Method for evaluating psychophysiological state according to human cardiac rhythm

FIELD: medicine, cardiology.

SUBSTANCE: one should register rhythmocardiogram, measure current total power in low-frequency and high-frequency areas of dynamic row of cardiointervals. Evaluation of psychophysiological state should be performed by the value of stress index S calculated due to original mathematical formula by taking into account the power of low-frequency and high-frequency constituents of the range of dynamic row of cardiointervals. In case of standard conditions of measurement - the rest lying at one's back position the value of S stress index should be considered to be equal to 1. The method enables to rapidly and noninvasively detect and range human psychophysiological state.

EFFECT: higher accuracy of evaluation.

2 dwg, 1 ex, 2 tbl

 

The invention relates to medical engineering, in particular to a method of assessing the physiological status of the organism in heart rhythm, and can be used to assess the physiological status of a person in everyday life, when his work as an operator, as well as for the comparative evaluation of the psychophysiological state of operators.

To assess the physiological status of the organism in practice, the use stress level. Under stress the body experiences stress voltage. Stress, Selye is the stress state of the body, any human condition is not stress-free, i.e. it is a "nonspecific (physiological) response of the body against him on any demand" (Selye, Stress without distress. - M.: Progress, 1979). The cardiovascular system is an indicator of adaptive activity of the whole organism. It should be noted that changes due to load in the parameters of the cardiovascular system are adaptive to the load, that is secondary. Change correlates with changes of inhibitory processes. Currently, the accumulated experience of probabilistic-statistical method of analysis of heart rate to assess adaptability to different kinds of stress on the heart and the vascular system and body in General. A high degree of correlation obtained information about the heart rhythm with the functional state allows for some of the indicators of rhythm to evaluate performance, to predict the state of a person. Under the influence of workload (physical, intellectual, emotional) due to increased tone of the sympathetic nervous system cardio-vascular reactions of the organism, as a rule, changes in the direction of improve the stationarity of the process. On the contrary, after their work period, characterized by the predominance of vagotonia, there is a weakening of the influence of the Central nervous system on heart rate, reduction of stationarity. Measurement of heart rate in real terms rather straightforward to implement and is the most effective means of obtaining information about the physiological state of a person. To assess the condition of the body most commonly used statistical analysis of the dynamic range of the R-interval, including an analysis of histogram - distribution curves of the R-interval and spectral analysis.

There is a method of assessing the degree of tension of regulatory systems on stress index, which is determined by the analysis of the histograms as the ratio of the height of the histogram to its width (Livshits ON Statistical research performance regulation of heart rate is. //Human physiology. - 1987. - So 13, No. 6. - S). The low reliability of this indicator is based on its shortcomings: nenormirovannogo (values may vary in an arbitrary range), non-linear changes and hypersensitivity.

Known methods of assessment of heart rate variability, based on the spectral analysis of the dynamic range of the R-interval, which is detected and quantitatively evaluated secretive frequency of regulatory processes. Thus allocate the frequency bands, reflecting the adaptive capacity of the organism or the current level of stress. High-frequency oscillations (HF) in the range from 0.4 to 0.15 Hz, caused by breathing, characterize the state of the parasympathetic division of the autonomic nervous system. Low-frequency oscillations (LF) in the range 0.04-0.15 Hz) reflects the activity of subcortical vascular center. They, together with the very low frequency oscillations (VLF) in the range of 0.015-0.04 Hz characterize the state of the system level of Central regulation circuit. In the spectral analysis of the dynamic range of the R-interval get a number of indicators, which assess the autonomic balance, the level of heart rhythm management and functional state of the organism (Baevsky R.M. Analysis of heart rate variability in space medicine. //Phi is iology person. - 2002. - T. 28, No. 2. - P.70-82).

The known method of the study of heart rate variability (EN 2141246 C1 IPC And 61 In 5/02, 1999), based on measurement of the power spectrum of HF, LF and VLF components and complete power spectrum, which is used to assess pathology regulation of heart rhythm. Big time required to obtain the VLF rate with period of oscillation 25-66 with, make it impossible to use this method for rapid assessment of psychophysiological state of a person.

There is a method of assessing the functional state of the operator to heart rhythm, which determine the power spectra of slow waves ramagrama in the range 4-720 (SU 1630028 A1, IPC And 61 In 5/00, 1995) and increase of capacity of the waves of the dynamic range of the R-interval variation during the transition from rest to load determine the functional reserve of operator activity. This method also cannot be used for rapid assessment of psychophysiological state of a person because of the need for time-consuming analysis.

