Method for optimizing chronic prostatitis treatment

FIELD: medicine.

SUBSTANCE: method involves introducing bio-organic preparation into patient organism. The preparation is introduced at a daily dose of 2 ml intramuscularly during 3-4 weeks.

EFFECT: enhanced effectiveness of treatment.

2 dwg

 

The invention relates to medicine, in particular to urology, and can be used for the treatment of chronic prostatitis using Bioorganic drug, “Squeaky”.

For chronic prostatitis is characterized by prolonged and relapsing course, leading to decreased performance, poor sexual and reproductive function in most patients. Known methods of treatment of chronic prostatitis with the use of stimulants is not specific resistantanti that improves trophism of the prostate and the microcirculation processes do not always result in a therapeutic effect. The need for long-term administration of antibiotics is not always carried out due to toxic side effects last.

Analogues used in the form of plain products, not fully possess a sufficient number of positive properties, the necessity arises to use them in combinations, which increases the likelihood of side reactions that change farmacocinetica.

There is a method of treatment of chronic prostatitis, including the introduction into the organism of doxazosin (see RF patent 2184543, IPC7A 61 f 13/08, publ. 10.07.2002,).

The lack of analog is short remission, coming after the end of treatment, the return of symptoms of bolezn the initial state, shortly after the end of treatment.

Closest to the proposed solution is a method of treatment of diseases of the prostate, including the introduction into the organism of organo-preparation, which is a complex of peptides from prostate cattle (see RF patent №2192889, IPC7A 61 f 13/08, publ. 10.07.2002,).

The disadvantage of the prototype is that the treatment provides only short-term effect and three months after completion of treatment the symptoms of dysuria return to the source.

The task of the invention is to increase the effectiveness of treatment, reducing the time and cost of treatment, achieving long-term remission and improved quality of life in patients with chronic prostatitis.

The solution proposed task is achieved by the fact that in the known method the optimal treatment of chronic prostatitis, including the introduction into the body of a medicinal product, which is used Bioorganic drug “Squeaky, which impose daily 2 ml intramuscularly within 3-4 weeks.

The drug, “Squeaky is highly active organo-preparation of the stabilized extract of liver cells Katran with multifaceted biological activity: adjuvant, immunostimulating, lipoic, antitoxic and antihyperprolactinemic properties (see RF patent №2211700, publ. 10.09.03).

The use of the drug “Squeaky” less than three weeks is not effective, as it reduces the probability of full recovery of patients with chronic prostatitis, and more than four weeks is not advisable, as the drug does not add to the percentage of improvement neither qualitative nor quantitative indicators therapy.

This method will increase the effectiveness of treatment, to reduce the treatment time, increase the duration of remission while improving the quality of life of patients with chronic prostatitis.

The essence of the method is illustrated on the examples of the treatment of patients with chronic prostatitis.

An example of a specific implementation of the method.

We were treated 88 patients suffering from chronic prostatitis, included in two groups: control 66 people and experienced group of 22 people.

The control group received basic therapy according to the following scheme.

1. T-activin in 1.0 ml intramuscularly, 1 times a day, starting from the first to the tenth day.

2. Pantogematogen 1 capsule 2 times daily, starting from the fourth to the thirteenth day (inclusive).

3. Nystatin 1 tablet 3 times daily, starting from the fourth to the twenty-third day.

4. Aevit 1 capsule 2 times daily, starting from the first to the thirtieth day.

5. Microclysters with chamomile for three weeks.

6. Massage of the prostate, starting with the sixth day of treatment within two weeks.

7. Doxycycline 1 capsule 2 times per day from the fourth to the thirteenth day.

8. Ciprolet 1 tablet 2 times a day, starting from the fourteenth to the twenty-third day.

9. Pyrogenes to increase body temperature (according to a certain scheme), which increases the sensitivity of tissues to therapeutic antibiotics.

