Disinfectant and method for treating objects, those of medicinal indication, among them

FIELD: medicine.

SUBSTANCE: the suggested disinfectant contains glutaric aldehyde, didecyldimethylammonium chloride, ethoxylated alcohol, propylene glycol and water at certain ratios. The method to treat objects, those of medicinal indications, among them, deals with treating an object with the above-mentioned disinfectant followed by keeping disinfectant on the object during the time and at temperature to provide disinfection and/or sterilization of the object followed by washing disinfectant off. The present innovation provides hermetic nature of elements and connective elements of flexible and rigid endoscopes, soldered and glued sites in the course of disinfection.

EFFECT: higher efficiency of application.

10 cl, 3 ex

 

The invention relates to medicine, more precisely relates to a disinfectant and method of treatment of a subject, including medical devices, which can be used for disinfection mainly instruments for medical purposes with a view to their processing, disinfection and sterilization.

Currently, there are many disinfectants, in which the active agent are same or different chemical compounds. The composition and ratio of ingredients in the well-known disinfectants provide the latest this or that action spectrum and activity in relation to, for example, bacteria, viruses and fungi, which causes the specific purpose disinfectant to ensure those or other sanitary regulations establishing requirements for organizational, hygienic and anti-epidemic measures, implementation of which contributes to the prevention of the spread of infectious diseases.

You know the agent with activity against Mycobacterium tuberculosis, sporicidal activity described in U.S. patent No. 5322856, publ. 21.06.1994, IPC: a 61 K 31/19. These tool has the following composition per 100 g of product: glutaric aldehyde - 25,00 grams, salt Quaternary ammonium (alkyldimethyl ethylammonium chloride) - 25,00 grams, paraterminal of 1.00 grams, orthophenylphenol of 1.00 grams of citric or acetic acid and 0.50 grams, sodium citrate - 0.25 grams of isopropyl or ethyl alcohol - 14,00 grams triethanolamine-hydrochloride - 1.00 grams, water - 32,25 grams. This tool is suitable for the implementation of disinfection and sterilization, if it requires activation by ultrasound, thermal factor, microwaves, radiation, and ultraviolet irradiation. In addition, the tool is multi-component, contains an increased amount of toxic ingredients, negative the effect of which increases with the aforementioned activation in the amount of limiting the use of this tool as the technological and environmental reasons.

It is also known disinfectant (Lithofin)described in EN, 2145238 C1 IPC: a 61 L 2/18, publ. 10.02.2000. This tool contains a 50% solution of alkyldimethylammonium chloride (25-35 wt.%), 25% solution of glutaraldehyde (0.3 to 0.7 wt.%), glyoxal (3.5 to about 6.5 wt.%), nonionic surfactant (4.0 to 8.0 wt.%), ethyl alcohol (6-10 wt.%), Trilon B (0,08-0,12 wt.%), water - the rest. The tool exhibits a broad spectrum of activity and high activity against gram-negative and gram-positive bacteria (including pathogens of tuberculosis), viruses (including hepatitis is “In” and HIV infection) and pathogenic fungi (Candida and Trichophyton), named the tool meets the established standards for the toxicity parameters. The composition of these agents allows when it is used to combine disinfection and pre-sterilization processing of medical devices. At that the disinfectant is not active against spore cultures, therefore not suitable for use in sterilization of medical products.

As a prototype we have chosen disinfectant, containing 50% glutaric aldehyde (1.4 to 1.8 wt.%), 50% alkyldimethylbenzylammonium chloride or didecylammonium chloride (1.6 to 2.0 wt.%), 1,4-butanediol (1.6 to 2.2 wt.%), nonionic surfactant, such as lutensol, citric acid (0.4 to 0.8 wt.%), odorant (0.01 to 0.05 wt.%), water - other (RU, 2203094, C1, IPC: A 61 L 2/16, publ. 27.04.2003). This tool possesses antimicrobial activity against gram-negative and gram-positive bacteria, including Mycobacterium tuberculosis, viruses, pathogenic fungi of the genus Candida, and Trichophyton.

According to this patent, to achieve disinfection in respect of the abovementioned bacteria, viruses and fungi of medical devices, including endoscopes, immersed in a 1-10% solution described disinfectant, maintain the product in the solution for 10 to 120 minutes, PEFC is then washed with running water, the remnants of the disinfectant with the surface of the product.

