Preparation and method for producing the preparation for treating alcoholism and drug addiction

FIELD: medicine.

SUBSTANCE: preparation is a crushed and UV-radiation activated β-(3-indolyl)-α-aminocapronic acid obtained by treating dry initial preparation (native aminocapronic acid) crushed to 1-5 mcm large particles with UV-radiation during 12-18 h to the moment the substance decomposition starts. Method involves crushing dry substance of β-(3-indolyl)-α-aminocapronic acid by means of vibration mill with 1500-3000 oscillations per min to 1-5 mcm large particles, activating the crushed product by exposing it to UV-radiation of 250-280 nm wavelength during 12-18 h to the moment the initial substance decomposition starts. The moment is determined by 3-5% large initial mass loss.

EFFECT: enhanced effectiveness of the preparation with no adverse side effects.

6 cl, 3 tbl

 

The invention relates to the field of pharmacology, more precisely to the drug against alcoholism and drug abuse, as well as the manner of its receipt.

The abuse of drugs and alcohol, known since ancient times, has been extended in size, disturbing the entire world community, in many countries they are considered social disaster. Drug mafia control States (Latin America), have their own army (Southeast Asia). Income clandestine corporations in the trade of narcotics exceed the known gains from trade in oil and approach the world profits from the arms trade. Especially disastrous misuse of drugs among youth: affect and the present and future society. Full, from the point of view of addiction, the pattern of abuse, including forms of substance abuse, even more tragic. Substances and preparations not included in the list of drugs, as a rule, more malignant, leading to further damage to the individual and society as a whole.

In modern youth subculture rapidly formed phenomenon (“abuse of consciousness: life success, spiritual development, sex, communication is starting to be considered inseparable from the drug “high.” The degree of material well-being is defined in addition to the Mar and car, expensive clothes, the ability to visit prestigious places of entertainment, and even the possibility of acquiring a “dose” prestigious drug. Philosophical concepts in youth the most fashionable are those that are based on the description and analysis of spiritual experience, acquired through drug use, some of which are ideological basis and justification of drug addiction.

Drug addiction (from the Greek. narke, catalepsy and mania) is a disease characterized by an irresistible attraction to drugs, causing in small doses, euphoria, large - stun, a narcotic sleep. The term “addiction” is etymologically related to the notion of “drug” (from GK. narkotikos - soporific). However, terminological ambiguity arises as soon as it comes to drugs, not related to the group of opium, as additional funds related to drugs, only opiates and noxian have a soporific effect. Other drugs in its pharmacological activity are psychostimulants, psychotomimetic etc. currently, the term “drug substance” (drug) applies to those poisons or substances that can cause when they use authoritysee, sleeping, soothing or stimulating effect.

Figuratively speaking, a drug is poison the brain. Poisons, poisoning the brain (in contrast to the effect on other organs of the human body such as the stomach), does not cause a person pain and negative emotions, because the human brain has no pain receptors. In this effect and hides the main attraction (and destructive) for the physiology of man power, the pursuit of “impunity” state of euphoria, hallucinations.

For the first time the term “Alcoholism” was used in 1849 by a Swedish doctor and social worker Hussam (Huss; M.Huss) to denote the aggregate of the pathological changes occurring in the body under the influence of alcohol. In the modern understanding of biological and medical meaning of the term “Alcoholism” is inseparable from its social content. However, you should not put a sign of equality between binge drinking (binge drinking) as a form of antisocial behavior, and alcoholism as a disease. Drinking generate alcoholism, but is not a disease. Alcoholism is characterized by certain characteristics that distinguish it from the so-called habitual or everyday drinking. Alcoholism, chronic intoxication by alcohol most often in the form of vodka that would cause him chronic catarrh of the gastro-intestinal canal, deep liver and other glands, rebirth is Asadov and especially of the brain, what causes damage to the Central and peripheral nervous system (neuritis - inflammation of the nerve trunks), a staggering gait, weakness of mental activity and the lowering of moral feelings, mental illness.

