Method and device for diagnosing biological object condition

FIELD: medicine; medical engineering.

SUBSTANCE: method involves applying electrodes to injured extremity tissue under study. The electrodes are arranged in diametrically opposite points of horizontal plane transaction to extremity surface. Two electrodes are applied to the other extremity. The electrodes are arranged in diametrically opposite points of horizontal plane transaction to extremity surface. An initial point is selected relative to which pairs of electrodes are equidistantly arranged on the extremity. Active and reactive impedance components are measured at the places of electrodes positioning. Viability condition of the injured extremity tissue under study is diagnosed depending on ratio of reactive to active impedance component on injured and intact extremity and difference between reactive impedance component on injured and intact extremity. Device has transducer unit, computer and unit for processing signals having interface units, central subscriber station, autonomous transmission center, commutator which input is connected to transducer unit output and commutator output is connected to central subscriber station input, the first input is connected to autonomous transmission center output.

EFFECT: high accuracy in diagnosing biological object condition.

5 cl, 5 dwg, 4 tbl

 

The invention relates to medicine and medical technology, and in particular to methods and devices for measuring electrical characteristics of biological objects, and can be used when conducting functional diagnostics of healthy and diseased tissues of biological objects by the method of comparative impedancometry to determine the border of the lesion tissue, for example, in patients with gangrene lower limbs.

There is a method of measuring electrical characteristics of a biological object by applying the electric pulses of the output signal of predetermined parameters, passing through a standard current pulse of predetermined parameters and the measurement of electric characteristics. In the passage of the current pulse measure the resistive component of the impedance, and absent pulse current capacitive component of the impedance. During the passage of the positive component of the current pulse through the biological object to measure its total conductivity, and during the passage of the negative component of the current pulse measured total capacitance characteristic of a biological object. While the total capacitive characteristic of the biological object is determined by the current depolarization (see RF patent for the invention №2128942, IPC And 61 In 5/05, publ. 20.04.1999,)./p>

The disadvantage of this method is the low diagnostic accuracy due to the lack of simultaneous measurements by several parameters, namely, capacitive and ohmic resistance of the object, necessary for reliable output when diagnosing different types of gangrene (dry, wet).

There is also known a method of regional bioimpendancemetria, consisting of flow through the limb in the analyzed region of the body of the probing AC and simultaneous measurement of AC voltage outside the studied region. This measures the voltage drop across the extremities, through which the current flows, and the total voltage drop across the body, and a voltage proportional to the impedance of the investigated region, obtained from the difference between the total voltage drop and the voltage on the limbs, and the voltage on the limbs is measured relative to extremities, through which no current passes. As the probing AC use current having a harmonic frequency components. Measure the voltage at the extremities, through which no current passes, produce relative to the point at which the AC voltage is equal to half of the total voltage drop on the body (see RF patent for the invention №2094013, IPC And 61 In 5/05, publ. 27.10.1997,).

Weeks the STATCOM of this method is the complexity of its implementation due to the necessary measurement parameters, inherent in many points different and separated from other parts of the body object, with subsequent analysis of the obtained results. In addition, the method of low accuracy due to the complexity of the exact location of the points where it is necessary to measure parameters.

There is a method of electromagnetic resonance impedancometry living tissues of a biological object that is implemented by determining the values of the resonant resistance and the resonant capacitance of the oscillating circuit containing an inductor and a capacitor, without exposure or exposure to a biological object to one of the components of this circuit. The definition of the values of the resonant resistance and the resonant capacitance of the oscillating circuit without exposure or exposure to a biological object are carried out by the corresponding amplitude-frequency characteristics of the oscillating circuit, which is determined by the feed resonance circuit formed by the voltage of the serial number of frequencies and frequency scanning with a step in the selected frequency range, and then determine the values of active and reactive components of the impedance of the biological object. Exposure is carried out by depositing the biological object in the internal or external solenoid of the second field coil inductance of the oscillating circuit. Exposure is carried out by galvanic contact tissue of a biological object with metal electrodes, electrically connected with the winding connection of the contour of the inductor of the oscillating circuit. Exposure is carried out by contact tissue of a biological object with metal electrodes, the working surface of which is covered with a dielectric, each electrode electrically connected to one of the terminals of the capacitor of the oscillating circuit (see RF patent for the invention №2182814, IPC And 61 In 5/053, publ. 27.05.2002,).

The disadvantage of this method is the increased complexity of the research process due to the need to move the biological object and its subsequent fixation on internal or external electromagnetic field of the inductor of the oscillating circuit, which also affects the accuracy of diagnostic procedures.

There is a method of diagnosing the condition of a biological object, namely, determine whether the patient has breast cancer, which consists in obtaining the two sets of values of the electrical impedance for each of the anatomically homologous parts of the object (breast), one of which may be susceptible. Thus the impedance values are obtained by measurement and is the impedance across the selected area of each part of the object. Many of the obtained values is processed and by comparing the values obtained between themselves, a conclusion regarding the presence of the disease (see U.S. patent for the invention №6122544, IPC And 61 In 5/053, publ. 19.09.2000,).

The disadvantage is the complexity and the complexity of the procedure, to obtain the result it is necessary to analyze a large number of values of the impedance, which increases the time of diagnosis.

A known method for the diagnosis of the viability of the tissue by measuring skin resistance to electric current at which the electrical resistance is measured simultaneously at symmetrical points of healthy and diseased sites, determine their value and when the values of 2.3 and above diagnosed with irreversible tissue changes (see USSR author's certificate for invention №1694110, IPC And 61 In 5/103, publ. 30.11.1991,).

The disadvantage of this method is the low accuracy of determination of the border of the lesion tissue, since the ratio of the electric resistance does not give comprehensive information for diagnosis. For example, it is found experimentally that for healthy tissue ratio, for example, the resistive component of resistance may be greater than the value of 2.3, which would entail the production of wrong diagnosis and the wrong method is ecene. Also used to diagnose invasive method of diagnosis involving penetration into the tissue studied diagnostic tools, which complicates the diagnosis and makes the procedure is painful for the patient.

