Method for diagnosing the cases of prostate diseases

FIELD: medicine.

SUBSTANCE: method involves studying biological material by applying infrared spectroscopy techniques. The obtained data are processed and diagnosis is set. Blood serum is used as the biological material. The study is carried out by preparing dried blood serum sample as suspension in Vaseline oil and doing the infrared spectroscopy analysis in the bandwidth of 120-1000 cm-1 and determining absorption strip peak heights having maximum at 1170; 1165; 1160; 1150; 1140; 1060; 1050; 1040; 1025 and then calculating the following ratio values like peak height with maximum at 1160 cm-1 to 1140 cm-1; 1165 cm-1 to 1150 cm-1; 1040 cm-1 to 1025 cm-1. The obtained distribution of this group is projected to frontal plane for calculating two-dimensional coordinates and comparing to flat reference diagnostic images of prostate pathologies and to a normal reference diagnostic image represented as flat polygons which boundaries are given by the following values. The norm is represented by X(-1.15;-0.9;0.45;0.0;-0.65) and Y(0.99;4.2;0.9;0.46), respectively. Pathology by X(-1.15;-1.15;0.35;0.0;0.65) and Y(0.99;-0.03; 0.48;0.09;0.46). The norm and pathology are differentiated. Additional mathematical processing is carried out on infrared spectra of blood serum samples of patients belonging to pathology image according to parameter values. First of all, three-dimensional distribution is calculated as peak having maximum at 1160 cm-1 to one having maximum at 1150 cm-1; 1170; 1160 cm-1; 1160 cm-1 to 1025 cm-1. It is projected then to frontal plane and compared to diagnosis images of prostate adenoma and images of prostate carcinoma. The second group relationships the following values are used: oncological cases - X(0.28;0.77;1.24;0.96), Y(0.75;0.46;-0.13;-0.02); adenoma - X(0.28;1.24;2.21;1.24;0.77), Y(0.75;1.24;-0.12;-0.13;0.46). Differential diagnosis of pathologies is set by interpreting point position within particular pathology image.

EFFECT: high accuracy of differential diagnosis.

 

The present invention relates to medicine, namely to urology and may be used in the diagnosis of pathological conditions of the prostate.

Timely and objective diagnosis of pathologies of the prostate is of great importance for the adequate remedial measures.

The closest and selected by the authors as a prototype is a method of diagnosis of diseases of the prostate by conducting infrared spectrograph biopsies of the prostate, described in the patent of the Russian Federation No. 2018829 [1].

However, this method has drawbacks associated with obtaining biopsies. This process is very traumatic for the patient, in addition, the procedure for obtaining biopsy requires the involvement of qualified personnel.

Pre-treatment of biological material requires the use of scarce and expensive reagents, and takes a long time.

The objective of the proposed invention is to develop a method for the diagnosis of prostate pathology, excluding the above-mentioned disadvantages and has high diagnostic accuracy.

The problem is solved by a method for the diagnosis of prostate diseases by the method of IR-spectroscopy of serum.

We offer the manual as follows: the patient produce the sampling of venous blood separate serum and prepare the sample for infrared spectroscopy, and this is dried and suspension with vaseline oil. Spectroscopic analysis of the sample perform in the field of 1200-1000 cm-1. Then make the determination of the peak heights of the absorption bands with maxima at 1160 cm-1to 1140 cm-1; 1165 cm-1to 1150 cm-1; 1040 cm-1to 1025 cm-1; received a three-dimensional distribution of this group is projected in the frontal plane to obtain two-dimensional coordinate and correlate with the boundaries of the flat reference diagnostic “images” pathologies of the prostate and an “image” of state standards. These “images” are presented in the form of a flat polyhedra, the boundaries of which are the following values: normal X(-1,15; -0,9; 0,45; 0,0; -0,65), accordingly(0,99; 4,2; 4,2; 0,9; 0,46); pathology - X(-1,15; -1,15; 0,35; 0,0; -0,65), accordingly(0,99; -0,03; 0,48; 0,09; 0,46). Next produce differentiation of norm and pathology depending on the location of the received point in the coordinate system. Then for the IR spectra of the samples of blood serum of patients relevant parameters “pathology”, produce additional mathematical processing. First calculate the three-dimensional distribution, namely the ratio of the peak height with a maximum of 1060 cm-1to the height of the peak with a maximum at 1050 cm-1; 1170 cm1 to 1160 cm-1; 1160 cm-1to 1025 cm-1and then projecting it onto the frontal plane and correlated with the reference diagnostic “images” benign prostatic hyperplasia and prostate cancer. Coordinate values of “images” for the ratios of the second group are: Oncology - X(0,28; 0,77; 1,24; 0,96); accordingly(0,75; 0,46; -0,13; -0,02); adenoma - X(0,28; 1,24; 2,21; 1,24; 0,77); The(0,75; 1,24; -0,12; -0,13; 0,46); differential diagnosis of pathology is conducted depending on the location of the point within the “image” of a particular pathology.