Closest to the present invention to the technical essence and the achieved result when use is a method of assessing the physiological status of the person on the rhythm of the heart, namely, that measure the power spectrum of low-frequency (LF) and high frequency (HF) components of the dynamic range is the R-interval, calculate the power ratio of the low and high frequency components of the LF/HF, which is judged on the condition of the operators (Heart Rate Variability Standards of measurement, physiological interpretation, and clinical use.// European Heart Journal. - 1996. - V. 17. - p.354-381). The disadvantage of the prototype is that it has poor reliability, provides an estimate only changes the state of a person and does not allow a comparative assessment of the condition of the operators.

The problem to which this invention is directed, is to create a method that provides a rapid assessment of the person with the opportunity to conduct a comparative assessment of operators.

Technical result achieved when using the present invention is to provide a method for assessing the physiological status of a person with high confidence in the assessment of the functional status of the individual and comparative evaluation of operators.

Tasked with achieving the above-mentioned technical result is solved in that in the method of assessing the physiological status of the person, namely, that measure the power of low frequency (LF) and high frequency (HF) components of the spectrum dynamic range of the R-interval, pre-measured standards of low-frequency (LFs), high frequency (HFs) isummary power in the low-frequency and high-frequency regions of the spectrum dynamic range of the R-interval, additionally measure the current total power in the low-frequency and high-frequency regions of the spectrum dynamic range of the R-interval, and assessment of psychophysiological state of a person spend on the stress index S is determined from the relationship

For normal values of spectral power in low frequency (LFs) and high frequency (HFs) regions of the spectrum dynamic range of the R-interval accept the values of the spectral power in low frequency (LF) and high frequency (HF) fields measured on a large population of people in the standard recording conditions (rest, lying on the back) and averaged over the entire population. In particular, for normal values of spectral power in low frequency (LFs) and high frequency (HFs) regions of the spectrum dynamic range of the R-interval variation taking values LFs=1170 [MS·MS], HFs=975 [MS·MS].

As assessment of the status of the body in the prototype is accepted, the balance between the levels of sympathetic and vagusnye divisions of the autonomic nervous system, i.e. the power ratio of the low frequency (LF) and high frequency (HF) components of the spectrum.

The novelty of the present invention is the inclusion of a General activation of the sympathetic and vagusnye divisions of the autonomic nervous system by measuring the total spectral power (LF+HF), as well as ASCI assess the level of stress to the standards of low-frequency (LFs), high-frequency (HFs) and the total power dynamic range of a number of cardiac intervals obtained under standard conditions (lying down, resting position) and averaged over a large population of people.

To justify the relation (1) consider the full range of manifestations of stress at work as an operator. Stress can take several forms activity: from passive stress response through the lack of severity of stress to the active stress response. This range of variation of the stress corresponds to the following change in the efficiency of operator activity:

termination of operator's activity (stress passivity);

a significant reduction in the effectiveness of operator activity; it is possible to stop the workflow;

the decrease in the efficiency of operator activity;

improving the efficiency of operator activity;

the average level of health (stress is not expressed);

improving the efficiency of operator activity;

the decrease in the efficiency of operator activity;

a sharp decrease in the efficiency of operator activity; possible failures and stop the workflow; termination effective carrier activity;

possible negative outcomes panic behavior (stress activity) (China is-Smyk L.A., Bobrov AS Stress as a psychological factor carrier activity // Psychological factors of operator activity: Proc. of art - M.: Science - 1988. - C.111-124).

As you can see, the manifestation of stress is associated with activation of the nervous system - stress activity and its decontamination - stress passivity. In standard conditions, the stress is not expressed. Further decrease or increase the level of activation of the nervous system should be accompanied by an increase in stress. Therefore, in standard conditions, the stress index should be equal to unity, while in the other condition, other than standard, the stress index should increase or decrease. This is ensured by the cofactorsandwhile factorbinds to the norm of the total capacity, and the cofactornormalizes the value of the stress index for standard conditions, is equal to 1.

