Container-type syringe

FIELD: medical engineering.

SUBSTANCE: device has sealed reservoirs, containing substances, and piston mechanism, having piston cylinder, piston and piston rod. Device for moving liquid between the reservoirs is mounted in piston cylinder lumen. The device has separating piston and compression unit arranged in series. The unit designed as casing or carcass is mounted in projection of its external cylindrical part along the perimeter. Hollow internal lumen of has exit to piston projection inward from its external perimeter. The separating piston makes two connections with the piston cylinder and compression unit at the same time. The separating piston is movable into compression unit lumen with compression or change in shape taking place at the same time. The compression unit allows to make communication between reservoirs.

EFFECT: simplified design.

5 cl, 8 dwg

 

The invention relates to medical equipment, namely, devices for injection in a syringe with the drug substance.

A device in the form of a multi-chamber syringe comprising two movable relative to each other, a reservoir substances and the mechanism to move the liquid in the form of a perforating device 1. The disadvantage of this syringe is the design complexity in the form of movable relative to each other reservoirs and the use of special devices for perforating a sealed compartment between the tanks.

The objective of the invention is the creation of a multi-chamber syringe with successive sealed tanks or compartments in the piston cylinder, and a simple device for moving fluid between the pressurized compartments without destroying the elements of the syringe.

This task is solved in that the device is made in the form of a syringe-container with sealed tanks with different substances and piston mechanism comprising a piston, piston rod and piston cylinder clearance between tanks which made the device for moving fluid, comprising movable relative to each other and sequentially arranged from the outlet of the separating piston and is made in the projection of its outer cylindrical part along the perimeter to impressionne device in the form of a hollow housing, hollow inner lumen or air chamber which is made with access to the projection of the piston within its outer perimeter, where the piston is made with the possibility of formation of two compounds with the piston cylinder and the compression device and the lumen of the piston cylinder can be divided by one or two pistons forming in the plane of movement of the piston and movable airtight connection.

Figure 1 shows the component parts of a variant of the device, the cut, side view. Figure 2 presents the syringe with dual substance in the collection, the cut, side view. Figure 3, figure 4 shows the principle of operation of the syringe with dual substance in the section, side view. Figure 5 shows a variant of the syringe with one separating piston, the cut, side view. Figure 6, 7 shows the principle of operation of this variant of the syringe, the cut, side view. On Fig shows a variant of the syringe with the elements of the mechanism to move the liquid in the form of a single device, the cut, side view.

Device 1 (Fig 1, 2, 5, 8) consists of the piston rod 2 with the piston 3 and the piston chamber 4, a sealed container vessel, the lumen 5 which are sequentially arranged compartments 6 and 7, separated by a device comprising (option 1) two independently movable piston 8 and 9 (Fig 1) or (Varian is 2) one piston 8 (figure 5) and the compression device 10 in the form of a housing or frame with a hollow inner lumen or air chamber 11, where the inner lumen of the chamber is a circular groove, end-to-end or closed with one hand channel with access to the side of the piston from inside the projection of its outer perimeter. The output piston chamber 4 is supplied with the adapter 12 and needle 13 for injection, which is hermetically closed by a stopper or other device type rubber cap 14. Piston chamber 4 is a piston cylinder for sealed piston connection with the piston 3 and the piston 8 and 9, both as a reservoir to accommodate different substances in a hermetically separated compartments 6 and 7. The piston rod 2 with the piston 3 represent typical device piston mechanism, designed to move fluid in the piston chamber when the reciprocating motion of the piston rod 2.

Actually the piston 3 (Fig 1, 5) may be made in the form of tightly adjacent the perimeter to the inner wall of the cylindrical channel 4 rubber, plastic or metal with elastic rim of the piston, fixed on the piston rod as a reference device or the piston and piston rod are made of a single elastic or rigid material, for example of plastic material, with the characteristic for each functional characteristics. Divided compartments 6 and 7 represent the reserve is ary with different substances, one of which is the solvent (water) 15, and the other dry substance of the medicinal product 16, and placing substances in a particular compartment for significant device does not matter.