The final diagnosis is established in the case of “set” of values obtained for a particular patient to pathology in both cases.

Mathematical processing of the received data, the proposed method is performed using a computer program, created specifically for this research.

This program allows you to uniquely identify the position of the point, reflecting the parameters of the patient's blood, and to determine the belonging to the “image” of the disease, in addition, it is not time-consuming.

As a result of implementation of the proposed invention, the physician receives an objective diagnosis that allows you to assign adequate optimal treatment and monitor the patient's condition.

The advantages of the proposed method one is the high level of diagnostic accuracy, low cost survey, using standard equipment, allowing to carry out this survey on the basis of the biochemical laboratories of hospitals.

For personnel conducting research proposed method requires no special preparation.

The proposed method was examined 125 patients at the regional hospital. Semashko and Paul CRH and 78 clinically healthy people enterprises of the Nizhniy Novgorod region.

The obtained results were verified blind, subsequently confirmed clinically.

The proposed method can be illustrated by the following examples from clinical practice.

Example 1.

Sick And 71. Admitted to the hospital 25.01.02 with complaints of frequent urination in six months. Was observed with a diagnosis of BPH. In December 2001 was suspected prostate cancer. Biopsy from 30.01.02 revealed a clear option for prostate cancer. DOG 9.8, Lymphocytosis - 81. Ultrasound size 49 37 49 mm Multiple hypoechoic areas. Produced by IR-spectroscopic analysis in accordance with the proposed method. Was taken blood and separated serum. Then there was prepared a sample for infrared spectroscopy. Serum was dried, prepared suspension in vaseline oil, IR-analysis about the Asti 1200-1000 cm -1. The obtained coordinate values of the first group of ratios X=-0,46; Y=0,32. (2) X=0,68; Y=0,42. The diagnosis of cancer, installed in a medical institution, confirmed by the method of IR-spectroscopy.

Example 2.

The patient P, 75 years. In 1989 moved adenomectomy. In 1998 produced a biopsy melkoatsinarnaya adenocarcinoma. Estrogen therapy from 1998-2002. DOG 5.9 Performed blood sampling 14.02.03 and study of serum by the method of IR-spectroscopy, described in the proposed invention, the obtained coordinate values of points (1) X=-0,3; Y=0,34; (2) X=0,64; Y=0,2. Diagnosed - cancer of the prostate. The diagnosis was confirmed in the result of intervention.

Example 3.

Patient, 70 years of age. Admitted to the hospital 15.01.02 with complaints of frequent urination, pain in the bladder for one and a half years. Was observed with a diagnosis of adenoma of the prostate during the same time. Preparing for surgical treatment is transurethral resection of the gland. Biopsy: Glandular-stromal hyperplasia.

Produced by IR-spectroscopic analysis in accordance with the above description. The obtained coordinate values of the first group of ratios X=-0,16; Y=0,62, (2) X=1,04; Y=0,80. The diagnosis of BPH, installed in a medical institution, confirmed by the method of IR-spectroscopy.

The examples suggest that proposed the initial diagnostic method can be used in the practice of medical institutions.

