Method for diagnosing the cases of hepatic pathologies

FIELD: medicine.

SUBSTANCE: method involves studying blood serum, processing obtained data and setting disease diagnosis. The study is carried out by preparing dried blood serum sample as suspension in Vaseline oil and doing the infrared spectroscopy analysis in the bandwidth of 120-1000 cm-1 and determining absorption strip peak heights having maximum at 1180; 1165; 1160; 1150; 1130; 1070; 1025 cm-1 and then calculating the following two ratio groups, the first of which is ratio of peak height with maximum at 1165 cm-1 to 1150 cm-1; 1160 cm-1 to 1130 cm-1; 1070 cm-1; 1025 cm-1. The second group has ratio peak having maximum at 1165 cm-1 to 1160 cm-1; 1180 cm-1 to 1130 cm-1; 1065 cm-1; 1070 cm-1. The obtained three-dimensional distribution of the first group is projected to frontal plane for calculating two-dimensional coordinates and comparing to flat reference diagnostic images of hepatic pathologies and to a normal reference diagnostic image represented as flat polygons which boundaries are given by the following values. The norm is represented by X(-2.3;2.0;4.0;4.0) and Y(1.6;0.8;0.8;1.6), respectively. Oncology is represented by X(1.7;1.7;0.0;0.0) and Y(1.9;1.25; 1.25;1.9). Hepatites are represented by X(1.9;2.2;1.8;1.4 and 1.9;1.8;4.0) and Y(1.9;1.9; 0.5;0.5 and 08;0.5;0.8). Cirrhosis is represented by X(1.9;2.6;1.4) and Y(1.6;0.8;0.4). Diseases are differentiated by interpreting point position within particular area. Three-dimensional distribution of the second group is projected to frontal plane and compared to diagnosis images of pathology and norm. Coordinate values of the second group are as follows: norm - X(1.8;2.9;2.5;1.5), Y(2.7;2.0;1.2;1.6); oncological cases - X(0.27;0.67;0.63), Y(0.27;0.67;0.3); hepatitis - X(1.5;2.5;2.4;1.2), Y(1.6;1.2;0.2;0.9); cirrhosis - X(1.1;0.9;0.9). Final diagnosis of pathology is set when particular data values belong to the corresponding pathology zone in both cases.

EFFECT: high accuracy of diagnosis.

 

The present invention relates to medicine, namely to methods of diagnosis, and can be used when establishing pathological conditions of the liver.

Timely and objective diagnosis of pathological conditions of the liver is of great importance for the adequate remedial measures.

The closest and selected by the authors as a prototype is a method of diagnosis of liver disease by irradiation of serum UV light and registration of luminescence measurement wavelength of the center of gravity of the spectrum. The known method described in the copyright certificate №948371, which depending on the wavelength diagnose viral hepatitis, cirrhosis of the liver or tumor jaundice.

However, this method has drawbacks associated with intensive exposure to serum UV light, which should lead to changes in the biochemical structure of the investigated sample and distortion of the results. In addition, in the known method for the diagnosis of each pathology is only one analytical parameter, namely the wavelength of the center of gravity of the spectrum of luminescence, which, according to the authors of the above invention, has different values in accordance with existing pathologies. The objective of the proposed invention, is the development of a method for the diagnosis of liver pathology, excluding the above-mentioned disadvantages and has high diagnostic accuracy. The problem is solved by a method for the diagnosis of pathology of the liver by the method of IR-spectroscopy.