10. Neosulin (food additive) 2 tbsp. spoon 3 times a day. To enhance the action of therapeutic drugs.

Then have a core group of basic therapy were excluded drugs: 1-St - t-activin, 2nd - pantogematogen, 9th - pyrogenes and 10th - neosulin and replaces them with a single injection of Squatina”, which was injected intramuscularly daily 2 ml within 30 days.

Examination of patients included clinical tests, digital rectal examination with a characterization of the prostate, the detection of infection by seeding secret and REEF or PCR and ultrasound of the prostate, evaluation of urological symptoms schemes IPSS, quality of life QOL and test SAN (health, activity, mood).

Control microscopy of prostate secretion in the experimental group normalization and improved health was in 64.3% of cases, compared to 44% in the control group.

According to the results of the coefficients: IPSS, QOL, SAN, full izle is giving took place at 31.3 percent of the patients in the experimental group, against 24.2% in the control group, a significant improvement in the experimental group it was noted in 50% of patients, against of 31.8% in the control group.

The results of the comparative analysis of effective treatment with the drug “Squeaky” and in the basic scheme presented in diagrams, in which figure 1 is shown the control group, and figure 2 - experimental group.

The use of the drug “Squeaky”, in the treatment of chronic prostatitis showed high multivalent properties due to the adjuvant, immunomoduliruushimi, lipoic, antitoxic, antiproliferative and antioxidant activity.

The effect of the drug, “Squeaky” continued for 6-12 months due to the activation of their own sanogenetic protective and adaptive mechanisms of the body and the effects produced by them (remission)is high and persistent.

The use of the proposed method of optimizing treatment of chronic prostatitis compared with the prototype will improve the effectiveness of treatment, to reduce the time and cost of treatment to achieve long-term remission and improve the quality of life of patients with chronic prostatitis.

Method of optimizing treatment of chronic prostatitis, including the introduction into the body of a medicinal product, characterized in that as Lekarstvo the th tools use Bioorganic drug “Squeaky”, which impose daily 2 ml intramuscularly for 3 to 4 weeks.



 

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FIELD: medicine.

SUBSTANCE: method involves introducing bio-organic preparation into patient organism. The preparation is introduced at a daily dose of 2 ml intramuscularly during 3-4 weeks.

EFFECT: enhanced effectiveness of treatment.

2 dwg

FIELD: veterinary medicine.

SUBSTANCE: the present innovation deals with methods to activate the activity of protective mechanisms and organs of hormonal regulations. One should introduce a tissue preparation for an animal, moreover, to obtain it is necessary to apply 2.5 g pregnant or postpartum uterus, per 1.5 g thyroid, parathyroid and thymus glands, 2.0 g pancreas, 2.5 g liver all purified against spare tissues from clinically and hematologically healthy animals from cattle group up to 4-6-yr-aged period. The organs mentioned should be reduced, then tissue mixture obtained should be mixed with fresh running water at 1:2 ratio to obtain emulsion to be thermally treated in water bath at 58-59 C. After cooling emulsion should be supplemented with formalin, ACD f-2 and natural bee honey to obtain the following ratio of components in ready-to-use product: tissue emulsion 10 g, 68.7%; ACD f-2 1.5 g, 10.3%; formalin 0.006 g, 0.4%; natural bee honey 3.0 g, 20.6%. Before being introduced for an animal one should carefully mix preparation to detect its dosage at 0.02-0.5 ml/kg animal body weight to be then introduced per Ѕ parts from the right and from the left into dorsal lumbar muscles either once or twice at interval of 7-9 d. The method enables to perform complex biostimulating and hormonal impact upon animal body due to keeping active substances of tissue preparation being obtained due to above-mentioned technique.

EFFECT: higher efficiency of prophylaxis and therapy.

FIELD: agriculture, veterinary science.