According to the sanitary-epidemiological rules set out in the document “Prevention of infectious diseases during endoscopic manipulation JV 3.1.1275-03”, approved by the Chief sanitary doctor of the Russian Federation April 02, 2003, endoscopes used in endoscopic procedures, subject to high-level disinfection and sterilization which involves the use of agents that have activity against spore cultures. Thus, known disinfectant in the light of modern requirements not suitable for sterilization of medical devices, such as endoscopes.

In addition, the above-described methods of processing of medical devices for the purpose of sterilization is carried out exclusively at elevated temperature, which, as mentioned above, increases the toxicity of the used disinfectant compositions, and also eliminates the possibility of recycling used resources.

The basis for the claimed of the invention is to create a disinfectant such composition and to develop a processing method using such a disinfectant, which would be implemented in accordance with modern sanitary-epidemiological requirements as disinfection, including disinfection high level is, and sterilization of medical products in a wide range of modes on temperature, concentration and time-keeping.

This problem is solved with the creation of disinfectants based on glutaraldehyde and Quaternary ammonium compounds, including non-ionic surfactant and water, which according to the invention contains as Quaternary ammonium compounds didecylammonium chloride, as a nonionic surfactant contains ethoxylated alcohol in combination with propylene glycol, the product contains these ingredients in the following amounts, wt.%:

glutaric aldehyde 0,06-14,00;

didecylammonium chloride 0,08-18,00;

ethoxylated alcohol of 0.04-10,00;

propylene glycol 0,02-6,00;

water to 100.

In accordance with the invention, it is useful to have a means additionally contains a dye and flavoring, taken in a total amount of from 0.001 to 0,440 wt.%.

Thanks to the invention created a means with spores and exhibiting antimicrobial activity against gram-negative and gram-positive bacteria, including Mycobacterium tuberculosis, viruses (pathogens of viral hepatitis, HIV, herpes, gastroenteritis, enteroviral infections, is of jemielita, influenza and other acute respiratory viral infections and pathogenic fungi of the genus Candida, and Trichophyton.

The task is solved by the creation of a method of processing items, including medical devices, comprising contacting the subject with a disinfectant, keeping and flushing, which according to the invention as a disinfectant use the tool, containing glutaric aldehyde 0,06-14,00; didecylammonium chloride 0,08-18,00; ethoxylated alcohol of 0.04-10,00; propylene glycol 0,02-6,00; water to 100, and its curing is carried out in a period of time and at a temperature that provide disinfection and/or sterilization of an object.

According to the invention is useful to use the tool, optionally containing a colorant and odorant taken in a total amount of from 0.001 to 0,440 wt.%.

One embodiment of the invention is that as a disinfectant use the tool, containing in wt.%: glutaric aldehyde 1,53-2,07; didecylammonium chloride 2,04 was 2.76; ethoxylated alcohol 1,02-1,38; propylene glycol of 0.51 to 0.69; water to 100, and the curing is carried out at a temperature of 20±2 degrees C for 5 minutes to achieve high-level disinfection.

Another embodiment of the invention is that as the disinfectant use the tool, wt.%: containing glutaric aldehyde 0,41-0,55; didecylammonium chloride 0.54-0,74; ethoxylated alcohol 0,27-0,37; propylene glycol 0,14-0,18; water to 100, and the curing is carried out at a temperature of 51±1 degrees C for 15 minutes to achieve high-level disinfection.

Another embodiment of the invention is that as a disinfectant use the tool, containing in wt.%: glutaric aldehyde 1,53-2,07; didecylammonium chloride 2,04 was 2.76; ethoxylated alcohol 1,02-1,38; propylene glycol of 0.51 to 0.69; water to 100, and the curing is carried out at a temperature of 20±2 degrees C for 480 minutes to achieve sterilization.

Another embodiment of the invention is that as a disinfectant use the tool, containing in wt.%: glutaric aldehyde 0,41-0,55; didecylammonium chloride 0.54-0,74; ethoxylated alcohol 0,27-0,37; propylene glycol 0,14-0,18; water to 100, and the curing is carried out at a temperature of 20±2 degrees C for 120 minutes to achieve sterilization.

Another embodiment of the invention is that as a disinfectant use the tool, containing in wt.%: glutaric aldehyde of 0.51 to 0.69; didecylammonium chloride of 0.68 to 0.92; ethoxylated alcohol 0,34-0,46; propylene glycol 0,17-0,23; water to 100, and the active extracts from jobstears is ivanie carried out at a temperature 51± 1 degrees C for 60 minutes to achieve sterilization.

Another embodiment of the invention is that as a disinfectant use the tool, containing in wt.%: glutaric aldehyde 1,02-1,38; didecylammonium chloride 0.54-0,74; ethoxylated alcohol of 0.68 to 0.92; propylene glycol of 0.51 to 0.69; water to 100, and the curing is carried out at a temperature of 20±2 deg. With over 960 minutes to achieve sterilization.

