Method for treating narcomania-suffering patients

FIELD: medicine, narcology.

SUBSTANCE: one should pre-detect the frequency of magnetic field ranged 1.0-15.0 Hz at which one should observe the shift of bioelectric activity waves towards deceleration, the decrease of motor thresholds, amplitude, the decrease of rhythmic disorders, and the increase of dopamine level in blood and/or liquor. Stimulation should be performed with magnetic field of certain frequency at induction being 0.5-1.2 Tl in projection of cerebral hemispheres. Simultaneously, one should carry out visual stimulation at frequency of stimuli presentation of 3-25/sec. Moreover, valuable visual stimuli should be presented at 0.1-20 msec, and invaluable ones at 35-350 msec. Seances take place every day for 30-60 min, therapeutic course consists of 10-20 seances. The method applies magnetic field at optimal induction for every patient in combination with psychotherapeutic impact.

EFFECT: higher efficiency of therapy.

1 ex

 

The invention relates to medicine, namely to addiction, and can be used for the treatment of patients with razlichnimi kinds of drug addiction.

There is a method of treatment of diseases of the optic tract by the action of pulsed magnetic field of 0.1-0.25 T, synchronized with the frequency of the electrical activity of the brain simultaneously with crescozhnoe stimulation of the optic nerve by electrical stimulation of the eyelids and photostimulation daily for 15-20 minutes 10-15 sessions (patent No. 2128485).

However, this method has significant drawbacks. Magnetic stimulation is carried out with a low magnetic field of 0.1-0.25 T, which in turn can lead to reduced efficiency impacts, and visual stimulation just flash that is not specific to the stimulation of mental processes.

The closest that we have chosen as a prototype is a method of treatment of patients in coma and vegetative state, including the effects of sinhronizovani magnetic field, visual and electrical stimulation of the most effective frequencies defined on the basis of registration and analysis of bioelectric activity of the brain, characterized in that the use of a pulsed magnetic field of 1.2 to 2 T in the projection of the brain stem, while conducting the visual stimulation is aciu important for the patient paintings for 5-10 s and electrical stimulation of the median nerve rectangular pulses at an amperage of 12-18 mA and pulse duration of 0.1-0.3 MS, frequency of 5-15 Hz, daily for 2-8 hours, 10-20 sessions per course of treatment (patent No. 2197294).

However, this method has drawbacks. Stimulation with induction of 1.2-2 T is in the brain stem area, and not in the projection of the fronto-temporal regions of the big hemispheres (where the greatest number of dopaminergic synaptic endings and mental representations in the cortex), and visual stimulation is only relevant incentives that hinders the activation of unconscious mental mechanisms.

The objective of the invention is to increase the efficiency of treatment of patients suffering from various forms of addiction.

The task is achieved by using a coil creates a magnetic field in the projection of the fronto-temporal regions of cerebral hemispheres and the frequency of the pulsed fields are selected according to the optimal reactions of the bioelectrical activity of the brain, and the maximum induction of a magnetic field provide in the range of 0.5 to 1.2 T, while conducting visual stimulation with meaningful visual stimuli with a duration of 0.1-20 MS and nonsignificant stimuli with a duration of 35-350 MS in the ratio of 1 to 2 or 1 to 24, when the frequency of presentation of images 3-25 per second, daily for 30-60 minutes, 10-20 sessions per course of treatment.

The authors have carried out the necessary exp the pilot work, allows you to define the characteristics of transcranial magnetic stimulation (TMS) and visual stimulation (CS) relevant and irrelevant stimuli.

Addiction has long been known. Drug use is often associated with the desire, at least temporarily hide, escape from the hardships of reality. The role of the lack of discipline, the immaturity of character, weak self-control, increased interest in the unfamiliar sensations that occur in some young people. First, depending on the type of higher nervous system, drug type, dose, method of introducing it into the body, the mental setup of the subject is called euphoric effect. Then develops the reactivity of the organism - disappear protective reaction. Drug use becomes systematic changes occur tolerance. Gradually formed the psychic and physical dependence to drugs, with irresistible attraction and expressed in withdrawal syndrome, in which the structure can be observed elements astenodepressivnyh, hypomanic, explosive (Babayan E.A., Ganopolski - Narcology. Moscow, 1990, 336 pages). In the dynamics of the formation of abstinent CSOs syndrome can distinguish three stages: 1 - adaptation (change of reactivity, the emergence of psychological dependence); 2 - in the causes physical dependence in the form of a withdrawal syndrome; 3 - the exhaustion of all systems (lower tolerance, protracted withdrawal syndrome, occurs in some cases of polyaramide). In the initial stages of monitoring violations reactions of neurons of the cerebral cortex, hypothalamus, reticular formation. Further violated receptive capabilities of neuronal metabolism and strucure-functional organization of the brain. Biochemical essence of addiction is the substitution of external chemical agents natural internal chemical reward. Such a substitution of internal factor available chemical equivalent does not require purposeful work and other processes to reach a state of satisfaction, pleasure, etc. Exogenous opiates - morphine and its analogues equivalents internal opioids, i.e. interact with the same classes of receptors that and opioide neuropeptides. Catecholamines in certain parts of the brain involved in the processes of internal reinforcement (Ashmarin I.P. Biochemistry of the brain, St. Petersburg, 1999, 328 pages). This is evidenced by the presence of zones located along the catecholamine - and serotoninergicheskih ways, when the irritation which you experience feelings of satisfaction, pleasure, etc. Especially these systems suffer when taking neopytnyh drugs (cocaine, LSD, heroin, etc).