SUBSTANCE: the present innovation deals with normalizing the flow of coupling, mating and lambing, the rate of growth for preventing and treating acute and chronic diseases of etiology in animals. One should prepare a tissue preparation due to applying cow's ovaries without yellow bodies, thyroid and parathyroid glands, thymus, pancreas and liver of cattle up to 4-yr-aged terms. The organs mentioned should be separately kept for 9-10 d in a fridge to be separately reduced thrice with a meat chopper, diluted with fresh running water at 1:2 ratio, extracted for 4 h in glassware at room temperature, thoroughly mixed every 10-15 min, treated in water bath for 1 h at 58-59 C, separately filtered through double-layered sterile gauze to keep a filtrate 4 times at 1-d-long interval in water bath at 58-59 C for 1 h. Components should be mixed so, that their ratio in preparation should be, weight%: ovarian tissue emulsion 10.3, thyroid and parathyroid emulsion 10.3, that of thymus 10.3, that of pancreas 17.2, that of liver 20.6, ACD f-2 10.3, formalin 0.4, natural bee honey 20.6. Before injection the preparation should be mixed and introduced per 1/2 dosage into dorsal lumbar muscles at 0.02-0.04 ml/kg animal body weight. The innovation provides complex biostimulation, activation of hormonal regulation of animal body.

EFFECT: higher efficiency of prophylaxis and therapy.

1 tbl

FIELD: medicine.

SUBSTANCE: device has Dacron sack usable as envelope introducible into soft tissues of the head. The envelope has two 0.5 mm thick liver tissue leaflets between which hypothalamus tissue leaflets taken from young animal brain and black substance or isolated suprarenal gland medullary substance cells or that of human glands or the like cells taken from human embryo. The Dacron envelope is 25-30 cm long, 5 mm wide and 2 mm thick.

EFFECT: enhanced effectiveness of treatment.

2 cl, 1 dwg

FIELD: medicine, hepatology, chemical-pharmaceutical industry, biotechnology.

SUBSTANCE: invention relates to a biotransplant used in treatment of chronic hepatitis and liver cirrhosis and comprising mesenchymal stem cells obtained from fetal or donor material. The parent tissue is subjected for disaggregation followed by culturing as fixed colonies in the growth medium containing fetal calve serum and glutamine and passage at low density value with change of medium composition and cultivation is carried out without accumulation cells with mature stroma in culture. Also, invention relates to a method for treatment of chronic hepatitis and liver cirrhosis that involves administration of indicated biotransplants by using venous catheter or by puncture in the portal system veins, or by using arterial catheter in splenic artery, or by puncture in spleen parenchyma, or by intraperitoneal route, or by puncture in gastrocolic omentum. Invention provides enhancing effectiveness in complex effect on damaged liver.

EFFECT: improved preparing method, improved treatment method.

13 cl

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with freezing the tissues of animal parenchymatous organs followed by defrosting, homogenization and hydrolysis. Hydrolysis should be conducted at the presence of succinic acid at pH being -4.0 and 45°C. Hydrolyzate should be decanted followed by addition of 3%-caustic soda solution up to pH=7.0; moreover, it is necessary to add novocain powder to hydrolyzate up to 0.4-0.5% concentration and gel of aluminium oxide hydrate at 2-3 mg/ml. The preparation obtained should be packed into 50-ml vials to be sterilized due to autoclaving at the mode of 1.0 atm. for 20 min. The innovation provides less reactogenic final product of prolonged action and increased anti-infectious activity.

EFFECT: higher efficiency.

2 ex, 2 tbl

FIELD: medicine, biochemistry.

SUBSTANCE: claimed method includes administration of uricase solution into at least one separation column at pH approximately 9-10,5 and reduction from the said column of one or more fractions containing isolated tetra-dimensional urecase aggregate-free uricase, wherein tetra-dimensional urecase aggregates are larger than tetra-dimensional urecase.

EFFECT: 9 cl, 12 ex, 13 dwg.

FIELD: medicine, peptides.

