Method for predicting the flow of gastric and duodenal ulcerous disease

FIELD: medicine, gastroenterology.

SUBSTANCE: one should carry out diagnostic studying, moreover, on the 5th -6th d against the onset of exacerbation in case of gastric and duodenal ulcerous disease one should detect the content serotonin, histamine and acetylcholine in blood, then during 2-3 wk one should conduct medicinal therapy to detect serotonin, histamine and acetylcholine level in blood again and at serotonin content being by 2-3 times above the norm, histamine - by 1.15-1.4 times above the norm and acetylcholine - by 20-45% being below the norm one should predict the flow of gastric and duodenal ulcerous disease as a non-scarring ulcer.

EFFECT: higher accuracy of prediction.

3 ex

 

The invention relates to medicine, namely to a gastroenterologist, and can be used in the prognosis of gastric ulcer and duodenal ulcer.

There is a method of predicting the course of disease, accepted for analogue by measuring physiological and biochemical parameters, including respiratory rate and recovery time HR after dose load, determine the diagnostic factors, which predict the development of the disease in the next five years (1).

There is a method of predicting the course of disease (burn the esophagus)adopted for the prototype through electromyography of the esophagus in the early stages after a chemical burn, and in the absence of electromyographic signals or a sharp decrease in their magnitude ascertain severe burn with the forecast in the structure of the esophagus (2).

However, the electromyography is not possible to predict the course of disease with a high degree of accuracy.

The aim of the invention is to improve the accuracy of predicting the course of gastric ulcer and duodenal ulcer.

The technical result is achieved by the fact that in 5-6 days from the beginning of exacerbation of peptic ulcer of stomach and duodenum spend the determination of serotonin, histamine and acetylcho is in the blood, then in 2-3 weeks conduct eradication therapy and treatment with blockers of the proton pump and re-determine the level of serotonin, histamine and acetylcholine in the blood, while increasing the serotonin levels in 2-3 times above the norm, histamine 1.15-1.4 times higher than normal, and acetylcholine - 20-45% below normal forecast for gastric ulcer and duodenal ulcer as probcause.

The method is as follows.

At admission the patient find out the duration of dyspeptic phenomena of pain, the duration of any periods of exacerbation and remission. When examining a patient to find out whether there is a dependence of pain on the physical properties and chemical composition of the food; in particular, there is a PI increased pain after taking chemically highly irritating, sharp and mechanically bad processed food. Periods of exacerbation of peptic ulcer last from 3-4 to 8 weeks and are followed by remission phase - bright intervals lasting from several months to several years, during which patients feel well.

Pain in peptic ulcer and its exacerbation can be aching, dull, burning, cramping, cutting and verlesha. Pains are progressive in nature, and greater intensity of pain marked by ulcers destalinization body of the stomach, with considerable size and depth of ulceration, the development of complications. Pain stymied by taking antacid drugs, anticholinergic and antispasmodic agents. A significant decrease in pain promotes frequent and fractional power.

Vomiting due to gastric ulcer and duodenal ulcer occurs at the height of pain and can be early or late in relation to food intake. Heartburn may be preceded by pain syndrome or be associated with him, persisting for a long time after remitting the other symptoms of exacerbation. Objective examination is determined by local tenderness in the epigastric region of the xiphoid process (the localization of the ulcer in cardiac and subcardial stomach), in the epigastric region to the left when mediagallery ulcers or right when the pyloric and duodenal ulcers. When combined with ulcers of the stomach and duodenum area palpation pain becomes more extensive. Positive symptom Mendel and symptom Vasilenko.

If gastroduodenoscopy appreciate ulcerative defect, accurately determine its location, shape, size and stage of development, the nature of the bottom and the edges of ulcers, the speed of its healing and condition of the mucous membrane.

Chronic ulcer in the acute stage the submitted is a defect in the mucosa of various sizes, form and depth. While often dominated by a round or oval shape, rarely polygonal or angular. The edges of the ulcer smooth, high, clearly defined, the slopes of the ulcer crater steep. The mucous membrane around the ulcer edematous, hyperemic, sometimes with punctulata by haemorrhages and erosions. The depth of the ulcers may be different, their bottom is often covered with a whitish or gray bloom. In the mucous membrane around the ulcer revealed a picture of acute inflammation with edema, plasmocytomas infiltration, the expansion of blood vessels. In the phase of healing observed decrease periultseroznoy inflammatory shaft, the lower zone of hyperemia and edema of the mucous oblucki around the ulcer. Regional inflammatory shaft is smoothed, reduced; the ulcer becomes less deep, the bottom is cleaned and covered with granulation.