Literature

1. A method for the diagnosis of diseases of the prostate. RF patent №2018829, ed. Cocos VI, Arrogant A.S. and others

A method for the diagnosis of diseases of the prostate, including the study of biological material by infrared spectroscopy method, data processing, diagnosis, characterized in that as the use of biological material serum, a study conducted by sample preparation dried whey in the form of a suspension in vaseline oil and then the infrared spectroscopic analysis in the field of 1200-1000 cm-1and the definition of the peak heights of the absorption bands with maxima 1170; 1165; 1160; 1150; 1140; 1060; 1050; 1040; 1025, then calculate the values of the following relations: height of the peak with a maximum at 1160 cm-1to 1140 cm-1; 1165 cm-1to 1150 cm-1; 1040 cm-1to 1025 cm-1obtained three-dimensional distribution of this group is projected in the frontal plane to obtain two-dimensional coordinate and correlate with the boundaries of the flat reference diagnostic “images” pathologies of the prostate and an “image” of state standards, which are in the form of a flat polyhedra, the boundaries of which are the following values: normal X(-1,15; -0,9; 0,45; 0,0; -0,65), accordingly(0,99; 4,2; 0,9; 0,46); pathologists who - X(-1,15; -1,15; 0,35; 0,0; 0,65), accordingly(0,99; -0,03; 0,48; 0,09; 0,46), produce differentiation of norm and pathology; next to the IR spectra of the samples of blood serum of patients corresponding to the parameters of the “image” of pathology, produce additional mathematical processing, and the rst calculate the three-dimensional distribution, namely the ratio of the peak height with a maximum of 1060 cm-1to the height of the peak with a maximum at 1050 cm-1; 1170 cm-1; 1160 cm-1; 1160 cm-1and 1025 cm-1and then projecting it onto the frontal plane and correlated with the reference diagnostic “images” benign prostatic hyperplasia and prostate cancer, the coordinate values of “images” for the ratios of the second group are: Oncology - X(0,28; 0,77; 1,24; 0,96), accordingly(0,75; 0,46; -0,13; -0,02); adenoma - X(0,28; 1,24; 2,21; 1,24; 0,77); The(0,75; 1,24; -0,12; -0,13; 0,46); differential diagnosis of pathology is conducted depending on the location of the point within the image” specific pathology.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method involves studying blood serum, processing obtained data and setting disease diagnosis. The study is carried out by preparing dried blood serum sample as suspension in Vaseline oil and doing the infrared spectroscopy analysis in the bandwidth of 120-1000 cm-1 and determining absorption strip peak heights having maximum at 1180; 1165; 1160; 1150; 1130; 1070; 1025 cm-1 and then calculating the following two ratio groups, the first of which is ratio of peak height with maximum at 1165 cm-1 to 1150 cm-1; 1160 cm-1 to 1130 cm-1; 1070 cm-1; 1025 cm-1. The second group has ratio peak having maximum at 1165 cm-1 to 1160 cm-1; 1180 cm-1 to 1130 cm-1; 1065 cm-1; 1070 cm-1. The obtained three-dimensional distribution of the first group is projected to frontal plane for calculating two-dimensional coordinates and comparing to flat reference diagnostic images of hepatic pathologies and to a normal reference diagnostic image represented as flat polygons which boundaries are given by the following values. The norm is represented by X(-2.3;2.0;4.0;4.0) and Y(1.6;0.8;0.8;1.6), respectively. Oncology is represented by X(1.7;1.7;0.0;0.0) and Y(1.9;1.25; 1.25;1.9). Hepatites are represented by X(1.9;2.2;1.8;1.4 and 1.9;1.8;4.0) and Y(1.9;1.9; 0.5;0.5 and 08;0.5;0.8). Cirrhosis is represented by X(1.9;2.6;1.4) and Y(1.6;0.8;0.4). Diseases are differentiated by interpreting point position within particular area. Three-dimensional distribution of the second group is projected to frontal plane and compared to diagnosis images of pathology and norm. Coordinate values of the second group are as follows: norm - X(1.8;2.9;2.5;1.5), Y(2.7;2.0;1.2;1.6); oncological cases - X(0.27;0.67;0.63), Y(0.27;0.67;0.3); hepatitis - X(1.5;2.5;2.4;1.2), Y(1.6;1.2;0.2;0.9); cirrhosis - X(1.1;0.9;0.9). Final diagnosis of pathology is set when particular data values belong to the corresponding pathology zone in both cases.

EFFECT: high accuracy of diagnosis.

FIELD: medicine, dermatology, clinical laboratory diagnostics.

SUBSTANCE: the present method deals with detecting the focus of neutrophilic phagocytic activity lesion in capillary blood. At the values of cells' capacity to phagocytosis in percentage and phagocytic number on the 10th d of therapy being below 20% and 3.3, correspondingly one should evaluate therapeutic efficiency to be low, if it is above 40% and 4.0, correspondingly - as high.

EFFECT: higher accuracy of evaluation.

2 ex, 3 tbl

FIELD: medicine, biochemistry.

SUBSTANCE: in blood serum one should detect the level of lactoferrin and biliary acids. At their ratio being equal to 5-17 it is necessary to detect chronic hepatitis of high activity.

