECT: higher efficiency of therapy.
3 ex, 3 tbl
SUBSTANCE: after keeping during pharmaceutically acceptable period oxaliplatinum is placed in transparent, colorless and residue-free solution at concentration of, at least, 7 mg/ml, and a solvent contains sufficient quantity of, at least, one hydroxylated derivative chosen among of 1.2-propandiol, glycerol, maltite, saccharose and inositol. The innovation describes the way to obtain such a preparation. The preparation is stable during pharmaceutically acceptable period of time, that is it remains transparent, colorless and free of any residue within the range of 2-30 C that could be available during its transportation, storage and/or any handling.
EFFECT: higher efficiency of application.
14 cl, 6 ex, 4 tbl
FIELD: pharmaceutics, veterinary science.
SUBSTANCE: the present innovation deals with preventing and treating hypomicroelementosis in different farm and domestic animals, furred animals, and, also, for enhancing the growth in animals, and treating a number of specific diseases and, also, for maintaining microelemental composition of feedstuffs. The suggested preparation includes chelated complex of iron, manganese, zinc, copper, cobalt, selenium and iodine with organic ligand of complexone type and water. According to the innovation as a chelation ligand it contains trisodium salt of methionine succinic (α-amino-γ-methylthiobutyric-N-succinic) acid at a certain ratio of components. The innovation provides to obtain preparation in soluble form being capable to be well digested by the animal.
EFFECT: higher efficiency.
FIELD: medicine, intensive therapy.
SUBSTANCE: the present innovation deals with body detoxication due to introducing sodium hypochlorite at concentration of 75-90 mg/l at the volume of 400 ml at the rate of 70-80 drops/min. The present innovation enables to restore hemodynamics, normalize the level of thyroid hormones and the values of immunological status and decrease the values of lipid peroxidation due to applying less concentration of sodium hypochlorite that, in its turn, also, prevents the damage of peripheral veins.
EFFECT: higher efficiency.
4 ex, 4 tbl
FIELD: veterinary sanitation.
SUBSTANCE: in the suggested disinfectant one should dissolve electrochemically activated neutral anolyte, containing 0.6 mg/ml active chlorine, with running water at 1:5 ratio and the composition of diluted electrochemically activated neutral anolyte should be supplemented with 1-1.5 mg acetic acid per 1 ml preparation. The innovation enables to decrease the concentration of active chlorine and energy expenses at keeping initial high bactericidal activity of electrochemically activated neutral anolyte and, also, apply it in aerosol form for air sanitation in poultry-breeding housings when poultry is present.
EFFECT: higher efficiency of disinfection.
SUBSTANCE: means comprises amber acid and/or its salts, fructose, dry extraction of Saint John's wort, magnesium ion sources, potassium ion sources as active bases and auxiliary substances, carriers and/or fillers when needed.
EFFECT: enhanced effectiveness of treatment.
4 cl, 4 tbl
SUBSTANCE: method involves preparation dental surface, covering it with 30% aqueous solution of silver nitrate and recovery agent for precipitating insoluble silver salts. Silver salts precipitation is carried out by exposing silver nitrate covering tooth surface with halogen radiation of the kind produced by halogen lamp of 12 W or 75 W having spectral bandwidth of 400…500 nm provided with light guide for concentrating luminous flux for 60 s.
EFFECT: enhanced effectiveness of treatment; localized treatment; reduced risk of complications and stress action upon child.