Method for preventing dysbacteriosis in patients having suffered from abdominal cavity trauma by applying low intensity laser radiation

FIELD: medicine.

SUBSTANCE: method involves administering laser radiation therapy once a day using low intensity pulsating radiation of wavelength equal to 890nmand power density of 0.03 mW/cm2. Injured organ projection to frontal abdominal wall is exposed to radiation at the first laser therapy stage in two fields acting upon each field for 2 min with radiation pulse succession frequency equal to 80 Hz in applying stable contact-type method. Total treatment dose on two fields is equal to 0.008 J/cm2. The second laser therapy stage begins immediately after having finished the first one in applying radiation along the large intestine path using labile contact-type method in a way that radiation pulse succession frequency equal to 80 Hz is applied first during 1 min and then frequencies of 600, 150 and 300 Hz are applied also during 1 min, respectively. Total treatment dose is equal to 0.032 J/cm2 at the second stage. Total treatment dose is equal to 0.04 J/cm2 at both stages.

EFFECT: enhanced effectiveness in inhibiting dysbacteriosis; reduced frequency of postoperative complications.

 

The invention relates to medicine and can be used for prophylaxis of a dysbacteriosis in the postoperative period in patients with trauma to the abdominal cavity.

Closest to the claimed method is for drug prevention of dysbacteriosis, consisting of destination pharmaceutical drugs such as nystatin and Lactobacterin etc. [1]. The method has contraindications individual hypersensitivity and intolerances to medications and allergies.

Object of the invention is the inhibition of the development of dysbiosis in the postoperative period in patients with trauma of the abdominal cavity and reducing the frequency of postoperative complications.

The problem is solved in that a method of prevention of dysbiosis in patients with trauma of the abdominal cavity, includes drug therapy, and that after the operation from the first through the seventh days are laser therapy once daily low-intensity pulsed radiation with a wavelength of 890 nm and with a power density of 0.03 mW/cm2at the first stage, the laser is irradiated to the projection of the damaged organ on the anterior abdominal wall from two fields on the contact stable method, influencing each field within 2 minutes with a pulse frequency of the radiation 80 Hz, and the total dose of exposure of the two floor is th shall be 0.008 j/cm 2immediately after the first stage of conducting the second phase of the laser, irradiating along the colon (clockwise) on the contact labile method so that the first impact with the pulse frequency of 80 Hz for one minute, then the frequencies of 600, 150 and 300 Hz for one minute, respectively, while the total dose effects in the second stage is to 0.032 j/cm2and the total dose for the two stages is 0.04 j/cm2.

Prevention of dysbiosis in patients with trauma of the abdomen is as follows.

After the operation, with the first on the seventh day hold a laser therapy once a day using a semiconductor infrared arsenicalis laser. Using low-intensity pulsed radiation with a wavelength of 890 nm and irradiated with a power density of 0.03 mW/cm2.

In the first stage, the laser is irradiated to the projection of the damaged organ on the anterior abdominal wall from two fields on the contact stable methodology (i.e. irradiated cutaneous in two nearby areas of the skin surface, with the contact end of the radiator with skin), acting on each field (the area of the surface of the skin) within 2 minutes with a pulse frequency of the radiation 80 Hz. The total dose of exposure of the two fields shall be 0.008 j/cm2.

the time after the first stage of conducting the second phase of therapy, namely irradiated along the colon (clockwise) on the contact labile methodology in the following order: first impact with a pulse frequency of 80 Hz for 1 minute and then, with a frequency of 600 Hz for 1 minute, then with frequencies of 150 Hz and 300 Hz for one minute. Total dose effects in the second stage is to 0.032 j/cm2.

Total dose effects of two stages should be of 0.04 j/cm2.

Examples of specific implementation method.

In the study of feces on a dysbacteriosis has revealed that in the group of victims who received irradiation of low-intensity laser radiation (NEELY), the dysbacteriosis is not detected. And in the control group, without laser irradiation, revealed a dysbacteriosis as a consequence of the use of antibiotics and intestinal motility disorders.