Consistently located airtight compartments or tanks 6 and 7 in the piston chamber 4 separated by two 8 and 9 (figure 1, 2) or one (figure 5, 8) piston 8, which are independently movable partitions, forming in combination with the compression device 10 and the gaseous substance in the inner lumen 21 or in the air chamber mechanism to move the liquid between the tanks 6 and 7, and the operation of the device as a whole is carried out by changing the pressure in the piston cylinder 4. In the initial state, the piston 3 is hermetically closed by the piston cylinder 4 and the proximal reservoir 7 from the entrance 17. Piston cylinder 4 is a standard element of the syringe and piston mechanism in the form of a housing with a cylindrical channel 5, in which moves the piston rod 2 with a piston 3 and the movable elements of the device for moving fluid. Piston chamber 4 may be a double layer, when the inner wall is made of glass and outer plastic, which makes the storage of the substance in a glass tank more stable. Thus, the piston chamber 4 will ustupaet not only as an element of the piston mechanism in the form of a piston cylinder, but is the reservoir for placement and long-term storage of two different substances 15 and 16, and the piston 3 at the same time performs the function of the tube, closing the piston chamber from the entrance 17.

Separating the openings of the reservoirs 6 and 7 the device in the first embodiment is (1, 2) of the consecutive two spaced interconnected with the formation of a sealed air compartment 18 within the lumen of the piston of the cylinder 4, the movable separation of the pistons 8 and 9, which may have circular grooves 19 and the projecting rim 20, and a compression device 10 in the form of a rigid or elastic hollow body type clutch, an inner lumen which is made open to the projection of the pistons 8 and 9 separate grooves 22 or through channel forming the air chamber 21 of the compression device 10, or a camera with a gaseous substance. The housing is made in the projection of the outer cylindrical portion along the perimeter of the dividing piston 8 or 9 and is sequentially output from the first separating piston. On the outer surface of the compression device 10 can be accomplished through longitudinal flow grooves 11 or through-flow channels through the housing to move the liquid between the tanks. These structural features of the compression device 10 allows you to create, if p is the excess pressure in the piston cylinder 4, communication between the tanks 7 and 8 through the slots 11 and the channels on the clutch 10 or flowing through the slit in the form of a gap between the coupling 10 and the wall of the piston cylinder 4. In the second case (figure 5), the device 1 includes sequentially arranged from one separating the movable piston 8 and the compression device 10 closed at one end by a circular groove 22 or channel forming an air chamber 21, having access to the side or the projection of the piston 8, while the body is made in the projection of the outer cylindrical portion along the perimeter of the dividing piston 8. Based mechanism to move the liquid in these embodiments, the syringe is the property of the pistons 8 and 9 to symmetric or asymmetric circular compression or deformation when scheduling in a smaller inner lumen 21 of the compression device 10 during a counter-move with each other or with compression device 10 when the pressure in the piston cylinder 4 due to the compression of air (gaseous substance) in the hollow lumen 21 of the device 10. The output of the air chamber 21 or the inner lumen of the device 10 initially and constructively always has a smaller diameter or size and shape of cross-section than the pistons 8 and 9, if directed in the direction of the piston that allows you to compress or deform the piston when it is moved. D is I the possibility of establishing communication between the compartments separating pistons 8 and 9 are made of elastic or resilient material, for example of rubber or flexible plastic, or any other deformable or back-and-deformable material that allows the compression or deformation of the pistons, while creating mobile sealed or piston connection with the wall of the piston cylinder 4 and the clearance of the compression device 10. In the first case (figure 2) movement of the pistons 8 and 9 is due to the compression of air or other gaseous substance, first in the space 18 of the piston 4 cylinder between the pistons 8 and 9, if the pistons removed from the device 10, and further due to the compression of air in the lumen of the air chamber 21 of the compression device 10, is designed as a channel or a circular groove 22. In the second case (figure 5) moving the separating piston 8 is caused by compression of air in a closed piston 8 air chamber 21, which is an open in the direction of the piston, the circular groove 22 or channel in the housing of the compression device 10. To reduce the effort on the piston surfaces of the pistons 8 and 9 are circular grooves 19 or protruding rim 20, which reduce the necessary force to compress the pistons, due to more light compression or inclination of the protruding rims 20, which may represent the outer cylindrical portion of the perimeter of the piston. In addition to hermeti the aqueous separation compartments 6 and 7 movable separating piston 8 or both of the piston 8 and 9, moving through the inner air chamber 21 from an opening of the piston of the cylinder 4 into the lumen of the compression device 10, open channel or message 23 to move the liquid between the split tanks 6 and 7. While the pistons 8 and 9, in the initial state (figure 5) or when moving form simultaneously two mobile tight connection with different channels in different planes, with subsequent separation of the sealed connection of the piston 8 or 9 with the wall of the piston cylinder 4 to form a communication between the compartments. This is achieved by the fact that the lumen of the circular grooves 22 or channel 21 which is open in the direction of the pistons, is originally and structurally smaller diameter or smaller and different in shape from the piston cross-sectional area that provides a circular compression pistons in the lumen 21 of the compression device 10. The lumen 21, which represents an air chamber of the compression device 10, made in the form of internal (2), open towards the piston and the axis of their motion through channel or two multidirectional grooves 22 in the first embodiment of the device or closed from one side of the circular groove or channel in the second case (figure 5), which form a tight sliding connection with the piston, to provide a compression or compression and the possibility of moving the compressed state in the internal lumen of the compression device 10. Over the grooves 22 or channel 21 of the device 10 can have a different shape cross-section, providing a symmetric or asymmetric compression of floating pistons. Assembled in the second variant of the device 1, the air chamber in the form of a closed on one end of the channel 21 is sealed by the piston 8, and the first variant of the lumen 21 of the device 10 is either part of the air compartment 18 between the pistons 8 and 9, or completely replaces it when the pistons 8 and 9 are initially fixed in the device 10 with the formation of two movable or reciprocating connection with the piston cylinder 4 and the lumen of the device 10. The air in the lumen of the compression device 10 and the air compartment 18 between the pistons 8 and 9, as a special case in the first embodiment, to allow the movement of the piston 8 in the lumen of the device 10 or the counter-movement of the two pistons 8 and 9 to each other with the movement of the pistons from the plane of one channel in the plane of the lumen or other channel or groove.