There is a method of measuring electrical characteristics of a biological object that is implemented in the device for the study of the functional state of the tissue (see USSR author's certificate for invention №1311707, IPC And 61 In 5/05, publ. 23.05.1987 year). A sinusoidal signal of variable frequency is supplied from the generator to the current electrode, which creates in some tissues the distribution of current and voltage, which is registered potentiometrically electrode. The signals characterizing the active and reactive components of the impedance of the biological tissue, is coming to the unit, the output of which a signal proportional to their ratio. The relation of these parts is a value that is proportional to the tangent of the angle of phase shift of the impedance of the active component of the impedance. Get after it curves dependency module full of impedance on frequency and the tangent of the phase angle against frequency gives information about the electrical properties of the tissue. For example, failure of the microcirculation in the capillaries that feed byebye is t, characteristic maximum in the curve of the phase angle against frequency at a frequency of 8-10 kHz. Characteristic data curves are obtained by inflammation, hypoxia, and already in the early stages of development of a particular type of pathology.

However, the disadvantage of this method is the complexity and low diagnostic accuracy, because there are no clear criteria for diagnosis of biological tissue. In various diseases ranges used in the survey fabric frequencies can be very different that in the early stages of disease development, when there is no visual confirmation of the disease, makes the correct diagnosis. This diagnosis also depends on the need assessment of additional criteria, namely the dependencies of a module full of impedance on frequency and the tangent of the phase angle of the frequency, which complicates the diagnostic process. In addition, the values of the impedances of the fabric of every human individual, which complicates the choice of the generic assessment criteria required for the application of the known method.

It is also known device for measuring electrical characteristics of a biological object that includes a controllable oscillator with one output and the input of the at least one current and indifferent elect the odes, the detection unit and the control system and display, analog switch with two outputs and an input connected to the output of the controlled oscillator. While the detection unit is designed as two amplitude detectors, with one digital output and analog inputs, connected respectively with one of the outputs of the analog switch, and analog outputs with at least one current electrode, and a control system, and display is made in the form of firmware of the controller with the control circuits of the analog switch and circuits of communication with the management PC, equipped with two digital buses, each of which is connected to one of the amplitude detectors through their digital outputs, and input and output, the first of which is connected to the indifferent electrode, and the second to the input of the controlled oscillator. Amplitude detectors made in the form of a semiconductor diode, and the analog switches in the form of integrated switches CMOS technology. A controllable oscillator standard pulses performed with a controlled pulse shaper predetermined shape with adjustable frequency 100 Hz-500 kHz and adjustable duty cycle 0.5 to 5 and an amplifier - shaper output signal to control through microcontroller output signal amplitude 1-12 Century Analog whom Uttar performed with two cascades of high-speed analog switches (see RF patent for the invention №2128942, IPC And 61 In 5/05, publ. 20.04.1999 year).

A disadvantage of the known device is the complexity of its design and cost. If this device does not allow to obtain high accuracy of determining the area of lesion of tissue of a biological object, because due to the lack of simultaneous measurements by several parameters, namely, capacitive and ohmic resistance of the object, not the primary information for reliable output when diagnosing different types of gangrene (dry, wet).

A device for regional bioimpendancemetria containing the AC generator, the output of which is connected to the current electrodes, connected in series switch, detector, analog-to-digital Converter and the processing unit and display unit, the output of which is connected with the control input of the switch, regional and peripheral potential electrodes are connected to signal inputs of the switch. The device includes a voltage divider connected between the regional potential electrodes, the output of which is connected to the signal input of the switch. The detector contains serially connected low pass filter, a selective amplifier and a detection unit of neosignal and connected in series filter high cha is the one an input connected to the input of the low pass filter and the detection unit of the high-frequency signal, and the detection unit of the low-frequency signal, an input connected to the output of the low pass filter, the input of which is the input of the detector, and the outputs of the detecting unit of neosignal, the detection unit low-frequency signal and the detection unit of the high-frequency signal are outputs of the detector (see RF patent for the invention №2094013, IPC And 61 In 5/05, publ. 27.10.1997,).

A disadvantage of the known device is the complexity of its design through the use of filters high and low frequencies and multiple detection units. It is also not possible to carry out diagnosis with high accuracy because the measurement of parameters in the set of points remote from each other parts of the body object. While locating desired locations which should make measurements very difficult.

It is also known a device for the study of the functional state of the tissue containing the controllable oscillator, the output of which is connected to a current electrode, the indifferent electrode, connected in series potentiometrically electrode, the amplifier and the unit of the phase detectors, with the aim of increasing the accuracy and reducing the value of time study the electrical parameter of the biological tissue, in the device entered sweep generator connected to the input of the controlled oscillator, the amplitude detector, an input connected to the output of the amplifier, the unit, the inputs of which are connected to the outputs of the block of phase detectors, and a dual-line display, the information input of which is connected to respective outputs of the unit and the amplitude detector and the input scanner is connected to the output of the sweep generator, and the output of the controlled oscillator is connected to the second input of the phase detector (see USSR author's certificate for invention №1311707, IPC And 61 In 5/05, publ. 23.05.1987 year).

However, a disadvantage of the known device is its complexity due to the large number of electronic devices (blocks of phase detectors and division, amplifier, peak detector), which due to noise and interference inherent in each instrument, increase the measurement error, which can lead to inaccurate diagnosis of the biological tissue. Processing of measurement results is additionally hampered by the need to evaluate graphical dependencies of a module full of impedance on frequency and the tangent of the phase angle of the frequency that unlike, for example, from the numerical evaluation complicates diagnostics of biological tissue.