Thanks to the invention it has become possible to carry out sterilization and high level disinfection of medical devices, including endoscopes, in a wide range of modes: temperature as at room temperature (20±2 degrees C)and at elevated temperature (51±1 C); the concentration of the inventive disinfectant and time-keeping products in a disinfectant.

Further objectives and advantages of the invention will become apparent from the subsequent detailed description of the disinfectant, the method of treatment of a subject, including medical devices, and specific examples of carrying out the invention.

Disinfectant, according to the invention contains as an active agent glutaric aldehyde and such Quaternary ammonium compound, as didecylammonium chloride.

Potrawy the aldehyde is a strong biocidal product. Known for its effectiveness against gram-negative and gram-positive bacteria (including pathogens of tuberculosis), viruses (including hepatitis b and HIV infections), pathogenic fungi (Candida and Trichophyton).

Quaternary ammonium compounds are cationic surface-active agent and active against gram-positive microorganisms, and at high concentrations, and against gram-negative microorganisms. While Quaternary ammonium compounds also exhibit and detergent properties.

In accordance with the invention, the content of glutaraldehyde (100% substance) in the inventive tool is from 0.06 to 14.00 wt.%, and the content of didecyldimethylammonium chloride (100% substance) is from 0.08 to 18,00 wt.%.

Disinfectant, according to the invention, also contains a nonionic surfactant is ethoxylated alcohol (taken in an amount from 0.04 to 10.00 wt%) in combination with steering his actions propylene glycol (taken in an amount from 0.02 to 6.00 wt%).

The combination of all of these chemicals taken in developed by us, an effect, which provides the claimed means excellent biocidal properties and extended antimicrobial spectrum of action. This glutaric aldehyde in the composition of the action is the future of the agent increases antiviral activity of the proposed drug, and the structure and properties of didecyldimethylammonium chloride was allowed to reach sporicidal action tools proposed in the present invention.

In addition to the above ingredients, the inventive tool may also contain a dye and flavoring, the total number of which is preferably from 0.001 to 0,440 wt.%.

Water is an essential component, providing the desired dilution of the proposed drug.

These compounds are known and industrially available products, for example, glutaric aldehyde, in particular, is issued by the company BASF, Germany; didecylammonium chloride (Arkad 2.10.50) issued by the company Akzo Nobel, Sweden; ethoxylated alcohol, in particular, is issued by the company BASF, Germany; propylene glycol produced according to TU 6-09-2434-84.

As suitable dyes may be used water-soluble synthetic dyes for the production of fragrances, shampoos, toilet Soaps and detergents, in particular the green spot (E102+E133) or food dyes. As a substitute it is possible to use water-soluble natural or synthetic aromatic substances used in the manufacture of perfumes, Soaps and detergents, such as fantasy scents, such as No. 3153 “Freshness”, No. 1887 “Summer breeze” (catalogue of the firm “Lori sia”)./p>

The tool proposed in the present invention, has antibacterial, antiviral, fungicidal and sporicidal activity.

The claimed combination of chemicals taken in the above specially designed quantities, creates a synergistic effect, which provides, in particular, the possibility of achieving sterilization of processed items at ambient temperature (20±2 degrees C) for really convenient duration of storage. Each of the above-named component funds adds a different aspect in achieving the unexpected performance of the developed disinfectant and the ability to carry out sterilization and high level disinfection of medical devices, including endoscopes, in a wide range of modes: temperature as at room temperature (20±2 degrees C)and at elevated temperature (51±1 C); the concentration of the inventive disinfectant and time-keeping.

The above ratio of these components in the inventive tool is important for maintaining maximum efficiency at the lowest values of the content. When the content of the active agent is glutaraldehyde and didecylammonium chloride in a quantity smaller than 0.06 wt.% and 0.08 wt.%, accordingly what about, not achieved above the effectiveness of the disinfectant. Increase the amount of the active agent is glutaraldehyde over 14,00 wt.% and didecylammonium chloride over 18,00 wt.% does not provide a tangible increase the efficiency of the developed disinfectant, but leads to increase of its toxicity. The content of the ethoxylated alcohol in the amount of from 0.04 to 10.00 wt.% and propylene glycol in the amount of from 0.02 to 6.00 wt.% when the above quantitative component of the current agent provides the full manifestation of ethoxylated alcohol, taken in combination with propylene glycol, their properties of surfactants. It is found experimentally that when the above content of the ethoxylated alcohol and propylene glycol provides the desired wettability of the treated surface of the inventive tool that allows reliable processing on hard to reach areas, for example in the channels of endoscopes. In addition, the presence of the ethoxylated alcohol and propylene glycol in these quantitative intervals allowed us to combine the proposed means of disinfecting/sterilizing properties and cleaning properties.

