Pharmaceutical composition for treating inflammatory processes in an eyeball named "gentalipos"

FIELD: medicine, ophthalmology.

SUBSTANCE: the suggested composition includes an antibacterial chemotherapeutic preparation, plant and/or animal phospholipids, sodium chloride, monosodium phosphate, disubstituted sodium phosphate and purified water at certain quantitative ratio of components, weight%. The innovation provides prolonged antiphlogistic action onto inflammatory focus.

EFFECT: higher efficiency of application.

5 ex

 

The invention relates to medicine, namely to ophthalmology, and is a drug for the treatment of inflammatory processes in the eyeball.

Known drug containing-lactam dihydrothiazine ring that has inhibiting effect on the enzyme transpeptidase required for the synthesis of the cell wall of bacteria (Kharkevich, D.A. Pharmacology. - M.: Medicine, 1999 C).

However, this drug has a number of significant drawbacks. The drug dissolved in distilled water, rapidly washed out from the cavity of the posterior eye segment, and does not have sufficient buffer capacity, resulting in decreased therapeutic effects of the actual drug and the possible occurrence of local swelling of the cells of the retina due to the lack of a balanced solution.

The technical result of the present invention is prolonged anti-inflammatory effect by maintaining a therapeutic concentration of the drug in the eyeball due to the presence in the composition of phospholipids.

The technical result is achieved in that the pharmaceutical composition (FC) for the treatment poplitealny diseases of the eyeball includes antibacterial chemotherapeutic drug, vegetable and/or animal phospholipids, sodium chloride, sodium phosphate clearly points to the displaced, sodium phosphate disubstituted and purified water in the following ratio of components, wt.%:

antibacterial chemotherapy drug 0.001-5

vegetable and/or animal phospholipids 0.001-2

sodium chloride 0.8-0.9

sodium phosphate one-deputizing 0.001-0.2

sodium phosphate disubstituted 0.001-0.2

purified water rest

FC may contain

antibacterial chemotherapy drug 0.001-5

plant phospholipids 0.001-2

sodium chloride 0.8-0.9

sodium phosphate one-deputizing 0.001-0.2

sodium phosphate disubstituted 0.001-0.2

purified water rest

FC may contain

antibacterial chemotherapy drug 0.001-5

animal and vegetable phospholipids 0.001-2

sodium chloride 0.8-0.9

sodium phosphate one-deputizing 0.001-0.2

sodium phosphate disubstituted 0.001-0.2

purified water rest

FC may contain

antibacterial chemotherapy drug 0.001-5

animals phospholipids 0.001-2

sodium chloride 0.8-0.9

sodium phosphate one-deputizing 0.001-0.2

sodium phosphate disubstituted 0.001-0.2

purified water rest

Phospholipids have a membrane, prolonging effect and are inhibitors of swelling of the cells of the retina. Their concentration may not be less than 0.001% due to a sharp decline decongestants and prolongers what about the effect and cannot be more than 2% of this concentration can cause unwanted macrophage response.

The concentration of sodium chloride, sodium phosphate and one-deputizing sodium phosphate disubstituted correspond to the solution of normal for the body osmolarity 300-310 mOsm, the concentration of phosphate may not be less than 0.001% due to Hypo osmotic swelling effect and can not be more than 0.2% due to the hyperosmolar effect.

Thus, the proposed pharmaceutical composition for the treatment of inflammatory processes in the eyeball “Gentoos” is a drug with an effective long-lasting anti-inflammatory effect.

The pharmaceutical composition Gentoos receive the following way: the starting substances are mixed under aseptic conditions, filtered through a 0.22 μm filter, packaged and sterilized by autoclaving.

Declared farmacevticheskaja composition “Gentoos” is used in acute or chronic inflammation of the eyeball and is introduced into the anterior chamber through a paracentesis, in the vitreous cavity by injection after the previously Subtotal vitrectomy.

Examples

EXAMPLE 1. The patient Century. 73 years with a diagnosis of right eye: chronic uveitis, stage of remission, Mature complicated cataract. After surgery, extracapsular cataract extraction with what plantasia IOL found thread exudation into the vitreous cavity. The patient produced Subtotal vitrectomy and once intraoperative entered the claimed pharmaceutical composition “Gentoos in the vitreous cavity in an amount of 5 ml through the pars plana by injection of the following composition, in wt.%:

gentamicin 0.1

phosphatidylcholine 0.08

sodium chloride 0.9

sodium phosphate one-deputizing 0.08

sodium phosphate disubstituted 0.08

purified water rest

3 days after administration of the composition of inflammation in the vitreous cavity was absent,