The closest-the m a solution to the claimed is a device for electromagnetic resonance impedancometry living tissues of a biological object, containing the generator test signals of variable frequency, sensor device, which includes an inductor and a capacitor forming a resonant circuit, and the Registrar, the input connected to the output of sensor devices. Generator test signals of variable frequency and the recorder is made in the form of a computer connected to the additional forming device and signal processing, the output of which is connected to the input of the sensor unit and the second input with the output of the sensor device, the device generating and processing signals includes an interface and a voltage controlled oscillator, a first input of which the first and the second output are respectively the input and output devices forming and signal processing, d / a Converter, synchronizer, frequency, analog-to-digital Converter and switch channels, the first group of outputs of the interface connected to the control inputs of the digital to analogue Converter, the second group of outputs - control inputs of the synchronizer, the third group of outputs - control inputs of the switch, the first group of input - parallel output frequency, the second group of input - parallel output analog-to-digital Converter, the output timeanal the new Converter connected to the generator input of voltage-controlled the first output of which is connected to the first input switch and the second output with the first input of the frequency counter, a second input connected to the first output of the synchronizer, the second output of the synchronizer is connected to the first input of the analog-to-digital Converter, whose second input is connected to output switch, the second, third and fourth outputs of which are the corresponding inputs of the device for forming and signal processing. Sensor device has connected in series matching device, the measuring oscillating circuit, a buffer amplifier and a detector, the output of which is connected with a second input device for forming and signal processing. The oscillating circuit is provided with a measuring inductor coil which can be placed on the frame of dielectric material, at the core of magnetodielectric, the flat frame made of dielectric or have frameless winding, it is possible to use a coil with split winding. Resonant circuit can be provided with an inductor containing a contour of the winding and the winding connection placed on the frame of dielectric material, and mounted in armored core from magnetodielectric with the pins of the winding connection are connected by conductors with two metal electrodes, respectively. Celebate the capacity of the circuit can also be provided with the inductor, winding which is placed on the frame of dielectric material and mounted in armored core from magnetodielectric with the pins of the capacitor of the oscillating circuit are connected by conductors with two metal electrodes, and each electrode working surface covered with a dielectric layer. The device can be equipped with additional sensors for temperature and pulse, the outputs of which are connected respectively with the third and fourth inputs of the device for forming and signal processing (see RF patent for the invention №2182814, IPC And 61 In 5/053, publ. 27.05.2002,).

A disadvantage of the known device is the complexity of its design and its complexity. The necessary fine tuning of the parameters of the device for its operation, namely the oscillating circuit, measuring inductors and other components of the device, which complicates the procedure and reduces the accuracy of diagnosis.

For the diagnosis of possible pathology of the living tissues of a single body known device initially examine the parameters of the oscillating circuit made by these bodies in healthy people of different age groups and establish the boundaries of these parameters for each age group. This greatly increases the number of measurements and increases the time of diagnosis

Experimental data showed that in each case of gangrene of the lower extremities of any Genesis individual must study the viability of the tissues and the determination of the level of amputation. Therefore, the experimental data obtained by a known device for a group of healthy people, can reduce the reliability of the diagnosis, as they have significant fluctuation relative to the individual data of the patient.

The challenge which seeks the proposed group of inventions is a method and device for the study of biological tissue affected by gangrene, which is characterized by ease of implementation and reliability of diagnostics of tissue.

Technical result achieved in the implementation of the claimed group of inventions is to provide a more precise definition is not installed visual boundaries affected by gangrene of the part of the extremity.

This object is achieved in that in the known method of diagnostics of biological tissue, which consists in the measurement of electrical parameters at the points of biological tissue by applying electrodes on the examined biological tissue through which the test tissue is excited by an electromagnetic field, where the quality of the estimated p and the diagnosis value is used the ratio of active and reactive components of the impedance, according to the invention, investigate biological tissue along the length of the lower limbs healthy and diseased gangrene, which in the analyzed tissue of the affected limb impose electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb to the other limb impose two electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb, while choosing a starting point against which a pair of electrodes placed on the limbs equidistant, then produce measurement values of active and reactive component of the impedance in the locations of the pairs of electrodes, determine the relationship reactive component of the impedance of the active component of the impedance on the affected limb (a) and the reactive component of the impedance of the active component of the impedance of the healthy extremity (C) and subject to ratio | And| ≤/5 diagnose viable state of the examined tissue of the affected limb.

With this as a starting point is chosen point on the patient's body, for example, the navel.

The task is achieved by the fact that in the known method of diagnostics of biological tissue, which consists in measuring ELEH the electrical parameters at the points of biological tissue by applying electrodes on the examined biological tissue, through which in the tested biological tissue is excited by an electromagnetic field, according to the invention, investigate biological tissue along the length of the limbs, healthy and diseased wet gangrene, which in the analyzed tissue of the affected limb impose electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb to the other limb impose two electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb, while choosing a starting point against which a pair of electrodes placed on the limbs equidistant, then produce a measurement value of a reactive component of impedance (S) on the affected limb and a reactive component impedance (D) of the healthy extremity and with respect to the ratio | D C| ≤ D/5 diagnose viable state of the examined tissue of the affected limb.

With this as a starting point is chosen point on the patient's body, for example, the navel.

The task is achieved by the fact that in the known device for diagnostics of biological tissue containing the sensor device, the computer and the device signal processing, containing the interface, zerohalogen the nd Converter (DAC), analog-to-digital Converter (ADC), switch, while switch input connected to the output of the sensor device, and the output of the switch is connected to the ADC input, the computer and the device to process signals are connected through an interface, port I/o which is connected to the bus connection of additional devices in the computer, and the output interface is connected to the input of the DAC and the input - output ADC according to the invention, the sensor device comprises at least two pairs of electrodes and at least two of the reference resistor, and the device signal processing is further provided with a timer, the DAC outputs are connected with the inputs of sensor devices, one of the DAC outputs are also connected with the second input of the switch, and one electrode of each pair is connected directly to the DAC, and the other through the reference resistor, the other outputs of the interface connected respectively to the input of the ADC, the input of the timer and the input of the switch, while the output of the timer is connected with the second input interface.

In the present application for a patent for invention complied with the requirement of unity of invention, since the method and the device (hardware complex) is intended for diagnostics of biological tissue. While the claimed invention solve the same task due to the age of one and t the th same technical result in the implementation of inventions.