In the inventive tool, toxic side effects are minimized due to sin is to gizmo, which allows you to successfully use the lower of the above concentrations.

The inventive tool has a speed that allows it to be used in a wide time interval, keeping the disinfectant on the surface of the object. The tool also shows the cleaning action, it does not corrode, is well tolerated by the skin and is easily removed.

The inventive tool is intended for use in medical institutions for disinfection of surfaces in premises, rigid furniture, surfaces, instruments and apparatus, sanitary-technical equipment and cleaning equipment, sanitary transport, laboratory glassware, patient-care items; for disinfection of medical devices (including dental and surgical instruments, rigid and flexible endoscopes and instruments to them, facilities for anaesthesia and intensive care), including combined with pre-sterilization; for the high-level disinfection of endoscopes; for sterilization of medical products from plastics, rubbers, glass, metals, including dental and surgical instruments, rigid and flexible endoscopes and instruments to them, facilities for anaesthesia and intensive care.

The high-level disinfection coz the ACLs sanitary-epidemiological rules, outlined in the document “Prevention of infectious diseases during endoscopic manipulation JV 3.1.1275-03”, represents the destruction on the treated surface of pathogenic and conditionally pathogenic microorganisms and most of the spore forms sporicidal means for modes of high-level disinfection.

The tool proposed in the present invention, the parameters of acute toxicity (GOST 12.1.007-76) when exposed to a warm-blooded organism when introduced into the stomach relates to 3-4 class of mild-hazard substances, when applied to the skin to the 4th class of low-hazard substances, working solutions a little dangerous. The inventive product has a local irritant effect on the skin.

Safety and efficiency determined in accordance with “test Methods for disinfectants to assess their safety and effectiveness”, Moscow, Russian Federation Ministry of health, 1996, 1 o'clock and according to the standards listed in the list of “Normative parameters of safety and efficacy of disinfectants subject to control under the mandatory certification”, No. 01-12/75 of 1997

The inventive tool is obtained by simple mixing of the starting components at room temperature.

In a container with a stirrer load consistently estimated number of glutaraldehyde, dodecyldimethylamine the th chloride, ethoxylated alcohol, propylene glycol, water, and possibly, dye, odorant.

Stirring is continued for 20-30 minutes.

The inventive disinfectant can be successfully used to process medical devices, namely disinfection; disinfection; sterilization, in particular, rigid and flexible endoscopes and instruments to them, intended for the visualization of organs and tissues and therapeutic and diagnostic procedures.

In accordance with the invention, a method of processing items, including medical devices. The proposed method includes contacting the subject with a disinfectant by his immersion in the tool or by drawing on the subject of the disinfectant containing in wt.%: glutaric aldehyde 0,06-14,00; didecylammonium chloride 0,08-18,00; ethoxylated alcohol of 0.04-10,00; propylene glycol 0,02-6,00; perhaps, dye and perfume, taken in a total amount of from 0.001 to 0,440; water to 100; subsequent exposure of the subject in a disinfectant or exposure (exposure) of the disinfectant on the surface of the object during the time and at a temperature that provide disinfection and/or sterilization of the subject; flushing means from a subject using water.

The home is aemy the method allows for both disinfection, including high-level disinfection and sterilization of items, including medical devices in a wide range of modes temperature is at ambient temperature (20±2 degrees C) and elevated temperature (51±1 C), concentration of the inventive disinfectant and time-keeping of the disinfectant on the surface of the object.

It should be noted that the invention allows to carry out at ambient temperature (20±2 C) sterilization and high level disinfection of medical devices, including dental and surgical instruments, rigid and flexible endoscopes and instruments to them, facilities for anaesthesia and intensive care. Thanks achieved to exercise at an ambient temperature of sterilization and high-level disinfection of medical devices appeared the validity of reusable developed a disinfectant.

According to the claimed method in a processing object such as medical devices, reaches its high-level disinfection using the following specific composition in wt.%: glutaric aldehyde 1,53-2,07; didecylammonium chloride 2,04 was 2.76; ethoxylated alcohol ,02-1,38; propylene glycol of 0.51 to 0.69; water, to 100, which immerse the workpiece. While keeping the subject in sanitizer is carried out at a temperature of 20±2 degrees C for 5 minutes to achieve high-level disinfection.