At this stage of development, problems of drug addiction and alcoholism among the population remain relevant. In international anti-drug center in new York there is a document indicating that the number of addicts on the globe - 1 mlrdchto.

What motivates people to take drugs or drink alcohol? How is addiction? Drug addiction and alcoholism - physical or social disease?

According to a recent survey, two-thirds of Russians (66%) consider drug addiction, physical illness, and only a quarter of respondents (27%) see it as a crime. Especially often think about addiction as a disease those who have among their acquaintances, friends or relatives there are people who use drugs (79%). Compared with this group of respondents, in whose environment there are no such people are twice as likely to consider drug addiction a crime (30% and 14%, respectively). But here is dominated by the view that drug dependence is a disease (63%).

One of the leading brain neurotransmitters - serotonin. Its action is associated with mood, emotions, motivations, Zelena allonym behavior, attention, thinking before doing something. If the currency serotonin broken, changed the balance of serotonin and dopamine - all of these essential mental functions will suffer, and the body will begin to find a way to eliminate the unpleasant feeling arises craving for alcohol, drugs, sweets, cigarettes. Different biochemical pathways nicotine, drugs, alcohol, glucose may reduce or even fully compensate the emotional stress, bad mood, distract from the feeling of failure to reach a goal; and healthy people to imagine it experienced [1].

Began the search for biochemical perpetrators of violations of serotonin metabolism. The predecessor of serotina is an essential amino acid - tryptophan, which we get from food. Its currency is involved enzyme tryptophanase.

Cloning of the gene of cryptotanshinone allowed to set its address - the long arm of the fourth chromosome. Then the method of analysis of the links showed that the gene of cryptotanshinone at the same time is the gene responsible for the occurrence of alcoholism. No doubt: the mutation of the open gene associated with a number of fan severe behavioral problems, including drug addiction and alcoholism.

In April 1999, a group of researchers from the Baltimore University also reported that very faith is possibly the cause of pathological dependence on alcohol can be genetic characteristics of the human body. Specific features of metabolism of endogenous opioids (endorphins and enkephalins). These are close chemical relatives of morphine in stressful situations have a “calming” effect on the brain of a person, thereby normalizing the body's stress response on the part of many other organs and systems (cardiovascular, immune, endocrine, etc.). Scientists from Baltimore has convincingly shown that children of alcoholics system of endogenous opioids is less effective than in the offspring of people, indifferent to ethyl alcohol. Failure natural relaxant, received by inheritance from ancestors, a person is forced to find another way to compensate for the stress. And often in this way becomes the systematic use of alcohol.

Consider now the cell and neuro-humoral mechanisms in the pathogenesis of drug addiction.

In the normal body of opioid neuropeptides perform the critical function of the balance between start - and stop-areas of the brain, the balance between “punishment” (negative emotions) and pleasure (positive emotions).

Given that the vast majority of biological processes in the organism exposed bioecological regulation, it is not surprising that every person, even without any visible and obvious reasons for experiencing periods Prip is datoga or depressed mood. In the first case, this may be a result of increased production of endogenous opioids, the second is a consequence of the reduction of the intensity of their synthesis or excessive decontamination. A certain number of people becoming alcoholics or drug addicts because in a period of prolonged depression caused purely internal (biological) and external (social) reasons, they tried to arrest this condition by administration of a dose of drug, alcohol, stimulants or used any psychotropic means of the antidepressant effect. In this case, the natural relative or absolute deficiency of endogenous opioids reimbursed by their exogenous agonist, and at this dose, hundreds or thousands of times greater than the volume of natural products of these neuropeptides. Powerful authoritysee the drug dramatically shifts the balance emotional state towards positive emotions. People well remembers his feelings, but changing physiological homeostasis good “remembers” system and emotional centers. And then perhaps zamykanie chain pathogenetic mechanisms of drug addiction [2].