Combined measurement of active and reactive component of the impedance healthy and diseased limbs significantly reduces the time of diagnosis. Conducting measurements at the diametrically opposite points of intersection of a horizontal plane with the surface of the legs allow the most reliable way to get the values of the impedance of the examined tissue, because the investigated limb throughout its thickness, and not the local area on its surface. Conducting measurements in symmetrical pairs of points on the healthy and diseased limbs allows you to obtain the most reliable data for analysis, since one of the received values corresponds to a patient limb, and the other is the most reliable test indicator (normal value for a particular patient). When used as a sensor device, two electrodes with a reference resistor allows without compromising measurement accuracy significantly speed up and simplify the process of measuring values of the impedance of biological tissue is required for diagnosis of the affected area.

In this application use the following terminology.

Below the horizontal plane refers to the plane that separates the underlying divisions of the human body from the overlying, while it is perpendicular sagittal the Noah (separating the right half of the human body from left) and frontal (separating the front divisions of the human body from the back) planes (see Human anatomy / edited Marsavina, vol. 1, M.: Medicine, 1987, s).

By "viable state" means the state of the tissue, which is missing its necrotization (see "Surgical treatment of purulent wounds", the mode of access in the information system of the General using the Internet in electronic form http://lib.msmi.minsk.by/cgi-bin/showdoc?file=learn/330205&line=291, 11.06.2003,), i.e., viability is the ability of the fabric exposed to the damaging factor in the depression of life, to move the surgical exposure, to restore their normal function and lead to healing of the wound.

The proposed method of diagnostics of biological tissue (variants) and a device for its implementation are illustrated by the following drawings, in which figure 1 shows a block diagram of a device for implementing the method of diagnostics of biological tissue; figure 2 shows an embodiment of sensor device; figure 3 shows the time dependence of the voltages on the electrodes; figure 4 - the dynamics of the relationship reactive component of the impedance of the active component of the impedance in healthy and diseased limbs along their length; figure 5 - the dynamics of change in value of a reactive component of impedance in healthy and diseased limbs on their length.

On the icii on the drawings indicate the following: 1 - sensor device 2 - device signal processing; 3 - computer 4 - interface; 5 - analog Converter (DAC); 6 - analog-to-digital Converter (ADC); 7 - switch; 8 - electrode; 9 - reference resistor; 10 - timer; 11 - biological tissue.

The device for diagnostics of biological tissue contains a sensor device 1, device 2 signal processing and computer 3 (Fig 1).

The device 2 signal processing contains the interface 4, the digital-to-analog Converter (DAC) 5, analog-to-digital Converter (ADC) 6, a switch 7.

The output of the switch 7 is connected to the ADC input 6, with one of the inputs ("potential") of the switch 7 is connected to the output of sensor device 1, containing at least two pairs of electrodes 8 and at least two of the reference resistor 9, and the second input (common) switch 7 is connected to one of the outputs (common) DAC 5. When the DAC output 5 is connected to the inputs of sensor devices as follows. One electrode 8 of each pair is connected directly to one of the outputs (common) DAC 5, and the other is connected with the second output (“potential”) DAC 5 through the reference resistor 9 (figures 1 and 2).

The device 2 signal processing is further provided with a timer 10, which is used to synchronize the data collection processes in this measuring system.

You the ode interface 4 connected respectively to the inputs of the DAC 5, ADC 6, switch 7 and the timer 10. One of the inputs of the interface 4 is connected to the output of the ADC 6 and the second output of the timer 10.

The computer 3 and the device 2 signal processing is connected through an interface 4 port input/output of which is connected to the internal bus of the computer 3 used to connect additional devices to the computer 3 (Fig 1 and 2).

The computer 3 is an IBM-compatible personal computer connected to the peripheral devices (monitor, printer, keyboard).

As the device 2, the signal processing can be used, for example, data acquisition Board model L-154 (producer company L-CARD, Russia), which is functionally complete system of collection and output of analog and digital data. Fee L-154 contains a 12-bit digital-to-analogue Converter (DAC) with a maximum conversion rate of 70 kHz, 12-bit analog-to-digital Converter (ADC), software-controlled multi-channel switch and timers. The Board is connected and the computer 3 is performed using the standard ISA bus connector located on the motherboard of the computer 3 via the interface 4, which control the transfer of data and control signals from the computer 3 and the data transfer from the device 2 signal processing in the computer 3.

Device for diagnosing sustainabilitythe fabric works as follows.

For carrying out of diagnostics of biological tissue one pair of electrodes 8 is superimposed on the examined tissue 11 of the affected limb, and the other pair on the examined tissue 11 healthy limbs. While the electrodes 8 should be arranged in a diametrically opposite points of intersection of a horizontal plane with the surface of the limb. A pair of electrodes 8 are equidistant with respect to the original point located on the patient's body, for example, the navel. In the initial state, the voltage at the electrodes is missing.

At time t0the computer 3 generates a 12-bit control code, which, through the interface 4 is transmitted to the DAC 5, forming a corresponding digital signal to an analog voltage UDAC, after which the analog signal at the sensor device 1 (Fig 1).

As from the physical point of view of biological tissue 11 can be represented in the form of a parallel-connected resistor Raboutand the capacitor Caboutat the moment of time t0begins the transition process associated with the conditional charge capacity of biological tissue 11. The voltage UEon the first pair of electrodes 8 begins to increase exponentially

UE=UDAC·Rabout/(RFL+Rabout)· (1-exp(-Δ t/t3)),

where t 3=(Cabout+CCR)· RFL·Rabout/(Re+Rabout) is the time constant of the charge circuit; RFLthe resistance value of the reference resistor 9; CCR- parasitic capacitance of the electric wires connecting the outputs of the sensor device 1 to the input of the switch 7; UDAC- output voltage (“potential”) DAC 5 and inlet sensor device 1; Δ t=t-t0the time from the beginning of the pulse voltage to the electrodes.

In the absence of the reference resistor 9, the charging process would occur almost instantly, that would not be allowed to perform the measurement process. The value of RFLis set so that the total transition time tCR=4· t3associated with the capacity charge was from 0.01 to 0.1 seconds. For time tCR>4· t3the voltage UEreaches a constant value UE=UDAC·Rabout/(RFL+Raboutand the process of change UEpractically ends.

