Agent "argolit" for treatment of infected wounds

FIELD: medicine, pharmacology, pharmacy.

SUBSTANCE: invention proposes an agent for treatment of infected wounds that comprises zeolite of Kcholinskiy deposit that represents zeolite powder modified with silver with particles size 17-20 . The proposed form provides enhancing the curative effect of agent due to elevating porosity of zeolite and increasing area in interaction of precipitated silver with wound surface. Invention can be used in surgery for healing wounds, among them chronic sluggish wound and trophic ulcers showing refractory properties to treatment with conventional agents.

EFFECT: improved and valuable properties of agent.

1 tbl, 7 ex

 

The invention relates to medicine and pharmacology, and can be used in surgery for wound healing, including long nonhealing chronic wounds and trophic ulcers, refractory to treatment by traditional means.

Currently, much attention is paid to the development of drug (and beauty) of products based on natural sorbents: zeolites and clays. So, in [1] described dry facial mask for skin care based on porous fine sorbent: zeolite or clay, or other containing the bacteriostatic and other additives.

Cons: the tool is applicable only to cleanse the surface of conditionally healthy skin, and not wound surface, inseminated different microflora.

Closest to the claimed means is considered "Healing tool" [2 - prototype]. This liniment containing as active substance zeolite Golynskogo field and lanolin basis, in the ratio of 1:4, which in laboratory animals (rats) on the 7th day saw the emergence of epithelial wedge, on the 14th - a significant increase in the degree of the covering epithelium of the wound surface. Complete wound healing was observed on the 21st day.

Disadvantages:

- duration and different efficacy of treatment of wounds with a high degree of bacterial contamination;

hydrophobin is here song adversely affecting the condition of the wound in the first phase of wound process;

a slow - speed cleansing wounds from infection and necrotic tissue due to disorders of gas exchange, limiting the supply of oxygen to the wound. It promotes the growth of wound infection, increasing the duration of the first phase and treatment in General.

The development of the proposed drug solves the problem of creating an effective treatment, with higher antibacterial properties, namely the modified silver zeolite.

To obtain the claimed funds used zeolite Golynskogo field, containing, according to [2], parts: SiO2- 66,5; Al2About3to 12.5, as well as Ti, Mn, Mo, Cu, Zn, Pb, Sn, Be, Sr, BA trace from 0.0005 to 0.13 concerns

Finely ground zeolite impregnated with a solution of silver salts and then dried. The result is a powder of zeolite, which contains the external and internal surfaces of the particles of metallic silver. The concentration of Ag particles on the surface of the zeolite depends on the technological parameters of the synthesis process and may vary depending on the nature of the problem being solved.

A characteristic feature of the so prepared drugs is the small particle size, which, according to ASDA, MMWR is 17-20. High specific surface of particles of this size provides a greater area of contact with the bacterial environment, which greatly increases the efficiency of the modified silver zeolite to pathogens.

To test the effectiveness of the treatment of infected wounds was selected zeolite modified with 0.1 to 0.4 wt%. Ag, as the most acceptable for a wide of surgical practice and from the point of view of the cost of the medication.

To test the effectiveness of the treatment of infected wounds was selected zeolite modified with 0.1 to 0.4 wt%. Ag, as the most acceptable for a wide of surgical practice and from the point of view of the cost of the medication.

Application of fine silver to the surface of the zeolite brings nonspecific antimicrobial, anti-inflammatory activity of the claimed therapeutic agent.

Having non-specific action level during colonization processes of the cell, silver blocking of sulfhydryl groups of the enzyme systems of pathogenic microorganisms. In addition, interacting with the molecules of nucleic acids, silver leads to inhibition of growth and reproduction of microorganisms. Particles of zeolite, on the background of its high sorption and ion-exchange properties, at the expense of primary and secondary porosity increase the area of the active interaction of deposited silver and wound content. This reduces the total amount of silver due to more fully engage in the wound is eacli. Sorption of wound, microorganisms modified zeolite promotes neutralization and subsequent removal of toxic products from the wound.

Preclinical testing of the proposed drug was carried out on rats breed Wister, whose treatment was started on the 6th day, i.e. after the wounds Autonomous developed an infectious process (suppuration). The results of bacteriological analysis are summarized in table 1.

The treatment was performed by application of a thin layer of powder of the proposed drug on the surface of the wound for the purpose of its detoxification and disinfection.

For the 9th day of treatment, there was complete cleaning of the wound and the beginning of the development of granulation tissue, regional epithelialization. Moreover, this effect was observed in the presence of a special device (fixing and insulating rings)to prevent contact of the wound with the environment.

In parallel studies with application for the treatment of animals powder original zeolite Golynskogo field showed that the total colonization of microflora wounds from falling below critical (100000 microbes/1 g tissue) in just 14 days, which corresponds exactly to the effect of treatment on the prototype.

Experimental by the positive result of the treatment of infected wounds of silver-containing zeolite is allowed to use it in chirurgiche is some practice at the regional hospital of Novosibirsk. Treated 7 patients, and all achieved complete wound healing without complications and recurrence of infection.

Example 1. Patient K., 23 years old, with diagnosis: fracture of cuboid bone of left foot, necrosis of soft tissue, with the formation of long-existing (2.5 months) infected wounds, on the background of the compression-ishemicheskoi polyneuropathy left lower extremity.

