Ointment of antiphlogistic and wound-healing action (variants)
SUBSTANCE: the present innovation deals with curative ointments of antiphlogistic and wound-healing action and could be applied for treating hemorrhoid, burns, bruises, fractures, wounds, chronic bronchitis, polyarthritis, periarthritis, radiculitis, trophic ulcer and psoriasis. Three variants of ointments have been suggested. They contain oily extract of plant components and, also, honey, mumiye, propolis and bear oil. This innovation enables to widen the assortment of ointments of antiphlogistic and wound-healing and the range of curative action upon a body.
EFFECT: higher efficiency of application.
3 cl, 11 ex
The invention relates to medicine, namely to treatment ointments that have anti-inflammatory and wound healing properties.
Known ointment with protivogemorroidal effect, containing vegetable ingredients of the following composition, parts by weight: oak bark 2-3, grass repacka ordinary 2-4, the flowers of red clover 2-4, chamomile flowers 3-5, grass budry plyuschevidnaya 4-6, grass clover medicinal 4-6, herb Hypericum perforatum 3-5, flowers, calendula 2-4, sheet polonica big 2-4, the leaf of Salvia officinalis 1-3, herb yarrow 2-4, grass cudweed herb swamp 5-7, flowers of tansy 4-6, grass cinquefoil goose 4-6, as well as the internal fat pork 160 (Patent No. 2008012, a 61 K 35/78, 1994).
For the prototype was chosen ointment, including botanicals in the form of a 40%alcohol tincture herbs Campion Tatar or drooping 3 parts by weight, the flowers of calendula medicinal 1 parts by weight, the leaves of fireweed herb 1 parts by weight, as well as petrolatum and lanolin, taken in the ratio of 7:2 (RF Patent No. 213S277, A 61 K 35/78, 9/06, 1999). The ointment is intended for the integrated treatment of burn and posttraumatic wounds.
The disadvantage of ointments is a narrow range of therapeutic effects on the body and expanding the range of ointments anti-inflammatory and wound-healing action.
The goal is istihaada fact, what ointment N 1 anti-inflammatory and wound-healing actions, including vegetable ingredients, petrolatum and lanolin, contains as plant components oil extract of melilot (color) and additionally contains honey, mummy at the following mass ratio of components 4,5:1,5:1,0:0,5:2,5.
Ointment No. 2, including botanicals and lanolin, as plant components contains oil extracts of clover (color), plantain and additionally contains honey, mummy, bear fat at the following mass ratio of components 1:1:1:1:1:1.
Ointment No. 3, including botanicals and lanolin, as plant components contains oil extracts of clover (color), plantain, aloe, Mandrake (root), nettle, karnali (seeds), ephedra homeboy and additionally contains honey, mummy and propolis at the following mass ratio of components 1:1:1:1:1:1:1:1:1:1:1.
Included in ointments components taken in optimal relations, anti-inflammatory, wound healing, resolving, blood-purifying, antiseptic, antibacterial, analgesic effect on the body. The ointment can be applied for the treatment of hemorrhoids, burns, bruises, wounds, fractures, arthritis, sciatica, frozen shoulder, trophic ulcers, psoriasis, chronic bronchitis, which allows to extend the spec is p a therapeutic effect on the body and to expand the range of ointments anti-inflammatory and wound-healing action.
The ointment is prepared as follows. Prepare oil extracts of medicinal plants known methods. In dosed mixture of the fatty components is injected alternately with vigorous stirring oil extracts of medicinal plants and solid components. Stirring is carried out until a homogeneous mass.
Examples of clinical application of ointments.
Example 1. Use the ointment No. 1 for the treatment of sciatica.
Patient A. - 55 years. Complaint of severe pain in the lumbar-sacral spine radiating to the legs, the limitation of mobility. The diagnosis of sciatica.
Assigned treatment ointment No. 1, which massaging movements rubbed in the lumbosacral spine 2-3 times a day, followed by a wrap woolen cloth. After a 2-week course of treatment is completely pain disappeared, restored mobility. The patient felt well.
Use the ointment No. 1 for the treatment of hemorrhoids.
Patient Century - 47 years. Complaints of pain, itching in the anus, prolapse of hemorrhoids, the difficulty of defecation.
Assigned treatment ointment No. 1 by its application to the outer hole of the rectum and insertion of a tampon with the ointment into the rectum 2-3 times a day. 9 days after application of the ointment the patient's condition has improved. Pain disappeared, the UD, became a free act of defecation. Seal hemorrhoids resorbed. Recommended to periodically apply ointment to prevent worsening of the disease.
Use the ointment No. 1 for the treatment of fracture.
Patient C. - 24 years. Complaints of pain in the wrist, swelling. X-rays showed a closed fracture of the wrist with some difference bones.