Currently, the reduction of alcohol consumption is relatively easily achieved by drugs, in varying degrees, with alkoholproblem effect (tranquilizers, Barbet is clear, GHB, antihistamines with a sedative effect). It is known, however, that this kind of therapy can lead to the formation of toxicomania, greatly complicating the course of alcoholism, as well as reduce mental performance. Reliable means of pathogenetic pharmacotherapy of alcoholism so far not created. Drugs use or for relief of withdrawal phenomena or to generate negative conditioned reflex reactions to alcohol. In the latter case by a special technique assign material resources (apomorphine, emetine), drugs that alter the metabolism of alcohol in the body (disulfiram, metronidazole, cyanamide, furazolidone).

Relief and relief of withdrawal phenomena is achieved by means of tranquilizers and sedatives, heminevrin, butirosin, naloxone. In the treatment of alcoholism is sometimes effective neuroleptics, antidepressants, vitamins and other medicines, improves metabolic processes in the body [3].

Use in the treatment of alcoholic liver disease including psychotropic substances, sensitizing drugs, also can not achieve the desired effect and, moreover, forms a sharply negative attitude to treatment.

In this regard, are of particular value is the search and creation of new alcohol and antynarkomaniynu drugs deprived of these disadvantages, reducing craving and simultaneously possessing useful properties (increase attention, improve memory, mental activity).

Known, for example, pharmacological composition for blockade of receptors neirokinina-1 in mammals (RF patent No. 2140914, 1999), anti-stress, nootropic agent (patent RF №2025124, 1999), derived acetaminophen and pharmaceutical composition alcohol focus (RF patent 2151769, 2000), a method of treatment of alcoholic liver disease (RF patent 2185189, 2002).

More physiologically acceptable alcohol group of substances is the group of pharmaceuticals on the basis of amino acids: composition, containing α-threonine and vitamin B6 (RF patent No. 2097034, 27.11.1997,), pharmaceuticals based on α-glutamyl - α-tryptophan and aminouksusnoy acid (patent RF №2136277, 09.10.1999).

Known drugs SAV and troponin Matrix Technologies, Ync, (Y.of Psychoactive Drugs, vol.20(3), Yul-Sep. 1988, p.333). SAAB is a combination of amino acids DL-phenylalanine, L-tryptophan, L-glutamine and pyridoxal-5-phosphate and is recommended as a Supplement to therapy for persons suffering from alcoholism and drug addiction (heroin, opiates and other). Troponin has advanced compared to SAAB composition of additional substances and amino acids in its composition entering the: DL-phenylalanine, L-tyrosine, L-tryptophan, L-glutamine, and pyridoxal-5-phosphate.

Recently on the Internet” became known to some drugs, the so-called orthomolecular therapy www.ortho.ru). Drugs, in particular, recommended for people with drug and alcohol addiction and are L-tryptophan or 5-hydroxy-tryptophane (data from 09.12.2003,).

Our offered product is new and not described in literature. The basis of the invention lies in the task of creating a new drug that has both alcohol and antynarkomaniynu action with high specificity, non-toxic with no side effects and does not cause negative attitudes towards therapeutic effect.

In accordance with the task was created the drug and how to obtain it. The preparation contains as an active agent crushed by means of a vibration mill and activated UV radiation β-(3-indolyl)-α-aminopropionic acid (AIPC). Grinding the original product is held until the particle size of 3-5 microns, activation of the crushed product is ultraviolet radiation with a wavelength of 250-280 nm within 12-18 hours prior to the beginning of decomposition of the original product. The method of obtaining the drug is as follows.

The drug is produced by rosmel the possible source of dry product β -(3-indolyl)-α -aminopropionic acid (IPC) using mills with frequency 1500-3000 per minute until the particle size of 3-5 μm, and then irradiated crushed powder UV rays at a wavelength of 250-280 nm for 12-18 hours (preferably 16 hours) to obtain a finished product with the above amount of loss of the initial mass of the substance.

The drug was experimental and clinical trials. Experimental tests were carried out on rats in 3 groups: control and 2 experimental (rats prepared with alcohol dependence). Control group with food received glycine, 1 experienced with food received tryptophan, 2 experimental group - AIPC. Testing was performed by standard methods. As a result of: 1 experimental group after 14 days 75% of animals 15 (out of 20) did not fit the drinkers with alcohol, in the 2nd experimental group 95% of 19 (out of 20) animals refused to accept ethanol, preferring plain water.