Conducted traditional methods of treatment using known antiseptics and multicomponent ointments did not lead to the healing of wounds (3×2.5 cm). Increased risk of contact of the damaged bone osteomyelitis. Time orthopedic surgery was postponed. After the application of the modified silver zeolite - within 10 days of the formation of the scab and the healing proceeded without infectious complications.

Example 2. Patient K., 62 years of age, with a diagnosis of diabetes mellitus, type 2, subcompensated, chronic trophic ulcer of the right tibia. The duration of the presence of ulcers 4 months.

Standard combined treatment with local application of ointment compositions without any visible effect. Ulcer in 1 stage of wound process with constant scant purulent discharge. The application of silver form of zeolite decrease of discharge, with the subsequent formation of a scab (10-14 days). Healing by second intention without infectious complications is s.

Example 3. Patient R., 69 years of age, with a diagnosis of erysipelas shoulder, bolesno-necrotic form, after how agressively to debride.

Made autodermoplasty, intraoperative, donor wound in the thigh, sizes 8 to 14 inches, made applique silver powder form of the zeolite. Without further manipulation, the formation of a dense scab over the entire surface of the wound, the need for subsequent dressings donor wound was not healing without secondary infection.

Example 4. Patient, 30 years of age, with a diagnosis of cellulitis of the lower third of the right tibia.

After opening, drainage was performed ligation with multicomponent water-soluble ointments. In terms of soft tissue deficit emerged chronic weeping ulcer (3×2 cm). When going on a dressing with silver form of zeolite happened drying ulcers with the formation of a scab and wound healing by second intention.

Example 5. Patient K., 35 years old, with a diagnosis of immature fistula of large intestine, after multiple operations on the intestines.

In the result of the corrosive action of the intestinal chyme, and forced use lamblasting shrinkage wound edges, formed a vast weeping erosions of the skin of the abdominal wall. Supported release of chyme, they were an additional source of infection, as well as the source of the om expressed the pain of the patient. After conducting applications of zeolite composition is reduction of pain, 3 days in the formation of a protective scab over erosions and further healing “under the scab”.

Example 6. Patient P., 72 years of age, with a diagnosis of postthrombotic syndrome, chronic venous insufficiency stage 3 chronic ulcer of the lower third of the left tibia.

Treatment in the previous steps without any visible effect. Attempts to conduct the wound process in the regeneration phase had no lasting effect. The application of silver forms of zeolites in the complex treatment is to reduce symptoms of inflammation, regional scab formation with particles of the zeolite with the underlying areas of the regional epithelialization. Discharged for outpatient monitoring, continued local treatment of Ag-form zeolite.

Example 7. Patient C., 17 years old, with diagnosis; furunculosis, relapsing course, boils right thigh, gluteal region, the left forearm.

After opening lesions (wounds 2×2 cm) was made applique silver form of zeolite on the wound. Achieved cleansing wounds (3, 4 days) without further infection, healing by second intention, recovery.

Examples of the use of zeolite modified with silver, in patients with a variety of suppurative diseases of soft tissues witness Tvout about its positive influence on the course of the wound process in the presence of infection. The use of this sorption and antibacterial active agent after the execution of the operational phase of treatment allowed:

1. To form local conditions in the wound, contributed to the favorable course of the wound process. The time change of the phases of wound healing was consistent with physiological.

2. To avoid secondary infectious complications (progression, disseminate or secondary infection).

3. To simplify and reduce quantitatively manipulation in the wound, which is important for the recovery of subjective patient comfort.

4. To reduce the period of stay of the patient in the hospital. When comparing the cost of treatment using other means of local application of economic benefit is achieved by acceleration term costly patient's stay in hospital. Also reduced the total period of disability in this disease.

Thus, the claimed means-tested on patients, is an effective treatment for various infected wounds, including long-term, not reacting in a few months for treatment by known means. It does not cause allergies, has no contraindications, it has high swelling, sorption, ion exchange and anti-inflammatory properties.

Sources of information

1. RU patent 2142757, the L. A 61 K 7/48, BI 35/94.

2. RU patent 2143908, CL. A 61 K 33/00, BI 1/2000, prototype.

Table 1

The qualitative composition of the microflora of the RAS in the development of local purulent process
View microfloraThe degree of contamination (ICRI. phone 1 gr. fabric)Frequency of detection (%)
Only4,3/106100%
GramThe genus Enterococcus (faecium, haemolyt., anhaemolyt.)1/10687%
The genus Staphylococcus (aureys, haemolyt., anhaemolyt., saprophytic.,faecalis)2/10523%
Genus Streptococcys (haemolt., anhaemolyt., faecalis)6/10617%
Only1,1/10690%
GramGenus Preudomonas5,5/10536%
The genus Proteus (vulgaris, mirabilis)3,1/10524%
Genus lebsilla (pheumonia)1,9/1047%
Genus Esherichia (coli)6,8/1067%
Only3,9/10665%

For the treatment of infected wounds, stereometric Golynskogo field, characterized in that it is a powder of zeolite modified with silver in an amount of 0.1-0.4 wt.% with particle sizes 17-20.



 

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9 cl, 6 dwg, 6 ex

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