Treatment ointment No. 1. After a week of applying the ointment pain had faded, the swelling disappeared. The patient applied the ointment for 3 weeks. Repeated x-rays showed that the bones had healed without complications.
Use the ointment No. 1 for the treatment of burns.
Patient Z. - 10 years. Complaints to burn legs, obtained by boiling water. The skin of the foot is inflamed and covered with bubbles. For the treatment applied ointment No. 1, which was daily applied to the burn area and recorded swathe bandage. After 3 days of feeling better, no pain, decreased redness around the burn. After 10 days disappeared inflammation and burn wound dragged new skin.
Use the ointment No. 2 for the treatment of chronic bronchitis.
Patient N. - 23 years. Addressed with chronic bronchitis, complaints on susceptibility to infectious colds. Appointed 25-day course l the treatment ointment No. 2 by rubbing in the chest area, submandibular lymph nodes, stop with the next wrap. After a week of treatment ointment No. 2, the patient began to move away phlegm, coughing became less frequent. Upon completion of the course of treatment, all symptoms disappeared without a trace and complications. During the epidemic of influenza, the patient was not susceptible to viral diseases, disease recurrence bronchitis was no longer observed.
Use the ointment No. 2 for the treatment of periarthritis.
Ball Acting - 45 years. Complaints of severe pain and limitation of motion in the left shoulder. Diagnosis: humeroscapular periarthritis.
Assigned treatment ointment # 2 by daily rubbing it in the area of the humeroscapular joint, cervical spine, followed wrap the painful area with a wool cloth. After 2 weeks of treatment with no pain, movement in the joints become loose. The patient felt well.
Use the ointment No. 2 for the treatment of bruises and lacerations.
Sick So 35 years. Filed a complaint on a bruise and torn wound in the right thigh, which ball immediately carefully treated with iodine. Assigned treatment ointment No. 2, which is daily put on the wound and rubbed into the area of injury. After 3 days of treatment disappeared redness, swelling and pain. The wounds began to heal. After a 10-day the aqueous treatment has been completely wound healing and resorption of hematoma in the area of injury.
Use the ointment No. 2 for the treatment of fracture.
Ill H - 37 years. Addressed with two broken ribs. The body temperature of 37.8°C.
Treatment ointment No. 2, which daily gently stabbed into the fracture. After 5 days, the pain eased, normalized temperature, improved overall health. After the end of treatment x-rays showed complete healing of the damaged ribs.
Use the ointment No. 3 for the treatment of arthritis.
Patient O. - 24 years. Complaints of pain and inflammation of the joints of the lower limbs and toes after viral infection.
Assigned treatment ointment No. 3, which every night rubbed in ankles, toes, foot and lumbar-sacral spine and wrapped up with a wool cloth. After a 2-week course of treatment with no pain, redness, slept swelling, restore joint mobility. The patient is advised to apply the ointment for the prevention of disease in spring and autumn infectious periods.
Use the ointment No. 3 for the treatment of venous ulcers.
Patient M - 49 years. Diagnosis: trophic ulcer of left lower limb.
To ensure assigned ointment No. 3. Bandage with ointment was applied to the area affected trophic ulcer, 2 times a day. During the first n the Delhi treatment was observed outflow of lymph and pus formations. After two weeks, the redness disappeared and the ulcer began to heal. Complete cure ulcers occurred three weeks. The patient was recommended to continue rubbing ointment for 2 weeks to prevent recurrence.
Use the ointment No. 3 for the treatment of psoriasis.
Patient K. 20 years. Came with a diagnosis of psoriasis. Affected forehead, chest, back of the hands. To ensure assigned ointment No. 3. After 3 days, the patient noted a decrease itching disappeared dryness and tightening of the skin. In the treatment of exacerbation of the disease was not observed. After a 3-week course of treatment disappeared peel and skin pigmentation. After a 2-week break, the patient continued the treatment to consolidate therapeutic effect.
From examples 1-11, it follows that the proposed ointment may be recommended for the treatment of hemorrhoids, burns, bruises, fractures, wounds, arthritis, sciatica, frozen shoulder, trophic ulcers, chronic bronchitis and psoriasis. When using the ointment does not have any harmful side effects on the body and has no contraindications for use. The ointment can be used for the treatment of adult patients and children.
1. Ointment anti-inflammatory and wound-healing actions, including vegetable component, petrolatum and lanolin, characterized in that as a vegetable component it contains mass the initial extract of melilot (color) and additionally contains honey, mummy, when the next mass ratio of components 4,5:1,5:1,0:0,5:2,5.
2. Ointment anti-inflammatory and wound-healing actions, including botanicals and lanolin, characterized in that the quality of herbal ingredients it contains oil extracts of clover (color), plantain and additionally contains honey, mummy, bear fat, at the following mass ratio of components 1:1:1:1:1:1.