To clarify the possible mechanism of action studies in vitro: from the faeces of patients with abdominal trauma and identified dysbiosis were allocated, were identified by lactose-negative Escherichia coli. Was perseval on Petri dishes with medium Levin. Then there was exposure to LLLT apparatus “Mustang” with pulse repetition rates of 80, 600, 150 and 300 Hz for one minute within 7 days with a total dose to 0.032 j/cm2. It was revealed a decrease in the number of colonies of lactose-negative symptoms such the big sticks, growth suppression. The number was less than 1%. The norm is not more than 2% in the normal microbial landscape of feces, when dysbiosis number of lactose-negative Escherichia coli reached 50%. In our opinion, presents a combination of frequencies NEELY negatively affects the membrane of the bacterial cell.

Example 1. Patient P., 53, was in the surgical Department with 20.07.2000 with the diagnosis of penetrating stab wound of the abdomen, injury of stomach injury of the lumbar region and right forearm. Alcohol intoxication. On the abdomen, under the xiphoid process of the linear wound a length of 1.2 cm with smooth edges. During the revision, the wound penetrates into the abdominal cavity. Surgery: laparotomy, wound closure stomach, abdominal drainage. Received infusion therapy, analgesics, kanamicin. The postoperative period was complicated by suppuration laparotomic wound. On the fifth day marked by diarrhea, flatulence, abdominal pain. On the seventh day taken the analysis of a feces on a dysbacteriosis. The dysbacteriosis is confirmed. Treatment added nystatin and Lactobacterin. The wound healed by secondary intention, a dysbacteriosis was stopped to the time of discharge.

Example 2. Patient M., 36 years old, was in the surgical Department with 11.05.2002 with the diagnosis of penetrating stab wound of the abdomen. A perforating wound of the stomach. On the abdomen, epigastric is Colo is about-incised wound with a fallen strand of the packing. Surgery: laparotomy, suturing wounds of the stomach. Received infusion therapy, analgesics, antibiotics, kanamycin, laser therapy LLLT for the claimed method with a total dose of 0.04 j/cm2. It was noted a smooth postoperative period, moderate pain, restoration of peristalsis on the second day, the absence of the phenomena of a dysbacteriosis, which is confirmed by the analysis of a feces on a dysbacteriosis on the seventh day (the dysbacteriosis is not revealed). Fibrogastroscopy on the eighth day: the healing knife wound to the stomach, the wound edges with slight edema, fibrin, without purulent-necrotic masses. Healing by first intention.

Therefore, the above two-step effect of LLLT on the claimed method with a total dose of 0.04 j/cm2in the postoperative period allows you to accelerate the healing process of the abdominal cavity and to prevent the development of dysbiosis, which usually occurs in victims with injuries of the abdominal cavity. No disruption of microbial associations in the intestine has a positive effect on reparative processes in tissues of the gastrointestinal tract and contributes to the reduction of complications.

Sources of information

1. Wounds and wound infection. Edited Migasena, Bmostacedo, M, Medicine, 1990, 592 S.

Method of prevention of dysbiosis in patients with TPA is my abdominal cavity, including medication, characterized in that after the operation from the first through the seventh days are laser therapy once daily low-intensity pulsed radiation with a wavelength of 890 nm and with a power density of 0.03 mW/cm2at the first stage, the laser is irradiated to the projection of the damaged organ on the anterior abdominal wall from two fields on the contact stable technique, acting on each field for 2 min with a pulse frequency of the radiation 80 Hz, and the total dose of exposure of the two fields 0,008 j/cm2immediately after the first stage of conducting the second phase of the laser, irradiating along the colon, contact labile method so that the first impact with the pulse frequency of 80 Hz for 1 min, then with frequencies of 600, 150 and 300 Hz for one minute, respectively, while the total dose effects in the second stage is to 0.032 j/cm2and the total dose for the two stages is 0.04 j/cm2.



 

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FIELD: medicine.

