Method for predicting hyperreactivity of respiratory tract

FIELD: medicine, pulmonology.

SUBSTANCE: in patients with chronic bronchitis one should detect the level of central frequency of diaphragmatic spectrum due to myography at attempt of inhalation in case of overlapping respiratory tract at the level of residual volume (CFRVD) in Hz. Simultaneously, one should detect maximal oral inspiratory pressure (Oip)in kPa. Due to mathematical formula including altered parameters it is necessary to calculate criterial D value to diagnose hyperreactivity of respiratory tract.

EFFECT: higher efficiency of diagnostics.

2 ex

 

The invention relates to medicine, namely to pulmonology, and can be used for the diagnosis of hyperresponsiveness of the Airways.

In the scientific literature known methods of diagnosis hyperresponsiveness of the Airways using bronchoprovocation samples with pharmacological agents (histamine, metacholine, acetylcholine), physical stimuli (cold dry air, exercise), sensitizing agents (allergens, occupational sensitizers) and bronchodilation samples (for example, β2agonists short-acting) (Bronchial asthma. Global strategy. Pulmonology (Appendix). - M., 1996. - P.4; Averna, By T.L. Pashkova. Bronchial asthma. Volume 1. - M., 1997. -S).

The prototype was elected as a method for the diagnosis of respiratory tract with the use of inhaled bronchoprovocation samples with acetylcholine (Nespelem. Seasonal dynamics of the ventilation of lung function and airway responsiveness in patients with chronic bronchitis. Dis. ... candles. the honey. Sciences. - Blagoveshchensk, 1991. 49 - 50).

The method consists in determining the reduction of forced expiratory volume in 1 sec. (ΔFEV1in % from baseline after inhalation of a standard dose of 0.1% solution of acetylcholine. The sample is considered positive if FEV1falls more than 15% from the base is about values.

The known method has the following disadvantages:

1. Requires the use of special diagnostic tools and medicines.

2. They may have limited use in people with bronchial obstruction.

3. The application is related to the possible development of adverse reactions in the form of shortness of breath, choking, dizziness, headache and other

4. Does not take into account the role of hyperresponsiveness of the Airways in the Genesis of violations of the functional state of the respiratory muscles.

The purpose of the invention is to improve the efficiency of diagnosis hyperresponsiveness of the Airways by assessing the functional state of the respiratory muscles.

The objective is achieved by the fact that the evaluation of the functional state of the respiratory muscles is based on the measurement of the center frequency of the spectrum of the diaphragm at the level of the residual volume of the lungs (CCOOLD) determining the maximum inspiratory mouth pressure (WFD), diagnosis and hyperresponsiveness of the Airways is performed using discriminant equation based on the measured values CCOOLD and the WFD.

The proposed method includes the following techniques:

using electromyography when you breath, when blocking the airway at the level of the residual volume of the lungs (OOL) register the Central frequency of the spectrum of the aperture the game at the level OOL in Hz;

using pneumotonometry determine the maximum inspiratory mouth pressure in kPa;

using the obtained values solve discriminant equation:

D=0,029×CCOOLD+to 0.645×WFD,

where D is the discriminant function, a limit value which is 16,06.

The Hyper-reactive Airways diagnosed at less 16,06, and when D is equal to or more boundary values, diagnose the absence of hyperresponsiveness of the Airways.

Below are two examples of using the proposed method.

Example 1. So, 53 years old, was admitted with a diagnosis of obstructive chronic catarrhal bronchitis, acute stage, respiratory insufficiency I-II degree.

Performance curve flow-forced expiratory volume: FEV1- 54%; FVC - 82%; FEV1/FVC - 65%; MOS50- 22%; MOS75- 41%.

The WFD of 6.1 kPa; CCOOLD - 340 Hz;

ΔFEV1after inhalation bronchodilation test with salbutamol is 17.2%.

For the diagnosis of respiratory tract solved discriminant equation:

0,029×340+to 0.645×6,1=13,8

Since the discriminant function is less than the boundary values 16,06, diagnosed with Hyper-reactive Airways.

Example 2. L., 22 years old, was admitted with a diagnosis of non-obstructive chronic catarrhal bronchitis, acute stage, breathing nedostatocnosti 0 degrees.