Determine blood serotonin and histamine method Sadovanquivad, and acetylcholine - by the method of Hestrin. The number of serotonine in the blood was significantly increased compared to the norm, accounting for 0.2 to 0.3 Ámol/l (norm - 0,1▒0.02 Ámol/l); number of histamine (0,22-0,28 mmol/l), normal (0,19▒0.01 Ámol/l); acetylcholine is 0.8 - 1.04 mmol/l (normal -1,3▒0.12 mmol/l).

Conduct eradication treatment and treatment with blockers of the proton pump appointment of omeprazole (20 mg 2 times a day) and amoxicillin 500 mg 3 times a day is within 2-3 weeks.

After medical treatment, there is a decrease in pain intensity, the disappearance of vomiting, symptoms of Mendel and Vasilenko. 2 weeks after first determining the content of biologically active amines in the blood content define them again. Found that the levels of serotonin in the blood decreases to a normal level, amounting to 0.12▒0.02 Ámol/l, the concentration of histamine was 1.05-1.1 times above normal, while the content of acetylcholine was reduced by 5-10% below normal. Predict the further course of the ulcer as cicatrizing.

Control gastroduodenoscopy 2 weeks after the prognosis of gastric ulcer and duodenal ulcer in the phase of healing notes the decrease in periolase inflammatory shaft, the reduction in the area of edema and hyperemia of the mucous around the ulcer, regional inflammatory shaft is smoothed, reduced the ulcer becomes less deep, the bottom is cleaned and covered with granulation. When this plague takes a characteristic appearance of the so-called stage red scar. The morphological examination gradual filling of the ulcer granulation tissue, reduction and disappearance of the inflammatory infiltration and epithelialization. Thus, gastroduodenoscopy painting phase of ulcer healing is characterized pony is the group of acetylcholine, by normalizing serotonin levels and a slight increase in the concentration of histamine. The prognosis of the disease as cicatrizing ulcers confirmed gastroduodenoscopy.

If the levels of biologically active substances after 2-3 weeks of drug therapy remained at the level of their first fix (when sick), namely: the serotonin (0.2 to 0.3 Ámol/l) increased; acetylcholine (0,8-1,03 mmol/l) reduced, and the content of histamine remains elevated (up to 0.23-0.27 Ámol/l). Predict the course of peptic ulcer how long probcause.

When the control gastroduodenoscopy in 1.5 months. after receipt of the patient and histological study of biopsy specimens of the mucosa find that in the field of bleeding ulcers along with hyperemia, edema, hemorrhages, mikrotrombozov in the capillary phenomena of necrosis in the number of cases found arose vessels, identified areas of massive destruction of tissue.

Thus, while maintaining the high content of serotonin and histamine and reduced acetylcholine state match actual course of the disease with the long-term forecast of probcause of peptic ulcer disease.

Way of the following examples.

Example 1.

Patient M., 32 years old, complains of epigastric pain, radiating to groudn the second spine, in the interscapular space. Pain begin in 5-8 hours after a meal. Pain is preceded by a feeling of discomfort, pressure and pain in the epigastric region.

Gastroduodenoscopy note 2 defect in the mucosa of the pyloric stomach and the Boulevard of the Department of the duodenum. The edges of the ulcer are clearly expressed, have an oval shape with a size of 0.5×0,7 see the Mucous membrane around the ulcer swollen, diperkirakan. In the area of the ulcer pyloric marked petechial hemorrhages. The bottom of the ulcer is covered with gray bloom. In biopsy samples from the bottom and edges of the ulcer is allocated detritus. In the mucous membrane around the ulcer of the duodenum revealed a picture of acute inflammation with edema, plasmocytomas infiltration, increased blood vessels.

Determine the content of serotonin, histamine and acetylcholine in the blood on day 5 of illness, then within 2 weeks conduct eradication therapy and treatment with blockers of the proton pump. After treatment again determine the level of serotonin, histamine and acetylcholine: the serotonin content is 0.2 Ámol/l (2 times normal), histamine - 0.22 mmol/l (1.15 times higher than normal), and acetylcholine 0.8 mmol/l (45% below normal). Forecast for gastric ulcer and duodenal ulcer as probcause ulcers.