Transcranial magnetic stimulation is widely and is used for research and treatment of lesions of the nervous system (patent RU № 2100037, №2134131, №2128485, №2194477). One of the purposes of the application of TMS in patients with drug addiction in our treatment is the possibility of activation of neurotransmitter systems of the brain, primarily catecholamin and serotoninergicheskie system, because TMS can affect different neurotransmitter systems, including serotonin and dopaminergic (Imranov Russia, having got Transcranial magnetic stimulation. M., “Allan”, 2002, page 164). The second objective of the use of TMS in these patients is the ability to decrease after stimulation manifestations astenodepressivnyh States. The third task TMS is the possibility of its influence on the bioelectrical activity of the brain and thereby change the modified activity of the drug with the aim of bringing to normal (better organization, often reduced to a more slow waves).

Also during the stimulation is the presentation of relevant and irrelevant visual stimuli. Significant stimuli with a short time interval presentation on the background of insignificant stimuli with a long interval of time of presentation and a large number - Nedostup for awareness and allow for multiple presentation to lay in the subconscious required information elements. In this case, it is information about the dangers of drugs, a way of life, the inevitability of a bad outcome if you continue taking prep the drugs, etc.

The method is as follows:

A patient with a drug record bioelectric activity of the brain - the electroencephalogram (EEG), (VIZ), somatosensory evoked potentials (ERPs)caused by motor potentials (GWP), determine the level of dopamine in the blood or cerebrospinal fluid) before and after TMS with different frequencies from 1 to 15 Hz (diagnostic TMS). Registration takes place on 18-channel electroencephalograph Nihon Koden "EEG-4217 (Japan) and neurocranial "Viking IVP" by Nicolet (USA). On the basis of spectral and coherence analysis of EEG amplitude and latency of the main components of ERPs, WUAs, VMP find the optimum amplitude and frequency of TMS, which is offset from the fundamental wave in the direction of deceleration, reducing motor thresholds, amplitudes of ERPs, WUAs and VMP, reduction in EEG disruption of basic rhythms and increase the level of dopamine in the blood or cerebrospinal fluid). After selection of the amplitude and temporal characteristics of exposure and the absence of side-effects the patient is assigned a treatment stimulation therapy.

Stimulation is carried out as follows: the patient lies on a couch in light-, sound-proofed room. The task is achieved by using a coil creates a magnetic field in the projection of the fronto-temporal regions of cerebral hemispheres and the frequency of them is osnago fields are selected according to the optimal reactions of the bioelectrical activity of the brain, and the maximum induction of a magnetic field provide in the range of 0.5 to 1.2 T, while conducting visual stimulation with meaningful visual stimuli with a duration of 0.1-20 MS and nonsignificant stimuli with a duration of 35-350 MS in the ratio of 1 to 2 or 1 to 24, when the frequency of presentation of images 3-25 per second, daily for 30-60 minutes, 10-20 sessions per course of treatment.

Transcranial magnetic simulation carried out by magnetostimulation “MS-1” firm “Neurosoft” (Ivanovo, Russia)connected through an external input from a personal computer, which allows using the software for magnetostimulation, to adjust the frequency and duration of the pulse magnetic field. Induction of a magnetic field of 0.5 to 1.2 T, pulse duration 0.3 MS, the frequency of 1-15 Hz (individually customized for each patient), the coil diameter of 80-120 mm with proceeds from this physical basis for the formation of excitation. While conducting visual stimulation through the computer monitor is showing significant and insignificant (for the patient with drug addiction) pattern.

The results can be illustrated by the following clinical example.