The value of the voltage UEthe output of sensor device 1 through the switch 7 is supplied to the ADC input 6, which according to the control signals generated by the computer converts the voltage into a digital 12-bit code. The conversion is performed at regular intervals of time (for example, 200 μs, what is necessary for subsequent digital processing of the measurement data. The time intervals set by the timer 10 and through the interface 4 is transmitted to the ADC 6. Digital data is being received via the interface 4 to the computer 3, which are stored in RAM.

After time tCRthe computer 3 sets the value of the voltage at the DAC output 5 is equal to zero (UDAC=0), which begins the process of discharge of biological tissue 11. To ensure the necessary accuracy of measurement due to the impact of natural and man-made noise measurement procedure is periodically repeated. For this purpose, the time interval from tCRup to 2· tCRis the discharge of the capacitor by an input to the measuring circuit voltage UDAC=0 at time t=tCR. After a full discharge at time 2· tCRthe computer 3 specifies the digital control code, which, through the interface 4 is transmitted to the DAC 5, forming an analog voltage - UDAC(figure 3).

Similarly to the previously considered case, the voltage UEon the first pair of electrodes 8 begins to increase exponentially, which is described by the following ratio

UE=-UDAC·Rabout/(RFL+Rabout)· (1-exp(-Δ t/t3)),

where t3=(Cabout+CCR)· R ·Rabout/(RFL+Rabout); Δ t=t-2· tCR.

Thus, the law of variation of the voltage in this case differs only in sign.

When stabilization of the changes UEthe analog video signal from the sensor device 1 through the switch 7 to the ADC 6.

In the time interval from 3· tCRup to 4· tCRsimilarly to the previous case there is a discharge of the capacitor and the process is repeated as many times as necessary to obtain the required accuracy.

This procedure of forming a bipolar voltage to sensor device 1 provides the leveling effects of the polarization of the electrodes 8 and components of living tissue associated with the inevitable rapid change in the electrical parameters under the action of DC.

To reduce the influence of noise and interference and obtain statistically reliable results, the specified measuring procedure is repeated several times (5 to 100). Reduction of errors caused by noise and interference, is provided by digital filtering data received from the sensor device 1.

After removing the data using computer software 3 and a standard mathematical algorithm calculates the values of RaboutWithaboutin the area of location of electrodes 8, which as the active and reactive components of the impedance of the investigated biological tissue 11. The calculation results can be presented in graphical and text form on the screen of the computer monitor 3. The data acquisition time and calculate measurements is approximately 10 seconds.

After measurement of tissue parameters in the zone of location of the first pair of electrodes 8, the measurement cycle is performed for the other pair of electrodes 8.

In the case of two pairs of electrodes 8 after the measurement, the electrode 8 should be placed in the above manner at other points of the limbs and to conduct similar measurements.

The method of diagnostics of biological tissue in the first embodiment is as follows.

In the study of biological tissues healthy and diseased gangrene of the lower extremities on the examined tissue 11 of the affected limb to impose the electrodes 8, having them at the diametrically opposite points of intersection of a horizontal plane with the surface of the limb. On the healthy limb overlap two electrodes, also having them at the diametrically opposite points of intersection of a horizontal plane with the surface of the limb. On the body of the patient choose a starting point, for example, navel, about which pairs of electrodes are placed on the extremities symmetrically. Through electrodes 8 in the biological tissue 11 vosburgh the conducted electromagnetic field. Then produce measurement values of active and reactive component of the impedance in the locations of the pairs of electrodes 8.

As evaluated in the diagnosis of values values are used relationship reactive component of the impedance of the active component of the impedance (A) on the affected limb and relationships reactive component of the impedance of the active component of the impedance (In) of the healthy extremity. With respect to the ratio | And| ≤/5 diagnose viable state of the examined tissue of the affected limb.

To obtain the most complete picture of the lesion limb gangrene such studies must be conducted along the length of the limbs.

Statistical data on the use of the method of diagnostics of biological tissue (in the first embodiment) shown in table 1.

Satisfactory
Table 1
The result of the treatment| And| ≤/6In/6≤ | And| ≤/5In/5≤ | And| </4In/4≤ | And| ≤/3In/3≤ | And| ≤/2Only
Good242310048(64,8%)
02105017(23,0%)
Poor006129(12,2%)
Total2425176274(100%)

In the process of clinical research to operations was determined relationship reactive component of the impedance of the active component of the impedance (A) on the affected limb and relationships reactive component of the impedance of the active component of the impedance (In) of the healthy extremity along the length of the limbs with a view to establishing the values of identified parameters appropriate to the level of viability of the tissues of the leg. Nice has considered the results of operations, after which occurred the primary healing of the wound. Satisfactory was considered results of operations, after which the healing of the wound through the suppuration. Poor was considered to be the results in which after the operation necrosis progressed, and wound healing has not occurred.

From table 1 it follows that good results were observed only when deviation of diseased limbs from the figures that the key to a healthy limbs no more than 20%, which corresponds to the ratio of | And| ≤/5. When larger deviations up to 25% (/5≤ | And| ≤/4) dramatically increased the number of poor and satisfactory results.

Further studies were chosen level of amputation ratio | And| ≤/5.

Table 2 presents comparative results of amputation after diagnosis using the proposed method (first embodiment) and the results of amputation with the use of clinical diagnosis of level of amputation.

Table 2
 The determination of the level of amputation
The result of the treatmentclinical diagnosticsafter applying the proposed method (the first alternative)
Good78(53.1 per cent)237(of 83.4%)
Satisfactory53(36,0%)46(16.2 per cent)
Poor16(10,9%)1(0,4%)
Total147(100%)284(100%)

Thus, the proposed method of diagnostics of biological tissue (the first alternative) resulted in a 1.5 times increase of the number of good results, to halve the number udovletvoritel the results and almost completely avoid the bad results in the subsequent amputation of limbs.

The method of diagnostics of biological tissue according to the second variant is as follows.