According to the invention achieve high-level disinfection is also possible with the use of a disinfectant containing in wt.%: glutaric aldehyde 0,41-0,55; didecylammonium chloride 0.54-0,74; ethoxylated alcohol 0,27-0,37; propylene glycol 0,14-0,18; water to 100, in which is immersed the treated subject. While keeping the subject in sanitizer must be conducted at a temperature of 51±1 degrees C for 15 minutes to achieve high-level disinfection.

According to the claimed method in the processing of medical products reach its sterilization when using a disinfectant containing in wt.%: glutaric aldehyde 1,53-2,07; didecylammonium chloride 2,04 was 2.76; ethoxylated alcohol 1,02-1,38; propylene glycol of 0.51 to 0.69; water to 100, in which is immersed the treated subject. While keeping the subject in sanitizer is carried out at a temperature of 20±2 degrees C for 480 minutes to achieve sterilization.

According to the invention achieve sterilization is also possible when used in the research Institute of the disinfectant, containing in wt.%: glutaric aldehyde 0,41-0,55; didecylammonium chloride 0.54-0,74; ethoxylated alcohol 0,27-0,37; propylene glycol 0,14-0,18; water to 100, in which is immersed the treated subject. While keeping the subject in sanitizer is carried out at a temperature of 51±1 degrees C for 120 minutes to achieve sterilization.

According to the invention achieve sterilization is also possible with the use of a disinfectant containing in wt.%: glutaric aldehyde of 0.51 to 0.69; didecylammonium chloride of 0.68 to 0.92; ethoxylated alcohol 0,34-0,46; propylene glycol 0,17-0,23; water to 100, in which is immersed the treated subject. While keeping the subject in sanitizer is carried out at a temperature of 51±1 degrees C for 60 minutes to achieve sterilization.

According to the invention achieve sterilization is also possible with the use of a disinfectant containing in wt.%: glutaric aldehyde 1,02-1,38; didecylammonium chloride 1,36-1,84; ethoxylated alcohol of 0.68 to 0.92; propylene glycol of 0.51 to 0.69; water to 100, in which is immersed the treated subject. While keeping the subject in sanitizer is carried out at a temperature of 20±2 degrees C for 960 minutes to achieve sterilization.

After contact with a solution of disinfectant subject of alasivut water and wash while the remnants of the disinfectant with the surface of the object.

The invention will find application in medical institutions for:

- disinfection of surfaces in premises, rigid furniture, surfaces, instruments and apparatus, sanitary-technical equipment and cleaning equipment, sanitary transport, laboratory glassware, patient-care items, for General cleaning with bacterial infections, including tuberculosis, viral, including parenteral hepatitis and HIV infection, and fungal etiology (candidiasis and tinea);

- disinfection of medical devices, including dental and surgical instruments, rigid and flexible endoscopes and instruments to them, accessories for anesthesia and resuscitation, including combined with pre-sterilization of bacterial infections, including tuberculosis, viral, including hepatitis and HIV infection, and fungal etiology (candidiasis and tinea);

for high - level disinfection of endoscopes;

- sterilization of medical products from plastics, rubbers, glass, metals, including surgical and dental instruments, rigid and flexible endoscopes and instruments to them, facilities for anaesthesia and intensive care, when bacterial infections, including tuberculosis, viral, including hepatitis and HIV infection, and fungal these is technology (candidiasis and tinea).

In accordance with the invention, the processing of endoscopes and instruments to them is carried out in accordance with the requirements of sanitary and epidemiological regulations SP 3.1.1275-03, registration No. 4417 from 14.04.03, “Prevention of infectious diseases during endoscopic manipulation”. Endoscopes used in non-sterile endoscopic manipulations directly after use, subject to pre-treatment; final cleaning by the method of sterilization processing; high-level disinfection, which is the destruction on the surface of medical devices pathogenic and conditionally pathogenic microorganisms, mostly spore forms.

The following examples in no way limit the present invention and is shown only with the purpose to illustrate the point.

Example 1.

To get 1000 grams of disinfectant mixed glutaric aldehyde (50%) - 280 g (which corresponds 14,00 wt.%; here and below in parentheses show the content when using 100%substance); didecylammonium chloride (50%) - 360 g (which corresponds to 18,00 wt.%); ethoxylated alcohol - 100 g (equivalent to 10.00 wt.%); propylene glycol - 60 g (which corresponds to 6.00 wt.%); the odorant No. 1887 “Summer breeze” - 4,0 g (which corresponds to 0.4 wt.%); the green dye mixed E102+E133 - 4,0 g (which correspond to 0.04 wt.%), and water, taken in an amount providing a total of 1,000 grams of disinfectant.

