Device for applying iontophoretic transcutaneous introduction of molecules

FIELD: medical engineering.

SUBSTANCE: device has container for keeping product to be applied, dosing unit for distributing the product, power supply element placed near the dosing unit. The dosing unit is designed as rotating element and is apiece of felt. Container walls are flexible. The dosing unit is manufactured from electric conducting material and connected to the power supply element.

EFFECT: enhanced effectiveness in carrying out viscous product iontophoresis.

8 cl, 7 dwg

 

The technical field

The present invention relates to a container for a gel suspension can be transferred molecules medicines, herbal medicines, homeopathic or cosmetic product, carbon dioxide or nitrogen, or other molecules and substances intended for use by means of iontophoresis, as well as other methods, requiring the use of energy, stimulate the penetration of the transported molecules through the epidermis and into the tissues inside the skin barrier.

The level of technology

It is known that iontophoresis is a method of percutaneous administration of medicines or other products for various purposes. This method can be performed by placing an ionisable molecules of the substance to be transfer into a container, followed by contacting one side of the container with the patient's skin, which used the substance in question. Portion of the container, in contact with skin, closed or osmotic semi-permeable membrane. Patient and a container designed for transporting molecules, attached to an electric circuit with a source voltage and/or frequency source that can be adjusted accordingly, resulting in the ionization of molecules and the migration of ions che is ez osmotic membrane, the skin of the patient and the passageways in the tissue beneath the epidermis, with the penetration depth, which is determined by the applied current frequency. The electric circuit is closed by one or more electrodes applied to the desired parts of the body of the patient receiving such treatment.

In the literature discloses various types of equipment for iontophoresis. For example, in EP-A-0292930 describes a device in which the container for the solution containing the molecules that you want to migrate, has an osmotic membrane through which ions migrate generated by an electric field generated by a suitable device. The considered molecules are in a liquid solution inside the container closed by the osmotic membrane.

In the application for U.S. patent 5084008 opened another container for medicines used by the method of iontophoresis. In this case, the container is particularly suitable for the transport of molecules contained in the gel, and it is closed permeable layer, which is intended to provide passage of ions and, at the same time, to prevent drying of the gel at the time of storage of the container. The specified container is of particular configuration of funds for the current distribution inside the drug.

In WO-8808729 disclosed an electrode for iontophoresis comprising a plate and the conductive material with a porous membrane, containing molecules that you want to migrate. The membrane is protected by a removable protective film that is removed at the time of application of the electrode on the patient.

In WO-9622810 disclosed a container for medicines used by the method of iontophoresis, with subsequent freezing of the solution containing the drug. In this case, the container consists of two parts connected with each other interchangeably and forming an internal volume, which is filled with a solution containing the drug to be used. After that, the container together with the contents freeze and, at the time of application, the upper part of the container is removed to provide access to the unit from the frozen solution. The specified block is brought into contact with the epidermis of the patient. The remaining portion of the container, which continues to be the main unit of the frozen solution, contains an electrode having a suitable shape for electrical contact with the frozen block solution.

Consider the container has significant drawbacks associated with the lack of accessories for secure attachment of the two parts of the container to each other, in the case where the container must be filled with a solution containing the drug, the absence of a suitable seal, ensure the sustained health product, because the container open top for filling it out, and the impossibility of a single use of the specified container for hygienic reasons. In addition, the container is designed exclusively for use pre-frozen solutions. The application of the electrode is not secure and it can easily immerse yourself inside because of the melting of the ice block, which can lead to electrical discharges.

Other known methods of application of the active elements through the epidermis require the use of forms of energy other than electrical. For example, it is known that the active elements can be brought into this state which provides a passage through the epidermis under the action of laser radiation, mainly using diode laser. In other cases, may require the use of ultrasound, infrared radiation or other methods.

In the context of the present invention, reference is made to the source of energy in the General sense of the term, as well as the means of the influence of such energy to the solution containing the molecules to be transported. This formula should be understood as denoting any system, allowing you to enter the active elements or molecules of any type percutaneous method is used for the output of energy of any type.