3. Ointment anti-inflammatory and wound-healing actions, including botanicals and lanolin, characterized in that the quality of herbal ingredients it contains oil extracts of clover (color), plantain, aloe, Mandrake (root), nettle, Rue (seeds), ephedra homeboy and additionally contains honey, mummy, propolis, at the following mass ratio of components 1:1:1:1:1:1:1:1:1:1:1.
FIELD: medicine, pharmacy.
SUBSTANCE: invention describes composition of a pressed tablet comprising multiple of hardened melted granules of nonsteroid anti-inflammatory preparation (NSAID) with a melting point in the range 30-300oC and comprising a loosening agent dispersed uniformly in it. Granules comprise a continuum phase of indicated nonsteroid anti-inflammatory preparation and the table composition comprises additionally silicon dioxide in the amount 0.05-5.0% of composition mass. Preferably, the composition comprises also a nongranulated component containing silicon dioxide and excipient. The preferable NSAID represents ibuprofen that has a melting point in the range 75-77oC. Method provides preparing tablet showing useful industrial properties and ability for dissolving.
EFFECT: improved preparing method, valuable pharmaceutical properties of agent.
34 cl, 16 tbl, 64 ex
FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to new spiroimidazolidine derivatives of the formula (1):
wherein R1 represents hydrogen atom or methyl; R2 represents phenyl or (C1-C4)-alkyl; X represents -CH2-CH2- or -CH2-CH2-CH2-; W represents isopropyl or cyclopropyl; V represents hydrogen atom or methoxy-group; E represents -CO-R3 wherein R3 represents hydroxy-group, (C1-C4)-alkoxy- or amino-group; phenyl represents unsubstituted phenyl residue or phenyl residue substituted with one or some similar or different substitutes taken among the group consisting of (C1-C4)-alkoxy-, methylenedioxy- and ethylenedioxy-group in all its stereoisomeric forms and their mixtures in all ratios, and to its physiologically acceptablesalts. Also, invention relates to a method for preparing compounds of the formula (1) and pharmaceutical composition based on these compounds. Invention provides preparing new compounds eliciting the inhibitory effect with respect o leukocytes adhesion.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
16 cl, 1 tbl, 41 ex
FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to compounds of the formula (I):
wherein X means group of the formula (X-1) wherein R15 means halogen atom, (lower)-alkyl and perfluoro-(lower)-alkyl; R16 means hydrogen, halogen atom and (lower)-alkyl; or X means group of the formula (X-2) wherein Het means 5- or 6-membered heteroaromatic ring comprising 1 or 2 heteroatoms as nitrogen (N) atom; R15 and R16 have values indicated above for (X-1); R30 means hydrogen atom or (lower)-alkyl; p means a whole number from 0 to 1; or X means group of the formula (X-3) wherein R18 means aryl; R19 means unsubstituted arylalkyl or heteroarylalkyl representing 6-membered heteroaromatic ring comprising nitrogen (N) atom as a heteroatom; R20 means unsubstituted (lower)-alkanoyl; Y means group of the formula (Y-1) wherein R22 and R23 mean independently from one another hydrogen atom, (lower)-alkyl, halogen atom or perfluoro-(lower)-alkyl and at least one of radicals R22 and R23 doesn't mean hydrogen atom; R24 means hydrogen atom; or Y means group of the (Y-3) wherein R25 means group of the formula: R26-(CH2)e- wherein R26 means (lower)-alkoxy-group, (lower)-alkylthio-group, (lower)-alkylsulfonyl; or R26 means group of the formula: -NR28R29 wherein R28 means hydrogen atom; R29 means (lower)-alkanoyl or (lower)-alkylaminocarbonyl; Q means -(CH2)f- wherein e means a whole number from 0 to 4; f means a whole number from 1 to 3; a bond denoted as a dotted line can be hydrogenated optionally; and to its pharmaceutically acceptable salts and esters. Also, invention proposes a pharmaceutical composition designated for treatment or prophylaxis of rheumatic arthritis, cerebrospinal sclerosis, intestine inflammatory disease and asthma and containing compound of the formula (I) or its pharmaceutically acceptable salt or ester in combination with a compatible pharmaceutical carrier. Invention proposes derivatives of thioamide inhibiting interaction between α4-comprising integrins and VCAM-1.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
20 cl, 1 tbl, 86 ex
FIELD: organic chemistry, medicine.