Get transparent liquid of green color having a density at 20°equal to 1.022 g/cm3, the rate of activity of hydrogen ions pH of 5.2, the rate of activity of hydrogen ions 1% aqueous solution, pH (drinking water) 6,8.

The resulting product is used for disinfection of products from metals, without locking parts (including surgical and dental instruments), as well as for disinfection of products from rubber, plastics, glass etc. 0.5% solution at a temperature of about 15 degrees C is used for disinfection of viral, bacterial (including tuberculosis) and fungal (candidiasis and tinea) infections, while keeping 60 minutes.

When all infections (including tuberculosis and tinea) modes of processing these products at a temperature of about 15 degrees C the following: surgical and dental instruments are immersed in a 1% solution obtained money, time keeping these tools in the solution for 60 minutes, or surgical and dental instruments are immersed in a 1.5% solution obtained money, time keeping these tools in the solution is about 30 minutes, or surgical and dental instruments is Agregat a 2% solution of the funds received, time keeping these tools in the solution is 15 minutes.

Disinfection of rigid and flexible endoscopes for viral, bacterial (excluding tuberculosis) and fungal infections is carried out at a temperature of about 15 degrees C, using a 1.5% solution obtained funds, which immerse the endoscope, the aging time of endoscopes in the solution is 15 minutes.

When a bacterial infection (tuberculosis) rigid and flexible endoscopes dipped in a 2% solution obtained money, time keeping endoscopes in the solution is 15 minutes.

The high-level disinfection of rigid and flexible endoscopes should be made in accordance with the requirements of sanitary and epidemiological regulations SP 3.1.1275-03, registration No. 4417 from 14.04.03, “Prevention of infectious diseases during endoscopic manipulation”. For the high-level disinfection is used at a temperature of 20±2 degrees C 10% solution obtained funds, the aging time of 20 minutes or 15% solution obtained funds, and the aging time is 5 minutes; at a temperature of 51±1C° use 4% solution obtained funds, and the aging time to 15 minutes, or use a 5% solution of the funds received, and the aging time is 5 minutes (short time for endoscope reprocessing).

Sterilization of medical products on the values of the metals, rubber, glass, plastics (including dental and surgical instruments, rigid and flexible endoscopes and instruments to them) is carried out at a temperature of 20±2 grads These products are immersed in a 10% solution obtained funds, at the same time keeping products in solution is 960 minutes; or such product is dipped in a 15% solution of the funds received, the time-keeping products in solution is 480 minutes.

Sterilization of medical devices made of metal, rubber, glass, plastics (including dental and surgical instruments, rigid and flexible endoscopes and instruments to them) are also carried out at a temperature of 51±1°C. To achieve sterilization of these products is dipped in a 4% solution obtained funds, at the same time keeping products in solution is 120 minutes, or the specified items is dipped in a 5% solution of the funds received, the time-keeping products in the solution for 60 minutes (a short time for endoscope reprocessing).

After each of the above keeping in the solution of the disinfectant product is then rinsed with water and washed off while the remnants of the disinfectant from the surface.

Received the tool according to the parameters of acute toxicity when exposed to about the body naturally warm-blooded animals according to GOST 12.1.007-76 when introduced into the stomach belongs to the 3rd class of mild-hazard, when applied to the skin to the 4th class of low-hazard substances, working solutions a little dangerous. The product has a local irritant effect on the skin. The threshold concentration for a single application to the skin is at the level of 0.5% solution, and when exposed to the mucous membranes of the eyes - 0.1% solution.

Shelf life obtained disinfectant is 3 years from date of manufacture. Working solutions at room temperature stable for two weeks, can be used repeatedly, allowing you to use the tool efficiently. Working solutions at elevated temperatures are used only once.

Example 2.

To get 1000 grams of disinfectant mixed glutaric aldehyde (50%), 1.2 g (which corresponds to 0.06 wt.%); didecylammonium chloride (50%) - 1.6 g (which corresponds to 0.08 wt.%); ethoxylated alcohol - 0.4 g (which corresponds to 0.04 wt.%); propylene glycol - 0.2 g (which corresponds to 0.02 wt.%) and water, taken in an amount providing a total of 1,000 grams of disinfectant.

Received disinfectant has antimicrobial activity against gram-negative and gram-positive bacteria (including Mycobacterium tuberculosis), viruses (pathogens of viral hepatitis, HIV, herpes, rotavirus gastroenteritis is, enteroviral infections, poliomyelitis, influenza and other acute respiratory viral infections and pathogenic fungi of the genus Candida, and Trichophyton.