Performance curve flow-forced expiratory volume: FEV1- 91%; FVC - 98%; FEV1/FVC - 93%; MOC50- 84%; MOC75- 59%.

ΔFEV1after inhalation bronchoconstricting samples with 0.1% solution of acetylcholine chloride to 7.6%.

The WFD and 8.6 kPa; CCOOLD - 400 Hz.

For the diagnosis of bronchial hyperresponsiveness resolved discriminant equation:

0,029×400+to 0.645×8,6=17,15

Because discriminant function more boundary values 16,06 diagnosed the absence of hyperresponsiveness of the Airways.

The proposed method was tested at the clinic of the far Eastern scientific center of physiology and pathology of respiration SB RAMS.

With the way the diagnosis hyperresponsiveness of the Airways in 23 cases. The results of the validation of the proposed method has shown its effectiveness. The correct diagnosis was determined in 84% of cases.

Method for the diagnosis of hyperresponsiveness of the Airways, including the determination of the parameters of the volume of breathing, characterized in that by myography determine the level of the Central frequency spectrum of the diaphragm when you inhale when blocking the airway at the level of the residual volume of the lungs (CCOOLD) in Hz and the maximum inspiratory mouth pressure (WFD) in kPa and decide discriminant equation

D=0,029· CCOOLD+to 0.645·WFD,

and when the value D is less than 16,06 diagnosed with Hyper-reactive Airways.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method involves determining prognostic parameter values like those of lung ventilation function after spoken rational and irrational test texts. Three values are calculated from the obtained data using linear classification functions. They are compared and functional cerebral asymmetry pattern is to be predicted from their values.

EFFECT: high accuracy and reliability of prognosis.

FIELD: medicine; medical engineering.

SUBSTANCE: method involves connecting patient to device via bite-board. The patient makes expiration via tube connected to inlet valve of respiratory sack. The expired air is accumulated in the respiratory sack in the amount of equal to the respiratory sack volume. Timer is set for 15 min after being filled. Microcompressor pumps the air expired by the patient via tube filled with silicagel at constant flow rate. The patient goes on filling the respiratory sack with expired air while the microcompressor is operating. After the timer expires, 0.5-1.0 ml of humidity is obtained from the expired air adsorbed on silicagel. Single-use tube containing silicagel is soldered and kept in frost chamber until its biochemical examination is carried out. The device has airtight respiratory sack having inlet and outlet valves. The inlet valve is connected to tube provided with bite-board. The outlet valve is connected to tube containing silicagel layer.

EFFECT: humidity sampling independence of patient state.

2 cl, 1 dwg

The invention relates to medicine, pulmonology and can be used to predict the progression of airway obstruction

The invention relates to medical diagnostic equipment and can be used for registration of respiration parameters in functional diagnostics, sports medicine and in scientific research

The invention relates to medicine, in particular to preventive medicine, and can be used to correct movement patterns in young people at high risk of developing hypertension

The invention relates to medicine, in particular to resuscitation, and can be used for the diagnosis of acute lung damage (plrs)
The invention relates to medicine, cardiology

The invention relates to medicine, pulmonology
The invention relates to medicine, otolaryngology
The invention relates to medicine, namely to orthopedics

The invention relates to medicine, namely to neurophysiology, and can be used in surgery

The invention relates to medicine, namely, neurology and physiotherapy
The invention relates to medicine and can be used for the diagnosis of progressive and non-progressive forms of idiopathic scoliosis

The invention relates to medicine and is intended to assess the condition of the stomach

The invention relates to medicine, and is intended for the diagnosis of diseases of the gastrointestinal tract
The invention relates to medicine, namely to orthopedics and neurology
The invention relates to medicine, namely to psychiatry

The invention relates to medicine, namely neurology

FIELD: medicine, pulmonology.

SUBSTANCE: in patients with chronic bronchitis one should detect the level of central frequency of diaphragmatic spectrum due to myography at attempt of inhalation in case of overlapping respiratory tract at the level of residual volume (CFRVD) in Hz. Simultaneously, one should detect maximal oral inspiratory pressure (Oip)in kPa. Due to mathematical formula including altered parameters it is necessary to calculate criterial D value to diagnose hyperreactivity of respiratory tract.

EFFECT: higher efficiency of diagnostics.

2 ex

Up!