Acyzol-based agent

FIELD: pharmaceutical industry.

SUBSTANCE: invention provides novel nontoxic and highly bioavailable acyzol-based agent characterized by high activity in treatment of skin diseases, in restoration of structural skin processes, suppression of nevus pigmentosis, and flattening of folds.

EFFECT: increased assortment of skin-healing drugs.

7 cl, 4 ex

 

The invention relates to medicine, namely to novim medicines for topical use in dermatology and cosmetology-based alzola: ointments (creams, gels, liniments, pastes and solutions.

Drug adisa (bis-(1-vinylimidazole) - cindicates) synthesized Irkutsk Institute of chemistry. Aesthetische and approved by the USSR Ministry of health (1991) in finished dosage form - 6% solution in 0.5% aqueous solution of novocaine in 1.0 ml in ampoules for intramuscular injection as an antidote carbon monoxide.

The essence of the proposed invention consists of using the dosage forms alzola in the form of ointments (creams, gels, liniments and paste) and solution for the treatment of skin diseases (psoriasis, neurodermatitis, allergic, long-term healing (trophic) ulcer, decubitus ulcers and other diseases, skin inflammatory diseases and as cosmetic restoring the structural processes of the skin, eliminate age spots, wrinkles and so on). The content of alzola in said dosage form ranges from 1 to 6%. The composition of ointments (creams, gels, liniments and pastes) can be simple (one-component) or complex (multi-component) depending on the disease and the severity of the pathological processes. For example, for the treatment of dermatitis, eczema, allergic and is of Artemiev you can apply 2-3% alsolove the ointment is petroleum based (grease, Naftalan oil, lanolin, tar or other ointment bases. In psoriasis, apply 4-6% ointment complex composition, where in addition to ointment bases include: anti-inflammatory drugs (salicylates, corticosteroids), antibacterial agents (tetracycline or other antibiotics), antiplatelet agents (heparin) and other

Specific therapeutic effect of ointments and solutions based alzola is connected, firstly, with the stimulation of etizolam as zinc-containing heterocyclic compound, antioxidant defense systems of cells of the epidermis from premature programmed cell death (apoptosis) and, secondly, with the stimulation mode oxygenation of the affected area due to the antihypoxic effect, which ensures the normalization of the main structural processes that shape the epidermis - the proliferation, differentiation and apoptosis.

Examples of the application of ointments and solutions based alzola.

Example 1. Patient C., 32 years. Diagnosis: Allergodermatozy (eczema) dorsal and Palmar surfaces of both hands. Treated unsuccessfully for more than 10 years. Patient treatment: 3% azizol on the basis of naphthalene containing 10% oil. Lubricate the affected skin 2 times a day. 2-3 days gone swelling and inflammation. Full recovery occurred at 7-8 day.

Example 2. Patient, 20 years. Diagnosis: Precinct (local) gipec is mentaly skin due to increased sensitivity to sunlight. Affected areas of skin were treated 2 times a day 1% alsolove cream (based on a generic baby cream). 3-4 day pigmentation completely disappeared.

Example 3. Patient S., 42 years. The Diagnosis Of Elephantiasis. Trophic ulcers of the lower third of both legs and lower thirds of the outer surface of the right forearm, complicated by bacterial eczema. Treated more than 20 years without success. Used 2% ointment arizola on the basis of naphthalene with tetracycline. Full recovery occurred on 6-7 day.

Example 4. Patient E., 49 years. Diagnosis: Primenenie (acne) skin rash facial, back neck and shoulder blades). The skin of the patient dry and wrinkled. Applied a cream containing 4% alzola. The acne was gone for 3-4 days. 10 day appointed additionally inside azizol 120 mg once a day for 20 days. 15-20 days there was a noticeable rejuvenation: recovered turgor of the skin, wrinkles are barely visible.

Examples of the treatment of psoriasis:

Patient L., 44 years. Diagnosis: Psoriasis, fixed form with predominant localization of psoriatic plaques in the field of hands, the palms of both hands, ankles and buttocks. It hurts more than 25 years. Repeatedly treated inpatient and outpatient, but remission does not occur. The skin is covered with fan-shaped psoriatic plaques. In the old plaques are mn is extensive bleeding cracks. Skin infiltrated, bright red color with a partially exfoliated Horny layers. In the area of the wrist joints and the finger joints, there is a slight swelling, movements are limited due to pain and tightening of the skin.

Treatment: lubricate the affected areas of the skin 4% liniment of arizola on the basis of the pure grease. 100 grams of ointment contained: 50 mg of hydrocortisone, 500 IU of heparin, 0.5 g of tetracycline and 2 g of albumin. On the second day infiltration and swelling around the psoriatic plaques are practically absent. On day 10 the skin of the palms acquired natural colouring. Psoriatic plaques on the back surface of the brush and in the area of the ankle joint have a pale pink color. The function of the ankle joints and hands fully restored. On day 12, the patient noted a strong psycho-emotional stress in connection with dismissal from her job. Against this background, in the area of the wrist joints of both hands has several petechial lesions of psoriasis. In addition to the main treatment is additionally assigned tranquilizers (tazepam 1 tab. 2 times a day).

14-20 days: no new rashes, the skin of the whole body practically cleansed from psoriatic plaques. To prevent recurrence assigned additional treatment: azizol inside 120 mg 1 time per su the key in for 10 days.