The proposed method is as follows: the patient produce the sampling of venous blood, separate the serum and prepare the sample for infrared spectroscopy, and this is dried and suspension with vaseline oil. Spectroscopic analysis of the sample perform in the field of 1200-1000 cm-1. Then make the determination of the peak heights of the absorption bands with maxima 1180; 1165; 1160; 1150; 1130; 1070; 1025 cm-1, and then calculate the values of the two groups of relationships: the first of which is the ratio of the peak height with a maximum at 1165 cm-1to the height of the peak with a maximum at 1150 cm-1; 1160 cm-1to 1130 cm-1; 1070 cm-1to 1025 cm-1; the second group is the ratio of the peak height with the maximum 1165 cm-1to the height of the peak with a maximum at 1160 cm-1; 1180 cm-1to 1130 cm-1; 1165 cm-1to 1070 cm-1. Correlations are the coordinates along the axes X, Y and Z respectively in each group. The obtained three-dimensional distribution of the first group project in the frontal plane to obtain two-dimensional coordinates correlated with the boundaries of the flat reference diagnostic “images” pathologies pecan and “image” of state standards, which are represented in the form of a flat polyhedra, produce differentiation of the disease depending on the location of the received point in one area or another. Border sample “images” is set empirically and tested on patients having a diagnosis. Border “images” rules are set by the study of blood serum of clinically healthy volunteers.

For ratios of the first group of coordinates “images” are the following values: normal X(2,3; 2,0; 4,0; 4,0), accordingly(1,6; 0,8; 0,8; 1,6); Oncology - X(1,7; 1,7; 0,0; 0,0); The(1,9; 1,25; 1,25; 1,9); hepatitis - X (1,9; 2,2; 1,8; and 1,4 1,9; 1,8; 4,0); (1,9; 1,9; 0,5; 0,5 and 0,8; 0,5; 0,8); cirrhosis - X (1,9; 2,6; 1,4); (1,6; 0,8; 0,4).

The diagnosis is established when the coordinate values that define the projected point within a specific “image”.

Three-dimensional distribution of the second group as projected on the frontal plane and correlated with the reference diagnostic “images” pathology and regulations.

Coordinate values of “images” for the ratios of the second group are: norm - X(1,8; 2,9; 2,5; 1,5); accordingly(2,7; 2,0; 1,2; 1,6); Oncology - X (0,27; 0,67; 0,63); (0,7; 0,67; 0,3); hepatitis - X(1,5; 2,5; 2,4; 1,2); The(1,6; 1,2; 0,2; 0,9); cirrhosis - X (2,4; 2,3; 2,1); (1,1; 0,9; 0,9).

Diagnostic pathology is also depending on the location of the point within the “image”.

The final chart on the lake is set in the case of a “set” of values obtained for a particular patient to the pathology in both cases.

Mathematical processing of the received data, the proposed method is performed using a computer program, created specifically for this research.

This program allows you to uniquely identify the position of the point, reflecting the parameters of the patient, and to determine the belonging to the “image” of the disease, in addition, it is not time-consuming.

As a result of implementation of the proposed invention, the physician receives an objective diagnosis that allows you to assign adequate optimal treatment and monitor the patient's condition. Advantages of the proposed method is the high diagnostic accuracy, low cost survey, using standard equipment, allowing to carry out this survey on the basis of the biochemical laboratories of hospitals. For staff conducting research proposed method requires no special preparation.

The proposed method was examined 564 patients Nizhny Novgorod EMC Hepatology center and 120 clinically healthy student volunteers Nizhny Novgorod state medical Academy. The obtained results were verified blind, confirmed later clinically. The proposed method can be illustrated by the following PR the measures of clinical practice. Patient H, 33 years. Admitted to the hospital 15.04.02 with complaints of nausea, weakness, feeling of heaviness in the right hypochondrium. Extracted blood, then preparing the sample for the study of separated serum analyzed by the method of IR-spectroscopy, after mathematical treatment of the obtained values of the relations of the frequencies of the first group is the ratio of the peak height with a maximum at 1165 cm-1to the height of the peak with a maximum at 1150 cm-1; 1160 cm-1to 1130 cm-1; 1070 cm-1to 1025 cm-1; and their conversion in planar coordinate system obtained values: X=1,92; Y=1, 84. Then made comparisons with images”

pathology - diagnosis of hepatitis. Further analysis of the obtained values of the relations of the frequencies of the second group is the ratio of the peak height with the maximum 1165 cm-1to the height of the peak with a maximum at 1160 cm-1; 1180 cm-1to 1130 cm-1; 1165 cm-1to 1070 cm-1and their transformation into a planar coordinate system, the values obtained: X=1,36; Y=1,03,. After correlation with the “images” of liver pathologies diagnosis is confirmed. Data from clinical and laboratory examination of the patient confirmed the established diagnosis.