The compression device 10, located in the lumen of one of the tanks (figure 5) or (2) between tanks, pressurized compartment 18 between the two pistons 8 and 9, may have a longitudinal flow grooves 11 or channels designed to move the liquid, if the external diameter of the device 10 corresponds to the diameter of the piston of the cylinder 4. When man is Shem, than the piston cylinder 4, the outer diameter of the compression device 10 is formed a flow channel is a gap or clearance between them. In this case, the device 10 is projected on the thickness of the outer cylindrical portion of the perimeter of the piston 8, which provides the scheduling of the piston into the lumen of the device. The device 10 in the second embodiment (figure 5) is initially formed with a piston 8 second sealed mobile or piston connection to another plane, as in the first embodiment, the device 10 can be placed freely in the lumen of the piston-cylinder 4 between the pistons 8 and 9. Mutatis circular compression piston device 10 in the first two variants is of elastic or rigid material, presenting an extended rim or coupling with the inner lumen in the form of a through channel 21 or circular grooves 22 with a round or oval cross-section, with a length sufficient for symmetric or asymmetric compression piston by moving them into the lumen of the device 10 to inhibit piston connection between the pistons 8 and 9 and the wall of the piston cylinder 4.

For compression and simultaneous fixing of the piston 8 or 9 in the lumen of the device 10, the shape of the cross section and the diameter of these elements can be performed such that allow the change of shape under compression and fixation of the piston in the lumen 21 recirculates the groove 22 of the device 10. For fixing the piston in the lumen of the channel or groove, the device 10 may have a special locking device type of the circular channels on the inner surface, which records the protruding rims 20 of the pistons 8 and 9, which prevents reverse movement of the piston from the high pressure in the air chamber 21 of the device 10 when the pressure in the piston cylinder 4.