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1 ex

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4 cl

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The invention relates to medicine, namely to Hepatology

FIELD: medicine.

SUBSTANCE: method involves introducing 0.1-0.3 ml of photosensitizing gel preliminarily activated with laser radiation, after having removed neovascular membrane. The photosensitizing gel is based on a viscoelastic of hyaluronic acid containing khlorin, selected from group containing photolon, radachlorine or photoditazine in the amount of 0.1-2% by mass. The photosensitizing gel is in vitro activated with laser radiation having wavelength of 661-666 nm during 3-10 min with total radiation dose being equal to 100-600 J/cm2. The gel is introduced immediately after being activated. To compress the retina, vitreous cavity is filled with perfluororganic compound or air to be further substituted with silicon oil. The operation is ended with placing sutures on sclerotomy and conjunctiva areas. Compounds like chealon, viscoate or hyatulon are used as viscoelastic based on hyaluronic acid. Perfluormetylcyclohexylperidin, perfluortributylamine or perfluorpolyester or like are used as the perfluororganic compound for filling vitreous cavity.

EFFECT: excluded recurrences of surgically removed neovascular membrane and development of proliferative retinopathy and retina detachment; retained vision function.

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FIELD: medicine.

SUBSTANCE: method involves making incision in conjunctiva and Tenon's capsule of 3-4 mm in size in choroid hemangioma projection to sclera 3-4 mm far from limb. Tunnel is built between sclera and Tenon's capsule to extrasclerally introduce flexible polymer magnetolaser implant through the tunnel to the place, the choroid hemangioma is localized, after performing transscleral diaphanoscopic adjustment of choroid hemangioma localization and size, under visual control using guidance beam. The implant has permanent ring-shaped magnet in the center of which a short focus scattering lens of laser radiator is fixed. The lens is connected to light guide in soft flexible envelope. The permanent implant magnet is axially magnetized and produces permanent magnetic field of 2-3 mTesla units intensity. It is arranged with its north pole turned towards the choroid hemangioma so that extrascleral implant laser radiator disposition. The other end of the implant is sutured to sclera 5-6 mm far from the limb with two interrupted sutures through prefabricated openings. The implant is covered with conjunctiva and relaxation sutures are placed over it. Light guide outlet is attached to temple using any known method. 0.1-1% khlorin solution is injected in intravenous bolus dose of 0.8-1.1 mg/kg as photosensitizer and visual control of choroid hemangioma cells fluorescence and fluorescent diagnosis methods are applied. After saturating choroid hemangioma with the photosensitizer to maximum level, transscleral choroid hemangioma laser radiation treatment is carried out via laser light guide and implant lens using divergent laser radiation at wavelength of 661-666 nm with total radiation dose being equal to 30-120 J/cm2. The flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, samarium-iron-nitrogen or neodymium-iron-boron system material. The photosensitizer is repeatedly intravenously introduced at the same dose in 2-3 days after the first laser radiation treatment. Visual intraocular neoplasm cells fluorescence control is carried out using fluorescent diagnosis techniques. Maximum level of saturation with the photosensitizer being achieved in the intraocular neoplasm, repeated laser irradiation of the choroid hemangioma is carried out with radiation dose of 30-60 J/cm2.

EFFECT: enhanced effectiveness of treatment.

4 cl

FIELD: medicine.

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EFFECT: complete destruction of neoplasm; excluded its further growth.

4 cl

FIELD: medicine.