In the text of this description specifically refer to the iontophoresis as a particularly successful method of application. However, this emphasis should be seen as an indication of a preferred but not exclusive form of application of the present invention.

The invention

The present invention is to develop a container for media such product with a relatively high viscosity, as the gel and the like, containing the molecules to be reposted by the method of iontophoresis, which eliminated the disadvantages and limitations of currently known traditional containers.

In a more General sense, the present invention is to create a container and switchgear suitable for any method of application active substances dispersed in the specified media, using any energy source.

The problem is solved by a device for percutaneous introduction of the molecules contained in the product media, comprising a container, a dispenser for product distribution, supply element connected to the specified dispenser, which according to the invention, the container means is connected to a distribution chamber for a product having a distribution orifice closed by a dispenser, and the power supply e is ement placed in a distribution chamber in the vicinity of the dispenser.

Consider the container has a main body and, if necessary, distribution chamber, in which there is specified the dispenser and in the immediate vicinity of the power supply element, and the specified distribution chamber can be means connected with the main body of the container.

It is reasonable that the distribution Luggage made with the possibility of separation from the main body of the container.

Specified the dispenser may be made in the form of a rotating element or piece of felt, or other porous material, or may be made of electrically conductive material. In the latter case can be established electrical contact with the specified power supply element to create an electrical potential directly on the epidermis.

Consider the container may contain a narrowing portion at the end of which are specified dispenser and the specified power supply element, and/or such container may contain, at least partially flexible wall, allowing you to manually exert pressure on the contents of the device to facilitate its distribution.

It is preferable that the opening for filling the container, intended for single use, closed using the side compression ratio, p is like the tube of toothpaste.

List of figures

The essence of the present invention will become clearer from the description text and the accompanying figures of the drawings, which illustrate an example of the technical solution of the invention, without restricting its scope.

On the accompanying drawings are presented:

figure 1 is a side view of the device according to the first embodiment of the present invention with a partial cross-section;

figure 2 is a side view of the device according to figure 1 in section along the plane II-II; and

figures 3-7 are corresponding side views of devices according to other variants of the present invention.

Information confirming the possibility of carrying out the invention

In figures 1 and 2 show a device containing a cylindrical container 1 with a threaded inlet 3 to the dispenser 7, forming a distribution chamber 5A. Such a distribution chamber is connected with the container 1 and has a rectangular hole 5B, which, except for the minimum gap is almost closed with the aid of a metering device 7 made in the form of a roller rotating around its own axis X-X. distribution Inside the camera fixed power supply element 9 in the form of metal clips, which are located mainly near the cylindrical surface of the roller, which can be applied electrical potential using the Lemma 11 and a flexible electrical conductor 13, moreover, the specified conductor is connected with a suitable source of electrical energy.

In the case when the container is placed medical or other product dispersed in media with high viscosity, for example in the gel, the device can be rotated to the position indicated in figures 1 and 2. The connection terminals 11 to a power source, the device can be used on parts of the body of the patient by prokachivanija on her roller. Thus, the roller, which in normal conditions prevents free access viscous components of the container 1, in this case, the causes for this part of the body is a thin layer of the specified media containing medicinal product, activated in the energy supply.

Figure 3-7 depict a similar device in which the containers 101, 201, 301, 401, 501 is filled through the main hole 103, 203, 303, 403, 503, accordingly, after which they can again be closed by a screw cap or lid that snaps on the body of the container, or, as shown in figure 7, the lateral compression of the edges of the holes and seal, just like a tube of toothpaste. In the latter case, dealing with the disposable device actions, because the filling is done only once. Each of these devices to them the et distribution chambers 105, 205, 305, 405, 505, the diameter of which decreases or tapers in the direction of the distribution holes V, W, V, W, V in such a way as to create a processing method of iontophoresis even in confined cavities, for example, in the oral cavity. In addition, the device shown in figures 3, 6, 7 have respective dispensers 107, 407, 507 in the form of a roller or ball, as depicted in figures 1 and 2, whereas the device shown in figures 4 and 5 have respective dispensers 207, 307 of pieces of felt, permeable media environment, which is cut in the shape of a cone. All devices include a power supply elements in the form of tapes 109, 209, 309, 409, 509, who can join using Windows Explorer to a source of electrical energy. The method of use is similar to that described for the case in figure 1.

