Ointment for treating burns and other skin diseases

FIELD: medicine.

SUBSTANCE: the present innovation deals with preparing ointments to be applied at treating both surface and deeply penetrating cutaneous burns and other skin diseases, as well. Composition of the suggested ointment includes, weight%: 45…67% food sunflower oil, 15…37% food olive oil, 1…2% Calendulae officinalis extract, 0.8…1.8% labdanum, 2.5…8% colophony, 6.5…11.5% white bee wax, 0.7…1.8% the main bismuth gallate and 0.7…1.8% camphor. The suggested ointment is highly efficient for rapid and successful treatment of burns III and IV degree. It should be also applied for treating shin's ulcer and, also, in gynecology - for treating inflammation of uterine cervix.

EFFECT: higher efficiency of therapy.

4 ex

 

The present invention relates to the ointments used in the treatment of both surface and deep penetrating skin burns and other skin diseases.

There are various pharmaceutical drugs used for the treatment of burns method for managing the process of formation of microorganisms in the background caused by pathological changes. They are based on synthetic chemicals that act as active components, which are used individually or in combination. The process of synthesis of these substances is associated with certain difficulties, which limits their application due to the low availability.

Known ointments, associating composed of active ingredients that provide anti-inflammatory effects that contribute to scarring and the formation of epithelium. Thus, the patent Romania RO 92445 protected ointment for the treatment of skin burns, which includes basic bismuth nitrate, Ichthyol, zinc oxide, oleum Jecoris, vitamin a acetate, vitamin F, ascorbic acid, hydrocortisone acetate, neomycin sulphate, lanolin and petrolatum.

Known ointment, described in the patent Romania RO 108.643, which includes white beeswax, rosin, incense, powder golovackogo bismuth and edible sunflower oil in the weight proportions 5...20: 2...15: 0,1...0,3: 0,5...2: 70...90. This is ASI like other well-known ointments has insufficient therapeutic effect, especially with deep burns.

Ointment disclosed in the present invention, based on natural products, which are used as active components, the effect on the human body parts of these components are known from the prior art. The combination of all these components ointments in accordance with the present invention allows not only to expand the range of pharmaceutical products of this kind, but also to exclude from the use of synthetic chemicals and achieve higher results of complex treatment.

According to the invention ointment consists of 45...67% of edible sunflower oil, 15...37% food grade olive oil, 1...2% extract of the herb Calendulae officinalis. 0,8...1,8% incense, 2,5...8% rosin, 6,5 11,5...% white beeswax,...1,8 0,7% main golovackogo bismuth and...1,8 0,7% camphor, and the composition is presented in weight percent.

All components of ointments in accordance with the present invention should be clean and their properties must meet the requirements for pharmaceutical products. For example, as sunflower and olive oil should be fresh preparation and before use to obtain the ointment to be subjected to analysis. These oils are stored in closed containers, in a cool dark place. Avoid clouding they are not on what ought to contain traces of water. These oils should be subjected to filtering in the absence of moisture, and before use, preferably, heated to ensure the process fluidization. The shelf life of the oils limited. White beeswax should also be cleaned before use for the preparation of ointments.

In accordance with the invention, the active ingredients of the ointment mutually activate each other, creating a synergistic effect in the treatment of some skin diseases or skin burns, including burns even III or IV level. Compared to existing tools such purpose ointment in accordance with the present invention has the following advantages:

- fast effect on the skin, causing her cure within a short period of time. For example, burns third degree education epithelium of the outer cover is a maximum of 14 days;

- wide bacteriostatic and fungicidal spectrum of effects due to the large number of components and the selection of the proportional correspondence between them; this ointment has a specific bactericidal spectrum;

the ointment does not contain a hard synthetic substances.

For a more detailed explanation of the invention the following are examples of preparation of ointments in accordance with this the image is the group. However, these examples in no way limit the scope of protection of this invention as defined by its essential attributes.

Example 1

In a metal vessel made of stainless steel, equipped with a mechanical stirrer, a thermometer, heat exchanger casing and lid with ventilation device and pressure gauge, fill in 415 ml of edible sunflower oil (density 0,920 kg/l) and 675 ml of edible olive oil (density 0,9118 kg/l), then the mixture, shaking, heated to a temperature of 145°C.

Separately prepare a mixture of 20 g of the extract of the herb Calendulae officinalis and 400 ml of sunflower oil (weight 5% oil composition of the extract of the plant), which is then added to the vessel under continuous shaking. Thus obtained mixture is shaken for 5...10 minutes, maintaining the temperature within 145°C. With continued shaking in a vessel introduced 30 g of incense, which are dissolved in the existing mixture for 10 minutes. Then to the mixture was added 100 g of rosin, still shaking over the next 8...10 minutes to complete homogenization, and then added to the mixture of 116 g white beeswax, and the resulting mixture is again shaken to continue until completes its full homogenization degree check by lifting the lid of the vessel on the Le stop shaking. If necessary, re-closing the vessel, continue to carry out the shaking at the same temperature. Then, to the obtained mixture when shaken add 25 g of the main golovackogo bismuth (basic gallate of bismuth) and the mixture is cooled to a temperature of 40°With, then add to 11.7 g of camphor, still shaking for 8...10 minutes. At the bottom of the vessel in which to prepare this mixture, there is provided the exhaust valve pipe made of the same stainless steel material as the vessel itself. Through the hole in the faucet obtained liquid mixture flows into the dispenser equipped with a cooling system, and received in the dispenser ointment using one of the known methods, Packed in tubes constructed of materials approved for use by standards appropriate to the requirements adopted in pharmacy.