Histologies the e study of biopsies of the gastric mucosa and duodenum showed in the field of bleeding ulcers marked edema, mikrotrombozov in capillary phenomenon necrosis and areas of massive destruction of tissue. Thereby confirmed the prognosis of the disease.

Example 2.

Patient G., 45 years old, complains of epigastric pain, radiating to the thoracic spine, in the interscapular space. Late pain begin after 6-7 h after a meal and arise when the localization of the ulcer in the pyloric part of stomach and in the duodenum.

Gastroduodenoscopy note the defect in the mucosa of the gastric body and rising division of the duodenum. The edges of the ulcer saped have a slit shape area of 0.2 square, see the Mucous membrane around the ulcer diperkirakan. In the area of the ulcer of the gastric body marked petechial hemorrhage and erosion. The bottom of the ulcer is covered with white bloom. In biopsy samples from the bottom and edges of ulcers of the gastric body and rising division of the duodenum is found detritus.

Determine the content of serotonin, histamine and acetylcholine in the blood on day 6 of illness, then 3 weeks after eradication therapy amoxicillin 500 mg 3 times a day and treatment with a proton pump blocker omeprazole 20 mg 2 times a day. The last definition of the serotonin is 0.25 Ámol/l (2.5 times higher than normal), histamine - 0.26 mmol/l (1.37 times higher n is RMI), and acetylcholine to 0.92 mmol/l (29% below normal). Forecast for gastric ulcer and duodenal ulcer as probcause.

Clinically later in this patient noted increasing pain. Gastroduodenoscopy the study showed that the ulcer with saped edges bleeds. Histologically, marked edema and hemorrhages, mikrotrombozov capillaries and phenomena necrosis. Forecast confirmed.

Example 3

Patient N., 56 years old, was admitted with complaints of dull aching pain in the epigastric region without irradiation. Pain occur after 4-5 hours after a meal. The patient States the aggravation of the disease during the last three years in spring and autumn periods. Superficial palpation of the anterior abdominal wall reveals local tenderness in epigastralgia the left pane, positive symptom Mendel, symptom Vasilenko. Gastroduodenoscopy in the body of the stomach has ulcerative defect polygon shaped area 0,17 CVS the edges of the ulcer are outlined clearly, the slopes of the ulcer crater steep, there periolase inflammation. In biopsy samples from the bottom and edges of the ulcer revealed a picture of acute inflammation with plasmacytomas infiltration and expansion vessels. The edges and bottom of the ulcer observed phenomena detritus. On the basis of clinical data and results of endoscopies is the first study DS updated: chronic ulcer of the gastric body, acute stage.

Determine the content of serotonin, histamine and acetylcholine in the blood on day 5 of illness, then 3 weeks after eradication therapy and treatment with blockers of the proton pump again determine the level of serotonin, histamine and acetylcholine: the serotonin content is 0.3 Ámol/l (3 times normal), histamine - 0.28 mmol/l (1.45 times higher than normal), and acetylcholine 1,03 mmol/l (20% below normal). Forecast for stomach ulcers as probcause ulcers. After 3 weeks forecast confirmed by gastroduodenoscopy and histological study.

Prognosis of gastric ulcer and 12 duodenal ulcer was performed in 26 patients. Subsequent follow-up surveillance for 1,3 and 5 years confirmed the conformity of the actual disease claimed prognostic criteria.

A method for predicting the course of ulcer disease of stomach and duodenum, including diagnostic studies, characterized in that 5-6 days from the start of the exacerbation of peptic ulcer of stomach and duodenum determine the content of serotonin, histamine and acetylcholine in the blood, then in 2-3 weeks conduct drug therapy and again determine the level of serotonin, histamine and acetylcholine in the blood and with whom Ergani serotonin in 2-3 times above the norm, histamine 1.15-1.4 times higher than normal, and acetylcholine 20-45% below normal forecast for gastric ulcer and duodenal ulcer as probcause ulcers.



 

Same patents:

FIELD: medicine, diagnostics.