We were also advanced clinical trials of a new drug with a multi-factorial assessment of its effectiveness.

Multifactor formalized assessment of the effectiveness of therapy was carried out using clinical-psychopathological observations, the method of integrated clinical experiences, psychological testing by the ham-d, reflecting the state of the affective sphere and step the new craving for alcohol scale (Hamilton), the score method of psychological self-being, activity, mood (method SAN), evaluation somatovegetative symptoms. We also analyzed bioelectrochemically activity of cell nuclei by the method of intracellular microelectrophoresis. The results are shown in the following examples.

EXAMPLE 1. Under supervision there were 65 patients aged from 22 to 59 years, 32 of which suffered from alcohol addiction (opium, heroin addiction). Table 1 shows the percentage distribution of the studied patients, depending on age. The prevalence of young people (see table 1) is explained by the number of patients with heroin dependence. The study followed the principles of voluntary participation of patients in the program, as well as privacy, anonymity. As a control in our studies were used retrospectively studied the same urgent clinical condition remitting period from the same patients, but which flowed spontaneously, without acute treatment and often ended with the relapse of alcoholism or drug.

All patients at the time of the study was observed recidivate situation, a brief clinical-psychopathological characteristics of which are given in the following examples.

EXAMPLE 2. Patients with predictions is a complex. This contingent of patients with alcohol dependence was characterized by the presence in the clinic so-called true of drinking bouts with the presence of periodic, cyclic arising periods of massive alcoholism. Binges are alternated with periods of abstinence (“bright intervals”) lasting from several weeks to several months. As a rule, the beginning of drinking bouts in each case can be reliably predicted on the basis of clinically well defined precursors (“predicciones complex”) and (or) available chronobiologically patterns (distribution start binge on specific dates of the month relationship with geliogeofizicheskikh factors). Most often a few days before the binge (prijepolje state) appeared nemoderovani mood swings, often with severe dysphoric radical. Deteriorated overall health, there was dysgraphia, ideational components (Intrusive memories, thoughts, mental modeling and longing for alcohol abuse), vegetative lability, sensory disturbances of different register, a kind of “behavioral repertoire”, pathologically appropriate behavioral activity with a distinctive emotion, attitude to alcohol, the pursuit of leaving home or finding reasons on which I travel. In accordance with the previous experience of alcohol dependence data predictors soon transformed into compulsive, uncontrollable, vital inevitable attraction to alcohol. Harbingers of alcoholic binge, of course, should be treated as an emergency requiring immediate acute treatment. Famous drunken state and drug dependence (“ephedrone binges” and others).

We applied AIPC at that stage “megapolis sobriety”when encountered harbingers testified about updating the vital forms of pathological craving for alcohol. AIPC preventively administered at a dose of 1 capsule 3-4 times a day orally. The duration of treatment corresponded to the duration of previous drinking bouts in each particular patient (average 5-10 days).

The main criterion for successful AIPC - therapeutic intervention - in this case, was a warning to another binge. The vast majority of patients as a result of application AIPC predicted binge periods have been prevented. In some cases, when patients are still not escaped drunken state, daily doses of alcohol were significantly less than usual, which was interpreted as a positive result. Positively evaluated the fact that we have not lost the work of the patients in this is the period lasted outputs to work. The data obtained indicate the possibility of applying AIPC with the aim of secondary prevention of drunken States.

EXAMPLE 3. Patients with the syndrome induced by alcohol and drugs. Among the many reasons alcoholic relapses significant clinical and psychological factors caused by the negative influence of the immediate environment (microenvironment), negative psychogenic emotions. However, the mechanism of development of pathological urge patients not to consume alcohol during remission (phase abstinence) prior to this time are not well understood. Not elucidated the mechanisms of emergence of the so-called “pseudoelements syndrome”.