SUBSTANCE: invention describes N-substituted azaheterocyclic carboxylic acids and their esters of the formula (I):
wherein R1 and R2 represent independently hydrogen, halogen atom, NR6R7 or (C1-C6)-alkyl; Y represents >N-CH2 or >C=CH2- wherein only underlined atom is a component of the ring system; X represents -O-, -S-, -CH2CH2- wherein R6 and R7 represent independently (C1-C6)-alkyl; r = 1, 2 or 3; Z represents heterocycle taken among formulas (a), (b), (c), (d), (f), (k), (g) and (j) given in the invention claim. Also, invention relates to a method for their preparing and pharmaceutical composition based on compounds of the formula (I). Invention describes a method for inhibition of neurogenous pain, inflammation and blood glucose level increase to patient by administration to patient the effective dose of compound of the formula (I). Compounds of the formula (I) elicit ability to inhibit the neurogenous pain and blood glucose enhanced level.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
13 cl, 1 tbl, 30 ex
in which R represents hydrogen or methyl; R1and R2both represent hydrogen or together form a chemical bond; R3represents hydrogen or linear or branched C1-C5alloy group, or a chain of formula
where a is a hydrogen or phenyl group, or a 5-or 6-membered heterocycle, saturated or unsaturated and contains from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, optionally substituted by one or two substituents selected from C1-C5alkyl groups or phenyl groups, X and Y, identical or different, represent O or NR4where R4is hydrogen, linear or branched C1-C5alkyl group, benzyloxycarbonyl group; r is an integer from 1 to 6; m is an integer from 1 to 8; n is an integer from 0 to 2; and their pharmaceutically acceptable salts; except for compounds of the oxime of 3’-destinationin-3’,4’-dihydroanthracene and 9-O-methyloxime 3’-descimated the
where R1represents hydrogen, hydroxy, protected hydroxy, or aryl, optionally substituted with a suitable(and) substituent(s) selected from the group consisting of halogen(lower)alkyl, halogen, hydroxy, protected carboxy, carbamoyl, lower alkylenedioxy, lower alkoxy, optionally substituted aryl, and lower alkyl, optionally substituted by hydroxy or protected carboxy; R2represents hydrogen or lower alkyl; R3is hydroxy or protected hydroxy; R4represents cyano, (hydroxy)minamino(lower)alkyl, carboxy, protected carboxy, N-containing heterocyclic group, optionally substituted amino, or carbarnoyl, optionally substituted with a suitable(s) of the substituent(s) selected from the group consisting of amino, hydroxy, lower alkyl, lower alkylsulfonyl, amidoamine(lower)alkyl, optionally substituted by hydroxy; and-And - is-Q -, or-O-Q-, where Q is a single bond or lower alkylene, or its salt, provided when R2is the lowest Ala the substituent(s), the above, and also provided that the compound of formula I is not 1-(hydroxyethyl)-4-(etoxycarbonyl)imidazole or anilide 1-(2-hydroxyethyl)imidazole-4-carboxylic acid
in which Ar1means pyrazole which may be substituted by one or more groups R1, R2or R3; Ar2means naphthyl, tetrahydronaphthyl, each of which is optionally substituted by 0-1 groups R2; X means5-C8cycloalkenyl, phenyl, optionally substituted by a hydroxy-group or1-C4alkoxygroup, furan, pyridinoyl, pyrazolyl, pyridinyl, optionally substituted by a hydroxy-group or1-C4alkoxygroup, piperidinyl; Y represents a bond or a saturated branched or unbranched1-C4the carbon chain, with one methylene group is optionally replaced with NH, or and Y is optionally independently substituted by oxopropoxy; Z means morpholine, group, pyridinyl, furanyl, tetrahydrofuranyl, thiomorpholine, pentamethylbenzene, pentamethylbenzene, secondary or tertiary amine, the nitrogen atom of the amino group covalently linked to the following groups selected from a range that includes the C1-C3alkyl and C1-C5alkoxyalkyl; R1means31-C6alkyl which is optionally partially or fully galogenidov, halogen; R3means phenyl, pyrimidinyl, pyrazolyl, which is substituted by one branched or unbranched1-C6the alkyl, and pyridinyl, optionally substituted C1-C3alkoxygroup or amino group, W denotes O and its pharmaceutically acceptable salts
man, is able to induce the formation of neutralizing antibodies to human tnfdna, its coding, vector (options), a method of obtaining a vaccine tnf(options), method of testing for the presence of tnfthe way to test body fluids of a person, the method of diagnosis, method of treatment and prophylaxis medication for the treatment of" target="_blank">
FIELD: medicine, pharmacology, pharmacy.
SUBSTANCE: invention proposes an agent for treatment of infected wounds that comprises zeolite of Kcholinskiy deposit that represents zeolite powder modified with silver with particles size 17-20 . The proposed form provides enhancing the curative effect of agent due to elevating porosity of zeolite and increasing area in interaction of precipitated silver with wound surface. Invention can be used in surgery for healing wounds, among them chronic sluggish wound and trophic ulcers showing refractory properties to treatment with conventional agents.
EFFECT: improved and valuable properties of agent.
1 tbl, 7 ex
FIELD: agriculture, animal husbandry, organic chemistry.
SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.
EFFECT: valuable antiseptic properties of ointment.
2 cl, 1 tbl, 22 ex