In the study of biological tissues healthy and diseased wet gangrene of the lower extremities on the examined tissue 11 of the affected limb to impose the electrodes 8, having them at the diametrically opposite points of intersection of a horizontal plane with the surface of the limb. On the healthy limb overlap two electrodes 8, also having them at the diametrically opposite points of intersection of a horizontal plane with the surface of the limb. On the body of the patient choose a starting point, for example, navel, about which pairs of electrodes are placed on the extremities symmetrically. Through electrodes 8 in the biological tissue 11 is excited by the electromagnetic field.

Then make measurements in several places along the length of the analyzed affected limb values of the reactive component of impedance in the locations of the pairs of electrodes 8.

As evaluated in the diagnosis values are the values of the reactive component of the impedance on the affected limb and the reactive component of the impedance of the healthy extremity.

Produce measurement values of the reactive component of impedance (S) on the affected limb and reactive costal is the MT impedance (D) of the healthy extremity and with respect to the ratio | D-C| ≤ D/5 diagnose viable state of the examined tissue of the affected limb.

To obtain the most complete picture of the lesion limb gangrene such studies should also be conducted along the length of the limbs.

Statistical data on the use of the method of diagnostics of biological tissue (the second option) are presented in table 3.

Table 3
The result of the treatment| D C| ≤ D/6D/6≤ | D-| ≤ D/5D/5≤ | D-| ≤ D/4D/4≤ | D-| ≤ D/3D/3≤ | D-| ≤ D/2Only
Good252100046(62,1%)
Satisfactory04105019(25.7 per cent)
Poor007029(12,2%)
Total2525175274(100%)

During clinical studies of the operation is determined by the values of the jet is leaving impedance (S) on the affected limb and a reactive component of impedance (D) of the healthy extremity along the length of the limbs with the aim of establishing a value-defined indicators appropriate to the level of viability of the tissues of the leg. Nice has considered the results of operations, after which occurred the primary healing of the wound. Satisfactory was considered results of operations, after which the healing of the wound through the suppuration. Poor was considered to be the results in which after the operation necrosis progressed, and wound healing has not occurred.

From table 3 it follows that good results were observed only when the deviation of the patient limb from similar indicators point to a healthy limbs no more than 20%, which corresponds to the ratio of | D C| ≤ D/5. When larger deviations up to 25% (D/5≤ | D C| ≤ D/4) dramatically increased the number of poor and satisfactory results.

Further studies were chosen level of amputation ratio | D C| ≤ D/5.

Table 4 presents comparative results of amputation after diagnosis using the proposed method (the second option) and the results of amputation with the use of clinical diagnosis of level of amputation.

Table 4
 The determination of the level of amputation
Rez is ltat treatment clinical diagnosticsafter applying the proposed method (the first alternative)
Good78(53.1 per cent)243(85,6%)
Satisfactory53(36,1%)41(14,4%)
Poor16(10,8%)0
Total147(100%)284(100%)

Thus, the proposed method of diagnostics of biological tissue (the second option) allowed 1.5 times to increase the number of good results, more than halving the number of satisfactory results and completely avoid bad results.

Analysis of the data presented in figure 4, which shows the dynamics of the relationship reactive component of the impedance of the active component of the impedance in healthy and diseased limbs along the length of the limb, and figure 5, which shows the dynamics of changes in the values of the reactive component of impedance in healthy and diseased limbs along the length of the limb, illustrates the application of the proposed method in practice, which allows you to draw a General conclusion about the defeat or absence of lesions gangrene certain areas of the extremities.

From the graphs presented in figure 4, shows that the ratio | And| ≤/5, where a is the ratio of reactive the th component of the impedance of the active component of the impedance on the affected limb; In the value of the ratio of the reactive component of the impedance of the active component of the impedance of the healthy extremity, is not only in the toe area, which allows to make a conclusion about the defeat of gangrene only the toe area and confine the exarticulation of the toes, keeping the patient the possibility of movement.

From the graphs presented in figure 5, shows that the ratio | D C| ≤ D/5, where C is the value of the reactive component of the impedance on the affected wet gangrene of the limb; D - value of the reactive component of the impedance of the healthy extremity, is not only in the toe area, which allows to make a conclusion about the defeat of wet gangrene only the toe area, and also as the first variant of the method be limited to exarticulation of the toes, keeping the patient the possibility of movement.

In the diagnostics of biological tissue on both versions of the complete method sets the border between healthy and diseased areas, which must be taken into account when further treatment, for example, the amputation of part of the affected limb.

Example. Patient B., 67 years old, was admitted to the clinic of faculty surgery of the Saratov state medical University, diagnosed with diabetes mellitus, diabetic wet gangrene levelstop". Objectively: there was necrosis 2 fingers of the left foot with the spread of acute inflammation on the whole foot and the lower third of the left tibia. We determined the symptoms expressed by the General intoxication. In traditional clinical criteria in such cases, there was little doubt about the need for amputation at the level of the middle third of the thigh. In the study of the affected limb proposed method found that it is possible to confine exarticulation 2 fingers of the left foot. The operation took place in the specified volume with the opening of the tendon sheath of flexor and subsequent milestone necrectomy. The supporting function of the foot is fully preserved. The patient is observed for 2 years. Difficulty in walking, not notes.

Using the proposed methods and devices, which is characterized by ease of implementation and accuracy of diagnosis, allows you to leave with amputation as possible a healthy part of the affected limb and, thus, to increase the number of people who have kept the basic function of the extremities, and re-receiving the opportunity to walk after surgery about different types of gangrene.

1. The method of diagnostics of biological tissue, including the assessment of the viability of biological tissues from patients affected by gangrene of the lower extremities, where PR is the usual measurement of active and reactive component of impedance, and is determined by the ratio of the reactive component of the impedance active, characterized in that the examined biological tissue along the length of the lower limbs healthy and diseased gangrene, which in the analyzed tissue of the affected limb impose electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb to the other limb impose two electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb, while choosing a starting point against which a pair of electrodes placed on the limbs equidistant, then produce measurement values of active and reactive component of the impedance in the locations of the pairs of electrodes define relationship reactive component of the impedance of the active component of the impedance on the affected limb (a) and the reactive component of the impedance of the active component of the impedance of the healthy extremity (In), and with respect to the ratio |And|≤/5 diagnose viable state of the examined tissue of the affected limb.