Studied clinical-psychopathological condition of the patient in various situations conducive to relapse, i.e. in a setting that allows you to drink alcoholic beverages, e.g., feast. It turned out that many patients in this situation, there is a kind of change in the psychosomatic state, objectively recorded by patients and others similar to clinical and behavioral manifestations of alcohol intoxication mild. This phenomenon (6) we called “syndrome induced intoxication” (CIO). The psychic component consists of the change in the emotional sphere: patients receive a state of mild euphoria, comparable with a slight alcoholic or narcotic intoxication.

As a rule, euphoria is replaced dysphoric effects: patients may irritability, restlessness, anxiety, tension, fear, feeling of emptiness, inability to stay among drinkers. Euphoric phase of development SIO in some cases may be rudimentary, and dysphoric (depressive-dysphoric) - dominant.

CIO in its formation and course subject to the General laws of reflex activity, there is a psychological phenomenon autotargeting personality of the patient with another person, group, sample, there is a mechanism of “empathy”. Of course, in the formation of the CIO role play and the senses: olfactory analyzer (perception of the smell of alcohol); visual analyzer (visualization of the whole procedure feast - from alcohol labels, pouring alcohol before use); the auditory analyzer (accompanying feast characteristic, the usual noise, verbal effects). However, to explain the emergence of the CIO only “inhalation of fumes of alcohol, it is not possible, since the individual components of the syndrome can occur in our patients, for example, when watching movies with long periods or reading literature with KRA the full description of these episodes.

Thus, the occurrence in a patient or drug dependence in remission SIO should consider how critical the situation, the resolution for which the patient may end up with a relapse of alcoholism.

The obtained data to determine the change in the diagnostic process and psycho-hygienic work for the prevention of relapse in alcohol dependence. When our patients syndrome induced intoxication and then pseudoelements syndrome we successfully applied to short courses of therapy, in particular through the appointment of the drug AIPC, which in these cases contributed to the empowerment of patients to abstain from alcoholic beverages. We also recommend AIPC as a pocket tool first aid for a period of several hours before the forthcoming participation of the patient in a pre-known for his drinking procedure and a few days after such episodes. The average duration of short-term interventions was about 5-7 days. According to our data, in case of participation of patients in this piece of research emerging CIO or the fact that the immediate stay of patients in the feast led to the relapse of alcoholism only 9.2%, while retrospective data showed that without preemptive prevention of the recurrence time is was ivalsa in 48% of cases of Zion.

EXAMPLE 4. Affective disorders outside of withdrawal disorders. One of the most frequent clinical situations encountered at all stages of formation, course and outcome of alcohol dependence, is affective pathology, in which structure the key importance of depression alcohol Genesis. In accordance with the canons of modern clinical addictions, the term “alcoholic depression” is a common term and is often seen not only in terms of addiction, but in the scale of depression as one of the most important interdisciplinary problems (obschepsihiatricheskoy, psychological, somatic, sociological, and so on). For our patients characteristic was the fact that the usual dose of alcohol did not suppress depressive symptoms, and in some cases in a state of intoxication she (symptoms) were updated. We also observed frequent comorbid predictor importance of depression in the “run” (recurrence) true and pseudotyping States. With the advent of so-called light between depressive anxiety, dysphoric and even hypomanic affect, as a rule, followed the outbreak of compulsive craving for alcohol and protracted binge period. In postabstinentne the period when patients was the touch stage in the formation of remitting (nosocomial) state, we observed clinical picture, which could be called “sober frustration”. Those were the cases where the expected patients initially psihoterapevticheskii “promised”, “guaranteed” staff “full recovery” after the cessation of alcohol consumption lightning did not occur and, conversely, health continued to deteriorate. In those cases, when depressive symptoms were premorbid, we watched its transformation due to chronic intoxication process. Table 2 shows the classification of the severity addictiondid depression on the Hamilton depression rating scale remitting period.

The idea of consideration attacks affective disorders in remitting period in patients with alcohol and drug dependence as evidence of exacerbation of craving and predictor of relapse remission was our rationale for short courses of treatment drugs AIPC (average from 7 to 14 days), the dose of 150 mg (1 capsule) 4 times a day. If necessary, the treatment was carried out on the background of antidepressant therapy (amitriptyline).