SUBSTANCE: the present innovation deals with genetic trials, with diagnostic field of oncological diseases due to analyzing DNA by altered status of gene methylation that take part in intracellular regulation of division, differentiating, apoptosis and detoxication processes. One should measure the status of methylation in three genes: p16, E-cadherine and GSTP1 in any human biological samples taken out of blood plasma, urine, lymph nodes, tumor tissue, inter-tissue liquid, ascitic liquid, blood cells and buccal epithelium and other; one should analyze DNA in which modified genes of tumor origin or their components are present that contain defective genes, moreover, analysis should be performed due to extracting and purifying DNA out of biological samples followed by bisulfite treatment of this DNA for modifying unprotected cytosine foundations at keeping 5-methyl cytosine being a protected cytosine foundation followed by PCR assay of bisulfite-treated and bisulfite-untreated genes under investigation and at detecting alterations obtained according to electrophoretic result of PCR amplificates, due to detecting the difference in the number and electrophoretic mobility of corresponding fractions at comparing with control methylated and unmethylated samples containing normal and hypermethylated forms of genes one should diagnose oncological diseases. The method provides higher reliability in detecting tumors, detection of remained tumor cells after operation.

EFFECT: higher efficiency of therapy.

1 cl, 3 dwg, 4 ex

FIELD: clinical medicine, pulmonology.

SUBSTANCE: one should carry out complex estimation of interleukin-1β) concentration in blood, saliva, bronchoalveolar liquid. Moreover, one should detect distribution coefficient (DC) for IL-1β as the ratio of IL-1β blood content to IL-1β salivary content. At increased IL-1β blood content by 10 times and more, by 2 times in saliva, unchanged level of bronchoalveolar IL-1β, at DC for IL-1β being above 1.0 one should predict bronchial obstruction. The method enables to conduct diagnostics of the above-mentioned disease at its earlier stages.

EFFECT: higher efficiency of prediction.

2 tbl

FIELD: medicine, juvenile clinical nephrology.

SUBSTANCE: disease duration in case of obstructive pyelonephritis should be detected by two ways: either by detecting the value of NADPH-diaphorase activity, as the marker of nitroxide synthase activity in different renal department and comparing it to established norm, or by detecting clinico-laboratory values, such as: hemoglobin, leukocytes, eosinophils, urea, beta-lipoproteides, lymphocytes, neutrophils, the level of glomerular filtration, that of canalicular reabsorption, urinary specific weight, daily excretion of oxalates, arterial pressure, and estimating their deviation against average statistical values by taking into account a child's age.

EFFECT: higher efficiency of detection.

7 dwg, 1 ex, 6 tbl

FIELD: medicine, clinical toxicology.

SUBSTANCE: at patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.

EFFECT: higher accuracy of prediction.

2 ex, 3 tbl

FIELD: medicine, infectology, hepatology.

SUBSTANCE: in hepatic bioptate one should detect products of lipid peroxidation (LP), such as: dienic conjugates (DC), activity of antioxidant enzymes, such as: catalase (CAT)and superoxide dismutase (SOD). One should calculate by the following formula: C = DC/(SOD x CAT)x100, where DC - the content of dienic conjugates, SOD - activity of superoxide dismutase, CAT - activity of catalase. At coefficient (C) values being above 65 one should predict high possibility for appearance of cirrhosis, at 46-645 - moderate possibility and at 14-45 -low possibility for appearance of cirrhosis.

EFFECT: higher accuracy of prediction.

3 ex

FIELD: medicine, hepatology.

SUBSTANCE: one should detect the level of hepato-specific enzymes (HSE) in blood plasma, such as: urokinase (UK), histidase (HIS), fructose-1-phosphataldolase (F-1-P), serine dehydratase (L-SD), threonine dehydratase (L-TD) and products of lipid peroxidation (LP), such as: dienic conjugates (DC), malonic dialdehyde (MDA). Moreover, one should detect the state of inspecific immunity parameters, such as: immunoregulatory index (IRI) as the ratio of T-helpers and T-suppressors, circulating immune complexes (CIC). Additionally, one should evaluate the state of regional circulation by applying rheohepatography (RHG), the system of microhemocirculation with the help of conjunctival biomicroscopy (CB) to detect intravascular index (II). In case of increased UK, HIS levels up to 0.5 mcM/ml/h, F-1-P, L-SD, L-Td, LP products, CIC by 1.5 times, higher IRI up to 2 at the norm being 1.0-1.5, altered values of regional circulation, increased II up to 2 points at the norm being 1 point, not more one should diagnose light degree of process flow. At increased level of UK, HIS up to 0.75 mcM/ml/h, F-1-P, L-SD, L-TD, LP products, CIC by 1.5-2 times, increased IRI up to 2.5, altered values of regional circulation, increased II up to 3-4 points one should diagnose average degree of process flow. At increased level of UK, HIS being above 0.75 mcM/ml/h, F-1-P, L-SD, L-TD, LP products, CIC by 2 and more times, increased IRI being above 2.5, altered values of regional circulation, increased II up to 5 points and more one should diagnose severe degree of process flow.