Received the disinfectant used in the health care setting - for 60 minutes at room temperature reach the disinfection of surfaces in premises, rigid furniture, surfaces, instruments and apparatus; patient-care items, products from rubber, plastics, glass, metals, including surgical and dental instruments, tools for endoscopes in viral, bacterial and fungal (Candida) infections.

The degree of impact on the body and when applied to the skin obtained disinfectant belongs to the 4th class of low-hazard substances according to GOST 12.1.007-76, to the 4th class of low-toxic substances when introduced into the abdominal cavity. After a single skin contact has no local irritation (is a threshold concentration in a single application to the skin).

The repeated application of the funds within two weeks allows you to use it sparingly.

Example 3

To get 1000 grams of disinfectant mixed glutaric aldehyde (50%) - 24 g (which corresponds to 1.2 wt.%); didecylammonium chloride (50%) of 32 g (equivalent to 1.8 wt.%); ethoxycarbonyl - 92 g (which corresponds to 9.2 wt.%); propylene glycol 20 g (which corresponds to 2.0 wt.%) and water, taken in an amount providing a total of 1,000 grams of disinfectant.

Using the obtained disinfectant at a temperature of about 15 degrees C carry out the following:

- disinfection of surfaces in premises of medical institutions, hard furniture, surfaces, devices, apparatus is performed by applying a 0.5% solution obtained disinfectant on these surfaces and keeping money within 60 minutes or put a 1% solution obtained disinfectant on these surfaces and spend keeping funds within 30 minutes.

- disinfection of sanitary-technical equipment and nursing care performed by applying a 1% solution obtained disinfectant on these surfaces and keeping money within 60 minutes.

- disinfection of medical devices (including dental and surgical instruments, rigid and flexible endoscopes and instruments to them) is conducted by immersing the product in a 2% solution obtained disinfectant and keeping it in the solution for 60 minutes;

- disinfection of products from rubber, plastics, glass, metals (including hir is rychecky and dental instruments, with locking parts, and tools for endoscopes) in viral, bacterial and fungal (Candida) infections carried out by immersing the product in a 2% solution obtained disinfectant and keeping it in the solution for 60 minutes;

- when a viral, bacterial (including tuberculosis) and fungal (candidiasis and tinea) infections disinfection perform when applied to the treated surface of the object 4% solution obtained disinfectant and subsequent storage solution on the treated surface during the 60 minutes, or when applied on the treated surface 6% solution obtained disinfectant and subsequent storage solution on the treated surface for 30 minutes, or when applied on the treated surface 8% solution obtained disinfectant and subsequent storage solution on the treated surface for 15 minutes.

To achieve disinfection of rigid and flexible endoscopes for viral, bacterial (excluding tuberculosis) and fungal (Candida) infections of the endoscope is immersed in a 6% solution obtained disinfectant and incubated in this solution for 15 minutes at a temperature of about 15 grads

To achieve disinfection of rigid and flexible endoscopes when TB is ulese these products are immersed in an 8% solution obtained disinfectant and incubated in this solution for 15 minutes at a temperature of about 15 grads

Preliminary, final cleaning of endoscopes (sanitary and epidemiological regulations SP 3.1.1275-03, registration No. 4417 from 14.04.03, “Prevention of infectious diseases during endoscopic manipulation”), and pre-sterilization of medical products, not combined with disinfection, spend 2% solution obtained disinfectant in time-keeping for 10 minutes at a temperature of about 15 grads

For sterilization processing endoscopes (combined with disinfection) endoscopes dipped in a 2% solution obtained disinfectant and maintain them in this solution for 30 minutes or immerse the endoscope in a 4% solution obtained disinfectant and maintain them in this solution for 20 minutes.

After each of the above keeping in the solution obtained disinfectant product is rinsed with water wash away the remnants of the disinfectant from the surface.

Assessment of the detergent properties of the fluids used is carried out in accordance with the above processing steps outlined in the East 42-21-2-85 “Sterilization and disinfection of medical devices. Methods, means, modes.

Quality control of sterilization processing assessed by asking aspirapolvere on the presence of residual amounts of blood, in accordance with the methodology set out in the guidance No. 28-6/13 from 28.05.88, “quality Control of sterilization processing of medical devices using reagent isopyrum”.