Patient K., 35 years. The diagnosis of palmoplantar psoriasis. Stage of disease progression. Suffers more than 16 years. Traditional treatment (based ointment corticosteroids, selective phototherapy, PUVA therapy, and others) was not effective, bringing only temporary relief.

Treatment: Receipt of alzola 100 mg once daily for 10 days and lubrication of the lesion 6% liniment of arizola on the basis of the pure grease. 100 grams of ointment contained: 50 mg of hydrocortisone, 500 IU of heparin, 0.5 g of tetracycline and 2 g of albumin.

Starting from the third day of the sharp decrease swelling, blanching the Palmar surface of the skin. There is softening of the skin of the soles and decrease infiltration around the old psoriatic plaques.

On day 14 the Palmar surface of the skin is completely cleansed from psoriatic plaques. On the soles, only at the edges and in the field of heels, saved a slight thickening of the skin type of hyperkeratosis.

On the 25th day the skin of the palms and soles has become the natural color and elasticity. To prevent recurrence the patient additionally appointed into apital 100 mg once a day for 10 days.

Patient C., 21 years. Diagnosis: psoriasis, generalized form. For stationary. Sick for more than 3 years. Almost the entire body surface is covered with psoriatic plaques of various shapes and sizes: from punctulata to large (8-10 cm in diameter).

Treatment: lubricate the affected areas of the skin 5% liniment of arizola on the basis of the pure grease. 100 grams of ointment contained: 50 mg of hydrocortisone, 500 IU of heparin, 0.5 g of tetracycline and 2 g of albumin.

On the 4th day of treatment, the formation of new foci stopped infiltration around existing plaques and no exudates. Noticeable resorption process of plaque from the center. In areas of delamination flakes of skin has a pale pink color.

On day 10 of treatment, the skin almost cleansed from psoriatic plaques. To prevent recurrence assigned additional treatment: azizol inside of 120 mg once daily for 10 days.

On the 20th day of treatment, new lesions have disappeared the last plaque. Treatment terminated.

Examples of external application of alzola in the treatment of geriatric patients.

Examination and treatment of the subject 10 patients. Among them: two - maceratesi skin, five - bedsores, three with erysipelatous inflammation. The age of patients ranged from 40 to 80 years.

In the case of treatment of MAZERATI under the Breasts of patients and X. B. was applied 6% solution of arizola on microcrystalline cellulose. Signs of inflammation in this case died on the first day. On the second day, the volume of lesions decreased by half, for 3-4 days the healing was complete.

In the case of treatment of erysipelas at bol is different N., K. and P. applied a 6% solution of alzola in 1% solution of collagen. The patient K. full recovery occurred on the second day. Patient N. external signs of inflammation disappeared gradually within two days. The volume of the affected skin during this period decreased in two and a half times. But the skin is still blotchy and swollen. These manifestations can be explained by the fact that the preliminary treatment was carried out was compresses +UFO. Patient N. suffer from cardiovascular disease. Amid additional treatment antispasmodics and cardiac drugs swelling disappeared, but light skin pigmentation remained. The patient P. full recovery occurred on 5-6 day.

In the case of treatment of bedsores in patients K., I. and K. applied traditional methods of treatment using 2% collagen or microcrystalline cellulose without alzola. In this case, the formation of bedsores stopped, but the healing does not come. And in the treatment of bedsores at F. and X. used 6% azizol +1% solution of collagen. Full recovery occurred within three to four days.

In all cases when applying ointments and solutions based alzola side effects were observed.

Thus, studies have shown high efficiency of external application of creams and solutions on the basis of alzola CA is in the treatment of skin diseases (psoriasis, neurodermatitis, allergic (diathesis), long-term healing (trophic ulcers, bedsores and other skin defects inflammatory nature), and when used as a cosmetic (recovery of structural processes in the skin, eliminate age spots, reduce wrinkles, and so on).

The BIBLIOGRAPHY.

1. The antidote carbon monoxide. Patent for invention No. 2038079, , Moscow, 1995

2. For the treatment of psoriasis. Patent for invention No. 2204392, , Moscow, 2003

3. Shilov, V.N. Psoriasis is a solution to the problem. Moscow. 2001

1. The use of alzola as a means for the treatment of skin diseases, restore the structural processes of the skin, the elimination of pigmented spots and wrinkles.

2. The use according to claim 1, where the specified skin disease is a psoriasis, neurodermatitis, allergic, long-term (trophic) ulcer, decubitus ulcers and skin lesions inflammatory nature.

3. For the treatment of skin diseases, restore the structural processes of the skin, the elimination of pigmented spots and wrinkles, characterized in that it contains azizol and the basis in the following ratio, wt.%: azizol 1-6, the basis of everything.

4. The tool according to claim 3, characterized in that it is made in the form of ointments, creams, gels, liniments, pastes or solution is.

5. The tool according to claim 4, characterized in that the base is a grease or naphthalene with 10% oil, or lanolin, or tar.

6. The tool according to claim 4, characterized in that the base is a microcrystalline cellulose or 1%solution of collagen.

7. The tool according to claim 4, characterized in that it further comprises hydrocortisone, heparin, tetracycline and albumin.



 

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