2. The method according to claim 1, characterized in that as a starting point, select the point on the patient's body, such as the navel.

3. The method of diagnostics of biological engineering is the second fabric, including the assessment of the viability of biological tissues from patients affected with wet gangrene of the lower extremities, which provides a measurement of the reactive component of impedance, characterized in that the examined biological tissue along the length of the limbs, healthy and diseased wet gangrene, which in the analyzed tissue of the affected limb impose electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb to the other limb impose two electrodes, arranged in diametrically opposite points of intersection of a horizontal plane with the surface of the limb, while choosing a starting point against which a pair of electrodes placed on the limbs equidistant, then make measurements values of the reactive component of impedance (S) on the affected limb and a reactive component of impedance (D) of the healthy extremity and with respect to the ratio |D C|≤D/5 diagnose viable state of the examined tissue of the affected limb.

4. The method according to claim 1, characterized in that as a starting point, select the point on the patient's body, such as the navel.

5. Device for measuring electrical characteristics of biological tissues containing the sensor device is STV, the computer and device for processing signals containing the interface, DAC, ADC, switch, the input connected to the output of sensor devices, and the output of the switch is connected to the ADC input, the computer and the device to process signals are connected through an interface, the output of which is connected to the input of the DAC, and the first input with the output of the ADC, wherein the sensor device includes at least two pairs of electrodes and at least two of the reference resistor, and the device signal processing is further provided with a timer, the second input of the switch and one electrode of each pair is connected directly with the input of the DAC connected to a common bus connected to the second input of the switch and the other connected to the DAC via the reference resistor, the other outputs of the interface are connected respectively to the input to the ADC, the input of the timer and the input of the switch, while the output of the timer is connected with the second input interface.



 

Same patents:

FIELD: medicine.

SUBSTANCE: the method deals with measuring geometric body size and electric impedances of patient's hands, body and legs at their probing with low- and high-frequency current due to current and potential electrodes applied onto distal parts of limbs, and, thus, detecting extracellular, cellular and total volumes of liquid in patient's hands, body and legs. While implementing the method one should additionally apply current electrodes onto left-hand and right-hand parts of neck, and potential electrodes - onto distal femoral parts. Body impedance (Zb) should be measured due to successive measuring the impedance of its right-hand Zrb and left-hand Zlb parts at probing current coming between electrodes of similar sides of patient's neck and legs to detect Zb, as Zb = Ѕ x (Zrb + Zlb), impedance of legs Zl should be detected due to measuring femoral impedance Zf and that of shins Zs, as Zl = Zf + Zs. At detecting the volumes of liquid in body and legs one should apply measured values of Zb and Zl, moreover, as geometric body size one should apply the distance against the plane coming through the upper brachial surface up to the middle of radiocarpal articulation in case of patient's hand being along the body.

EFFECT: higher accuracy of detection.

5 dwg, 2 ex, 3 tbl

FIELD: poultry science.

SUBSTANCE: the present innovation deals with visual evaluation in chicken followed by testing them by the value of bioelectric potential. Chickens with bioelectric potential being significantly higher against average values are considered to be stress-resistant ones and those with bioelectric potential being significantly lower against average values in concrete population are concluded to be stress-sensitive ones. The method is very simple in its implementation and efficient for large-scale selection in poultry on stress-resistance.

EFFECT: higher efficiency.

1 cl, 2 dwg, 2 ex, 4 tbl

FIELD: medical engineering.

SUBSTANCE: device has acting upon skin between electrodes with DC potential of given magnitude for producing temporary breakdown. Skin impedance is measured between measuring electrode first negatively polarized relative to control electrode and the control electrode, and then, DC current resistance is measured once more by means of measuring electrode positively polarized relative to the control electrode. Ratio of the obtained values is used for determining internal organ health state, corresponding to skin area.

EFFECT: enhanced accuracy of diagnosis.

11 cl, 14 dwg, 2 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medicine.

SUBSTANCE: one should measure electric impedance of patient's middle ear. Electrodes should be applied in three localizations: auditory canal, anterior end of lower nasal concha and frontal skin. Electric impedance should be measured at the frequencies of sinusoidal signal being equal to 10, 30, 250 and 1000 Hz, the data obtained should be compared by values of electric impedance in the given area (middle ear) in the group of healthy patients. This method provides the chance to obtain comparative data for diagnostics of middle ear diseases.

EFFECT: higher accuracy of evaluation.

2 ex

FIELD: medicine.

SUBSTANCE: method involves carrying out urological examination for determining hydrodynamic resistance of ureter calculated from formula Z=8Lμ/(πR4), where Z is the hydrodynamic resistance of ureter, L is the ureter length, R is the ureter radius, μ is the urine viscosity. Angle α at which the ureter enters the urinary bladder is determined from formula cosα = 8l1μ/(ZπR4), where l1 is the perpendicular drawn from the upper edge of the ureter to the its exit projection line, μ is the urine viscosity, Z is the hydrodynamic resistance of ureter, R is the ureter radius. Vesicoureteral reflux recidivation is predicted when the angle of α+90° is less than 120°.

EFFECT: enhanced effectiveness in reducing the number of recidivation cases.

2 dwg, 1 tbl

The invention relates to medical equipment, namely to diagnostic devices for measuring impedance in specified parts of the body, and can be used for non-invasive determination of volumes of body fluids

The invention relates to medicine, namely to a gastroenterologist, and can be used for both adults and school-aged children
The invention relates to the field of veterinary medicine

The invention relates to animal husbandry

FIELD: medicine.

