Screaning method for detecting persons consuming narcotic drugs

FIELD: medicine.

SUBSTANCE: method involves recording rhythmocardiogram. Then, spectral analysis of RR intervalogram components in frequency bandwidth from 0.04 to 0.4 Hz is carried out and information value Z is determined from formula Z=Ahf/Alf, where Ahf is the maximum of high frequency component in bandwidth from 0.14 to 0.4 Hz, Alf is the minimum of high frequency component in bandwidth from 0.04 to 0.14 Hz. Z value being greater than 45 and lower than 14, persons consuming narcotic drugs are detected. Z value being lower than 14, persons consuming sedative drugs like opium, morphine, heroine are detected. Z value being greater than 45, persons consuming psychostimulating drugs like cocaine, amphetamine, efedrone, sydnocarb are detected.

EFFECT: high reliability of screening study data.

4 cl, 6 dwg

 

The invention relates to medicine, namely to addiction, and can be used when conducting a screening of a large number of persons.

Currently, the problem of drug addiction remains relevant. In the last 2-3 decades have seen the growth of people using drugs, especially among young people. Drug use leads to serious problems in the social sphere and in private life. During anesthesia in the painful process involved all of the vital multi-functional systems of the organism and, mainly, the system drives.

In this regard, earlier detection of drug, allows, on the one hand, to conduct timely and effective treatment, and on the other hand, to identify persons who are in the social plan can be dangerous for society because of the psychological and behavioral inadequacy.

You know the identification of persons with the attraction of drugs through clinical trials. An example of such a method may include work: Ivanets I.E. Vinnikov M.A. Clinical diagnostic criteria craving for the drug” in the Journal of neuropathology and psychiatry. Saw, M, Medicine, 2001, 8, p.35-39.

The disadvantage of this approach is its subjectivity, as well as the identification of razvivashegosya drugs.

There are many ways to identify drug users, using research biosubstrates and body fluids (EN 2122735, SU 944545, EN 2140637), as well as on the study of tactile and pain sensitivity in patients (EN 2222253, EN 2195158).

Counterparts in their mechanism of action is a method of diagnosis of opium addiction, the so-called Alexeeva test (test "Naloxone"), which studied the face of parenterally administered 0.2-0.4 mg of naloxone and identifying mydriasis, behavioral disorders, signs of opiate withdrawal diagnose drug addiction (Pyatnitskaya NN. Clinical narcology, L., Medicine, 1975, p.68), as well as the way in which intramuscularly mezaton and determine the heart rate before and 5 minutes after injection, and the increase compared to the baseline diagnose craving for opiates (EN 2211030).

However, these methods are insufficient operational and essentially also diagnose the presence of disease.

The closest analogue for the problem at hand, i.e. Express-diagnostics of the availability of drugs in the body, is a way in which to determine the immunoreactivity of serum of the subject, and when it is increased, due to antipyrine antibody or the antigen-specific antioncogene, more than 50%of diagnosed opium addiction (EN 2221251).

However, this method, like the previous one, establishes the existence of the disease and not allows you to quickly and accurately identify individuals receiving drugs in the early stages, when the dependence is not formed.

Thus, the task was to develop a rapid method that allows a high degree of accuracy to identify persons receiving drugs.

The technical result of the claimed method is achieved by assessment of chronotropic effects of the drug on the human body, which is expressed in the shift of the high-frequency relations n low-frequency components of the spectrum of ramachandiran.

The method is as follows.

Register rytmikorjaamo (RKG) in the first standard abstraction of Einthoven. For analysis write 200-300 intervals (about 5 minutes). Then carry out a spectral analysis of RR interferogram in the frequency range from 0.04 to 0.4 Hz.

The analysis of the registered curve can be schematically represented by two blocks in figure 1.

Legend:

1. T(n) discrete input (RKG) represents interferogram, i.e. the dependence of the duration of the RR-interval (T) from its non (n). (n=0... N-1), n is the size of the processed sample.

2. Y(n) is discrete the output signal (RKG) represents interferogram after filtering anomalous emission.

3. G(ω ) is the spectral density.

Block 1, which filters abnormal emission is adaptive nonlinear filter, which operates according to the following algorithm:

Let Tk(n) - interferogram on which iteration, and T0(n)=T(n)

Step 1. the calculation of Tkcp- average

Step 2. computation γDAC- the standard deviation

Step 3. calculation of threshold βk=λ *γkcpwhere (constant λ =1,... ,3)

Step 4. Tk+1(n)=Tk(n)if Tk(n)<=|βk|, otherwise, Tk+1(n)=TDACkif Tk(n)<Tkcpkotherwise Tk+1(n)=Tkcpkif Tk(n)>Tkcpk

Step 5. the calculation of Tk+1cp

Step 6. computation γk+1cp

Step 7. computation ψ =|γk+1cp-γkcp|/γkcp

Repeat steps 1 through 7 until ψ >=ψ00is a given constant 0.05-0.1)

Step 8. To select all values of Tk(n)for which |Tk(n)-Tkcp|<βk

Get interferogram with irregular grid of values of n

Step 9. The calculation of Y(n) using interpolation piecewise polynomial smooth filling, ensuring the smoothness of Y(n) and its derivatives up to the 2nd order, inclusive, by a known method (Marchuk Hietory computational mathematics, M., Nauka, 1977, str-148).