SUBSTANCE: method involves applying transscleral diaphanoscopic examination method for adjusting intraocular neoplasm localization and size. Rectangular scleral pocket is built 2/3 times as large as sclera thickness which base is turned from the limb. Several electrodes manufactured from a metal of platinum group are introduced into intraocular neoplasm structure via the built scleral pocket. Next to it, intraocular neoplasm electrochemical destruction is carried out in changing electrodes polarity with current intensity of 100 mA during 1-10 min, and the electrodes are removed. Superficial scleral flap is returned to its place and fixed with interrupted sutures. 0.1-2% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, transpupillary laser radiation of 661-666 nm large wavelength is applied at a dose of 30-120 J/cm2. the operation is ended with placing sutures on conjunctiva. Platinum, iridium or rhodium are used as the metals of platinum group. The number of electrodes is equal to 4-8. 0.1-1% khlorin solution, selected from group containing photolon, radachlorine or photoditazine, is additionally repeatedly intravenously introduced in 2-3 days at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells is carried out by applying fluorescence and fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, repeated laser irradiation of the intraocular neoplasm is carried out with radiation dose of 30-45 J/cm2.

EFFECT: complete destruction of neoplasm; excluded tumor recurrence; reduced risk of tumor cells dissemination.

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FIELD: medicine.

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EFFECT: higher therapeutic and cosmetic effect.

1 ex

FIELD: medicine.

SUBSTANCE: method involves intravitreously introducing two electrodes into intraocular neoplasm after carrying out vitrectomy and retinotomy to expose the intraocular neoplasm. The electrodes are manufactured from platinum group metal. Electrochemical destruction is carried out with current intensity of 100 mA during 1-10 min or 10 mA during 10 min in changing electrodes polarity and their position in the intraocular neoplasm space, and the electrodes are removed. 0.1-1% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, intravitreous laser radiation is carried out in parallel light beam of wavelength equal to 661-666 nm is applied at a dose of 30-120 J/cm2.The transformed retina and tumor destruction products are intravitreally removed. Boundary-making endolasercoagulation of retinotomy area is carried out after having smoothed and compressed retina with perfluororganic compound. The operation is finished with placing sutures on sclerotomy and conjunctiva. Platinum, iridium or rhodium are used as the platinum group metals. Another embodiment of the invention involves adjusting position and size of the intraocular neoplasm in trans-scleral diaphanoscopic way. Rectangular scleral pocket is built above the intraocular neoplasm to 2/3 of sclera thickness with its base turned away from limb. Several electrodes are introduced into intraocular neoplasm structure via the built bed. The electrodes are manufactured from platinum group metal. Electrochemical destruction is carried out with the same current intensity in changing electrodes polarity and their position in the intraocular neoplasm space, and the electrodes are removed. Superficial scleral flat is returned to its place and fixed with interrupted sutures. 0.1-1% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg after having carried out vitrectomy and retinotomy. Visual control of intraocular neoplasm cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, intravitreous laser radiation is carried out in parallel light beam of wavelength equal to 661-666 nm is applied at a dose of 30-120 J/cm2. The transformed retina and tumor destruction products are intravitreally removed using vitreotome. Boundary-making endolasercoagulation of retinotomy area is carried out after having smoothed and compressed retina with perfluororganic compound. The operation is finished with placing sutures on sclerotomy and conjunctiva. Platinum, iridium or rhodium are used as the platinum group metals. The number of electrodes is equal to 4-8.

EFFECT: reduced risk of metastasizing.

4 cl, 13 dwg

FIELD: medicine.