Dispensers 7, 107, 207, 307, 407, 507 can be made of electrically conductive material being in electrical connection with the respective power supplying elements 9, 109, 209, 309, 409, 509. In the use of energy with a relatively low capacity to prevent harmful effects on the patient, this energy can be fed directly into the epidermis of the patient through the film of the applied product.

In each of the above is use options presented invention can be used in the container 1, 101, 201, 301, 401, 501 with a thin flexible plastic walls, so that, during use, the contents of the container may be caused by exposure to hand pressure, stimulating the distribution.

It should be borne in mind that the figures presented are only examples of practical demonstration of the invention, and the present invention can be applied in other forms using other devices that do not violate the main principles of the invention.

1. Device for percutaneous introduction of the molecules contained in the product media, comprising a container, a dispenser for product distribution, supply element connected to the specified dispenser, characterized in that the container means is connected to a distribution chamber for a product having a distribution orifice closed by a dispenser, and the power supplying element is placed in a distribution chamber in the vicinity of the dispenser.

2. The device according to claim 1, characterized in that the distribution chamber with the possibility of separation from the main body of the container.

3. The device according to claim 1 or 2, characterized in that the dispenser is made in the form of a rotating element.

4. The device according to claim 1 or 2, characterized in that the metering device is a piece of felt.

5. The device according to any one of claims 1, 2, 4, Otley is aldeasa fact, the container has a tapered part at the end where the feeder and the power supplying element.

6. Device according to any one of claims 1 to 5, characterized in that the container contains at least partially flexible wall.

7. The device according to claim 6, characterized in that the filling of the container, intended for single use, closed with lateral compression, like a tube of toothpaste.

8. Device according to any one of claims 1 to 7, characterized in that the dispenser is made of electrically conductive material and is electrically connected to the power supplying element.



 

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FIELD: medical engineering.

SUBSTANCE: device has container for keeping product to be applied, dosing unit for distributing the product, power supply element placed near the dosing unit. The dosing unit is designed as rotating element and is apiece of felt. Container walls are flexible. The dosing unit is manufactured from electric conducting material and connected to the power supply element.

EFFECT: enhanced effectiveness in carrying out viscous product iontophoresis.

8 cl, 7 dwg

FIELD: medicine, juvenile surgery.

SUBSTANCE: the method is characterized by the fact that 3 wk before surgical dissection of adhesions due to laparoscopy one should prescribe bifiform per 1 capsule and Hilak-Forte per 10-15 drops thrice daily. Moreover, 7 d before surgical interference it is necessary to conduct 7 seances of electrophoresis with irucsol and prescribe smekta sorbent per 1 packet thrice daily. Then comes laparoscopic dissection of adhesions, and after surgical interference one should perform electrophoresis with irucsol for 7 d. After appearance of intestinal peristaltics it is necessary to apply smekta per 1 packet thrice daily for 7 d. Since the 8th after operation one should prescribe bifiform per 1 capsule and Hilak-Forte per 10-15 drops thrice daily for 1 mo. Then 1 mo after laparoscopy one should prescribe electrophoresis with collalysine up to 8-10 procedures at simultaneous abdominal massage and curative-physical culture complex for 8-10 d. The method enables to obtain antiadhesive effect in 92% cases of surgical dissection of adhesions due to complex impact upon pathogenesis of adhesive disease, at decreased number of relapses.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: medicine.

SUBSTANCE: method involves introducing oxybutinine solution into the urinary bladder via catheter in the amount of 5-10 mg per 20-30ml of sterile water once a day. Electrophoresis is concurrently carried out on the urinary bladder projection region using current intensity of 0.02-0.04 mA/cm2 during 15-20 min. The total treatment course is 10-12 daily procedures long.