Plants extract Calendulae officinalis prepared on the following technology. The plant is harvested in the morning, while the calyx of the flowers have not yet opened. The stem, leaves and flowers of the plant are crushed to 1...2 cm, then mixed and placed in a container where add ethyl alcohol. Mixture is allowed to stand for 10 minutes, after which the ethyl alcohol is removed from the vessel, and the vessel is closed and closed incubated for 24 hours. To the contents of vessel type of edible sunflower is aslo and the mixture is heated for 24 hours, providing a temperature of about 60...70°With from time to time shaking contained in a vessel mix. In conclusion, the mixture is filtered under pressure to obtain a composition comprising 5% by weight of the extract of the herb butter. This method of preparation of the extract of the plant is based on the phenomenon of maceration. Double maceration may be performed using techniques known in this technical field. The extract is kept in securely closed containers, in a dark place at a temperature of 6...8°C.

Example 2

Ointment in accordance with the present invention is prepared using the techniques described in Example 1. The difference is in the number of components, namely the use of 615 ml of edible sunflower oil, 275 ml of edible olive oil, previously separately prepared mixture of 27.4 g of the extract of Calendulae officinalis and 595 ml sunflower oil (mixture containing 5% by weight of the extract of the herb), 15 grams of incense. 50 g of rosin. 166 g white beeswax and 30 g of the main golovackogo bismuth. Mixing these components and homogenization of the composition is carried out at a temperature of 185°C. thereafter the mixture is cooled to 45°and to it was added 11.7 g of camphor In the completion of the discharging fluid from the vessel, the cooling and packaging of ointments perform identical to the process described in Example 1.

the data mixture contains more beeswax and fewer incense and rosin compared with the mixture, prepared according to the technology described in Example 1.

Example 3

The ointment is prepared using the techniques described in Example 1. The difference consists in the introduction into the vessel 217 ml of edible sunflower oil, 546 ml food olive oil, previously separately prepared mixture of the 33.2 g of the extract of Calendulae officinalis and 685 ml sunflower oil, 13.3 g of incense, 133 g of rosin, 111 g white beeswax and 11.6 g of the main golovackogo bismuth. Mixing these components and homogenization of the resulting composition is carried out at a temperature of 200°C. thereafter the mixture is cooled to a temperature of 60°and to it was added 30 g of camphor. In conclusion, carry out the same operations as in Example 1.

Compared with ointments, resulting technology presented in Examples 1 and 2, this mixture contains a greater number of plants extract, rosin and camphor and fewer beeswax.

Example 4.

Ointment in accordance with the present invention is prepared using the techniques described in Example 1. The difference lies in the fact that the vessel is injected 740 ml of edible sunflower oil, 400 ml of edible olive oil, previously separately prepared mixture of 16.6 g of an extract of Calendulae officinalis and 343 ml sunflower oil (mixture containing 5% by weight of the extract of the herb), 25 g of frankincense is, 42 g of rosin, 190 g white beeswax and 11, 6 g of the main golovackogo bismuth. Mixing these components and homogenization of the resulting composition is carried out at a temperature of 160°C. thereafter the mixture is cooled to 45°and to it was added 13.3 g of camphor. In conclusion, carry out the same operations described in Example 1.

Ointment in accordance with the present invention is preferably used for the treatment of burns. Burns of III degree, regardless of their location on the human body layer of ointment thickness of 2...3 mm is applied to a sterile bandage, after which the bandage is applied on the burned area. In the first 4...6 days dressing change every 24 hours, as follows: the bandage is removed, the burn is treated with aerosols of chamomile infusion, the products of the disintegration of the protoplasm of a cell necrosis is removed is much less painful than treatment with other ointments, then re-treat the burn with an infusion of chamomile, then the affected area dry, dabbing it with a sterile cloth, and then put another sterile dressing with a layer of ointment. Starting from the seventh day of treatment and up until the fourteenth day of treatment, or even earlier, depending on the severity of the disease and dimensions of the burnt surface, the band changed every 48 choose recovery epithelium treatment continued with a very thin layer of ointment, which is applied on the area treated blotting movements swab in order to avoid cracking and other damage of the outer surface of the skin.

Burns IV degree of removal of the products of the disintegration of the protoplasm of a cell necrosis should be managed very carefully to avoid the formation of air connections.

Ointment in accordance with the present invention can give very good results in the treatment of leg ulcers. In these cases, the thickness of the layer of ointment on the bandage is 10 mm with the aim of creating conditions that ensure good absorption of the resulting products of the disintegration of the protoplasm of the cell. The duration of treatment is 4 to 8 weeks depending on the extent of the surface and depth of the wound.

Another area of application of ointments in accordance with the present invention is gynecology, in particular the treatment of trahlyta (inflammation of the cervix). In this case, use a small sterile swab, well impregnated with an ointment which is applied to the affected area. The swab is changed every 24 hours, and the affected area is washed with a large number of infusion of chamomile. The duration of treatment is 2 to 3 weeks depending on the degree of inflammation.

Ointment for the treatment of burns and other skin diseases, characterized in that it consists of 45...67% pisew the th sunflower oil, 15...37% food grade olive oil, 1...2% extract of the herb Calendulae officinalis,...1,8 0,8% incense, 2,5...8% rosin, 6,5 11,5...% white beeswax,...1,8 0,7% main golovackogo bismuth and...1,8 0,7% camphor, and the composition is presented in weight percent.



 

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