SUBSTANCE: method involves building tunnel to posterior eyeball pole in inferoexterior and superexterior quadrants. The tunnel is used for implanting flexible polymer magnetolaser implant to the place, the subretinal neovascular membrane is localized. The implant has a permanent magnet shaped as a cut ring and is provided with drug delivery system and a short focus scattering lens of laser radiator connected to light guide. The permanent implant magnet is axially magnetized and produces permanent magnetic field of 5-7 mTesla units intensity. It is arranged with its north pole turned towards sclera at the place of the subretinal neovascular membrane projection with extrascleral arrangement of laser radiator lens membrane being provided in the subretinal neovascular membrane projection area. The other implant end is sutured to sclera 5-6 mm far from the limb via holes made in advance. The implant is covered with conjunctiva and retention sutures are placed thereon. Light guide and drug supply system lead is attached to temple with any known method applied. Drugs are supplied via the implant drug supply system in retrobulbary way in any order. Triombrast is given in the amount of 0,4-0,6 ml and dexamethasone or dexone in the amount of 0,4-0,6 ml during 3-4 days every 12 h. 0.1-1% aqueous solution of khlorin is intravenously introduced at the third-fourth day after setting the implant as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, at a bolus dose of 0.8-1.1 mg/kg. Visual control of subretinal neovascular membrane cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the subretinal neovascular membrane with the photosensitizer to maximum saturation level, intravitreous, transretinal laser radiation of 661-666 nm large wavelength is applied at general dose of 30-120 J/cm2. The flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, samarium-iron-nitrogen or neodymium-iron-boron system material. The photosensitizer is repeatedly intravenously introduced at the same dose in 2-3 days after the first laser radiation treatment. Visual intraocular neoplasm cells fluorescence control is carried out using fluorescent diagnosis techniques. Maximum level of saturation with the photosensitizer being achieved in the subretinal neovascular membrane via laser light guide and implant lens, repeated laser irradiation of the subretinal neovascular membrane is carried out with radiation dose of 30-60 J/cm2.

EFFECT: accelerated subretinal edema and hemorrhages resorption; regression and obliteration of the subretinal neovascular membrane; prolonged vision function stabilization.

6 cl

FIELD: medicine.

SUBSTANCE: method involves filling vitreous cavity with perfluororganic compound. Two electrodes manufactured from platinum group metal are intravitreally, transretinally introduced into intraocular neoplasm. Electrochemical destruction is carried out with current intensity of 10-100 mA during 1-10 min in changing electrodes polarity and their position in the intraocular neoplasm space, and the electrodes are removed. 0.1-1% aqueous solution of khlorin as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, is intravenously introduced at a dose of 0.8-1.1 mg/kg. Visual control of intraocular neoplasm cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the intraocular neoplasm with the photosensitizer to maximum saturation level, intravitreous, transretinal laser radiation of 661-666 nm large wavelength is applied at a dose of 30-120 J/cm2 in perfluororganic compound medium. The transformed retina and tumor destruction products are intravitreally removed with perfluororganic compound volume being compensated with its additional introduction. Boundary-making endolasercoagulation of retinotomy area is carried out. The perfluororganic compound is substituted with silicon oil. The operation is ended in placing sutures over sclerotmy areas and over conjunctiva. Perfluormetylcyclohexylperidin, perfluortributylamine or perfluorpolyester or like are used as the perfluororganic compound for filling vitreous cavity. Platinum, iridium or rhodium are used as the platinum group metals.

EFFECT: complete destruction of neoplasm; reduced dissemination risk.

6 cl, 12 dwg

FIELD: medicine, applicable for stopping of pains of various nature.

SUBSTANCE: the device has a quantum-mechanical oscillator located in a casing, magnet, vessel for medicinal agent and a hollow cylinder. The magnet is installed between the oscillator and the vessel. Positioned in the vessel is a hollow cylinder having through holes on its surface.

EFFECT: quick and absolute anestesia.

2 ex, 1 dwg

FIELD: medicine.

SUBSTANCE: method involves administering laser radiation therapy once a day using low intensity pulsating radiation of wavelength equal to 890nmand power density of 0.03 mW/cm2. Injured organ projection to frontal abdominal wall is exposed to radiation at the first laser therapy stage in two fields acting upon each field for 2 min with radiation pulse succession frequency equal to 80 Hz in applying stable contact-type method. Total treatment dose on two fields is equal to 0.008 J/cm2. The second laser therapy stage begins immediately after having finished the first one in applying radiation along the large intestine path using labile contact-type method in a way that radiation pulse succession frequency equal to 80 Hz is applied first during 1 min and then frequencies of 600, 150 and 300 Hz are applied also during 1 min, respectively. Total treatment dose is equal to 0.032 J/cm2 at the second stage. Total treatment dose is equal to 0.04 J/cm2 at both stages.

EFFECT: enhanced effectiveness in inhibiting dysbacteriosis; reduced frequency of postoperative complications.

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