Patient A., aged 32 years, within 2 years had used marijuana, then within 2 months of heroin. Complaints on mental and physical dependence, as undepressing syndrome. The patient truly wants to get rid of drug addiction. The patient was registered EEG, ERPs, WUAs, VMP, determining the level of dopamine in TMS with different frequencies and identified on the basis of the analysis of the obtained data, the optimal frequency of stimulation: TMS - 4,6 Hz. Prepared by the significant (negative attitudes to drug use, the belief in the possibility of cure) and insignificant paintings (nature, animals, paintings).

The patient held 20 sessions, TMS, with the induction of a magnetic field of 1.0 T and visual stimulation. The duration of each session was 30 minutes a day.

After the treatment notes:

1. Sick for 6 months doesn't do drugs.

2. The patient notes the absence of withdrawal symptoms.

3. Positive dynamics in the EEG and EP - reducing disruption basic rhythms, slow alpha rhythm (8,8 Hz), the decrease in the amplitude of ERPs, VMP, increased MT in TMS.

4. Reduction astenodepressivnyh States, improvement of sleep.

Using the proposed method allows to obtain the following positive effects:

1. Allows you to reduce or reduce the manifestation of withdrawal symptoms during withdrawal from drugs.

2. Improve sleep and reduce astenodepressivnyh state.

3. To ensure the effectiveness of the treatment p and the absence of positive results in the treatment of other treatment methods.

4. To slow down or stop the processes of addiction. The proposed method of treatment can be used in the treatment of patients with various types of addiction.

A method of treating patients with drug addiction, including the effects of magnetic field, wherein the pre-determined frequency magnetic field in the range from 1.0 to 15.0 Hz, at which the shifting waves of bioelectric activity in the direction of deceleration, decrease of motor threshold, amplitude, reducing the disruption of rhythms, as well as increase the level of dopamine in the blood and/or cerebrospinal fluid; stimulation carried out by the magnetic field of the found frequency induction 0.5 to 1.2 T in the projection of the big hemispheres; while conducting visual stimulation with a frequency of stimuli presentation 3-25 per second, with significant visual stimuli have a duration of about 0.1-20 MS and insignificant visual stimulus - duration 35-350 MS; sessions are conducted daily for 30-60 min, the treatment is 10-20 sessions.



 

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FIELD: medicine.

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FIELD: medicine; medical engineering.

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19 cl, 5 dwg, 5 tbl

FIELD: medicine.

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4 cl, 11 ex, 9 dwg

FIELD: medicine.

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FIELD: medicine.

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FIELD: medicine, psychotherapy.

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1 cl, 1 ex, 3 tbl

FIELD: medicinal cosmetology.

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1 cl, 4 ex

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1 cl, 1 tbl

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2 cl, 3 dwg, 1 ex

FIELD: medicine, human weight correction.

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EFFECT: higher efficiency of weight correction.

1 cl, 1 ex

FIELD: medicine.

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FIELD: medicine, in particular, narcology.

SUBSTANCE: method involves using computer as apparatus for displaying on monitor screen of brain colored images reflecting at least two states of brain: before coding by separating portions colored with yellow, green and blue colors and tints thereof reflecting increasing extent of brain affection, and after coding by separating big portion of bright-red color on the background of portions colored with yellow, green and blue colors and tints thereof, respectively; explaining to patient that portion of bright-red color is his dominant code resulted from treatment; before coding procedure, applying and fixing on patient's forehead electrodes simulating elimination of brain potentials; in the course of coding, exposing patient to light flashes with switched-off common illumination and to continuous acoustic signals generated by means of acoustic synthesizer; during coding procedure, exposing patient to light flashes issued from, for example, stroboscope, said light flashes being emitted at frequency of 1-3 Hz; providing immediate suggestion by means of microphone and telephone headsets electrically connected to microphone and secured on patient's head. Method allows preliminary treatment procedure to be avoided.

EFFECT: increased therapeutic effect.

4 cl, 3 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: the present innovation deals with the ways to treat alcoholism, narcomania, tobacco smoking, obesity, sexual disorders, gambling-mania and others. Videopicture contains either one or two additional exposures, the 25th and 26th, correspondingly, each of them contains verbal information of either prohibiting or encouraging character and depictive information that corresponds to the character of verbal information. Moreover, at first, it is necessary to show the 25th exposure only, then - the 25th and the 26th exposures together, then again - the 25th exposure only. Duration of seance for videopicture watching should last for about 20-40 min. The method enables to perform less severe impact upon a patient.

EFFECT: higher efficiency of therapy.

1 cl

FIELD: medicine, psychiatry, psychotherapy.

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EFFECT: higher efficiency of therapy.

1 tbl

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