EFFECT: higher accuracy of detection.

3 ex

FIELD: medicine, infectology.

SUBSTANCE: one should detect the level of terminal stable metabolites of nitrogen oxide (NOx) in whole blood. At its value ranged 39.6-86.0 mcM/l one should evaluate hemorrhagic fever accompanied with renal syndrome (HFRS) of average severity, at NOx value ranged 86.7-141.5 mcM/l - severe form of HFRS and at its values ranged 88.2-128.6 mcM/l at the background of pronounced clinical picture - as complicated disease flow. The method enables to shorten the terms for carrying out the assays.

EFFECT: higher accuracy of evaluation.

3 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: method involves studying blood samples with venous blood mixed with vital stain like methylene blue. Degree of vital stain absorption by erythrocytes is determined by applying photocolorimetry. The value drop being more than 25%, extracorporal detoxication is to be predicted as ineffective.

EFFECT: simplified method.

6 tbl

FIELD: medicine, analytical biochemistry.

SUBSTANCE: invention relates to laboratory methods of investigations. Method involves sampling specimen from patient to be inspected, extraction of serotonin and histamine from a specimen, chromatography of extract and determination of concentration of serotonin and histamine by the fluorescence intensity value. Saliva is used as biological fluid. Saliva by volume 1 ml is extracted with 4 ml of 1 N hydrochloric acid solution, 2 g of anhydrous potassium carbonate and 5 ml of mixture of butanol and chloroform in the ratio 3:2 are added, extract is shaken up and centrifuged. Organic phase (4 ml) is sucked off from extract and passed through chromatography column (diameter is 3 mm, height is 16 mm) filled with ion-exchange resin KB-4 or KB-4P-2 or Bio Rex-70 in H+-form, size of granules is 0.1 ± 0.02 mm. Histamine is eluted with 4 ml of 0.1 N hydrochloric acid at the rate of eluting solution 0.4 ml/min. Histamine concentration is determined by reaction with ortho-phthalic aldehyde dissolved in ethanol. Serotonin concentration is determined by reaction with ninhydrin in organic passed through column. Method provides assaying the saliva concentration of serotonin and histamine with high precision.

EFFECT: improved assay method.

The invention relates to medicine, namely to surgery

The invention relates to the encoded Micronesia, which is encoded using a stored code written by bleaching of fluorescent molecules on the surface of or inside microsites using impact Micronesian light radiation from a source with high spatial resolution

The invention relates to medicine, namely to laboratory diagnosis

FIELD: medicine.

SUBSTANCE: method involves studying blood serum, processing obtained data and setting disease diagnosis. The study is carried out by preparing dried blood serum sample as suspension in Vaseline oil and doing the infrared spectroscopy analysis in the bandwidth of 120-1000 cm-1 and determining absorption strip peak heights having maximum at 1180; 1165; 1160; 1150; 1130; 1070; 1025 cm-1 and then calculating the following two ratio groups, the first of which is ratio of peak height with maximum at 1165 cm-1 to 1150 cm-1; 1160 cm-1 to 1130 cm-1; 1070 cm-1; 1025 cm-1. The second group has ratio peak having maximum at 1165 cm-1 to 1160 cm-1; 1180 cm-1 to 1130 cm-1; 1065 cm-1; 1070 cm-1. The obtained three-dimensional distribution of the first group is projected to frontal plane for calculating two-dimensional coordinates and comparing to flat reference diagnostic images of hepatic pathologies and to a normal reference diagnostic image represented as flat polygons which boundaries are given by the following values. The norm is represented by X(-2.3;2.0;4.0;4.0) and Y(1.6;0.8;0.8;1.6), respectively. Oncology is represented by X(1.7;1.7;0.0;0.0) and Y(1.9;1.25; 1.25;1.9). Hepatites are represented by X(1.9;2.2;1.8;1.4 and 1.9;1.8;4.0) and Y(1.9;1.9; 0.5;0.5 and 08;0.5;0.8). Cirrhosis is represented by X(1.9;2.6;1.4) and Y(1.6;0.8;0.4). Diseases are differentiated by interpreting point position within particular area. Three-dimensional distribution of the second group is projected to frontal plane and compared to diagnosis images of pathology and norm. Coordinate values of the second group are as follows: norm - X(1.8;2.9;2.5;1.5), Y(2.7;2.0;1.2;1.6); oncological cases - X(0.27;0.67;0.63), Y(0.27;0.67;0.3); hepatitis - X(1.5;2.5;2.4;1.2), Y(1.6;1.2;0.2;0.9); cirrhosis - X(1.1;0.9;0.9). Final diagnosis of pathology is set when particular data values belong to the corresponding pathology zone in both cases.