EFFECT: higher accuracy of diagnostics.

3 ex

The invention relates to the field of medicine
The invention relates to the field of medicine

The invention relates to the field of analytical chemistry and relates to the quantitative determination of antibiotic groups, macrolide azithromycin dihydrate (azithromycin)

FIELD: medicine, hepatology.

SUBSTANCE: one should detect the level of hepato-specific enzymes (HSE) in blood plasma, such as: urokinase (UK), histidase (HIS), fructose-1-phosphataldolase (F-1-P), serine dehydratase (L-SD), threonine dehydratase (L-TD) and products of lipid peroxidation (LP), such as: dienic conjugates (DC), malonic dialdehyde (MDA). Moreover, one should detect the state of inspecific immunity parameters, such as: immunoregulatory index (IRI) as the ratio of T-helpers and T-suppressors, circulating immune complexes (CIC). Additionally, one should evaluate the state of regional circulation by applying rheohepatography (RHG), the system of microhemocirculation with the help of conjunctival biomicroscopy (CB) to detect intravascular index (II). In case of increased UK, HIS levels up to 0.5 mcM/ml/h, F-1-P, L-SD, L-Td, LP products, CIC by 1.5 times, higher IRI up to 2 at the norm being 1.0-1.5, altered values of regional circulation, increased II up to 2 points at the norm being 1 point, not more one should diagnose light degree of process flow. At increased level of UK, HIS up to 0.75 mcM/ml/h, F-1-P, L-SD, L-TD, LP products, CIC by 1.5-2 times, increased IRI up to 2.5, altered values of regional circulation, increased II up to 3-4 points one should diagnose average degree of process flow. At increased level of UK, HIS being above 0.75 mcM/ml/h, F-1-P, L-SD, L-TD, LP products, CIC by 2 and more times, increased IRI being above 2.5, altered values of regional circulation, increased II up to 5 points and more one should diagnose severe degree of process flow.

EFFECT: higher accuracy of diagnostics.

3 ex

FIELD: medicine, infectology, hepatology.

SUBSTANCE: in hepatic bioptate one should detect products of lipid peroxidation (LP), such as: dienic conjugates (DC), activity of antioxidant enzymes, such as: catalase (CAT)and superoxide dismutase (SOD). One should calculate by the following formula: C = DC/(SOD x CAT)x100, where DC - the content of dienic conjugates, SOD - activity of superoxide dismutase, CAT - activity of catalase. At coefficient (C) values being above 65 one should predict high possibility for appearance of cirrhosis, at 46-645 - moderate possibility and at 14-45 -low possibility for appearance of cirrhosis.

EFFECT: higher accuracy of prediction.

3 ex

FIELD: medicine, clinical toxicology.

SUBSTANCE: at patient's hospitalization one should gather the data of clinical and laboratory values: on the type of chemical substance, patient's age, data of clinical survey and laboratory values: body temperature, the presence or absence of dysphonia, oliguria being below 30 ml/h, hemoglobinuria, erythrocytic hemolysis, exotoxic shock, glucose level in blood, fibrinogen and creatinine concentration in blood serum, general bilirubin, prothrombin index (PTI), Ph-plasma, the state of blood clotting system. The state of every sign should be evaluated in points to be then summed up and at exceeding the sum of points being above "+20" one should predict unfavorable result. At the sum of "-13" prediction should be stated upon as favorable and at "-13" up to "+20" - prediction is considered to be doubtful.

EFFECT: higher accuracy of prediction.

2 ex, 3 tbl

FIELD: medicine, juvenile clinical nephrology.

SUBSTANCE: disease duration in case of obstructive pyelonephritis should be detected by two ways: either by detecting the value of NADPH-diaphorase activity, as the marker of nitroxide synthase activity in different renal department and comparing it to established norm, or by detecting clinico-laboratory values, such as: hemoglobin, leukocytes, eosinophils, urea, beta-lipoproteides, lymphocytes, neutrophils, the level of glomerular filtration, that of canalicular reabsorption, urinary specific weight, daily excretion of oxalates, arterial pressure, and estimating their deviation against average statistical values by taking into account a child's age.