EXAMPLE 2. Patient Z. 32 years with a diagnosis of right eye: post-traumatic proveit. At admission the patient had strong pain in the right eye, when biomicroscopy revealed sesenna injection, discoloration of the iris, corneal edema; in indirect ophthalmoscopy on ONE of the threads of the fluid in the cavity of the ARTICLE. The patient was prizvedeno Subtotal vitrectomy and once intraoperative introduced the proposed pharmaceutical composition “Gentoos in the cavity of the ARTICLE through the pars plana by injection of 5 ml and the anterior chamber of the eye by paracentesis in 2 ml of the following composition, in wt.%:

gentamicin 2.1

phosphatidylcholine and egg phospholipid (50/50) 1.9

sodium chloride 0.9

sodium phosphate one-deputizing 0.2

sodium phosphate disubstituted 0.2

purified water of Stalin is e

On the 4th day after the introduction of the proposed pharmaceutical composition by biomicroscopy and indirect ophthalmoscopy showed positive treatment panuveitis: reduction of corneal edema, the phenomenon of Tyndale 0-1 Art. in the cavity CT - suspension proposed pharmaceutical composition. On the 7th day - the absence of signs of inflammation in the anterior chamber and the cavity of the ARTICLE of the eye.

EXAMPLE 3: Patient K. 65 years with a diagnosis of left eye: chronic uveitis, stage of remission, Mature complicated cataract. After surgery, extracapsular cataract extraction with IOL implantation discovered the threads of the fluid in the vitreous cavity. produced Subtotal vitrectomy and once intraoperative entered the claimed pharmaceutical composition “Gentoos in the vitreous cavity through the pars plana by injection of the following composition, in wt.%:

gentamicin 0.1

egg phospholipid 0.08

sodium chloride 0.9

sodium phosphate one-deputizing 0.08

sodium phosphate disubstituted 0.08

purified water rest

4 days after the introduction of this combination of inflammation in the vitreous cavity was absent.

Example 4. Patient P. 60 years with a diagnosis of left eye: chronic uveitis in the acute stage, complicated overripe cataract. After surgery, extracapsular cataract extraction with impl what stacia IOL detected organized exudation into the vitreous cavity, held total vitrectomy and once entered intraoperative pharmaceutical composition “Gentoos in the vitreous cavity through a surgical incision of the following composition, in wt%:

Claforan 0.3

Egg phospholipid 0.1

Sodium chloride 0.9

Sodium phosphate one-deputizing 0.001

Sodium phosphate disubstituted 0.001

Purified water rest

After 5 days the inflammation was absent. Example 5. Patient I. 67 years with a diagnosis of left eye: chronic uveitis in the acute stage, immature cataract. After surgery, extracapsular cataract extraction with IOL implantation detected a flicker of fluid in the vitreous cavity, spent a total vitrectomy and once entered intraoperative pharmaceutical composition “Gentoos in the vitreous cavity through a surgical incision of the following composition, in wt%:

Vancomycin 0.5

Egg phospholipid 0.1

Sodium chloride 0.9

Sodium phosphate one-deputizing 0.001

Sodium phosphate disubstituted 0.001

Purified water rest

After 2 days the inflammation was absent.

Pharmaceutical composition for treatment of inflammatory processes of bacterial etiology in the eyeball, which contains the antibacterial chemotherapeutic drug, characterized in that it additionally which contains vegetable and/or animal phospholipids, sodium chloride, sodium phosphate one-deputizing, sodium phosphate disubstituted and purified water in the following ratio of components, wt.%:

Antibacterial chemotherapeutic drug of 0.001-5

Vegetable and/or animal phospholipids of 0.001-2

Sodium chloride 0,8-0,9

Sodium phosphate one-deputizing of 0.001 to 0.2

Sodium phosphate disubstituted of 0.001 to 0.2

Purified water Rest



 

Same patents:

FIELD: medicine, ophthalmology.

SUBSTANCE: the suggested composition includes a steroid-free antiphlogistic preparation, plant and/or animal phospholipids, sodium chloride, monosodium phosphate, disubstituted sodium phosphate and purified water at certain quantitative ratio of components, weight%. The innovation provides prolonged antiphlogistic action.

EFFECT: higher efficiency of application.

3 ex

FIELD: pharmaceutics.

SUBSTANCE: the present innovation deals with medicinal preparations designed as solution and indicated for therapeutic needs. Eye drops contain ciprofloxacin hydrochloride monohydrate being equivalent to 0.3% free foundation, a buffer system that keeps pH within 3.5-5.5 interval, as a conserving agent - benzalconium chloride and a s a stabilizer - the salt of disodium ethylenediamine tetraacetic acid, moreover, their range of osmolality values correspond to 150-450 mM/kg H2O. Eye drops should be obtained by preparing buffer system in which mannitol should be dissolved followed by the salt of disodium ethylenediamine tetraacetic acid, benzalconium chloride, ciprofloxacin hydrochloride. Then one should perform the control for the quality of obtained solution to be then filtered by applying sterilizing elements and packed. This innovation provides treatment of eyes at creating the pressure in an eye and at certain desired osmolality.