The device in the first embodiment is completed as follows (figure 2). In the piston chamber 4, after sealing of the adapter 12 and needle 13 special cap 14, is introduced solvent 15 (water), which occupies part of the volume of the piston cylinder 4. Then you enter the first movable piston 8, which hermetically closes the distal compartment 7 with one hand, forming a sealed tank with a liquid substance 15. Behind the piston 8 is inserted a compression device in the form of, for example, rigid coupling 10 and then the second piston 9, which is closed by a sealed air compartment 18 between the pistons. In the modification options movable pistons 8 and 9 are initially close to the internal lumen with the formation of the air chamber 21 of the compression device 10 and two mobile sealed joints in different planes, followed by the introduction of this combined device into the lumen of the piston of the cylinder 4. The remaining volume of the piston cylinder 4 is filled su is th substance 16 of the medicinal product, and the output of the piston-cylinder 4 is sealed with the actual piston 3. This forms a sealed proximal reservoir 6 with another substance, such as dry substance 16. The device 1 in the second embodiment is completed as follows. In the piston chamber 4, after sealing of the adapter 12 and needle 13 special cap 14 is inserted the solvent (water), which occupies part of the volume of the piston cylinder 4. The piston 8 is partially introduced into a closed circular channel 21 and the groove 22 of the device 10 with the formation of a sealed movable or reciprocating connection, closing the sealed air chamber device 10. After that, the combined device is inserted into the lumen of the piston of the cylinder 4, which extends from the lumen of the device 10 of the piston 8 forms a second sealed connection in the form of a piston connection with the wall of the piston cylinder 4, hermetically closing the tank with one of the substances, for example with a liquid substance 15. In the remaining volume of the piston chamber 4 is filled with a dry substance of the medicinal product and the proximal reservoir 6 is sealed from the entrance of the actual piston 3.

In the third variant (Fig) the device and principle of operation do not differ substantially from the work of the first two options, with the only difference that the piston is initially hermeticallysealed through elastic or deformable connection to the housing of the compression device 10 and is made of the same elastic or deformable material, for example of rubber, as the device 10, with which the piston 8 is a constructive a single device. This elastic or deformable tight connection 26 allows the piston 8 to wedge into the lumen of the sealed air chamber 21 of the compression device 10 to change its shape or diameter and to establish communication between the pressurized tanks 6 and 7.

The following variant of the device 1 may be a syringe with the location of the compression device 10, which represents a rigid frame with running grooves 11 or prominent longitudinal elements, between the separating piston 8 and the piston 3, the lumen formed by these pistons distal reservoir 6 with one of the substances. The longitudinal elements rigid frame or hollow body is made in the projection of the outer cylindrical portion of the perimeter of the separation of the piston 8, and a hollow inner lumen between the longitudinal elements of the frame or casing made with access to the projection of the dividing piston 8, inward from the outer perimeter. When this is required in the tank 6, except for liquid or dry substance, air or gaseous substance which moves freely in the hollow lumen of the device 10 and is essential for the movement of the pistons 8 and 3 towards each other. This DOS is ikaetsya fact, in the initial state, the tank is filled with a substance with the calculation of the free inner lumen of the compression device. The compression device 10 is moved relative to the piston 8 due to the pressure on him actually of the piston 3 during its movement, forming with the piston 8 fixed connection, deforming or compressing the piston on a limited one or more areas, for example in place longitudinally protruding element of the framework, which takes place between the piston 8 and the wall of the piston 4 cylinder, or the piston is compressed between two spaced elements. In this place, and formed a flow communication between the pressurized tanks 6 and 7. In the presence of the liquid substance in the tank 7, the piston 8 is not moved at all, and in the presence of dry substance movement of the piston 8 is the way into this substance. Running message 23 through the slots 11 between the tanks 6 and 7 is formed by the movement of the piston 8 and its deformation inside the plane moved in this direction from the direct pressure the actual piston 3 rigid frame compression device 10. For this compression device 10 is either in the form of a hollow body or a rigid frame, or the frame is loose or hollow inner lumen is directed towards the piston, which remains free when filling the drop tank substance. The principle of this variant of the syringe is similar to other variants of the device, with the only difference that the movement of the pistons 8 and 3 is due to the free movement of air in the hollow inner lumen of the compression device 10.