EFFECT: high accuracy of diagnosis.

FIELD: medicine.

SUBSTANCE: method involves carrying out medical genetic examination of a patient. Auricular sulfur type is additionally determined. Ecological examination is carried out with region and habitation time therein being determined. Basic indices describing patient vital activity are detected and estimated in scores from formula Kv= A+B+C+D+E+F+G, where A is the age, when less than 18, score is equal to 0.1 points, equal to 19-39, the score is equal to 1 point, equal to 40-59, the score is equal to 2 points, equal to 60-79, the score is equal to 3 points, higher than 80 years, the score is equal to 3 points. B is the smoking time. When less than 10 years, the score is equal to 0.1 points, when equal to 10-19, the score is equal to 1 point, when equal to 20-29, score is equal to 2 points, when equal to 30 and longer, score is equal to 3 points. C is the alcohol consumption. When being irregular, score is equal to 0.1 points, when regular, the score is equal to 1 point. D is the harmful domestic factors. When no domestic harm being available, score is equal to 0.1 points, otherwise the score is equal to 1 point. E is for the ecological factors. Clean region being the case, score is equal to 0.1 points, moderately contaminated one - 1point, dirty one being the case, the score is equal to 2 points. F is the habitation time in contaminated region. When less than 10 years, score is equal to 0.1 points; equal to 10-19, the score is equal to 1 point. G is the auricular sulfur type. Wet type being the case, score is equal to 0.1 points, dry one - the score is equal to 1 point. Kv is calculated. The value being less than 6, low probability risk factor is predicted. Kv being between 6 and 8, moderate probability value is predicted. The value being greater than 8, the case is predicted to be of high probability.

EFFECT: high reliability of prognosis.

FIELD: medicine, obstetrics, gynecology.

SUBSTANCE: in the first trimester of pregnancy one should study the content of CD8+CD11b lymphocytes and at their values being either equal or above 2% it is possible to predict gestosis. The present innovation enables to choose correct tactics of treating pregnant women that, in its turn, leads to decreased frequency of this complication of pregnancy and the risk for the development of fetal and neonatal pathology.

EFFECT: higher accuracy of prediction.

3 ex, 1 tbl

FIELD: medicine, neurology.

SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.

EFFECT: higher reliability of prediction.

2 ex, 1 tbl

FIELD: medicine, cardiology.

SUBSTANCE: one should register rhythmocardiogram, measure current total power in low-frequency and high-frequency areas of dynamic row of cardiointervals. Evaluation of psychophysiological state should be performed by the value of stress index S calculated due to original mathematical formula by taking into account the power of low-frequency and high-frequency constituents of the range of dynamic row of cardiointervals. In case of standard conditions of measurement - the rest lying at one's back position the value of S stress index should be considered to be equal to 1. The method enables to rapidly and noninvasively detect and range human psychophysiological state.

EFFECT: higher accuracy of evaluation.

2 dwg, 1 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: before applying substitute hormonal therapy (SHT) on should evaluate antithrombogenic activity of vascular wall in women. For this purpose one should determine quantitative values of ADP-induced aggregation of thrombocytes, activity of antithrombin III in blood and fibrinolytic blood activity both before and after "cuff"-test. Then one should detect the indices calculated as the ratio of mentioned values both before and after carrying out the mentioned test. If mentioned indices are decreased against the norm by 20-40% women should be prescribed to undergo SHT at additional introduction of aspirin and supradin. The method provides prophylaxis of cardio-vascular diseases in this category of female patients due to correcting affected functional activity of vascular endothelium.

EFFECT: higher efficiency of prophylaxis.

1 cl, 1 ex, 4 tbl

FIELD: medicine, oncology.

SUBSTANCE: one should study the activity of catalase in the tissue of malignant mammary tumor and its perifocal area, and at ratio coefficient of catalase activity in the tissue of malignant mammary tumor to that in the tissue of perifocal area being equal to 1.0 ± 0.2 one should predict the chance for the development of new foci of lesion before their clinical manifestation, that provides necessary treatment in due time.

EFFECT: higher efficiency of prediction.

1 ex, 1 tbl

FIELD: medicine, pediatrics.