Physiological interpretation of the stress index, calculated by the formula (1)is the following. The autonomic nervous system consists of sympathetic and vagusnye departments, regulates the relations between the organs and tissues inside the body, performs adaptive trophic function, fitting organs and tissues for the best, the most the more perfect fulfillment of all activities. Working closely with the endocrine system, it ensures the integrity of the body, the constancy of its internal environment (homeostasis). The sympathetic division promotes rapid mobilization of energy and adaptation to constantly changing conditions of the external environment. This is mainly ergotron system associated with catabolic processes. Wagusnye Department, on the contrary, contributes to maintaining the constancy of the internal environment of the body. Through cholinergic structures it manages the processes of restoration of body energy and nutrients, increases the activity assimilatory processes. This tropocana system associated with anabolic processes. Sympathetic and vagusnye divisions of the autonomic nervous system are functioning under the influence of higher vegetative center of the hypothalamus. Hypothalamic region ensures the constancy of the internal environment of the body and adequate response to stimuli of different forces. In a healthy person the norm with good resistance to the effects of stimuli of different power indices of sympathetic and vagusnye divisions of the autonomic nervous system are in equilibrium.

When stress occurs, the fall of the absolute power of all components of the spectrum ramagrama (LF+HF). Biological positions, when the state is tressa all body systems subject to achieving vital goals, requirements to the heart, on the contrary, simpler: it only has a maximum productivity. The influence of the sympathetic nervous system leads to the alignment of the heart rhythm.

Under standard conditions for the average person, the stress index is equal to 1. For a person with a high level of functioning of the cardiovascular system, under standard conditions, the stress index is reduced to 0.1. When the 8-hour intelligent load, the stress index may increase from initial level 1.0-5.0-10.0. As can be seen from expression (1), the stress index is a dimensionless quantity and can be used for absolute estimates of body condition, and also for comparative assessment of different operators.

The invention is illustrated in the drawings, which depict:

figure 1 presents a graph of the stress index in subjects when solving arithmetic problems;

figure 2 presents a graph of the stress index in subjects while conducting practice flight on the simulator.

The method is as follows. Prior and current measurements of the spectral capacity is conducted according to the same algorithm described below. With the sensor removed cardioseal. Measure the R-interval between R-teeth and form the dynamic range is the second series of R-interval.

The dynamic range of the R-interval is subjected to spline interpolation to connect the experimental points values of the R-interval is not a broken line, and a smooth curve. The best for this purpose suitable interpolation u(x) is a quadratic or cubic splines, i.e. segments of a quadratic or cubic parabolas. The meaning of spline interpolation is that in each interval between points is approximated by a parabola. Parts of the parabolas are called splines. Spline interpolation provides equality in the nodes themselves are not solely adjacent parabolic interpolating functions (splines), and their 1st derivatives. Thanks spline interpolation looks like a very smooth function and allows you to get the values of the R-interval equal intervals of time. The values of the samples of the R-interval equal intervals of time required for the spectral analysis of the dynamic range of the R-interval using the fast Fourier transform (FFT).

Perform spectral analysis of the dynamic range of the R-interval FFT-based and measure the spectral power of the signal separately in the low-frequency (LF) and high frequency (HF) and total spectral power in the low-frequency and high-frequency regions of the spectrum (Attributed R., L. Enochson Applied analysis the time series, the main methods. - M.: Mir, 1982, P.52-56). Use the lowest possible sampling to obtain the minimum-time spectral analysis. Preliminary measurements for the spectral power in low frequency (LF) and high frequency (HF) conducted on a large population of people in the standard recording conditions (rest, lying on the back). The obtained experimental data are averages for the entire population and take over the normal values of the spectral power in low frequency (LFs) and high frequency (HFs). In the particular case you can use the experimental data shown in (Heart Rate Variability Standards of measurement, physiological interpretation, and clinical use.// European Heart Journal. - 1996. - V. 17. - p.354-381), where LFs=1170 [MS·MS], HFs=975 [MS·MS], respectively low and high frequency components of the spectrum dynamic range of the R-interval, obtained in the standard recording conditions (rest, lying on the back) for a large population of people regardless of gender, age and other factors and accept the norm. Thus the expression (1) for an index of stress takes the form (2)

Then carry out current measurements and calculate the stress index of the ratio of (1) or (2), which assess a person's state.

The method can be implemented using devices containing connected in series Yes the cheek cardiomegaly (for example, based on the lapel belt company "POLAR"), the R-interval meter, the driver of the dynamic range of the R-interval, the block of input data into the computer via the serial channel and the computer.