EFFECT: enhanced effectiveness of treatment.

1 tbl

FIELD: medicine.

SUBSTANCE: method involves placing active electrode like metal conductor in canal and passive electrode on body surface zone and applying DC action. The metal conductor is coated with dielectric layer spread to its working part. The working part is brought close to impassable area through badly or well-passable zones of the root canal. Gap filled with electrolyte is left between the impassable area and electrode end. The active electrode is connected to electric current source plus terminal and the passive one to minus terminal.

EFFECT: enhanced effectiveness of treatment.

6 dwg

FIELD: medicine.

SUBSTANCE: method involves dropping 1% midriacyl solution into conjunctival cavity in postoperative period. Then, lidase electrophoresis is applied to orbicular muscle zones. Plaster wetted with Okovidit gel is applied to the lower eyelid.

EFFECT: accelerated treatment course.

FIELD: medical engineering.

SUBSTANCE: device has reservoir, containing medicament, with electrode fixed therein. The device is to be held with patient hand. Eye-bath end surface designed for making contact with orbit boundary is of oval shape having broad and narrow end approximating orbit form. The narrow eye-bath end is raised above its broad end. The electrode is removable and remountable. The eye-bath is manufactured from flexible biologically neutral thermosetting polymer stable with respect to temperature and medicament action.

EFFECT: improved adjacency to orbit in performing electrophoresis procedures.

3 dwg

FIELD: medicine, endocrinology.

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EFFECT: higher efficiency of therapy.

3 ex

FIELD: physiotherapy and health resort treatment.

SUBSTANCE: method envisages drinking mineral water, performing intragastric electrophoresis with mineral water, magnet-laser therapy, massage, and baths. Additionally, 2-3 days before physiotherapy and during physiotherapy, biologically active additive "succinic acid" is administered in daily dose 3 x 0.5 g after meal. Intragastric and magnet-laser therapy are performed every day consecutively without interval between them. Treatment course consists of 8-10 procedures. Method allows achieving stable remission in case of indicated diseases thanks to integrated positive effect produced on inflammatory process, velocity of epithelization of ulcerous and erosive defects, acid-forming, neutralizing, and motor functions in gastroduodenal region on the whole.

EFFECT: enhanced treatment efficiency.

5 tbl, 2 ex

FIELD: medicine; infectious therapy.

SUBSTANCE: device for plasma-dynamic treatment of infected wounds and cavities has high voltage electric pulse oscillator provided with low-sized high voltage pulse electric-charge unit housed inside carrier dielectric case. The case has co-axial electrode system which has ring-shaped and rod electrodes separated by dielectric insulator. Co-axial electrode system is placed inside optical-transparent quartz member made in form of flask which has perforated semispherical working end. Co-axial system is disposed to have space relatively inner surface of carrier case of unit. Part of internal surface of the unit - at the area of semispherical working end of flask - is made of material which is able to reflect radiation of visible and UF range of spectrum. Removable outlet union, provided with branch pipe connected to union, is mounted onto working part of carrier case of unit. Branch pipe is connected with member having perforated semispherical working end at the opposite side. Opposite edge part of carrier case has support sealing bushing with inlet pipe which is connected with ozone generator conjugated with vessel for containing oxygen. Inlet pipe communicates with space to inner surface of carrier case of the unit and outer surface of flask.

EFFECT: improved efficiency of treatment; improved reliability of operation.

10 cl, 2 ex

FIELD: medicine.

SUBSTANCE: method involves applying decompression cholecystostoma over the gallbladder. Gallbladder lavage is carried out using the cholecystostoma. Then gallbladder cavity is filled with antibacterial preparation. Electrophoresis is carried out directly in inflammatory changed area through electrodes mounted corresponding to preparation polarity in the gallbladder cavity and externally on patient skin in hepatobiliary organs projection zone.

EFFECT: accelerated treatment course.

1 dwg

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