Data treatment alcohol and drug affective pathology using AIPC on the background of pharmacotherapy were statistically more effective already from the third day of treatment (table 3). Table 3 shows CPA is additional data edema affective pathology (on the model of alcoholic depression) using AIPC and traditional pharmacotherapy (in points, on the Hamilton depression rating scale).

EXAMPLE 5. Pseudoactivity syndrome; the Phenomenon of theme (alcohol-drug) dreams; Alcohol-drug prestazione state. In remitting the period when alcohol and drug dependency may intermittently occur symptom complex resembling withdrawal syndrome - mental stress combined with somatovegetative disorders. Partly this state is described in the section “Syndrome induced intoxication”. This condition, of course, is a clinical symptom of acute craving and indications for treatment AIPC. Known in clinical addictions phenomenon themed dreams, and alcohol-drug frustrated state, which is a reliable sign of acute craving, we have also included in the registry of evidence for AIPC therapy. According to our observations, edema pseudoactivity disorders was enough purpose AIPC on average 7 days.

The total evaluation of the results of psychological tests before and after taking AIPC showed a positive and statistically significant dynamics of indicators of the scale of Hamilton and self-assessment SAN (“Health”; “Active”; “Mood”).

Clinical effectiveness AIPC was ObjectServer method of intracellular microelectrophoresis. It is established that bioelectrochemically activity of cell nuclei when remitting period recidivating clinical status was sharply decreased and averaged 28,6±3,15%, and 75.5% lower middle-age norms. After acute treatment with the use of AIPC this homeostatic parameter was reset to 51,3±to 5.21%.

Complications in the process of applying AIPC not identified. The specific activity of the drug is also supported by specific clinical examples for individual patients, volunteers.

EXAMPLE 6. Patient C., 24 years. Born and raised in a wealthy family, an only child. The development of childhood and youth good was active and had time for all subjects enrolled in the Academy. On the 4th course was introduced to a drug-stimulant Meth, which in the future he could not refuse. Since 2001 repeatedly treated in specialized medical institutions, after a short remission was resumed taking drugs. Medical center delivered the parents after the regular detoxification. Diagnosis at admission: Neuroleptic syndrome. Cerebellar ataxia. Polyneuropathy. Parkinson Syndrome. Organic psychosyndrome 2-3 degrees. Pervitinovaja drug addiction. Severe depressive state. Selection of amino acid preparations was aimed at eliminating never the pathological disorders. To resolve obessive desire and depression was appointed AIPC with increasing dose, weekly from 600 mg to 1200 mg per day. Recovery of mental status, including intellectual-mnesticheskoe sphere, it took 6 weeks. Currently, the patient retains the reception AIPC to 600 mg per day, adequate behavior, anesthesia is not committed, optimistic, physiological sleep, when you checked the IQ to 89 (before treatment 63), in parallel receives aminocaproic to eliminate the residual effects of toxic polyneuropathy.

After 10 weeks of treatment with the drug was gradually abolished (dose reduction during the week). The state remained stable for 8 months, after which the patient became occasionally use Meth. By the end of 11 months, the reception became regular and the patient was re-referred to the clinic. On the 8th day after the appointment AIPC dose of 800 g per day (1 capsule × 4 times) was able to completely get rid of drug addiction and start to work.

EXAMPLE 7. The patient M is observed to be receiving treatment center since September 1999. Diagnosis: Opium (heroin addiction), 2 stage. A year ago, received higher education - interpreter. The society of communication specific, frequent trips abroad, often emotional cpsds and depression. Reports EP is sodah receive new drugs (cocaine, "ecstasy"), after which there was obessive-depressive States, what was the reason for another visit. Since June 2003, the patient is prescribed the drug AIPC at a dose of 600 mg per day (1 capsule × 3 times a day). On day 3 the patient has reduced heroin use by 20%, decreased depressive complex.

Increase the dose to 1200 mg (2 capsules × 3 times) led to the suppression of craving thoughts about the need for anesthesia. Depressive complex was completely eliminated by the end of 7 days of admission. The duration of treatment in this case 28 days resulted in sustained remission within 6 months.