EFFECT: higher efficiency of therapy.

4 cl, 1 ex

FIELD: medicine, ophthalmology.

SUBSTANCE: one should introduce 1.0% serotonin adipinate solution intravenously due to infusion once daily for 10-12 d. The method enables to increase visual functions due to decreased tissue hypoxia and normalization of retinal microcirculation, resorption of hemorrhages, reverse development of retinal edema, normalization of functional thrombocytic activity and hemostatic values.

EFFECT: higher efficiency for therapy.

1 ex

FIELD: medicine, in particular ophthalmology.

SUBSTANCE: treatment of ophthalmology diseases by administration in conjunctival sac of patient eye as well as injection of medicine, in particular alkali salt of 5-amino-2,3-dihydro-1,4-phtalasindione is disclosed. Eye drops, eye ointment contain alkali salts of 5-amino-2,3-dihydro-1,4-phtalasindione or mixture thereof, wherein lithium or sodium, or potassium, or calcium salt of 5-amino-2,3-dihydro-1,4-phtalasindione is selected as alkali salt, and mixture of above mentioned salt in equal ratio is used as mixture salts of 5-amino-2,3-dihydro-1,4-phtalasindione.

EFFECT: treatment method with improved effectiveness and reduced treatment duration.

16 cl, 6 ex

FIELD: medicine, in particular ophthalmology.

SUBSTANCE: claimed composition contains (mass %): antiviral drug 0.001-5; vegetable and/or animal phospholipids 0.001-2; sodium chloride 0.8-0.9; sodium hydrophosphate 0.001-0.2; sodium dihydrophosphate 0.001-0.2; and balance: distilled water.

EFFECT: composition with prolonged and effective action.

3 ex

FIELD: medicine.

SUBSTANCE: method involves introducing hypotensive means by means of instillations. Eye drops of emoxipin are instilled 20-30 min later twice a day during 4-8 weeks. The treatment course is repeated in 2-3 months.

EFFECT: improved vision function; normalized hemodynamic values.

1 tbl

The invention relates to medicine, namely to ophthalmology, and is intended for the treatment of inflammatory processes in the eyeball

The invention relates to the field of medicine

The invention relates to medicine, in particular to ophthalmology

FIELD: medicine, otolaryngology.

SUBSTANCE: the present innovation deals with introducing neomycin sulfate antibiotic in granules prepared by the following technique. Tablet of neomycin sulfate 1.0g should be put into a vial with 100 ml distilled water till tablet's decomposition. Then vial's content should be shaken and kept till suspension sedimentation. In a day one should take 1 ml of supernatant liquid to be put into another vial and diluted with distilled water at 1:100 ratio. This procedure should be repeated 4 times more, moreover, during the last procedure one should apply alcohol for dilution. Then one should transfer the drop of alcoholic solution into a vial with granules out of milk sugar to then shaken and kept open for 1 d till granules" drying up. The suggested preparation should be applied per 1 granule under the tongue, moreover, multiplicity and duration of the above-suggested intake should be matched individually by patient's sensitivity and obtaining the clinic effect. The method enables to improve the value of tonic threshold audiometry by about 30-50 dB, decrease perception threshold of vocal range frequencies and widen the range towards high frequencies.

EFFECT: higher efficiency of therapy.

1 dwg

The invention relates to medicine, namely purulent surgery
The invention relates to medicine, in particular for laboratory diagnosis

The invention relates to polymer compositions of antibiotics and can be used in medicine and veterinary medicine

The invention relates to veterinary medicine, in particular to long-acting drugs for the treatment of animal diseases caused by bacteria and chlamydia

The invention relates to the field of veterinary medicine

The invention relates to the field of clinical medicine - Phthisiology and can be used in the treatment of patients with caseous pneumonia to reduce the severity of the intoxication syndrome, normalization of blood system, withdrawal side effects from anti-TB therapy

The invention relates to the field of medicine and relates to a pharmaceutical for the treatment of skin diseases

The invention relates to medicine, cosmetology and can be used to treat acne

FIELD: medicine, ophthalmology.

SUBSTANCE: the suggested composition includes a steroid-free antiphlogistic preparation, plant and/or animal phospholipids, sodium chloride, monosodium phosphate, disubstituted sodium phosphate and purified water at certain quantitative ratio of components, weight%. The innovation provides prolonged antiphlogistic action.

EFFECT: higher efficiency of application.

3 ex

Up!