Method for treating chlamydiosis in calves

FIELD: veterinary science.

SUBSTANCE: the method deals with injecting oxylate once daily for 3 d at the dosage of 1 ml/30 kg body weight at repeated therapy course in 5 d at the background of antibioticotherapy. The method enables to normalize biochemical and morphological blood values and increase average daily body weight gain in sick animals.

EFFECT: higher efficiency of therapy.

2 ex, 2 tbl

 

The invention relates to veterinary medicine, in particular to a method of treatment of chlamydia calves.

There is a method of treatment with tetracycline antibiotics, namely oxytetracycline (Chlamydia farm animals. - M.: Kolos, 1984. - S).

The disadvantages of this method of treatment can be considered one-way causal influence on the organism of the animal, the possible development of dysbacteriosis and secondary immunodeficiency.

There is a method of treatment of feed antibiotics: biovet - 40, 80, 120 (Biology and environmental problems of infectious diseases of wild animals and their role in the pathology of farm animals and people. (Materials of the International scientifically-practical conference. - Cover. 2002. - S).

This method is based on monotherapy and eliminates the use of immunocorrective drugs that improve treatment efficacy and reduce side effects of antibacterial drugs.

The technical problem solved by the invention consists in the extension of the treatment of chlamydia.

The invention consists in that for the treatment for chlamydia calves used drug oxalat (RF patent No. 2076702, THE 9336-02-16923913-00) on the background of antibiotic drugs tetracycline group.

With this method of treatment using Biovit - 80 in d is se 6 g per head, with morning and evening feeding of milk, for 7-10 days and oxalat by subcutaneous injection once a day for 3 days, at a dose of 1 ml/30 kg body weight. Treatment oxylator repeated after five days. The use of this method of treatment improves the efficiency of treatment by 20%, increase average daily weight gain of animals affected by 29.9%.

In experiments to study the effectiveness of treatment used calves postnatal period, with clinical signs of gastroenterocolitis, which by polymerase chain reaction in the scrapings of the mucous membrane of the rectum and blood samples allocated DNA of chlamydia. To assess the effectiveness of treatment before conducting experiments and 10 days after treatment was performed morphological and biochemical blood tests, was determined lysozime, bactericidal and macrophage activity, 2 months - took samples for DNA extraction chlamydia by PCR using the test-system “Glocom”.

Example 1. The experience was 15 calves, patients with chlamydia. The calves of the first group (5 animals) used Biovit - 80 at a dose of 6 g per head, with a morning and evening feeding of milk, for 7-10 days and oxalat by subcutaneous injection once a day for 3 days, at a dose of 1 ml/30 kg body weight. After five days treatment with oxylator repeated.

Calves second GRU the dust was fed to Biovit - 80 at a dose of 6 g per head, with a morning and evening feeding of milk, for 7-10 days.

Animals of the third group (5 animals) treated by oxylator by subcutaneous injection once a day for 3 days, at a dose of 1 ml/30 kg body weight. After five days the treatment was repeated.

After treatment of the DNA of chlamydia isolated from one calf of the first group, two second and three third. Safety in all groups was 100%. Clinical signs (diarrhea) remained one of the calves treated with biovita - 80. Average daily weight gain in calves the first group amounted to 633 g, the second group 344 g, third - 540, the Effectiveness of the treatment in the first group was 80%, the second is 60%, in the third to 40%. Data reflecting the effectiveness of the treatment, are presented in table 1.

Example 2. Calves from the experimental group, patients with chlamydia, with signs of gastrointestinal tract (5 goals), was used nicox-200 as a deep intramuscular injection at a dose of 1 ml/10 kg of body weight, once and oxalat by subcutaneous injection once a day for 3 days, at a dose of 1 ml/30 kg body weight. After five days treatment with oxylator repeated.

The calves of the control group, with signs of gastrointestinal tract (5 goals), was used nicox - 200 as a deep intramuscular injection at a dose of 1 ml/10 kg of body weight, onocr the IDT.

After treatment of the DNA of chlamydia isolated from one calf from the experimental group, two - control. Safety in groups was 100%. Clinical signs of diarrhoea after treatment were noted. Average daily weight gain in calves from the experimental group amounted to 485 g, control 610, the effectiveness of the treatment in the experimental group was 80%control 60%. Data reflecting the effectiveness of the treatment, are presented in table 2.

According to the results of laboratory studies, the level of red blood cells in calves of all groups were consistent with physiological norm and did not differ significantly. The number of cells on the 10th day after treatment was increased by 18,67% in calves of the first group, 11,72% calves third and 16,67% in animals exposed to treatment Nicolson. The amount of hemoglobin was significantly increased in calves of most groups. The exception was the animals, which was used nicox. The indicator in this case declined to 7.64% and amounted to 98,99±of 7.48 g/L. At the same time, in calves, which used complex nitox/oxalat, the indicator has not changed and amounted to 102,45±2.20 g/L. In the same group in calves increased levels of circulating immune complexes: 7,69%. In calves the third group, this indicator increased by 38,67%. At the same time in the blood samples of calves of these groups increased the authors estimated the effect activity. In calves, which were used only nor the ACS and Biovit, FOREPLAY decreased by 43,81% and 34.6%, respectively. BASK decreased in animals of all groups. Macrophage activity was increased in all calves, but also increasingly subjected to comprehensive treatment oxalat/Biovit (32,15%) and amounted to 48,42%.

Thus, the use of oxalate by subcutaneous injection once a day for 3 days, at a dose of 1 ml/30 kg body weight with repeat treatment after five days and biovita - 80 at a dose of 6 g per head, with a morning and evening feeding of milk within 7-10 days promotes recovery calves and elimination of the pathogen chlamydia in 80% of cases.

The application of this method of treatment can improve the economic efficiency of treatment by 20% compared with traditional schemes monotherapy antibiotics, helps to normalize biochemical and morphological parameters of blood, increase average daily weight gain of infected animals, on average, 187,

The treatment for chlamydia calves with clinical signs of gastroenterocolitis, including the use of the drug, characterized in that the quality of drug use oxalat, which is injected once a day for 3 days, at a dose of 1 ml/30 kg body weight with a repetition rate of treatment oxylator through p is th days on the background of antibiotic therapy.



 

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