EXAMPLE 8. Patient C., 45 years. Live in a happy family, have a child. Addicted to alcohol at the age of 37 years. First of alcoholism were innocent, it is not reflected on the work and in the family. The transition from a weakly alcoholic beverages to strong (brandy, vodka) and the formation of alcohol dependence occurred quickly, within 5-7 months the patient received monotherapy drug AIPC 900 mg per day, tolerance decreased from 0.5 l (40% drink) up to 40-50 g of vodka, mood stabilized, displays vegeto-vascular dystonia offset, became cheerful and active, from alcoholic beverages refused on the 9th day absolutely. Prognostically favorable. Repeated courses of drug treatment AIPC on 600-90 mg / day was held annually prophylaxis for 4 weeks. During 4 years of follow-up alcohol consumption is not marked.

2-year observation on 32 patients with alcohol dependence varying degrees showed that the minimum therapeutic dose is 10 mg/kg weight of the patient. Increase dose to 15 mg/kg increases therapeutic effect. At the same time, further increase in the number AIPC does not accelerate the time of elimination of alcohol dependence, but has a more pronounced anti-depressive effect.

New drug AIPC is a useful tool for the treatment of patients with alcohol and drug dependence, which does not cause patients negative attitude to treatment effects. Specific clinical situations in which the clinical effect are: clinical-psychopathological harbingers of drunken States, the syndrome induced by alcohol and drug intoxication, seizures, mood disorders, a phenomenon thematic alcohol-drug dreams, pseudoactivity syndrome, a frustrated state alcohol and drug Genesis.

New drug extends base physiological and non-toxic products such relevant pathology, as alcoholism and drug addiction.

References

1. Bilibin D.P., Janitorial VE Pathophysiology of alcoholism and drug abuse. M.: Izd-vo UDN, 1991

2. Pyatnitskaya I.N. The addiction. M.: Medicine, 1994.

3. Encyclopedia of drugs, ed. 7, 2000

Table 1
 Age ranges (in years)Only
20-3031-4041-5051-6021-59
Abs.(people)251617765
In %termsa 38.524,626,110,8100
Table 2
Abs.The severity of alcoholic depression (in points)
1516-2021-2526-3031-40
In %terms10,462,4a 21.5a 3.91,8
Table 3
№ p/pTreatmentThe days of testing on the Hamilton depression rating scale
1st2nd3rd6th12th
The severity of alcoholic depression (in points)
1Pharmacotherapy19,69,15,32,41,8
2AIPC19,78,93,00,90,5
P1-2>0,05>0,05<0,05<0,05<0,05

1. The drug against alcoholism and drug addiction, which does not cause side effects and negative attitude to the process of therapeutic effects, representing crushed and activated UV β-(3-indolyl)-α-aminopropionic acid (AIPC), obtained by effects on dry crushed to particle size of 1-5 the km of the source agent - native PCI - UV rays within 12-18 h before the decomposition of the original substance, this point is determined by the loss of 3-5% of the initial mass of the substance.

2. The preparation according to claim 1, characterized in that can be used in a variety of alcoholic and narcomaniac dependencies in effective dose.

3. The preparation according to claim 2, characterized in that the optimally effective dose is 10-15 mg/kg weight of the patient.

4. The method of producing drug against alcoholism and drug addiction, characterized in claim 1, comprising grinding the original dry matter - β-(3-indolyl)-α-aminopropionic acid (IPC) - using mills to a fine particle size of 1-5 microns, activate the crushed product due to exposure to ultraviolet radiation with a wavelength of 250-280 nm for 12-18 h before the decomposition of the original substance, this point is defined as a loss of 3-5% of the initial mass of the substance.

5. The method according to claim 4, characterized in that the grinding is carried out at the oscillation frequency 1500-3000 per minute.