The device 1 is (3, 4, 6, 7) as follows. When pressed on the piston rod 2 and the movement itself of the piston 3 in the lumen of the piston-cylinder 4 increases the pressure in all three pressurized compartments. In the first embodiment, when the pressure in the sealed air compartment 18 or 21 begins to compress the air between the pistons 8 and 9 and in the lumen of the device 10 and due to this there is a counter movement of the pistons 8 and 9 to each other. When the opposite movement of the pistons 8 and 9 rest against the compression device 10 and start (figure 3) to intervene and (or) to move in the lumen of the inner channel 21 of the device 10. Due to inconsistencies in diameter or square-shaped cross-section is the compression ratio of the pistons or the inclination of the circular rim 20. In this embodiment, the pistons 8 and 9 form at some point the second sealed sliding connection of the adjacent part of the piston surface of the piston with the inner channel 21 or circular grooves 22 of the device 10, if initially the connection has not been set. Simultaneously operating two PE ewiglich tight connection of the pistons 8 and 9 with the wall of the piston cylinder 4 and the device 10 will move the piston movement from the plane of one channel (piston-cylinder 4) in the plane of the other channel (lumen 21 of the device 10). This preserves the integrity of the air space between the pistons 8 and 9 for the possibility of oncoming traffic and the movement of the pistons from the plane of one channel in the plane of the other channel at high pressure in the piston cylinder 4. When the movement of the pistons 8 and 9 toward each other in the lumen of the device 10 with simultaneous compression or change the shape disappears separating tanks piston connection of the pistons 8 and 9 with the wall of the piston cylinder 4 and the message between the tanks through the flow channels 11 in the device 10, or between a wall of the device body 10 and the wall of the piston cylinder 4. In this position, the fluid moves freely from one tank 7 in the other 6, dissolving the dry substance 16 drug. After dissolving the dry substance 16 drug syringe flips the piston rod up and ready solution 25 drug moves back and takes a distal or outlet compartment 7 in the piston cylinder 4. When the abstraction of the piston rod 2 ago and the reduction of pressure in the piston cylinder 4, the pressure in the circular groove 22 or the air chamber 21 pushes one or both of the piston ago, which again form a piston connection with the wall of the piston cylinder 4 and through the transfer of pressure from custom the NGOs piston 3 provide a syringe. When fixed in the lumen of the device 10 pistons 8 and 9 of the syringe at the expense of the actual piston 3 with the piston rod 2, which simultaneously moves and ready solution 25, and the device itself to the exit of the piston of the cylinder 4. Then removed the cap 14 with the needle 13 or adapter 12 and moving the piston rod 2 with the piston 3 forward ready solution 25 medicinal product is administered to the patient.

In the second embodiment, when the pressure movable piston 8 due to concurrent dual sealed connection begins to move in a circular channel 21 and the groove 22 of the device 10 and to compress the air or gas in a sealed air chamber between the piston 8 and the wall of the housing of the device 10. Next, (6), the piston 8 is fully wedged into the lumen of the coupling 10, opening communication between the reservoirs 6 and 7, as in the first embodiment, due to the uncoupling of the piston connection with the wall of the piston cylinder 4. When the abstraction of the actual piston back pressure in the air chamber device 10 may return the piston 8 to its original position. Fundamental differences in the various variants of the device no. The pistons in both cases, the device 1 in the initial state can be maintained so as to simultaneously form two sealed mobile is connection in different planes with different diameter and shape of the cross section of the channels, representing the channel piston-cylinder 4 and the lumen 21 of the compression device 10, initially or during the closing movement of the air chamber of the device 10. The air compartment 18 between the pistons 8 and 9 in the piston cylinder 4 in the first embodiment of the device solves the problem of the counter-movement of the pistons to each other, between which is located a compression device. Available sealed second mobile or piston connection in the second embodiment, and formed an airtight mobile or piston connection of the pistons 8 and 9 with the channel wall 21 of the device 10 in the first embodiment allow you to save at a certain stage, the tightness of both compounds and to produce movement of the pistons 8 and 9 relative to the compression device 10 by compressing the air environment air chamber device 10, where the piston or protruding rims 20 are circularly symmetric or asymmetric compression, depending on the shape of the inner lumen of the device 10, which may be in the form of a right cylinder or to have an oval or other cross section. As the advancement of the pistons 8 and 9 in the lumen of the compression device 10, as in the first and second embodiments of the device, disappear (3, 6) simultaneously or sequentially sealed piston connection of the pistons 8 and 9 with the wall of the piston cylinder 4 and paavle the Xia message 23 between the compartments 6 and 7 through the flow channels 11 of the device 10 or through the gap between the wall of the housing of the device 10 and the wall of the piston cylinder 4. When asymmetric resistance to advancement of the pistons in the lumen of the device 10, in the second embodiment, the sleeve 10 may have a limiting protrusion 24 within the channel 21, which limits the promotion of one of the pistons to that level and retains the ability to move the second piston.

