Biologically active additive for preventing and treating flu cases

FIELD: medicine.

SUBSTANCE: biologically active additive has propolis and pot marigold tincture, ascorbic acid, calcium gluconate, benadryl, rutin and auxiliary substances like starch, calcium stearate, talc taken in known proportion. The biologically active additive is produced as tablets of mass 0.55 g.

EFFECT: enhanced effectiveness of prophylaxis.

 

The invention relates to medicine, in particular to pharmacology, producing drugs for the prevention and treatment of influenza, preventing the spread of infections. It can be used as self medication, and as an additive to food.

It is known for the treatment of influenza and other acute respiratory diseases containing paracetamol (see, e.g., Drugs permitted for use in the USSR”, M, Medicine, 1979, s).

Known composition for the treatment of influenza with antipyretic, analgesic and anti-inflammatory properties, containing acetylsalicylic acid, ascorbic acid, rutin, diphenhydramine, calcium gluconate (see, e.g., Loginov WL (EDS) Manual on the organization of the store preparing control, M, Medicine, 1979, p.55-56).

The composition is made in the form of several powders and has a small shelf life. The disadvantage is separate administration of acetylsalicylic acid and other components, which is an inconvenience for the reception.

Closest to the invention the solution (prototype) is a dietary Supplement for the prevention and treatment of influenza, comprising as active ingredients ascorbic acid, calcium gluconate, diphenhydramine and rutin (see, provisional patent of the RK No. 9326, class a 61 K 31/00, 200 g).

A disadvantage of the known medicines is the presence in its composition of paracetamol that causes allergies in some patients, and the absence of antiviral components.

The objective of the invention is to eliminate said drawbacks, i.e. the creation of biologically active additives (BAA), which has antiviral, antipyretic, analgesic and anti-inflammatory properties and contains no allergens.

Summary of the invention in that the proposed biological active additive for the prevention and treatment of influenza, containing tincture of propolis and calendula, ascorbic acid, calcium gluconate, diphenhydramine, rutin and excipients - starch, calcium stearate, talc in the following ratio of components a tablet weight of 0.55 g, g:

tincture of propolis 0,04±0,008

tincture of calendula 0,02±0,004

ascorbic acid is 0.15±0,03

diphenhydramine 0,005±0,001

rutin 0,02±0,004

calcium gluconate 0,1±0,02

excipients else

The choice of technological forms of run BAD is determined by the production technology, the specific conditions of use, in particular, the requirements to the convenience of its application, the magnitude of individual doses, and other similar requirements.

The optimal number of components included in the BUD, get experimental way is.

One of the best technological forms is BAD tablet, because it is most convenient to use.

The BAD can be performed also in the form of krivoruchka, tinctures, infusions, extracts and other technological forms.

Below is a possible option technology SUPPLEMENTS in pill form.

1. Metered ingredients: calcium gluconate in the amount of 20.4 kg, ascorbic acid in the amount of 10.2 kg rutin in the number 4,08 kg diphenhydramine in number is 0.102 kg, starch in the amount of 14.28 kg talc in the amount of 1.02 kg, calcium stearate in the amount of worn : 0.505 kg

2. Calcium gluconate, ascorbic acid, rutin, diphenhydramine, starch is sifted through a sieve with holes of 1 mm; calcium stearate and talc sieved through a sieve with holes of 0.5 mm Tincture of propolis and calendula, which are used as drugs, manufactured in accordance with the State Pharmacopoeia, as well as purified water filtered through 4 layers of gauze.

3. From 0.2 kg of starch, 0.3 kg of water at room temperature and 1.6 kg of water, heated to boiling, cook the starch paste. The yield of 2 kg

4. From 20,4 kg of calcium gluconate, 14,08 kg of starch, is 0.102 kg Dimedrol, 4,08 kg rutin, 10.2 kg of ascorbic acid prepare a mixture, which moisturize 70% tincture of propolis in the number 8,16 kg, 70% tincture of calendula in to the number 4,08 kg and starch paste - 2 kg. Output wet weight of 63.1 kg

5. Wet raw mass granularit. The output of the wet granulate - 62,85 kg

6. The wet granulate is dried to a residual moisture content of 2%. The output of the dry granulated mass - 49,225 kg

7. The dry granulate is forced through a sieve with holes of 1.5 mm and mixed with sifted worn : 0.505 kg of calcium stearate and 1.02 kg of talc. The yield of dry product was 50.5 kg

8. The dry granulate tabletirujut, obtaining tablets with a diameter of 12±0.2 mm, a height of 6.0±0.2 mm, average weight of 0.55±0,02, the product Yield 50,25 kg

The finished tablet weight 0,55±0.12 g contains approximately the following amount in grams of each component:

Tincture of propolis 0,04±0,008

Tincture of calendula 0,02±0,004

Ascorbic acid is 0.15±0,03

Diphenhydramine 0,005±0,001

Rutin 0,02±0,004

Calcium gluconate 0,1±02

Excipients Else

9. The obtained tablets dedust, sifting the vibrating sieve with the hole diameter 10 mm Out of the finished tablets 50 kg

therapeutic efficacy of the invention was confirmed by clinical trials.

The medication was prescribed 1 tablet 3-5 times a day.

When assigning BAD “Picogreen” noted mild catarrhal phenomena pharynx and conjunctiva during the first three days. Febrile period was 18-48 hours. Symptoms of intoxication (weakness, adynamia, potlivosti, myalgia, headache, eye pain, lacrimation, photophobia) were stopped to the second day of drug administration. Symptoms of the respiratory tract (dry cough, sore throat, nasal congestion) decreased significantly within 2-4 days.

Resulting in patients with clinical influenza symptoms resolved within 4-5 days, therapy duration of colds was reduced to 2-4 days, tonsillitis and pharyngitis up to 5-7 days.

As has been shown in clinical trials BAD “Picogreen” not only makes it easier for SARS, but also prevents the exacerbation of chronic diseases and the development of secondary bacterial infections. Patients treated BAD “Picogreen”, recorded a favourable resolution from the disease during the observation period there were no recorded complications. While 37% of patients treated with standard therapy, stated exacerbation of chronic diseases, and in 25% of patients in this group developed a secondary bacterial infection.

Thus, the invention is allergens as an alternative to known drugs, has a high antipyretic, analgesic, anti-inflammatory and antiviral properties, and, in addition, in the manufacture in the form of pills is very comfortable to use and long term storage.

Biologically active additive for profilaktiki treatment of influenza, characterized in that it contains tincture of propolis and calendula, ascorbic acid, calcium gluconate, diphenhydramine, rutin and excipients - starch, calcium stearate, talc in the following ratio of components, g a tablet weight of 0.55 g:

Tincture of propolis 0,04±0,008

Tincture of calendula 0,02±0,004

Ascorbic acid is 0.15±0,03

Diphenhydramine 0,005±0,001

Rutin 0,02±0,004

Calcium gluconate 0,1±0,02

Excipients Else



 

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