6. The method according to claim 3, characterized in that the optimal time of exposure to UV radiation is 16 hours



 

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SUBSTANCE: invention relates to compounds designated for applying in photochemotherapy or diagnosis and indicated compounds represent 5-aminolevulinic acid aryl-substituted esters, their derivatives or pharmaceutically acceptable salts. In particular, invention provides preparing compounds of the general formula (I): R

22
N-CH2COCH2CH2CO-OR1 wherein R1 represents aryl-substituted C1-alkyl group, preferably C1-alkyl group substituted with non-heteroaromatic aryl wherein indicated group aryl is substituted group, and especially preferable this radical is substituted with one or more alkyl groups (for examples, (C1-C2)-alkyl), alkoxy- (for example, methoxy-) groups, fluorine, chlorine atoms, nitro- or trifluoromethyl groups; R2 being each of that can be similar or different represents hydrogen atom or alkoxycarbonyloxy-; indicated alkyl group is broken optionally with one or more groups: -O-, -NR3-, -S- or -PR3- wherein R3 represents hydrogen atom or (C1-C6)-alkyl group, and their salts for applying in diagnosis and photochemotherapy of injures and disorders of internal and external surfaces of body, and products and sets for realization of this invention also.

EFFECT: valuable medicinal properties of compounds.

18 cl, 17 dwg, 2 tbl, 3 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

FIELD: medicine, narcology.

SUBSTANCE: one should detect satisfaction insufficiency syndrome due to performing genetic analysis by the presence of, at least, one of the genes coding the exchange of neuromediators being the constituents of human satisfaction system. One should compensate satisfaction insufficiency due to performing, at least, one complex of physical exercises. Moreover, in case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture in patient one should apply the complex of physical exercises including those to provide sedative effect, and in case of availability of pathological gene allele of dopamine-beta-hydroxylase protein one should apply the complex of physical exercises including those that induce an activating effect. In case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture one should apply additional food biologically active additives based upon amino acids being the precursors of neuromediators, such as taurine, D-, L-phenylalanine in combination with 5-hydroxytryptophan, hypericin and vitamin B6, and in case of pathological gene allele of dopamine-beta-hydroxylase protein one should additionally apply food biologically active additives based upon amino acids being the precursors of neuromediators, such as: taurine, tyrosine and/or dimethylaminoethanol, lecithin and group B-vitamins. The present innovation enables to take into account pathological disease mechanism.

EFFECT: higher efficiency of prophylaxis.

14 cl, 5 ex

The invention relates to the field of pharmaceutical industry, namely pharmaceutical compositions for the manufacture of tablets and prolonged action, in particular tablets for sublingual application, and to methods of producing such compositions

The invention relates to new and nitrate salts of compounds of formulas (I) to(VI), which can be used in medicine for the treatment of bone disorders such as abnormalities in bone and joints

The invention relates to medicine, namely cardiology, and for the treatment of cardiomyopathy

The invention relates to pharmaceutical and veterinary use, namely, to pharmaceutical compositions containing ondansetron, metacin and benzamid

The invention relates to medicine, in particular to immunology and dermatology, and for metabolic immune psoriasis patients

FIELD: medicine, narcology.

SUBSTANCE: one should detect satisfaction insufficiency syndrome due to performing genetic analysis by the presence of, at least, one of the genes coding the exchange of neuromediators being the constituents of human satisfaction system. One should compensate satisfaction insufficiency due to performing, at least, one complex of physical exercises. Moreover, in case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture in patient one should apply the complex of physical exercises including those to provide sedative effect, and in case of availability of pathological gene allele of dopamine-beta-hydroxylase protein one should apply the complex of physical exercises including those that induce an activating effect. In case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture one should apply additional food biologically active additives based upon amino acids being the precursors of neuromediators, such as taurine, D-, L-phenylalanine in combination with 5-hydroxytryptophan, hypericin and vitamin B6, and in case of pathological gene allele of dopamine-beta-hydroxylase protein one should additionally apply food biologically active additives based upon amino acids being the precursors of neuromediators, such as: taurine, tyrosine and/or dimethylaminoethanol, lecithin and group B-vitamins. The present innovation enables to take into account pathological disease mechanism.

EFFECT: higher efficiency of prophylaxis.

14 cl, 5 ex

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