SUBSTANCE: method involves carrying out urological examination for determining hydrodynamic resistance of ureter calculated from formula Z=8Lμ/(πR4), where Z is the hydrodynamic resistance of ureter, L is the ureter length, R is the ureter radius, μ is the urine viscosity. Angle α at which the ureter enters the urinary bladder is determined from formula cosα = 8l1μ/(ZπR4), where l1 is the perpendicular drawn from the upper edge of the ureter to the its exit projection line, μ is the urine viscosity, Z is the hydrodynamic resistance of ureter, R is the ureter radius. Vesicoureteral reflux recidivation is predicted when the angle of α+90° is less than 120°.

EFFECT: enhanced effectiveness in reducing the number of recidivation cases.

2 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: one should measure electric impedance of patient's middle ear. Electrodes should be applied in three localizations: auditory canal, anterior end of lower nasal concha and frontal skin. Electric impedance should be measured at the frequencies of sinusoidal signal being equal to 10, 30, 250 and 1000 Hz, the data obtained should be compared by values of electric impedance in the given area (middle ear) in the group of healthy patients. This method provides the chance to obtain comparative data for diagnostics of middle ear diseases.

EFFECT: higher accuracy of evaluation.

2 ex

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medical engineering.

SUBSTANCE: device has acting upon skin between electrodes with DC potential of given magnitude for producing temporary breakdown. Skin impedance is measured between measuring electrode first negatively polarized relative to control electrode and the control electrode, and then, DC current resistance is measured once more by means of measuring electrode positively polarized relative to the control electrode. Ratio of the obtained values is used for determining internal organ health state, corresponding to skin area.

EFFECT: enhanced accuracy of diagnosis.

11 cl, 14 dwg, 2 tbl

FIELD: poultry science.

SUBSTANCE: the present innovation deals with visual evaluation in chicken followed by testing them by the value of bioelectric potential. Chickens with bioelectric potential being significantly higher against average values are considered to be stress-resistant ones and those with bioelectric potential being significantly lower against average values in concrete population are concluded to be stress-sensitive ones. The method is very simple in its implementation and efficient for large-scale selection in poultry on stress-resistance.

EFFECT: higher efficiency.

1 cl, 2 dwg, 2 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: the method deals with measuring geometric body size and electric impedances of patient's hands, body and legs at their probing with low- and high-frequency current due to current and potential electrodes applied onto distal parts of limbs, and, thus, detecting extracellular, cellular and total volumes of liquid in patient's hands, body and legs. While implementing the method one should additionally apply current electrodes onto left-hand and right-hand parts of neck, and potential electrodes - onto distal femoral parts. Body impedance (Zb) should be measured due to successive measuring the impedance of its right-hand Zrb and left-hand Zlb parts at probing current coming between electrodes of similar sides of patient's neck and legs to detect Zb, as Zb = Ѕ x (Zrb + Zlb), impedance of legs Zl should be detected due to measuring femoral impedance Zf and that of shins Zs, as Zl = Zf + Zs. At detecting the volumes of liquid in body and legs one should apply measured values of Zb and Zl, moreover, as geometric body size one should apply the distance against the plane coming through the upper brachial surface up to the middle of radiocarpal articulation in case of patient's hand being along the body.

EFFECT: higher accuracy of detection.

5 dwg, 2 ex, 3 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves applying electrodes to injured extremity tissue under study. The electrodes are arranged in diametrically opposite points of horizontal plane transaction to extremity surface. Two electrodes are applied to the other extremity. The electrodes are arranged in diametrically opposite points of horizontal plane transaction to extremity surface. An initial point is selected relative to which pairs of electrodes are equidistantly arranged on the extremity. Active and reactive impedance components are measured at the places of electrodes positioning. Viability condition of the injured extremity tissue under study is diagnosed depending on ratio of reactive to active impedance component on injured and intact extremity and difference between reactive impedance component on injured and intact extremity. Device has transducer unit, computer and unit for processing signals having interface units, central subscriber station, autonomous transmission center, commutator which input is connected to transducer unit output and commutator output is connected to central subscriber station input, the first input is connected to autonomous transmission center output.

EFFECT: high accuracy in diagnosing biological object condition.

5 cl, 5 dwg, 4 tbl

FIELD: medicine, psychotherapy.

SUBSTANCE: the method deals with correcting neurological and psychopathological disorders with anxiety-phobic symptomatics due to individual trainings. The method includes evaluation of body reaction to stimulating signals, seances of individual training performed due to the impact of two quasiantipodal stimulating signals of similar physical modality applied in time of sporadic character, and as a signal one should present biological feedback for the altered value of physiological parameter adequately reflecting body reaction to the impact of stimulating signal. At the first stage of training it is necessary to achieve body adaptation to the impact of quasiantipodal stimulating signals, at the second stage it is necessary to obtain conditional reflex for one out of stimulating signals, for this purpose one should accompany this stimulating signal with discomfort impact, during the third stage, finally, due to volitional efforts one should suppress body reaction to stimulating signal. The devise suggested contains successively connected a transformer of physiological parameter into electric signal and a bioamplifier, an analysis and control block with a connected block to present the signals of biological feedback, a block for presenting discomfort impact, an indication block and that of forming and presenting quasiantipodal stimulating signals. The innovation enables to have skills to control one's emotions, decrease sensitivity threshold to environmental impacts and learn to how behave during stress situations.

EFFECT: higher efficiency of training.

15 cl, 8 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medical engineering.

SUBSTANCE: device has divider, comparison unit, oscillator, acoustic radiator, controllable current source, stable constant voltage source, perspiration equivalent unit, key member, illumination source, conductivity transducer having two electrodes, the first commutator, delay unit, trigger, inverter, discharge unit, the second commutator and feeding voltage availability indicator unit. The first delay unit inputs and the first commutator inputs are connected to comparison unit output. The first commutator input is connected to the first oscillator input which delay unit, trigger and inverter are connected in series. Inverter output is connected to the second input of the first and the second commutator. The first input of the second commutator is connected to the other conductivity transducer electrode and its output is connected to device body via resistor.

EFFECT: reduced current intensity passing through patient skin; excluded negative influence upon skin during prolonged operation time on patient arm during hypoglycemia attack; low power consumption.

2 cl, 4 dwg

Up!