Thus, in all embodiments of the device 1, the mechanism for moving fluid includes sequentially located from the outlet of the separating piston and the compression device, which is located in the projection of the outer cylindrical perimeter of the piston and is in the form of a hollow body or a rigid frame with a hollow inner lumen aimed in the direction of the piston inward from its outer perimeter.

This device can be widely used in industrial pharmacology for the production of finished dosage forms of certain drugs, in particular, syringes with two medicinal substances.

Sources of information:

1. U.S. patent No. 5785682, publ. July 28, 1998

1. The device is a syringe sealed containers with substances and piston mechanism comprising a piston cylinder, piston and piston rod, characterized in that the clearance of the piston cylinder made device for moving fluid between the tanks, including sequentially arranged dividing p is rchen and made in the projection of its outer cylindrical part along the perimeter of the compression device in the form of a casing or frame, hollow inner lumen which is made with access to the projection of the piston inward from its outer perimeter, where the piston is made with the possibility of formation of two compounds with a piston cylinder and a compression device, and can move in the lumen of the compression device with simultaneous compression or change shape, and a compression device configured to create a communication between the tanks.

2. The device according to claim 1, characterized in that it contains the second separating piston is arranged to move in the lumen of the compression device with simultaneous compression or change shape in the lumen of the piston cylinder tanks are hermetically separated by two spaced elastic piston, closing the air compartment, the lumen of which is located a compression device with flow grooves on the outer surface and the inner lumen in the form of an air chamber, where the piston is arranged to move from the piston chamber into the inner lumen of the compression device with a smaller diameter or size and shape of the section.

3. The device according to claim 1, characterized in that it includes movable relative to each other, the piston and the compression device in the form of a hollow housing type coupling with tamcn is th at one end of the groove or the through channel, where the piston is made with the possibility of formation of two sealed mobile connection with a piston cylinder and a compression device, forming a chamber with a gaseous substance.

4. The device according to claim 2, characterized in that it includes movable relative to each other pistons and the compression device in the form of a hollow housing type clutch with a through channel, where the pistons are made with the possibility of formation of two sealed mobile connection with a piston cylinder and a compression device, forming a chamber with a gaseous substance.

5. The device according to claim 1, characterized in that the piston and the compression device is made as a single device.



 

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Safe syringe // 2329067

FIELD: medicine.

SUBSTANCE: invention refers to syringes. First version of design implies safe syringe including injector as tube with centre aperture, forming internal container, push rod inserted into injector container by flanged piston, bush with hollow sleeve being hold by injector aperture, needle assembly and sealing element. Sleeve is equipped by upper detachable junction and lower bush in its cavity so that needle base is supplied with connecting insert forming upper detachable junction. Lower push provides connection with flanged push rod. Needle assembly consists of needle base and needle body. Needle base is mounted outside of bush sleeve. Sealing element is made of elastic materials and preliminary formed by bush sleeve, and include external section provided outside of sleeve and forming air-tight connection with internal wall of injector container. Second version implies that needle base is supplied by connecting insert for upper detachable sleeve junction sealing element is furnished with lower bottom bush inside of sleeve for detachable junction with flanged push rod. In third version needle base is mounted outside of bush sleeve, and sealing element inside of sleeve is provided with upper and lower bushes, and needle base is furnished with connecting insert forming upper detachable junction, and lower bush provides connection with flange of pusher rod. In fourth version needle base is mounted outside of bush sleeve, but thus sealing element is equipped with internal threaded section, and forms lower bush inside of sleeve, and needle base is supplied with external threaded section to form connection with external threaded section, and lower bush provides connection with flange of push rod. In fifth version needle base also is mounted outside of bush sleeve, and sealing element is supplied with lower bush inside of sleeve to form connection with flange of push rod.

EFFECT: assemblage simplification, productivity increase, and profitability increase.

15 cl, 18 ex

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