In the graphs shown in figures 1 and 2, the abscissa represents time, the ordinate value of the stress index in dimensionless quantities. In figure 1 the change in the index of stress corresponds to the decision the subject of an arithmetic problem within two minutes. Figure 2 the change in the index of stress corresponds to the conducting practice flight simulator aircraft within 14 minutes. From a comparison of the maximum values of the stress curves shown in figures 1 and 2, it is seen that the individual feels about 3 times more stress when working on the simulator than when solving arithmetic tasks.

Assessment of the validity of the proposed stress index was conducted in relation to the critical frequency of flicker fusion (ccsm), which characterizes the functional condition of the Central nervous system, which, in turn, is associated with the stress level of the person. Methods of measuring ccsm is the most sensitive technique for assessing the status and the most statistically reliable - 100% (Integrated assessment of health when mental and physical labor. Methodical recommendations..): Economics, 1990 - P.32, 33).

experiment was organized as follows. Surveyed continuously made measurements ccsm according to standard methods (Integrated assessment of health when mental and physical labor. Methodical recommendations...): Economics, 1990 - Pp.96). At the same time under the proposed method was measured stress index. On the basis of experimental data for each subject according to the formula of calculation of the correlation coefficient Kg Pearson (Weinberg, J., Shumaker J. Statistics/ Lane. from English. Lagrimeo and Biglione; Ed. and Annot. Isomerase. - M.: Statistics, 1979. - S) was determined correlation between ccsm and stress index

where

The XI - values ccsm;

Yi - values of the proposed stress index or index of stress on the prototype;

N is the sample size.

The significance of the correlation coefficient Kg was evaluated using t-statistics, calculated by the formula (Weinberg, J., Shumaker J. Statistics/Lane. from English. Lagrimeo and Biglione; Ed. and Annot. Isomerase. - M.: Statistics, 1979. - S)

6 minutes of each experiment the subject spent about 35 measurements ccsm and measuring stress index with a sliding window of 2 minutes. Values ccsm and stress index were averaged at intervals of 6 minutes. Per working shift (8 hours) each surveyed spent 9 experiments. Check with what omashu t-statistics correlation coefficient Kg showed its importance.

In table. 1 shows an example of measurement data for one subject. Table 2 shows the data of the correlation coefficient ccsm relative stress index of the prototype and the proposed method for the group surveyed from 5 people.

The highest correlation coefficient, averaged over the group of subjects, observed in the proposed method of assessing stress and, on average, equal to 0.824. Average surveyed the correlation coefficient for the index of stress for the prototype equal to 0.632

It should be noted that the proposed method of monitoring physiological control due to their nature (the use of spectral analysis has its limitations: the control on the proposed stress index are not subject people with health deviations.

Using the proposed control method allows comparison of the current state of a person registered at any time. In the control condition from a group of people on the basis of the evaluation results can be ranked by the psychophysiological state of a person by rating. Using the proposed evaluation of stress can improve the accuracy of evaluation of the psychophysiological state of a person when the minimum time data analysis through the use of low-frequency and high-frequency part of the spectrum of the shining.

Table 1
№ p/p experimentExamined No. 1
 Ccsm [Hz]Indices of stress
  The placeholderOffer
128,522,45a 3.87
228,104,044,65
327,823,214,50
428,033,525,19
528,872,613,24
628,462,163,48
728,582,773,11
829,341,772,55
928,562,052,95
the table 2
The subject

№ p/p
The correlation coefficient on kcsm
 The stress index of the prototypeThe proposed stress index
1-0,868-0,947
2-0,770-0,871
3-0,292-0,848
4-0,858-0,929
5-0,374-0,527
   
Average-0,632-0,824

The method of assessing the physiological status of a person in cardiac rhythm, namely, that measure the capacity of low and high frequency components of the spectrum dynamic range of the R-interval, characterized in that the measured current total power in the low-frequency and high-frequency regions of the dynamic range of the R-interval, and evaluation of psychophysiological state of a person spend on the stress index S, bycicle is the PTO by the formula

S=1787,5/(LF+HF)×LF/HF,

where LF - power low-frequency component of the spectrum dynamic range of the R-interval,

HF - power high-frequency component of the spectrum of the dynamic range of the R-interval,

and under standard conditions of measurement - rest, lying on his back, the value of the stress index S is considered equal to 1.



 

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