SUBSTANCE: in neonatals one should apply control set of risk factors that includes detection of maternal body temperature in the course of delivery, evaluation of neonatal's body weight at birth (g), one should characterize each risk factor and evaluate in points and by the value of the sum of points predict the risk for intrauterine infection, moreover, this set of risk factors includes extragenital pathology and its availability, chronic foci of infection and their exacerbation, acute infectious diseases occurred during pregnancy, prenatal waters, the nature of waters, moreover, if risk factors are characterized, correspondingly: the presence of one pathological disease, the presence of infection at no exacerbation, single acute infectious disease occurred during pregnancy, waters at mature pregnancy, waters color - light, moderate polyhydramnios, maternal body temperature in the course of delivery up to 37.5 C, evaluation by a certain scale being 7-8,neonatal's body weight at birth being above 2500 but below 2900 each of them should be evaluated per 1 point, if risk factors are characterized: combination of pathologies, exacerbation of chronic foci of infection occurred more than once, acute infectious diseases happened twice during pregnancy, prenatal waters at 36-wk-pregnancy, the nature of waters - meconial, pronounced polyhydramnios, maternal body temperature during delivery ranged 37.5-38 C, evaluation by a certain scale being 5-6, neonatal's body weight at birth being 1500-2500 each factor should be evaluated per 2 points, if risk factors are characterized: the presence of three and more pathological diseases, exacerbation of chronic foci of infection in every trimester of pregnancy, acute infectious diseases occurred during pregnancy in every trimester, prenatal waters 6 wk earlier the delivery terms, the nature of waters - turbid, with flavoring, maternal body temperature during delivery being above 38 C, evaluation by a certain scale being below 5, neonatal's body weight at birth being below 1500 every factor should be evaluated per 3 points, moreover, if the sum of points is not above or equal 8 points the risk for intrauterine infection in neonatals ins minimal, at the sum of points ranged 9-13 the risk is average and at the sum of points being 13 or above 13 the risk is maximal. The method takes into account extragenital pathology that creates the foundation for initial shifts in homeostasis and weakens resistance to external impacts.

EFFECT: higher accuracy of prediction.

1 ex, 1 tbl

FIELD: medicine, toxicology.

SUBSTANCE: at patient's hospitalization one should detect the values of patient's state such as: the state of consciousness, availability of spasms, scleral injectivity degree, headache, nystagmus, vertigo, ataxia, respiration frequency, exposure of poisoning substance, patient's age, concentration of carboxyhemoglobin, prothrombin index (PTI), creatinine amount and that of leukocytes, sedimentation rate and patient's body temperature. Each parameter should be evaluated in points to sum them up finally. By the value of summed up points it is possible to evaluate indication for urgent hospitalization into resuscitation department. The method enables to obtain objective evaluation for the necessity in resuscitation aid.

EFFECT: higher accuracy of evaluation.

3 ex, 4 tbl

FIELD: medicine, urology.

SUBSTANCE: the present innovation deals with differential diagnostics of prostatic cancer and other prostatic diseases at the stage of primary inspection. The method includes the detection of PCA and calculation of probability coefficient for prostatic cancer (PCC) by the following formula: where e - the foundation of natural logarithm (e=2.718…), PCA - the level of total blood PCA in ng/ml, V - patient's age in years. At PCC value being above 0.2 one should diagnose prostatic cancer and to establish final diagnosis one should perform polyfocal prostatic biopsy. The method enables to increase accuracy of diagnostics at decreased number of unjustified prostatic biopsies.

EFFECT: higher efficiency of diagnostics.

2 ex

FIELD: medicine.

SUBSTANCE: method involves carrying out ultrasonic scanning examination of subclavian artery over its whole extent in physiological arm position with arterial blood pressure being measured in the middle one third of the arm. Next, when applying compression tests, blood circulation parameters variations are recorded in distal segment of the subclavian artery with arterial blood pressure being concurrently measured. Three degrees of superior thorax aperture syndrome severity are diagnosed depending on reduction of linear blood circulation velocity and arterial blood pressure compared to their initial values. Mild one takes place when linear blood circulation velocity reduction reaches 40% and arterial blood pressure 20% of initial level, moderate one when linear blood circulation velocity reduction reaches 70% and arterial blood pressure 50% and heavy one when linear blood circulation velocity reduction is greater than 70% of initial level and arterial blood pressure is greater than 50% to the extent of no blood circulation manifestation being observed in the subclavian artery.

EFFECT: high accuracy of diagnosis.

Up!