The degree of impact on the body when introduced into the stomach, and when applied to the skin used solutions obtained disinfectant belong to class 4 a little dangerous substances according to GOST 12.1.007-76, to the 4th class of low-toxic substances when introduced into the abdominal cavity. Used solutions on the degree of volatility of little dangerous. After a single skin contact does not cause local irritation, but repeated exposure is characterized by a moderately strong local action.

Shelf life obtained disinfectant is 3 years from date of manufacture. Working solutions at room temperature stable for two weeks, can be used repeatedly, allowing you to use sparingly.

All disinfectant solutions obtained in examples 1, 2 and 3, when exposed in the recommended modes do not have a destructive effect on medical endoscopes domestic and foreign production, elements and instruments to them and not cause changes in their functional and physico-mechanical properties.

Studies show the Lee, there was no violation of the integrity of the samples, adhesive and solder; not found corrosion on the surfaces of metal parts and change the original color of surfaces of details; sizing the ends of optical fibers after the tests have not been breached.

Also disinfectant solutions obtained in examples 1, 2 and 3, do not violate the integrity of the elements and compounds of flexible and rigid endoscopes, not cause changes in the strength of glued and soldered joints flexible and rigid endoscopes and instruments to them.

1. Disinfectants based on glutaraldehyde and Quaternary ammonium compounds, including non-ionic surfactant and water, characterized in that the Quaternary ammonium compound tool contains didecylammonium chloride, as a nonionic surface-active substances the product contains ethoxylated alcohol in combination with propylene glycol, the product contains these ingredients in the following ratio, wt.%:

glutaric aldehyde 0,06-14,00;

didecylammonium chloride 0,08-18,00;

ethoxylated alcohol of 0.04-10,00;

propylene glycol 0,02-6,00;

water to 100.

2. The disinfectant according to claim 1, characterized in that it dopolnitelnaja dye and perfume, taken in the total quantity of 0.001 - 0,440 wt.%.

3. The method of processing objects, including medical devices, including contact of the disinfectant with the subject, his keeping and flushing means, characterized in that as a disinfectant taking a preparation containing, wt.%: glutaric aldehyde 0,06-14,00; didecylammonium chloride 0,08-18,00; ethoxylated alcohol of 0.04-10,00; propylene glycol 0,02-6,00; water to 100, and its keeping on the subject carried out in the course of time and at a temperature that provide disinfection.

4. The processing method according to claim 3, characterized in that used vehicle, optionally containing a colorant and odorant taken in a total amount of 0.001 - 0,440 wt.%.

5. The processing method according to claim 3, characterized in that as a disinfectant use tool that contains, wt%: glutaric aldehyde 1,53-2,07, didecylammonium chloride 2,04 was 2.76; ethoxylated alcohol 1,02-1,38; propylene glycol of 0.51 to 0.69; water to 100, and the curing is carried out at a temperature of 20±2 °C for 5 minutes

6. The processing method according to claim 3, characterized in that as a disinfectant use tool that contains, wt%: glutaric aldehyde 0,41-0,55; didecylammonium chloride 0.54-0,74; ethoxylated alcohol 0,27-0,37, propylene glycol 0,14-0,18; water to 100 and wederive the e is carried out at a temperature of 51± 1 °C for 15 minutes

7. The processing method according to claim 3, characterized in that as a disinfectant use tool that contains, wt%: glutaric aldehyde 1,53-2,07; didecylammonium chloride 2,04 was 2.76; ethoxylated alcohol 1,02-1,38; propylene glycol of 0.51 to 0.69; water to 100, and the curing is carried out at a temperature of 20±2 °C for 480 minutes

8. The processing method according to claim 3, characterized in that as a disinfectant use tool that contains, wt%: glutaric aldehyde 0,41-0,55; didecylammonium chloride 0.54-0,74; ethoxylated alcohol 0,27-0,37; propylene glycol 0,14-0,18; water to 100, and the curing is carried out at a temperature of 51±1 °C for 120 minutes

9. The processing method according to claim 3, characterized in that as a disinfectant use tool that contains, wt%: glutaric aldehyde of 0.51 to 0.69; didecylammonium chloride of 0.68 to 0.92; ethoxylated alcohol 0,34-0,46; propylene glycol 0,17-0,23; water to 100, and the curing is carried out at a temperature of 51±1 °C for 60 minutes

10. The processing method according to claim 3, characterized in that as a disinfectant use tool that contains, wt%: glutaric aldehyde 1,02-1,38; didecylammonium chloride 1,36-1,84; ethoxylated alcohol of 0.68 to 0.92; propylene glycol of 0.51 to 0.69; water to 100, and the curing is carried out at a temperature of 20±2 °SV for 960 minutes



 

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