Patient T., 55 years. Admitted to the hospital 17.09.02 complaining of periodic weakness, occasional shortness of breath, increase in the abdomen, swelling in the legs. Produced by IR-spectroscopic analysis according to the according to the above description. The obtained coordinate values of the first group of ratios X=1,80; Y=1,16. (2) X=2,38; Y=1,05. The diagnosis is established by the proposed method cirrhosis.

The diagnosis was confirmed by clinical and laboratory research. Patient M, 64 years. Admitted to the hospital 13.02.01 with complaints appeared 2 days ago jaundice, dragging pain in the right hypochondrium, the temperature increase to 38.2°, weakness, pronounced weight loss of 13 kg for the last six months.

Performed blood sampling day later - 14.02.01 and study of serum by the method of IR-spectroscopy, obtained coordinate values of points (1) X=1,2; Y=1,83; (2) X=0,58; or=0.6. Diagnosed - Oncology. The patient was transferred to the surgical hospital with suspected mechanical jaundice, where was established the final diagnosis: biliary tract cancer with liver metastases. The diagnosis was confirmed at surgery. The proposed method can be used in diagnostic practice.

Method for the diagnosis of liver disease, including the study of blood serum, the processing of the received data, diagnosis, characterized in that the study was conducted by preparing a sample of dried whey in the form of a suspension in vaseline oil and then the infrared spectroscopic analysis in the field of 1200-1000 cm-1and the definition of the peak heights of the absorption bands of the maxima 1180; 1165; 1160; 1150; 1130; 1070; 1025 cm-1, and then calculate the values of the two groups of relationships: the first of which is the ratio of the peak height with a maximum at 1165 cm-1to the height of the peak with a maximum at 1150 cm-1; 1160 cm-1to 1130 cm-1; 1070 cm-1to 1025 cm-1; the second group is the ratio of the peak height with the maximum 1165 cm-1to the height of the peak with a maximum at 1160 cm-1; 1180 cm-1; to 1130 cm-1; 1165 cm-1to 1070 cm-1obtained three-dimensional distribution of the first group project in the frontal plane to obtain two-dimensional coordinate and correlate with the boundaries of the flat reference diagnostic “images” pathologies of the liver and an “image” of state standards, which are represented in the form of a flat polyhedra, the boundaries of which are the following values: normal - X(-2,3; 2,0; 4,0; 4,0), accordingly(1,6; 0,8; 0,8; 1,6); Oncology - X(1,7; 1,7; 0,0; 0,0), The(1,9; 1,25; 1,25; 1,9), hepatitis - X (1,9; 2,2; 1,8; and 1,4 1,9; 1,8; 4,0); (1,9; 1,9; 0,5; 0,5 and 0,8; 0,5; 0,8); cirrhosis - X (1,9; 2,6; 1,4); (1,6; 0,8; 0,4); produce the differentiation of the disease depending on the location of the received point in a particular area, then the three-dimensional distribution of the second group is projected on the frontal plane and correlated with the reference diagnostic “images” pathology and regulations, coordinate values of “images” for the ratios of the second group are: normal - X(1,8; 2,9; 2,5; 1,5), respectively,(2,7; 2,0; 1,2; 1,6); Oncology - X (0,27; 0,67; 0,63); (0,7; 0,67; 0,3); hepatitis - X(1,5; 2,5; 2,4; 1,2); The(1,6; 1,2; 0,2; 0,9); cirrhosis - X (1,1; 0,9; 0,9), diagnose pathology, the final diagnosis is established in the case of a “hit” values obtained for a particular patient, in the area corresponding pathology in both cases.



 

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