SUBSTANCE: invention relates to a method for preparing a peptide complex from animal raw possessing the tissue-specific activity. Method for preparing an agent for maintaining therapy possessing tissue-specific activity involves milling calf or pig organs of age 12 months, not above, addition of 3% acetic acid solution at temperature 20 ± 5°C and extraction is carried out at constant stirring. Then, in 30 min zinc chloride 1% solution is added, mixture is cooled to temperature 7-16°C at constant stirring followed by stirring for every 1 h in each 4 h and settling for 48 h. Extract is separated from inert substances by separation and acetone is added to extract in the volume ratio = 1:5, mixture is kept at 3-5°C for 4 h and formed precipitate is washed out with out with two-fold volume of acetone cooled to temperature 7-16°C, formed precipitate is rubbed through a metallic sieve and prepared end product is dried at temperature 18 ± 2°C. The end product represents a peptide complex with the content of low-molecular peptide fraction from 70% to 90% and with molecular mass of its peptide components in the range 1000-12000 Da wherein this complex comprises amino acids, mineral substances, trace elements and vitamins in biologically bound form. The complex elicits the expressed tissue-specific activity based on the proposed sequence of technological procedures and conditions for their realization involving temperature, temporal and other indices, and by using substances including the parent raw, a definite extractant and others. Peptide component in the prepared complex has no denaturating properties and retains its regulatory properties that suggests its using as an agent for carrying out the maintaining therapy. The proposed agent can be used in medicinal practice as an agent used in carrying out the maintaining therapy.

EFFECT: improved preparing method, valuable medicinal properties of agent.

9 cl, 42 tbl, 14 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of a medicament used in carrying out the supporting therapy in metabolism disturbance caused by increased blood cholesterol and made as a tablet. Agent is proposed as two tablets taken in different times. "Litokhol" enhances bile solubility effectively, inhibits formation of cholesterol crystals and stones. Also, it doesn't inhibit cholesterol biosynthesis in hepatocytes and its excesses are removed from body being without its slagging and doing reasons for development of systemic complications.

EFFECT: valuable medicinal property of agent.

7 cl

FIELD: biologically active substances, medicine.

SUBSTANCE: claimed agent for parantheral administration represents peptide complex containing 70-90 % of low molecular fraction comprising peptide components with molecular mass 70-184 Da, and peptide concentration of 2.5-2.9 mg/ml. Said agent is obtained from liver of calf not older than 12 months or hog by extraction with acetic acid in presence of zinc chloride. Calf or hog liver are frozen at not less -40°C, conditioned at -20-22°C for at least two months, and ground. Then 3 % acetic acid solution in volume ratio of 1:5 is added at 20±5°C. Extraction is carried out under continuous stirring to produce homogenous slurry. Then 1 % zinc chloride solution is added into slurry in volume ratio of 50:1; mixture is cooled under continuous stirring to 7-16°C; stirred during 1 h after each 4 h defecation for 48 hours. Extract is separated from ballast substances; acetone is added to extract in volume ratio of 1:5, followed by conditioning at 3-5°C for 4 hours. Obtained homogenized deposition is deposited again with acetone two time or more. Further active substance containing precipitate is washed on gravity filter with two-fold volumes of acetone cooled to 7-16°C to produce light-gray precipitate. Precipitate is passed through metal sieve, dried, dissolved in distilled water at room temperature and continuous stirring to produce polypeptide concentration of 2.5-2.9 mg/ml. Solution is centrifuged, filtered, subjected to ultrafiltration purification under back pressure of 1.0 kgf/cm2 or less trough materials with retentiveness of 15000 Da. Glycocol is added into ultrafiltrate up to finish concentration of 10-20 mg/mg at pH 5.6-6.6. Solution is subjected to sterilizing filtration under pressure of 2.0 kgf/cm2 or less, poured in 2 ml ampoules, and autoclaved for 8 min, at 120°C and atmospheric pressure of 1.1 kgf/cm2.

EFFECT: method of increased yield, non-toxic and apirogenic agent of improved purity.

2 cl, 5 ex, 4 tbl, 1 dwg

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