Then carry out a spectral analysis of RKG (block 2).

In the core block is the method of averaging modified periodograms (L.M. Goldenberg and other Digital signal processing. M, Chapman and hall, 1985, str-227). Sets the smoothing function and the size of the sliding window processing. In each window, we calculated the spectral power density of the variable components RKG current window. The output unit calculates the power spectral density of the variable components RKG G(ω )averaged over the number of Windows that provides a reduction in the variance of the estimate of the spectral plane RKG G(ω ).

After obtaining spectral density count information index (Z) by the formula

Z=AVC/Equipment

where

AVC - amplitude high-frequency component in the range from 0.14 to 0.4 Hz;

Equipment - the maximum amplitude low-frequency component in the range from 0.04 to 0.14 Hz.

When values of Z greater than 45 and less than 14 determine persons taking drugs.

In this case, when the value Z is less than 14, determine persons taking drugs sedative action, such as opium, morphine, heroin, etc. and when values of Z greater than 45 - makers psychostimulant drugs such as cocaine, amphetamine, efedron, sidnokarb etc.

P and diagnosis must be considered, that there are five groups of drugs that are used in therapeutic practice, when you receive them as a result of this calculation is obtained values go beyond the norm. Such preparations are means of a Central (benzodiazepines, barbiturates, and other), ganglioblokatory (benzocaine, Gironi, Tacconi), sympatholytic (galidor, no-Spa, reserpine), blockers (inderal, piroxin, inderal, metoprolol) and myotropic funds (nitroglycerin, nitrosorbid ernits).

Their localization steps presented in figure 2.

In this regard, upon receipt of the values of Z greater than 45 and less than 14 subjects interviewed in the process, find out what medicines he takes, and if necessary, conduct additional research aimed at the identification of the drug received, for example by liquid chromatography.

In the process, was conducted 600 surveys of drug dependent persons screening-diagnosis identified in 580 cases (96.6 percent) receiving narcotic drugs, which was later confirmed by liquid chromatography instrument company LKB.

Examples of implementation of the method.

Example 1. Subject A., 28 years. Patient seated in a chair, her wrists fastened the electrodes (the first standard abstraction) and che the standard ez cardiograph entered data into the computer with a sampling frequency of 5 kHz, provide accurate values of RR-intervals.

Conducted registration ramachandiran 215 RR-intervals in the first standard lead and obtained the following values (See. 3).

In the top graph presents rhythmogram, where the ordinate axis is specified interval, and the abscissa axis is its duration. In the bottom graph, Figure 3 shows the spectrum of ramagrama, where on the y-axis shows the relative frequency and the vertical lines define boundaries of high-frequency (0.14 to 0.4 Hz) and low frequency (0,04-0,14 Hz) regions, and on the x - axis range relative density in percent. From the obtained values to determine the maximum amplitude of high-frequency (AVC) to low frequency (Equipment) component of the parameter Z.

Conclusion: the Obtained value Z=2,7 indicates the reception of the drug means a sedative action.

In an interview with the patient revealed that he for six hours before the study took heroin at a dose of 0.5 grams.

Example 2. The subject M, 20 years. Analogously to example 1 were registered ramachandiran 188 RR-intervals in the first standard lead and obtained the following results (see figure 4).

Conclusion: the Obtained value Z=213,63 indicates the reception of a drug stimulating action.

In an interview with the patient revealed that two hours prior to the experiments the deposits he took Terpincod at a dose of 0.01 gram.

Example 3. Test B., 25 years. Analogously to example 1 were registered ramachandiran 302 RR-interval in the first standard lead and obtained the following results (see figure 5).

Conclusion: the Obtained values Z=29.67 per shows that drug in the body to be tested is missing.

Example 4. Subject F., 34 years. Analogously to example 1 were registered ramachandiran 310 RR-intervals in the first standard lead and obtained the following results (see Fig.6).

Conclusion: get the value Z=13,35 indicate that the subject took a drug sedative action.

In an interview with the test revealed that the doctor he takes fenazepam, four hours before the test he took his dose of 0.001 gram.

1. Method of identification of the persons receiving the drug, characterized in that the register rytmikorjaamo, perform spectral analysis and calculate the information rate (Z) by the formula

Z=AVC/Equipment,

where AVC - amplitude high-frequency component in the range from 0.14 to 0.4 Hz,

Equipment - the maximum amplitude low-frequency component in the range from 0.04 to 0.14 Hz,

and when the value (Z) is greater than 45 or less than 14 determine persons taking drugs.

2. The method according to claim 1, the tives such as those when the value (Z) is less than 14 determine persons taking drugs sedative action, such as opium, morphine, heroin.

3. The method according to claim 1, characterized in that when the value (Z) is greater than 45 determine persons taking psychoactive drugs, such as cocaine, amphetamine, efedron, sidnokarb.

4. The method according to claims 1 to 3, characterized in that the identified persons taking drugs, by polling determine patients taking medications for health reasons, and if necessary, conduct additional research, identification of received funds.



 

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