EFFECT: higher efficiency of detection.

7 dwg, 1 ex, 6 tbl

FIELD: clinical medicine, pulmonology.

SUBSTANCE: one should carry out complex estimation of interleukin-1β) concentration in blood, saliva, bronchoalveolar liquid. Moreover, one should detect distribution coefficient (DC) for IL-1β as the ratio of IL-1β blood content to IL-1β salivary content. At increased IL-1β blood content by 10 times and more, by 2 times in saliva, unchanged level of bronchoalveolar IL-1β, at DC for IL-1β being above 1.0 one should predict bronchial obstruction. The method enables to conduct diagnostics of the above-mentioned disease at its earlier stages.

EFFECT: higher efficiency of prediction.

2 tbl

FIELD: medicine, diagnostics.

SUBSTANCE: the present innovation deals with genetic trials, with diagnostic field of oncological diseases due to analyzing DNA by altered status of gene methylation that take part in intracellular regulation of division, differentiating, apoptosis and detoxication processes. One should measure the status of methylation in three genes: p16, E-cadherine and GSTP1 in any human biological samples taken out of blood plasma, urine, lymph nodes, tumor tissue, inter-tissue liquid, ascitic liquid, blood cells and buccal epithelium and other; one should analyze DNA in which modified genes of tumor origin or their components are present that contain defective genes, moreover, analysis should be performed due to extracting and purifying DNA out of biological samples followed by bisulfite treatment of this DNA for modifying unprotected cytosine foundations at keeping 5-methyl cytosine being a protected cytosine foundation followed by PCR assay of bisulfite-treated and bisulfite-untreated genes under investigation and at detecting alterations obtained according to electrophoretic result of PCR amplificates, due to detecting the difference in the number and electrophoretic mobility of corresponding fractions at comparing with control methylated and unmethylated samples containing normal and hypermethylated forms of genes one should diagnose oncological diseases. The method provides higher reliability in detecting tumors, detection of remained tumor cells after operation.

EFFECT: higher efficiency of therapy.

1 cl, 3 dwg, 4 ex

FIELD: medicine, gastroenterology.

SUBSTANCE: one should carry out diagnostic studying, moreover, on the 5th -6th d against the onset of exacerbation in case of gastric and duodenal ulcerous disease one should detect the content serotonin, histamine and acetylcholine in blood, then during 2-3 wk one should conduct medicinal therapy to detect serotonin, histamine and acetylcholine level in blood again and at serotonin content being by 2-3 times above the norm, histamine - by 1.15-1.4 times above the norm and acetylcholine - by 20-45% being below the norm one should predict the flow of gastric and duodenal ulcerous disease as a non-scarring ulcer.

EFFECT: higher accuracy of prediction.

3 ex

FIELD: medicine.

SUBSTANCE: method involves taking blood from ulnar vein (systemic blood circulation) and from large vein of the injured extremity proximal with respect to lesion focus (regional blood circulation). Spontaneous NST-test value is determined and difference is calculated in systemic and regional blood circulation as regional-to-systemic difference. The difference value is used for predicting clinical course of pyo-inflammatory disease in extremities.

EFFECT: high accuracy of diagnosis.

4 cl, 2 tbl

FIELD: medicine, gastroenterology.

SUBSTANCE: one should introduce biologically active substance, moreover, in patient's blood serum one should detect the content of acetyl choline and choline esterase activity followed by 2-h-long intragastric pH-metry at loading with biologically active substance as warm 40-45%-honey water solution at 35-40 C, and at increased content of acetyl choline being above 1.0 mM/l, choline esterase being above 0.5 mM/l/30 min and pH level being 6.0-6.9 it is possible to consider apitherapy to be useful for treating ulcerous duodenal disease.

EFFECT: higher efficiency and accuracy of detection.

3 ex

FIELD: medicine, gastroenterology.

SUBSTANCE: it has been suggested a new method to detect pharmacological sensitivity to preparations as acidosuppressors. After the intake of the preparation a patient should undergo fibrogastroduodenoscopy 3 h later, then, through endoscopic catheter one should introduce 0.3%-Congo red solution intragastrically and the test is considered to be positive at keeping red color that indicates good sensitivity to the given preparation, and in case of dark-blue or black color the test is considered to be negative that indicates resistance to this preparation. The suggested innovation widens the number of diagnostic techniques of mentioned indication.

EFFECT: higher efficiency of diagnostics.

2 ex

Up!